{"id":84876,"date":"2019-04-16T00:00:50","date_gmt":"2019-04-17T03:16:29","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/84876\/"},"modified":"2019-04-17T11:16:31","modified_gmt":"2019-04-17T03:16:31","slug":"c79fd2bda6","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/84876\/","title":{"rendered":"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;text-align: center;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657607803&amp;idx=2&amp;sn=0ae58a9d5ee3da4d5b7e6428662d19f8&amp;chksm=80f7c9abb78040bd88223e7ce0e1ff884b265e03a57b28d9a8bbb273b7dc8ebf92414828b4a1&amp;scene=21#wechat_redirect\" target=\"_blank\"  ><span style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><img class=\"\"          style=\"height: 116px;width: 556px;top: auto;left: auto;right: auto;bottom: auto;margin: 0px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/4-1555470989.jpeg\" alt=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\" title=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\"  \/><\/span><\/span><\/a><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u542b\u6709\u6c28\u7532\u57fa\u7247\u6bb5\u7684\u624b\u6027\u5206\u5b50\u7ed3\u6784\u5e7f\u6cdb\u5b58\u5728\u4e8e\u8bb8\u591a\u5929\u7136\u4ea7\u7269\u3001\u751f\u7269\u78b1\u548c\u836f\u7269\u5206\u5b50\u3002\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u53ef\u4ee5\u76f4\u63a5\u5c06\u6c28\u7532\u57fa\u7247\u6bb5\u5f15\u5165\u5230\u6709\u673a\u5c0f\u5206\u5b50\u4e2d\uff0c\u662f\u4e00\u7c7b\u9ad8\u6548\u5408\u6210\u542b\u6709\u6c28\u7532\u57fa\u5316\u5408\u7269\u7684\u6709\u6548\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u7531\u4e8e\u6c28\u7532\u57fa\u7247\u6bb5\u7684\u7a7a\u95f4\u4f4d\u963b\u5c0f\u3001\u6d3b\u6027\u9ad8\u3001\u7acb\u4f53\u9009\u62e9\u6027\u63a7\u5236\u96be\uff0c\u56e0\u6b64\u7acb\u4f53\u9009\u62e9\u6027\u63a7\u5236\u7684\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u4e00\u76f4\u662f\u4e0d\u5bf9\u79f0\u50ac\u5316\u9886\u57df\u7684\u70ed\u70b9\u548c\u96be\u70b9\u4e4b\u4e00\u3002\u8fd1\u5e74\u6765\uff0c\u4eba\u4eec\u901a\u8fc7\u624b\u6027\u80fa\u6216\u624b\u6027Lewis\u9178\u6d3b\u5316\u7fb0\u57fa\u5316\u5408\u7269\u5b9e\u73b0\u4e86\u919b\u6216\u916e\u03b1\u4f4d\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u3002\u8fd9\u4e9b\u50ac\u5316\u7b56\u7565\u90fd\u662f\u57fa\u4e8e\u5bf9\u4eb2\u6838\u8bd5\u5242\u7684\u4e0d\u5bf9\u79f0\u50ac\u5316\u5b9e\u73b0\u53cd\u5e94\u7684\u9009\u62e9\u6027\u63a7\u5236\uff0c\u56e0\u800c\u9700\u8981\u5e95\u7269\u5177\u6709\u6f5c\u5728\u7684\u53ef\u914d\u4f4d\u57fa\u56e2\u6216\u8005\u53ef\u6d3b\u5316\u4f4d\u70b9\uff08Scheme&nbsp;1a\uff09\u3002\u4e5f\u6b63\u662f\u8fd9\u4e00\u539f\u56e0\uff0c\u4f7f\u5f97\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u7684\u4eb2\u7535\u5e95\u7269\u7c7b\u578b\u5c40\u9650\u4e8e\u919b\u3001\u916e\u53ca1,3-\u4e8c\u7fb0\u57fa\u5316\u5408\u7269\uff0c\u800c\u9488\u5bf9\u916f\u57fa\u03b1\u4f4d\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u4e00\u76f4\u6ca1\u80fd\u5b9e\u73b0\u3002<\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/2-1555470989.jpeg\" alt=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\" title=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"color: rgb(136, 136, 136);font-size: 15px;\">Scheme 1. Asymmetric Induction Models in Mannich-type Aminomethylation Reaction<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong>\u4e2d\u5c71\u5927\u5b66\u836f\u5b66\u9662<\/strong>\u7684<strong>\u80e1\u6587\u6d69<\/strong>\u6559\u6388\u8bfe\u9898\u7ec4\u957f\u671f\u4ece\u4e8b\u57fa\u4e8e\u6d3b\u6cfc\u53f6\u7acb\u5fb7\/\u4e24\u6027\u79bb\u5b50\u5bf9\u4e2d\u95f4\u4f53\u6355\u6349\u7684\u591a\u7ec4\u5206\u65b0\u53cd\u5e94\u7814\u7a76\uff0c\u901a\u8fc7\u5171\u50ac\u5316\u7b56\u7565\u53ef\u4ee5\u5b9e\u73b0\u4e00\u7cfb\u5217\u03b1,\u03b2-\u53cc\u5b98\u80fd\u5316\u624b\u6027\u7fa7\u9178\u7c7b\u5316\u5408\u7269\u7684\u5feb\u901f\u3001\u9ad8\u6548\u6784\u5efa\uff08Scheme&nbsp;1c\uff09\u3002\u8be5\u53cd\u5e94\u5177\u6709\u64cd\u4f5c\u7b80\u5355\u3001\u539f\u5b50\u7ecf\u6d4e\u6027\u3001\u6210\u952e\u6548\u7387\u9ad8\u3001\u4ea7\u7269\u7ed3\u6784\u591a\u6837\u6027\u7b49\u7279\u70b9\u3002\u5176\u4e3b\u8981\u7814\u7a76\u5de5\u4f5c\u53d1\u8868\u5728\uff1a<em>Nat.&nbsp;Chem<\/em>.,&nbsp;<strong>2012<\/strong>,&nbsp;<em>7<\/em>,&nbsp;733;&nbsp;<em>Angew.&nbsp;Chem.&nbsp;Int.&nbsp;Ed<\/em>.,&nbsp;<strong>2013<\/strong>,&nbsp;<em>125<\/em>,&nbsp;13598;&nbsp;<em>Angew.&nbsp;Chem.&nbsp;Int.&nbsp;Ed.<\/em>,&nbsp;<strong>2013<\/strong>,&nbsp;<em>52<\/em>,&nbsp;9289;&nbsp;<em>Acc.&nbsp;Chem.&nbsp;Res<\/em>.,&nbsp;<strong>2013<\/strong>,&nbsp;<em>46<\/em>,&nbsp;2427;&nbsp;<em>Angew.&nbsp;Chem.&nbsp;Int.&nbsp;Ed<\/em>.,&nbsp;<strong>2014<\/strong>,&nbsp;<em>53<\/em>,&nbsp;13136;&nbsp;<em>Angew.&nbsp;Chem.&nbsp;Int.&nbsp;Ed.<\/em>,&nbsp;<strong>2014<\/strong>,&nbsp;<em>53<\/em>,&nbsp;13098;&nbsp;<em>Nat.&nbsp;Commun.<\/em>,&nbsp;<strong>2015<\/strong>,&nbsp;<em>6<\/em>,&nbsp;5801;<em>&nbsp;Sci.&nbsp;Adv<\/em>.,&nbsp;<strong>2017<\/strong>,&nbsp;<em>3<\/em>,&nbsp;e1602467\u7b49\u3002\u8fd1\u671f\uff0c\u80e1\u6587\u6d69\u6559\u6388\u548c\u5f90\u65b0\u82b3\u6559\u6388\u5408\u4f5c\uff0c\u5229\u7528\u7094\u70c3\u4f5c\u4e3a\u91d1\u5c5e\u5361\u5bbe\u524d\u4f53\uff0c\u901a\u8fc7\u91d1(I)\/\u624b\u6027\u81a6\u9178\u5171\u50ac\u5316\u7684\u591a\u7ec4\u5206\u53cd\u5e94\u9ad8\u6548\u5408\u6210\u4e86\u624b\u6027\u4e8c\u6c22\u544b\u5583-3-\u916e\u884d\u751f\u7269\uff08<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657599539&amp;idx=3&amp;sn=b22c242387194b175e86d7a8e1ab62a7&amp;chksm=80f7e9e3b78060f5824b5537413be7d8e27d5758a1a97c57d3b88851b2179d4ffeb31719d97b&amp;scene=21#wechat_redirect\" target=\"_blank\"  >\u70b9\u51fb\u67e5\u770b\u539f\u6587<\/a>;&nbsp;<em>Angew.&nbsp;Chem.&nbsp;Int.&nbsp;Ed<\/em>.,&nbsp;<strong>2018<\/strong>,&nbsp;<em>57<\/em>,&nbsp;17200\uff09\u3002<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u5728\u6b64\u7814\u7a76\u57fa\u7840\u4e0a\uff0c\u4e3a\u4e86\u53d1\u5c55\u9ad8\u7acb\u4f53\u9009\u62e9\u6027\u63a7\u5236\u7684\u6c28\u7532\u57fa\u5316\u53cd\u5e94\uff0c\u89e3\u51b3\u6d3b\u6cfc\u4e9a\u7532\u57fa\u4e9a\u94f5\u76d0\u53cd\u5e94\u9009\u62e9\u6027\u63a7\u5236\u96be\u7684\u95ee\u9898\u3002\u8fd1\u65e5\uff0c<strong>\u80e1\u6587\u6d69<\/strong>\u6559\u6388\u548c<strong>\u5f90\u65b0\u82b3<\/strong>\u6559\u6388\u5229\u7528\u624b\u6027\u9634\u79bb\u5b50\u5bfc\u5411\u7684\u50ac\u5316\u7b56\u7565\uff08Scheme&nbsp;1b\uff09\uff0c<strong>\u901a\u8fc7\u751f\u6210\u624b\u6027\u79bb\u5b50\u5bf9\u7684\u65b9\u5f0f\u6d3b\u5316\u4e9a\u7532\u57fa\u4e9a\u94f5\u76d0\uff0c\u5b9e\u73b0\u4e86\u916f\u57fa\u03b1\u4f4d\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94<\/strong>\uff0c\u4ece\u672c\u8d28\u4e0a\u7a81\u7834\u4e86\u8fd9\u7c7b\u53cd\u5e94\u4eb2\u7535\u8bd5\u5242\u5e95\u7269\u7c7b\u578b\u5c40\u9650\u6027\u7684\u95ee\u9898\u3002\u7814\u7a76\u5de5\u4f5c\u5229\u7528[PdCl(\u03b7<span style=\"font-size: 14px;\"><sup>3<\/sup><\/span>-C<span style=\"font-size: 14px;\"><sub>3<\/sub><\/span>H<span style=\"font-size: 14px;\"><sub>5<\/sub><\/span>)]<span style=\"font-size: 14px;\"><sub>2<\/sub><\/span>\u548c\u624b\u60271,2,3,4,5-\u4e94\u916f\u57fa\u73af\u620a\u4e8c\u70ef\uff08CPCCP\uff09\u5171\u50ac\u5316\uff0c\u5b9e\u73b0\u4e86\u91cd\u6c2e\u5316\u5408\u7269\u3001\u82c4\u9187\u548c<em>N,O<\/em>-\u7f29\u919b\u80fa\u53c2\u4e0e\u7684\u4e0d\u5bf9\u79f0\u4e09\u7ec4\u5206\u53cd\u5e94\uff08Scheme&nbsp;1d\uff09\u3002\u8be5\u53cd\u5e94\u662f\u9996\u4f8b\u57fa\u4e8e\u7f9f\u57fa\u53f6\u7acb\u5fb7\u4e2d\u95f4\u4f53\u6355\u6349\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\uff0c\u5408\u6210\u4e86\u4e00\u7cfb\u5217\u5149\u5b66\u7eaf\u7684\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b2<span style=\"font-size: 14px;\"><sup>2<\/sup><\/span>-\u6c28\u57fa\u9178\u884d\u751f\u7269\uff08Scheme&nbsp;2\uff09\u3002<\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/3-1555470990.jpeg\" alt=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\" title=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">Scheme 2. Representative Examples of Asymmetric Aminomethylation Reaction<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u63a7\u5236\u5b9e\u9a8c\u7814\u7a76\uff0c\u5e76\u4e0e\u4e2d\u5c71\u5927\u5b66\u836f\u5b66\u9662\u7684\u5deb\u745e\u6ce2\u6559\u6388\u5408\u4f5c\uff0c\u5229\u7528DFT\u8ba1\u7b97\u7814\u7a76\u4e86\u53cd\u5e94\u7684\u673a\u7406\u548c\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u7684\u7acb\u4f53\u9009\u62e9\u6027\u63a7\u5236\u673a\u5236\u3002\u7814\u7a76\u8868\u660e\uff0c\u94af\u5361\u5bbe\u4e0e\u9187\u751f\u6210\u7684\u7f9f\u57fa\u53f6\u7acb\u5fb7\u4e2d\u95f4\u4f53\u5feb\u901f\u53d1\u751f\u5206\u5b50\u5185\u8d28\u5b50\u8fc1\u79fb\u8f6c\u5316\u6210\u70ef\u9187\u5f62\u5f0f\uff0c\u70ef\u9187\u662f\u771f\u6b63\u53c2\u4e0e\u53cd\u5e94\u7684\u4eb2\u6838\u7269\u79cd\u3002\u624b\u60271,2,3,4,5-\u4e94\u916f\u57fa\u73af\u620a\u4e8c\u70ef\uff08CPCCP\uff09\u9634\u79bb\u5b50\u4e00\u65b9\u9762\u901a\u8fc7\u9759\u7535\u4f5c\u7528\u529b\u4e0e\u4e9a\u7532\u57fa\u4e9a\u6c28\u76d0\u9633\u79bb\u5b50\u5f62\u6210\u7d27\u5bc6\u79bb\u5b50\u5bf9\uff0c\u53e6\u4e00\u65b9\u9762\u901a\u8fc7\u6c22\u952e\u4e0e\u70ef\u9187\u4e2d\u95f4\u4f53\u4f5c\u7528\uff0c\u4ece\u800c\u5b9a\u5411\u62c9\u8fd1\u4e24\u4e2a\u6d3b\u6cfc\u4e2d\u95f4\u4f53\u4e4b\u95f4\u7684\u8ddd\u79bb\uff0c\u5b9e\u73b0\u53cd\u5e94\u7684\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u63a7\u5236\uff08Scheme&nbsp;3\uff09\u3002<\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/7-1555470990.jpeg\" alt=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\" title=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">Scheme 3. DFT-calculated transition state structures for the formation of (<em>R<\/em>)-<strong>4a <\/strong>(<em>v<\/em><em>ia <\/em><strong>TS3-Re<\/strong>) and (<em>S<\/em>)-<strong>4a <\/strong>(<em>via <\/em><strong>TS3-Si<\/strong>).<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u76f8\u5173\u7ed3\u679c\u53d1\u8868\u5728<strong><em>J.&nbsp;Am.&nbsp;Chem.&nbsp;Soc.<\/em><\/strong>\u4e0a\uff0c\u4e2d\u5c71\u5927\u5b66\u836f\u5b66\u9662\u7684\u535a\u58eb\u540e<strong>\u5eb7\u6b63\u8f89<\/strong>\u548c<strong>\u738b\u6c38\u6052<\/strong>\u4e3a\u8be5\u8bba\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002<\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n<p><img class=\"rich_pages\"       style=\"text-align: left;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/1-1555470990.jpeg\" alt=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\" title=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">Asymmetric&nbsp;Counter-Anion-Directed&nbsp;Aminomethylation:&nbsp;<\/span><span style=\"font-size: 14px;\">Synthesis of Chiral&nbsp;\u03b2-Amino Acids via Trapping of&nbsp;an&nbsp;Enol&nbsp;Intermediate<\/span><\/p>\n<p><span style=\"font-size: 14px;\">Zhenghui Kang, Yongheng Wang, Dan Zhang, Ruibo Wu, Xinfang Xu and Wenhao Hu<\/span><\/p>\n<p><em><span style=\"font-size: 14px;\">J.&nbsp;Am.&nbsp;Chem.&nbsp;Soc.<\/span><\/em><span style=\"font-size: 14px;\">,&nbsp;<strong>2019<\/strong>,&nbsp;<em>141<\/em>,&nbsp;1473,&nbsp;DOI:&nbsp;10.1021\/jacs.8b12832<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><strong>\u80e1\u6587\u6d69\u6559\u6388\u7b80\u4ecb<\/strong><\/p>\n<p style=\"text-align: center;line-height: normal;\"><strong><br  \/><\/strong><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u80e1\u6587\u6d69\u535a\u58eb\uff0c\u4e2d\u5c71\u5927\u5b66\u836f\u5b66\u9662\u6559\u6388\u3001\u9662\u957f\uff0c\u5148\u540e\u5728\u56db\u5ddd\u5927\u5b66\u83b7\u5f97\u5b66\u58eb\u5b66\u4f4d\uff081987\uff09\u3001\u4e2d\u79d1\u9662\u6210\u90fd\u6709\u673a\u7814\u7a76\u6240\u83b7\u5f97\u7855\u58eb\u5b66\u4f4d\uff081990\uff0c\u5bfc\u5e08\uff1a\u848b\u8000\u5fe0\u7814\u7a76\u5458\uff09\u548c\u9999\u6e2f\u7406\u5de5\u5927\u5b66\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\uff081998\uff0c\u5bfc\u5e08\uff1a\u9648\u65b0\u6ecb\u9662\u58eb\uff09\uff0c\u968f\u540e\u5728\u7f8e\u56fd\u4e9a\u5229\u6851\u90a3\u5927\u5b66\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\uff081998-2002\uff09\uff0c\u4e4b\u540e\u5728\u7f8e\u56fdGenesoft\u548cBristol-Myers&nbsp;Squibb\u516c\u53f8\u62c5\u4efb\u9ad8\u7ea7\u7814\u7a76\u5458\uff0c\u4e8e2006\u5e74\u56de\u56fd\u52a0\u5165\u534e\u4e1c\u5e08\u8303\u5927\u5b66\uff0c\u4efb\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u5316\u5b66\u7cfb\u6559\u6388\uff0c2016\u5e748\u6708\u5168\u804c\u52a0\u5165\u4e2d\u5c71\u5927\u5b66\uff0c\u4efb\u6559\u6388\u3001\u836f\u5b66\u9662\u9662\u957f\uff1b\u5e7f\u4e1c\u7701\u201c\u73e0\u6c5f\u4eba\u624d\u8ba1\u5212\u201d\u521b\u65b0\u521b\u4e1a\u56e2\u961f\u5e26\u5934\u4eba\u3001\u5e7f\u4e1c\u7701\u624b\u6027\u5206\u5b50\u4e0e\u836f\u7269\u53d1\u73b0\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u4e3b\u4efb\uff082019\u8d77\uff09\uff1b\u76ee\u524d\u62c5\u4efb\u4e2d\u56fd\u5316\u5b66\u4f1a\u624b\u6027\u5316\u5b66\u4e13\u4e1a\u59d4\u5458\u4f1a\u3001\u4e0a\u6d77\u5e02\u836f\u5b66\u4f1a\u836f\u7269\u5316\u5b66\u4e13\u95e8\u59d4\u5458\u4f1a\u3001\u5e7f\u4e1c\u7701\u836f\u5b66\u4f1a\u5236\u836f\u5de5\u7a0b\u4e13\u4e1a\u59d4\u5458\u4f1a\u548c\u836f\u7269\u624b\u6027\u4e13\u59d4\u4f1a\u7b49\u5b66\u672f\u56e2\u4f53\u59d4\u5458\uff1b\u66fe\u83b7\u4e0a\u6d77\u5e02\u81ea\u7136\u79d1\u5b66\u4e00\u7b49\u5956\uff082016\uff09\u3001\u6559\u80b2\u90e8\u81ea\u7136\u79d1\u5b66\u4e8c\u7b49\u5956\uff082010\uff09\u3001\u6559\u80b2\u90e8\u201c\u957f\u6c5f\u5b66\u8005\u201d\u7279\u8058\u6559\u6388\u548c\u56fd\u5bb6\u767e\u5343\u4e07\u4eba\u624d\u5de5\u7a0b\u4eba\u9009\u3001\u6709\u7a81\u51fa\u8d21\u732e\u4e2d\u9752\u5e74\u4e13\u5bb6\u7b49\u56fd\u5185\u5916\u4e8c\u5341\u4f59\u9879\u5956\uff1b\u7814\u7a76\u65b9\u5411\u4e3b\u8981\u96c6\u4e2d\u5728\u6709\u673a\u5408\u6210\u65b9\u6cd5\u5b66\u3001\u4e0d\u5bf9\u79f0\u50ac\u5316\u3001\u591a\u7ec4\u5206\u53cd\u5e94\u3001\u65b0\u53d1\u548c\u836f\u7269\u5408\u6210\u5de5\u827a\u7b49\uff0c\u81f3\u4eca\u5df2\u5728<span style=\"font-size: 16px;\"><em>Nature&nbsp;Chemistry\u3001Nature&nbsp;Communications\u3001Science&nbsp;Advances\u3001J.&nbsp;Am.&nbsp;Chem.&nbsp;Soc.\u3001Angew.&nbsp;Chem.&nbsp;Int.&nbsp;Ed.<\/em><\/span>\u548c<span style=\"font-size: 16px;\"><em>J.&nbsp;Med.&nbsp;Chem.<\/em><\/span>\u7b49\u9876\u7ea7\u671f\u520a\u4e0a\u53d1\u8868\u8bba\u6587200\u4f59\u7bc7\uff0c\u5f15\u75285000\u4f59\u6b21\u3002<\/p>\n<p style=\"text-align: justify;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 13px;\">https:<\/span><span style=\"font-size: 13px;\">\/\/www.x-mol.com\/university\/faculty\/49984<\/span><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><strong>\u5f90\u65b0\u82b3\u6559\u6388\u7b80\u4ecb<\/strong><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u5f90\u65b0\u82b3\u535a\u58eb\uff0c\u4e2d\u5c71\u5927\u5b66\u836f\u5b66\u9662\u6559\u6388\uff0c\u5148\u540e\u5728\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u83b7\u5f97\u5b66\u58eb\u5b66\u4f4d\uff082001\uff09\u548c\u535a\u58eb\u5b66\u4f4d\uff082010\uff0c\u5bfc\u5e08\uff1a\u80e1\u6587\u6d69\u6559\u6388\uff09\uff0c\u968f\u540e\u5728\u7f8e\u56fd\u9a6c\u91cc\u5170\u5927\u5b66\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\uff082010-2014\uff09\uff1b\u4e4b\u540e\u4e8e2014\u5e749\u6708\u56de\u56fd\u52a0\u5165\u82cf\u5dde\u5927\u5b66\u6750\u5316\u90e8\u4efb\u6559\u6388\uff0c2015\u5e74\u5165\u9009\u4e2d\u7ec4\u90e8\u9752\u5e74\u5343\u4eba\u8ba1\u5212\uff0c2017\u5e74\u5165\u9009\u6c5f\u82cf\u7701\u7279\u8058\u6559\u6388\uff0c2019\u5e74\u52a0\u5165\u4e2d\u5c71\u5927\u5b66\u836f\u5b66\u9662\uff1b\u7814\u7a76\u65b9\u5411\u4e3b\u8981\u96c6\u4e2d\u5728\u4e0d\u5bf9\u79f0\u50ac\u5316\u3001\u91d1\u5c5e\u5361\u5bbe\u4e32\u8054\u53cd\u5e94\u3001\u5361\u5bbe\/\u7094\u70c3\u590d\u5206\u89e3\u53cd\u5e94\u3001\u624b\u6027\u836f\u7269\u5408\u6210\u7b49\uff0c\u81f3\u4eca\u5df2\u5728<span style=\"font-size: 16px;\"><em>Acc.&nbsp;Chem.&nbsp;Res.\u3001J.&nbsp;Am.&nbsp;Chem.&nbsp;Soc.\u3001Angew.&nbsp;Chem.&nbsp;Int.&nbsp;Ed.\u3001ACS&nbsp;Catalysis\u3001Chemical&nbsp;Science<\/em><\/span>\u548c<span style=\"font-size: 16px;\"><em>Organic&nbsp;Letters<\/em><\/span>\u7b49\u671f\u520a\u53d1\u8868\u8bba\u658770\u4f59\u7bc7\uff0c\u5f15\u75281000\u4f59\u6b21\u3002<\/p>\n<p style=\"text-align: justify;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/10-1555470991.jpeg\" alt=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\" title=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><br  \/><\/p>\n<section style=\"white-space: normal;\">\n<section class=\"Powered-by-XIUMI V5\" >\n<section class=\"\">\n<section class=\"\">\n<p style=\"text-align: center;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657608573&amp;idx=2&amp;sn=f2abf3b8761e88b92582e8dbb250d794&amp;chksm=80f7caadb78043bb6946c8de55a3263838240f4675f42a90bd1069a9fd16c028f5dfd5745b96&amp;scene=21#wechat_redirect\" target=\"_blank\"  ><span style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><img class=\"\"          style=\"height: 116px;width: 556px;top: auto;left: auto;right: auto;bottom: auto;margin: 0px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/5-1555470991.jpeg\" alt=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\" title=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\"  \/><\/span><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;line-height: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 25.6px;text-align: center;\"><img      style=\"font-size: 18px;background-color: rgb(255, 255, 255);line-height: 25.6px;width: 556px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/0-1555470991.png\" alt=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\" title=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\"  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section class=\"\" style=\"height: 16px;box-sizing: border-box;\">\n<section style=\"height: 15.9961px;width: 24px;float: left;border-top: 6px solid rgb(9, 158, 206);border-left: 6px solid rgb(9, 158, 206);border-right-color: rgb(9, 158, 206);border-bottom-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"height: 15.9961px;width: 24px;float: right;border-top: 6px solid rgb(9, 158, 206);border-right: 6px solid rgb(9, 158, 206);border-bottom-color: rgb(9, 158, 206);border-left-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<\/section>\n<section class=\"\" style=\"margin: -13px 3px;padding: 12px;border-width: 1px;border-style: solid;border-color: rgb(9, 158, 206);border-radius: 6px;overflow-wrap: break-word;box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u672c\u6587\u7248\u6743\u5c5e\u4e8e<span style=\"color: rgb(9, 158, 206);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">X-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(9, 158, 206);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u957f\u6309<\/strong><\/span>\u4e0b\u56fe<strong style=\"box-sizing: border-box;\">\u8bc6\u522b\u56fe\u4e2d\u4e8c\u7ef4\u7801<\/strong>\uff0c\u8f7b\u677e\u5173\u6ce8\u6211\u4eec\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<p style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\"><img class=\"\"     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/1-1555470991.jpeg\" alt=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\" title=\"\u3010\u6709\u673a\u3011\u624b\u6027\u9634\u79bb\u5b50\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u6784\u5efa\u03b1-\u5b63\u78b3-\u03b1-\u7f9f\u57fa-\u03b22-\u6c28\u57fa\u9178\u884d\u751f\u7269\"  \/><\/p>\n<\/section>\n<\/section>\n<section class=\"\" style=\"height: 16px;box-sizing: border-box;\">\n<section style=\"height: 15.9961px;width: 24px;float: left;border-bottom: 6px solid rgb(9, 158, 206);border-left: 6px solid rgb(9, 158, 206);border-top-color: rgb(9, 158, 206);border-right-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"height: 15.9961px;width: 24px;float: right;border-bottom: 6px solid rgb(9, 158, 206);border-right: 6px solid rgb(9, 158, 206);border-top-color: rgb(9, 158, 206);border-left-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"white-space: normal;\">\n<section >\n<section>\n<section>\n<section>\n<section >\n<section>\n<section>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;line-height: 25.6px;font-size: 18.018px;max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 17px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u70b9\u51fb\u201c<span style=\"max-width: 100%;color: rgb(0, 122, 170);\">\u9605\u8bfb\u539f\u6587<\/span>\u201d\uff0c\u67e5\u770b&nbsp;<strong>\u5316\u5b66 \u2022 \u6750\u6599&nbsp;<\/strong>\u9886\u57df<span style=\"max-width: 100%;background-color: rgb(255, 218, 81);\">\u6240\u6709\u6536\u5f55\u671f\u520a<\/span><\/span><\/p>\n<p style=\"white-space: normal;line-height: 25.6px;font-size: 18.018px;max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u542b\u6709\u6c28\u7532\u57fa\u7247\u6bb5\u7684\u624b\u6027\u5206\u5b50\u7ed3\u6784\u5e7f\u6cdb\u5b58\u5728\u4e8e\u8bb8\u591a\u5929\u7136\u4ea7\u7269\u3001\u751f\u7269\u78b1\u548c\u836f\u7269\u5206\u5b50\u3002\u6c28\u7532\u57fa\u5316\u53cd\u5e94\u53ef\u4ee5\u76f4\u63a5\u5c06\u6c28\u7532\u57fa\u7247\u6bb5\u5f15\u5165\u5230\u6709 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":84877,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/84876"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=84876"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/84876\/revisions"}],"predecessor-version":[{"id":84887,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/84876\/revisions\/84887"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/84877"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=84876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=84876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=84876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}