{"id":84744,"date":"2019-04-17T00:00:50","date_gmt":"2019-04-17T03:15:32","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/84744\/"},"modified":"2019-04-17T11:15:34","modified_gmt":"2019-04-17T03:15:34","slug":"a3f853aa35","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/84744\/","title":{"rendered":"\u3010\u6709\u673a\u3011\u56db\u5ddd\u5927\u5b66\u738b\u5929\u5229\u8bfe\u9898\u7ec4Angew. Chem.\uff1a\u9996\u6b21\u5b9e\u73b0\u5b63\u93fb\u76d0\u50ac\u5316\u7684\u56db\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7\u4e0d\u5bf9\u79f0\u5408\u6210"},"content":{"rendered":"
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\"\u3010\u6709\u673a\u3011\u56db\u5ddd\u5927\u5b66\u738b\u5929\u5229\u8bfe\u9898\u7ec4Angew.<\/span><\/span><\/a><\/p>\n


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\u6c2e\u6742\u73af\u4e19\u70f7\u7ed3\u6784\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\u548c\u624b\u6027\u533b\u836f\u5206\u5b50\u4e4b\u4e2d\uff0c\u8fd1\u5e74\u6765\u624b\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u884d\u751f\u7269\u7684\u9ad8\u9009\u62e9\u6027\u5408\u6210\u53d7\u5230\u5316\u5b66\u5bb6\u4eec\u5173\u6ce8\u3002Wulff\u548cMaruoka\u7b49\u7814\u7a76\u5c0f\u7ec4\u53d1\u5c55\u4e86\u5e03\u6717\u65af\u7279\u9178\u50ac\u5316\u4e9a\u80fa\u548c\u03b1-\u91cd\u6c2e\u9178\u916f\u7684\u73af\u5316\u53cd\u5e94\u5b9e\u73b0\u4e86\u4e8c\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7\u5206\u5b50\u7684\u9ad8\u6548\u6784\u5efa (J. Am. Chem. Soc<\/em>., 2009<\/strong>, 131<\/em>, 15615\uff1b J. Am. Chem. Soc<\/em>., 2008<\/strong>, 130<\/em>, 14380\uff1bJ. Am. Chem. Soc<\/em>., 2011<\/strong>, 133<\/em>, 9730)\u3002\u7136\u800c\uff0c\u4e09\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u5408\u7269\u7684\u4e0d\u5bf9\u79f0\u5408\u6210\u4f8b\u5b50\u5374\u5f88\u5c11 (K. Maruoka*, J. Am. Chem. Soc<\/em>., 2011<\/strong>, 133<\/em>, 9730; B. M. Trost*, Angew. Chem. Int. Ed.<\/em>, 2017<\/strong>, 56<\/em>, 2440)\uff1b\u800c\u56db\u53d6\u4ee3\u7684\u6c2e\u6742\u73af\u4e19\u70f7\u884d\u751f\u7269\u7684\u4e0d\u5bf9\u79f0\u5408\u6210\u4f8b\u5b50\u81f3\u4eca\u672a\u89c1\u62a5\u9053\uff0c\u4f9d\u7136\u662f\u4e0d\u5bf9\u79f0\u5408\u6210\u5316\u5b66\u7814\u7a76\u7684\u6311\u6218\u4e4b\u4e00\u3002<\/p>\n


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\u56db\u5ddd\u5927\u5b66<\/strong>\u5316\u5b66\u5b66\u9662\u7684\u9752\u5e74\u5343\u4eba\u738b\u5929\u5229<\/strong>\u6559\u6388\u8bfe\u9898\u7ec4\u81f4\u529b\u4e8e\u53d1\u5c55\u65b0\u578b\u624b\u6027\u5b63\u93fb\u76d0\u53ca\u76f8\u5173\u50ac\u5316\u4f53\u7cfb\u548c\u4e0d\u5bf9\u79f0\u5408\u6210\u65b0\u65b9\u6cd5\u5b66\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7814\u7a76\u80cc\u666f\uff0c\u8be5\u8bfe\u9898\u7ec4\u5229\u7528\u5929\u7136\u6c28\u57fa\u9178\u884d\u751f\u7684\u67d4\u6027\u9aa8\u67b6-\u53cc\u529f\u80fd\u624b\u6027\u5b63\u93fb\u76d0\u50ac\u5316\u5242\uff0c\u9996\u6b21\u5b9e\u73b0\u4e86\u56db\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7\u884d\u751f\u7269\u7684\u9ad8\u6548\u9ad8\u9009\u62e9\u6027\u4e0d\u5bf9\u79f0\u5408\u6210<\/strong>\uff0c\u8be5\u50ac\u5316\u65b9\u6cd5\u540c\u6837\u9002\u7528\u4e8e\u4e8c\u53d6\u4ee3\u548c\u4e09\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7<\/strong>\u7684\u9ad8\u6548\u4e0d\u5bf9\u79f0\u5408\u6210\uff08\u56fe1\uff09\u3002<\/p>\n

\"\u3010\u6709\u673a\u3011\u56db\u5ddd\u5927\u5b66\u738b\u5929\u5229\u8bfe\u9898\u7ec4Angew.<\/p>\n

\u56fe1. \u624b\u6027\u5b63\u93fb\u76d0\u50ac\u5316\u4e0d\u5bf9\u79f0\u5408\u6210\u56db\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7\u884d\u751f\u7269<\/span><\/p>\n


<\/p>\n

\u7ecf\u8fc7\u4e00\u7cfb\u5217\u6761\u7b5b\u9009\uff0c\u4f5c\u8005\u53d1\u73b0\u4ee5\u624b\u6027\u4e8c\u80bd\u5b63\u93fb\u76d0P<\/strong>\u4e3a\u50ac\u5316\u5242\u548cK3<\/sub><\/span>PO4<\/sub><\/span>\u00b77H2<\/sub><\/span>O (4.0 equiv.) \u4e3a\u78b1\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u73af\u72b6\u4e9a\u80fa\u548c\u03b1-\u5364\u4ee3\u916e\u7684aza-Darzens\u53cd\u5e94\uff0c\u5e76\u4ee593% yield\u548c>99% ee\u83b7\u5f97\u6c2e\u6742\u73af\u4e19\u70f7\u4ea7\u7269 (3a<\/strong>)\u3002\u5728\u6700\u4f18\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u9996\u5148\u5c1d\u8bd5\u4e86\u4e09\u53d6\u4ee3\u548c\u4e8c\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u5408\u7269\u7684\u4e0d\u5bf9\u79f0\u5408\u6210\uff0c\u5e76\u8003\u5bdf\u4e86\u5e95\u7269\u7684\u666e\u9002\u6027\u3002\u4ed6\u4eec\u53d1\u73b0\u5728\u6784\u5efa\u4e09\u53d6\u4ee3\u548c\u4e8c\u53d6\u4ee3\u73af\u4e19\u70f7\u7684\u53cd\u5e94\u4e2d\uff0c\u4e9a\u80fa\u5e95\u7269\u4e0a\u53d6\u4ee3\u57fa\u7535\u5b50\u6548\u5e94\u548c\u4f4d\u963b\u6548\u5e94\u5bf9\u53cd\u5e94\u6d3b\u6027\u548c\u7acb\u4f53\u9009\u62e9\u6027\u5747\u6ca1\u6709\u5f71\u54cd\u3002\u540c\u65f6\uff0c\u4e00\u7cfb\u5217\u542b\u6709\u7ed9\u7535\u5b50\u57fa\u3001\u5438\u7535\u5b50\u53d6\u4ee3\u57fa\u3001\u591a\u53d6\u4ee3\u57fa\u3001\u6742\u73af\u53d6\u4ee3\u57fa\u3001\u4ee5\u53ca\u7a20\u82b3\u73af\u7684\u03b1-\u5364\u4ee3\u916e\u5747\u80fd\u591f\u53c2\u4e0e\u53cd\u5e94\u5e76\u83b7\u5f97\u76f8\u5e94\u7684\u591a\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7\u4ea7\u7269\uff08up to >99.9% ee\uff09\u3002<\/p>\n

\"\u3010\u6709\u673a\u3011\u56db\u5ddd\u5927\u5b66\u738b\u5929\u5229\u8bfe\u9898\u7ec4Angew.<\/p>\n

\u56fe2. \u4e09\u53d6\u4ee3\u548c\u4e8c\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7\u884d\u751f\u7269\u7684\u4e0d\u5bf9\u79f0\u5408\u6210<\/span><\/p>\n


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\u4f5c\u8005\u5728\u4e0a\u8ff0\u6700\u4f18\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86\u5177\u6709\u6311\u6218\u6027\u7684\u56db\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7\u7684\u9ad8\u6548\u4e0d\u5bf9\u79f0\u5408\u6210\uff0c\u5e76\u8003\u5bdf\u4e86\u5e95\u7269\u7684\u666e\u9002\u6027\u3002\u4ed6\u4eec\u53d1\u73b0\u4e00\u7cfb\u5217\u73af\u72b6\u916e\u4e9a\u80fa\u548c\u5404\u79cd\u7ed3\u6784\u7684\u03b1-\u5364\u4ee3\u916e\u90fd\u80fd\u53c2\u4e0e\u8be5\u53cd\u5e94\uff0c\u751f\u6210\u76f8\u5e94\u7684\u56db\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7\u4ea7\u7269\uff0c\u5e76\u53d6\u5f97\u6709\u4f18\u79c0\u7684\u4ea7\u7387\u548c\u7acb\u4f53\u9009\u62e9\u6027\uff08up to > 99.9% ee\uff09\u3002<\/p>\n

\"\u3010\u6709\u673a\u3011\u56db\u5ddd\u5927\u5b66\u738b\u5929\u5229\u8bfe\u9898\u7ec4Angew.<\/p>\n

\u56fe3. \u56db\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7\u884d\u751f\u7269\u7684\u4e0d\u5bf9\u79f0\u5408\u6210<\/span><\/p>\n


<\/p>\n

\u968f\u540e\uff0c\u4f5c\u8005\u7814\u7a76\u4e86\u514b\u7ea7\u89c4\u6a21\u53cd\u5e94\u548c\u4ea7\u7269\u884d\u751f\u5408\u6210\uff0c\u53d1\u73b0\u4e0a\u8ff0\u50ac\u5316\u53cd\u5e94\u80fd\u591f\u88ab\u653e\u5927\u5230\u514b\u7ea7\u89c4\u6a21\u5408\u6210\uff0c\u5176\u4ea7\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4fdd\u6301\uff1b\u57fa\u4e8e\u4e0a\u8ff0\u50ac\u5316\u65b9\u6cd5\uff0c\u4f5c\u8005\u5408\u6210\u4e86\u5177\u6709\u6f5c\u5728\u6291\u5236HIV-1\u7684\u6d3b\u6027\u624b\u6027\u5316\u5408\u7269\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u901a\u8fc7\u5b9e\u9a8c\u548cDFT\u7406\u8bba\u8ba1\u7b97\u5bf9\u8be5\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5e76\u53d1\u73b0\u50ac\u5316\u5242\u4e0e\u5e95\u7269\u4e4b\u95f4\u7684\u53ccH-\u952e\u4f5c\u7528\u662f\u8be5\u53cd\u5e94\u624b\u6027\u8bf1\u5bfc\u7684\u672c\u8d28\uff08\u56fe4\uff09\u3002<\/p>\n

\"\u3010\u6709\u673a\u3011\u56db\u5ddd\u5927\u5b66\u738b\u5929\u5229\u8bfe\u9898\u7ec4Angew.<\/p>\n

\u56fe4. \u53cd\u5e94\u8fc7\u6e21\u6001<\/span><\/p>\n


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\u7efc\u4e0a\uff0c\u738b\u5929\u5229\u6559\u6388\u56e2\u961f\u5229\u7528\u6c28\u57fa\u9178\u884d\u751f\u7684\u624b\u6027\u4e8c\u80bd-\u5b63\u93fb\u76d0\u76f8\u8f6c\u79fb\u50ac\u5316aza-Darzens\u53cd\u5e94\u7b56\u7565\uff0c\u9996\u6b21\u5b9e\u73b0\u4e86\u56db\u53d6\u4ee3\u6c2e\u6742\u73af\u4e19\u70f7\u884d\u751f\u7269\u7684\u9ad8\u6548\u9ad8\u9009\u62e9\u6027\u5408\u6210\uff0c\u8fd9\u4e00\u7814\u7a76\u6210\u679c\u8fd1\u671f\u53d1\u8868\u4e8eAngew. Chem. Int. Ed.<\/em><\/strong><\/span>\uff0c\u56db\u5ddd\u5927\u5b66\u5316\u5b66\u5b66\u96622018\u7ea7\u535a\u58eb\u751f\u6f58\u5efa\u79d1<\/strong>\u548c2018\u7ea7\u7855\u58eb\u751f\u5434\u4f73\u9e3f<\/strong>\u4e3a\u5171\u540c\u4e00\u4f5c\u3002<\/p>\n


<\/p>\n

\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762<\/span>\uff09\uff1a<\/span><\/p>\n

\"\u3010\u6709\u673a\u3011\u56db\u5ddd\u5927\u5b66\u738b\u5929\u5229\u8bfe\u9898\u7ec4Angew.<\/p>\n

Highly Enantioselective Synthesis of Fused Tri\u2010 and Tetra\u2010substituted Aziridines via Bifunctional Phosphonium Salt\u2010Catalyzed Aza\u2010Darzens Reaction<\/span><\/p>\n

Jianke Pan, Jia-Hong Wu, Hongkui Zhang, Xiaoyu Ren, Jian-Ping Tan, Lixiang Zhu, Hong-Su Zhang Chunhui Jiang, Tianli Wang<\/span><\/p>\n

Angew. Chem. Int. Ed<\/span><\/em>., 2019<\/strong>, DOI:<\/span> 10.1002\/anie.201900613<\/span><\/p>\n


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\"\u3010\u6709\u673a\u3011\u56db\u5ddd\u5927\u5b66\u738b\u5929\u5229\u8bfe\u9898\u7ec4Angew.<\/span><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\"\u3010\u6709\u673a\u3011\u56db\u5ddd\u5927\u5b66\u738b\u5929\u5229\u8bfe\u9898\u7ec4Angew.<\/p>\n

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\u672c\u6587\u7248\u6743\u5c5e\u4e8eX-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/p>\n


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\u957f\u6309<\/strong><\/span>\u4e0b\u56fe\u8bc6\u522b\u56fe\u4e2d\u4e8c\u7ef4\u7801<\/strong>\uff0c\u8f7b\u677e\u5173\u6ce8\u6211\u4eec\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u3010\u6709\u673a\u3011\u56db\u5ddd\u5927\u5b66\u738b\u5929\u5229\u8bfe\u9898\u7ec4Angew.<\/p>\n<\/section>\n<\/section>\n

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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587<\/span>\u201d\uff0c\u67e5\u770b \u5316\u5b66 \u2022 \u6750\u6599 <\/strong>\u9886\u57df\u6240\u6709\u6536\u5f55\u671f\u520a<\/span><\/span><\/p>\n

\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u6c2e\u6742\u73af\u4e19\u70f7\u7ed3\u6784\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\u548c\u624b\u6027\u533b\u836f\u5206\u5b50\u4e4b\u4e2d\uff0c\u8fd1\u5e74\u6765\u624b\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u884d\u751f\u7269\u7684\u9ad8\u9009\u62e9\u6027\u5408\u6210\u53d7\u5230\u5316\u5b66\u5bb6\u4eec\u5173\u6ce8\u3002 […]<\/p>\n","protected":false},"author":1,"featured_media":84745,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/84744"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=84744"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/84744\/revisions"}],"predecessor-version":[{"id":84755,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/84744\/revisions\/84755"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/84745"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=84744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=84744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=84744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}