{"id":85202,"date":"2019-04-17T00:00:50","date_gmt":"2019-04-17T03:18:47","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/85202\/"},"modified":"2019-04-17T11:18:48","modified_gmt":"2019-04-17T03:18:48","slug":"dd28472b15","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/85202\/","title":{"rendered":"Nature\u6df1\u5ea6\u7efc\u8ff0\uff1a\u9488\u5bf9\u6700\u5e38\u89c1\u7684\u8840\u6db2\u764c\u75c7\uff0c\u54ea\u4e9b\u521b\u65b0\u7597\u6cd5\u503c\u5f97\u5173\u6ce8\uff1f"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\u7f16\u8bd1\u6574\u7406\uff08\u6765\u6e90\uff1a\u300aNature Reviews Drug Discovery\u300b\uff09<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/h1>\n

\u6839\u636e\u4e16\u754c\u764c\u75c7\u7814\u7a76\u57fa\u91d1\u4f1a\uff08WCRF\uff09\u7684\u7edf\u8ba1\uff0c\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u662f\u4e16\u754c\u4e0a\u6700\u5e38\u89c1\u7684\u8840\u6db2\u764c\u75c7<\/span><\/strong>\uff0c\u60a3\u8005\u4eba\u6570\u5360\u6240\u6709\u764c\u75c7\u60a3\u8005\u76843%\u3002\u6839\u636e\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\uff08American Cancer Society\uff09\u7684\u4f30\u8ba1\uff0c\u57282019\u5e74\uff0c\u5c06\u6709\u8d85\u8fc77.4\u4e07\u4eba\u786e\u8bca\u60a3\u4e0aNHL\uff0c\u5176\u4e2d\u5305\u62ec\u6210\u4eba\u548c\u513f\u7ae5\uff0c\u800c\u4e14\u6709\u5927\u7ea62\u4e07\u4eba\u4f1a\u56e0\u6b64\u53bb\u4e16\u3002\u7537\u6027\u4e00\u751f\u4e2d\u60a3\u4e0aNHL\u7684\u98ce\u9669\u4e3a1\/42\uff0c\u5973\u6027\u4e3a1\/54\u3002<\/span>\u5728\u4e16\u754c\u8303\u56f4\u5185\uff0cNHL\u60a3\u8005\u8fbe\u5230150\u4e07\u4eba<\/span><\/strong>\u3002<\/span><\/p>\n


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NHL\u662f\u4e00\u7c7b\u6dcb\u5df4\u80bf\u7624\u7684\u603b\u79f0\uff0c\u5b83\u662f\u7531\u4e8e\u6dcb\u5df4\u7ec6\u80de\u764c\u53d8\u800c\u5bfc\u81f4\u7684\u6076\u6027\u764c\u75c7\u3002\u5176\u4e2dB\u7ec6\u80de\u6dcb\u5df4\u7624\uff08BCL\uff09\u5360NHL\u7684\u5927\u591a\u6570\uff08>85%\uff09\uff0c\u5176\u5b83\u764c\u75c7\u6e90\u4e8eT\u7ec6\u80de\u6216\u8005\u5929\u7136\u6740\u4f24\u7ec6\u80de\u7684\u764c\u53d8\u3002NHL\u901a\u5e38\u88ab\u5212\u5206\u4e3a\u75be\u75c5\u8fdb\u5c55\u7f13\u6162\u7684\u60f0\u6027NHL\uff08iNHL\uff09\uff0c\u548c\u75be\u75c5\u8fdb\u5c55\u8fc5\u901f\u7684\u4fb5\u88ad\u6027NHL\uff08aNHL\uff09\u3002\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08FL\uff09\u548c\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u662f\u6700\u5e38\u89c1\u7684\u60f0\u6027\u548c\u4fb5\u88ad\u6027\u6dcb\u5df4\u7624\u4e9a\u578b\uff0c\u5b83\u4eec\u5206\u522b\u5360NHL\u60a3\u8005\u603b\u6570\u76841\/5\u548c1\/3\u3002<\/span><\/p>\n


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\"Nature\u6df1\u5ea6\u7efc\u8ff0\uff1a\u9488\u5bf9\u6700\u5e38\u89c1\u7684\u8840\u6db2\u764c\u75c7\uff0c\u54ea\u4e9b\u521b\u65b0\u7597\u6cd5\u503c\u5f97\u5173\u6ce8\uff1f\"<\/p>\n

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\u5728\u6cbb\u7597NHL\u7684\u7597\u6cd5\u591a\u79cd\u591a\u6837\uff0c\u5305\u62ec\u5c0f\u5206\u5b50\u9776\u5411\u836f\uff0c\u751f\u7269\u5236\u5242\u548c\u6700\u65b0\u7684\u764c\u75c7\u514d\u75ab\u7597\u6cd5\uff0c\u800c\u4e14\u5728\u7814\u7597\u6cd5\u4e2d\u5305\u542b\u4e86\u591a\u79cd\u521b\u65b0\u6cbb\u7597\u6a21\u5f0f\u548c\u91cd\u78c5\u836f\u7269<\/span><\/strong>\u3002\u65e5\u524d\uff0c\u300aNature Reviews Drug Discovery\u300b\u4e0a\u7684\u4e00\u7bc7\u6587\u7ae0\u5bf9\u6cbb\u7597NHL\u7684\u83b7\u6279\u548c\u5728\u7814\u7597\u6cd5\u8fdb\u884c\u4e86\u76d8\u70b9\uff0c\u4eca\u5929\uff0c\u7684\u5fae\u4fe1\u56e2\u961f\u5c06\u4e0e\u8bfb\u8005\u5206\u4eab\u8fd9\u7bc7\u6587\u7ae0\u7684\u7cbe\u5f69\u5185\u5bb9\u3002<\/span><\/p>\n


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\u6cbb\u7597NHL\u7684\u83b7\u6279\u7597\u6cd5<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524d\u6cbb\u7597NHL\u7684\u6307\u5357\u63a8\u8350\u4f7f\u7528\u6297CD20\u9776\u5411\u7597\u6cd5\u2014\u2014\u4e3b\u8981\u662f\u7f57\u6c0f\u7684Rituxan\uff08rituximab\uff09\u6216Gazyva\uff08obinutuzumab\uff0c\u53ea\u9002\u7528\u4e8e\u6cbb\u7597FL\uff09\u4e0e\u5316\u7597\u8054\u7528\uff0c\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u9009\u62e9<\/strong>\u3002\u5927\u591a\u6570NHL\u4e9a\u578b\u60a3\u8005\u5bf9\u4e00\u7ebf\u7597\u6cd5\u7684\u53cd\u5e94\u7387\u5f88\u9ad8\uff08DLBCL 80%\uff1bFL 90%\uff09\uff0c\u4e09\u5e74\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u8fbe\u523070%\u5de6\u53f3\u3002\u7136\u800c\u5f88\u591a\u60a3\u8005\u4f1a\u51fa\u73b0\u764c\u75c7\u590d\u53d1\u3002\u5bf9\u590d\u53d1\/\u96be\u6cbb\u6027NHL\uff08R\/R NHL\uff09\u60a3\u8005\u7684\u6cbb\u7597\u4ecd\u7136\u662f\u4e00\u4e2a\u91cd\u5927\u6311\u6218<\/strong>\u3002\u901a\u5e38\u7684\u7597\u6cd5\u662f\u6297CD20\u6297\u4f53\u548c\u66f4\u9ad8\u5242\u91cf\u7684\u5316\u7597\uff0c\u5bf9\u4e8e\u90a3\u4e9b\u65e0\u6cd5\u8010\u53d7\u9ad8\u5242\u91cf\u5316\u7597\u7684\u60a3\u8005\u6765\u8bf4\uff0c\u4f7f\u7528\u514d\u75ab\u8c03\u8282\u836f\u7269\u4e0erituximab\u76f8\u7ed3\u5408\u662f\u4e00\u79cd\u6cbb\u7597\u9009\u62e9\u3002\u6709\u4e9b\u60a3\u8005\u53ef\u4ee5\u901a\u8fc7\u63a5\u53d7\u81ea\u4f53\u79fb\u690d\u6765\u5bfc\u81f4\u957f\u671f\u7f13\u89e3\u3002<\/span><\/p>\n


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\u6700\u8fd1\uff0c\u591a\u6b3e\u521b\u65b0\u836f\u7269\u4e5f\u83b7\u5f97\u6279\u51c6\u6cbb\u7597R\/R NHL\uff0c\u5176\u4e2d\u5305\u62ec\u9776\u5411CD30\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09brentuximab vedotin\uff08Seattle Genetics\uff09\uff1b\u4e24\u6b3e\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5242\u2014\u2014ibrutinib\uff08\u6768\u68ee\/\u827e\u4f2f\u7ef4\uff09\u548cacalabrutinib\uff08\u963f\u65af\u5229\u5eb7\uff09\uff1b\u4e09\u6b3ePI3K\u03b3\/\u03b4\u6291\u5236\u5242\u2014\u2014idelalisib\uff08\u5409\u5229\u5fb7\u79d1\u5b66\uff09\uff0ccopanlisib\uff08\u62dc\u8033\uff09\uff0cduvelisib\uff08Verastem Oncology\uff09\u3002FDA\u4e5f\u6279\u51c6\u9ed8\u6c99\u4e1c\u7684Keytruda\uff08pembrolizumab\uff09\u6cbb\u7597R\/R\u539f\u53d1\u6027\u7eb5\u9694\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u3002<\/span><\/p>\n


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\u5982\u679c\u60a3\u8005\u5df2\u7ecf\u7a77\u5c3d\u4e86\u8fd9\u4e9b\u4e00\u4e8c\u7ebf\u7597\u6cd5\uff0c\u4ed6\u4eec\u7684\u6cbb\u7597\u9009\u62e9\u662f\u9776\u5411CD19\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u5b83\u4eec\u5305\u62ec\u8bfa\u534e\u7684Kymriah\uff08tisagenlecleucel\uff09\u548cKite Pharma\u7684Yescarta\uff08axicabtagene ciloleucel\uff09\u3002<\/span><\/p>\n


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\u6cbb\u7597NHL\u7684\u5728\u7814\u7597\u6cd5<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524d\u6709\u591a\u79cd\u521b\u65b0\u5728\u7814\u7597\u6cd5\u5904\u4e8e\u540e\u671f\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff0c\u5e76\u4e14\u8868\u73b0\u51fa\u826f\u597d\u7684\u7597\u6548\uff0c\u5176\u4e2d\u5305\u62ec\uff1a<\/span><\/p>\n


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\"Nature\u6df1\u5ea6\u7efc\u8ff0\uff1a\u9488\u5bf9\u6700\u5e38\u89c1\u7684\u8840\u6db2\u764c\u75c7\uff0c\u54ea\u4e9b\u521b\u65b0\u7597\u6cd5\u503c\u5f97\u5173\u6ce8\uff1f\"<\/p>\n

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\u25b2\u90e8\u5206\u5904\u4e8e\u4e34\u5e8a\u540e\u671f\u7684NHL\u5728\u7814\u7597\u6cd5\uff08\u6570\u636e\u6765\u6e90\uff1a<\/span><\/strong>\u53c2\u8003\u8d44\u6599[1]\uff0c\u5236\u56fe\uff09<\/span><\/strong><\/span><\/h1>\n


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\u5b89\u8fdb\u516c\u53f8\u7684Blincyto\uff08blinatumomab\uff09\u662f\u4e00\u6b3e\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u63a5\u5408\u5668\uff0c\u5b83\u662f\u4e00\u79cd\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u4e00\u7aef\u53ef\u4ee5\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u7684CD3\u53d7\u4f53\uff0c\u53e6\u4e00\u7aef\u7ed3\u5408B\u7ec6\u80de\u8868\u9762\u7684CD19\u6297\u539f\uff0c\u5c06T\u7ec6\u80de\u62c9\u5230\u80bf\u7624\u7ec6\u80de\u9644\u8fd1\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002Blincyto\u5df2\u7ecf<\/span>\u83b7\u5f97\u6279\u51c6\u6cbb\u7597B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5<\/span><\/a>\u3002\u5b83\u76ee\u524d\u57282\/3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u6cbb\u7597R\/R\u4fb5\u88ad\u6027B\u7ec6\u80deNHL\u60a3\u8005\u3002\u8fd9\u4e9b\u60a3\u8005\u5df2\u7ecf\u63a5\u53d7\u8fc7\u4e24\u8f6e\u5316\u7597\u3002Blinatumomab\u8868\u73b0\u51fa69%\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\uff0c\u5176\u4e2d37%\u7684\u60a3\u8005\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09<\/strong>\u3002<\/span><\/p>\n


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\u7f57\u6c0f\u7684polatuzumab vedotin\u662f\u4e00\u79cd\u9776\u5411CD79B\u6297\u539f\u7684ADC\u3002\u5b83\u76ee\u524d\u5728\u4e0e\u5316\u7597\u548crituximab\u8054\u7528\uff0c\u7528\u4e8e\u6cbb\u7597\u521d\u6cbbDLBCL\u60a3\u8005\u3002\u57282\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8fd9\u4e00\u7ec4\u5408\u7597\u6cd5\u8868\u73b0\u51fa\u5353\u8d8a\u7684\u7597\u6548\uff0c\u4e0e\u6d3b\u6027\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u5c06polatuzumab vedotin\u52a0\u5165\u6cbb\u7597\u65b9\u6848\u5c06PFS\u63d0\u9ad82\u500d\u591a\uff086.7\u4e2a\u6708\u6bd42\u4e2a\u6708\uff09\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u63d0\u9ad81\u500d\u591a\uff0812.4\u4e2a\u6708\u6bd44.7\u4e2a\u6708\uff09<\/strong>\u3002\u76ee\u524d\u68c0\u9a8c\u8fd9\u4e00\u7ec4\u5408\u7597\u6cd5\u76843\u671f\u8bd5\u9a8c\u9884\u8ba1\u5728\u4eca\u5e7412\u6708\u83b7\u5f97\u4e3b\u8981\u7ec8\u70b9\u6570\u636e\u3002<\/span>\u8fd9\u6b3eADC\u7684\u76d1\u7ba1\u7533\u8bf7\u5df2\u7ecf\u83b7\u5f97FDA\u7684<\/span><\/strong>\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c<\/span><\/strong><\/a>\uff0c\u5b83\u53ef\u80fd\u6539\u53d8\u6cbb\u7597DLBCL\u7684\u4e00\u7ebf\u6cbb\u7597\u6807\u51c6<\/span><\/strong>\u3002<\/span><\/p>\n

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MorphSys\/Xencor\u8054\u5408\u5f00\u53d1\u7684MOR28\u662f\u4e00\u6b3e\u9776\u5411CD19\u7684\u5355\u514b\u9686\u6297\u4f53\u3002\u5b83\u76ee\u524d\u57282\/3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4e0ebendamustine\u8054\u7528\uff0c\u6cbb\u7597R\/R DLBCL\u60a3\u8005\u3002\u57282\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cMOR208\u4e0e\u5316\u7597\u548clenalidomide\u8054\u7528\uff0c\u5728\u6cbb\u7597R\/R DLBCL\u60a3\u8005\u65f6\u8fbe\u5230<\/span>49%\u7684ORR\u548c31%\u7684CR<\/span><\/strong><\/a>\u3002\u57283\u671f\u8bd5\u9a8c\u4e2d\uff0cMOR208\u7684\u7597\u6548\u5c06\u4e0erituximab\u8fdb\u884c\u6bd4\u8f83\uff0c\u5982\u679cMOR208\u7684\u7597\u6548\u4f18\u4e8erituximab\uff0c\u5b83\u4e0e\u5316\u7597\u7684\u7ec4\u5408\u53ef\u80fd\u63d0\u4f9b\u4e00\u7ebf\u6cbb\u7597DLBCL\u7684\u53e6\u4e00\u79cd\u9009\u62e9\u3002<\/strong><\/span><\/p>\n


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\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u65b9\u9762\uff0c\u5fb7\u56fd\u9ed8\u514b\/\u8f89\u745e\u8054\u5408\u5f00\u53d1\u7684\u6297PD-L1\u6297\u4f53Bavencio\uff08Avelumab\uff09\u548c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u7684Opdivo\uff08nivolumab\uff09\u5747\u57282\/3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4e0e\u5176\u5b83\u7597\u6cd5\u8054\u7528\u6cbb\u7597R\/R DLBCL \u6216R\/R NHL\u3002\u8fd9\u4e9b\u7597\u6cd5\u7684\u7597\u6548\u53ef\u80fd\u4e0e\u9ed8\u6c99\u4e1c\u7684Keytruda\u76f8\u5f53\u3002<\/span><\/p>\n


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Juno Therapeutics\/\u65b0\u57fa\u516c\u53f8\u8054\u5408\u5f00\u53d1\u7684\u9776\u5411CD19\u7684CAR-T\u7597\u6cd5lisocabtagene maraleucel\uff08JCAR017\uff09\u76ee\u524d\u57282\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u6cbb\u7597R\/R B\u7ec6\u80de\u8840\u764c\u3002<\/span><\/p>\n


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\"Nature\u6df1\u5ea6\u7efc\u8ff0\uff1a\u9488\u5bf9\u6700\u5e38\u89c1\u7684\u8840\u6db2\u764c\u75c7\uff0c\u54ea\u4e9b\u521b\u65b0\u7597\u6cd5\u503c\u5f97\u5173\u6ce8\uff1f\"<\/p>\n

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\u25b2\u7d22\u5143\u751f\u7269\u7684\u836f\u7269\u5f00\u53d1\u7406\u5ff5\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong>\u7d22\u5143\u751f\u7269\u516c\u53f8\u5b98\u7f51\uff09<\/span><\/strong><\/span><\/h1>\n


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\u5728\u4e09\u6b3e\u53e3\u670d\u86cb\u767d\u6fc0\u9176\u6291\u5236\u5242\u4e2d\uff0c\u7d22\u5143\u751f\u7269\uff08Denovo Biopharma\uff09\u7684enzastaurin\u5df2\u7ecf\u8fdb\u51653\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5b83\u4e0erituximab\u548c\u5316\u7597\u8054\u7528\uff0c\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\uff0c\u6cbb\u7597DGM1\u9633\u6027\u7684\u9ad8\u98ce\u9669DLBCL\u60a3\u8005\u3002<\/span>\u7d22\u5143\u751f\u7269\u7684\u7814\u53d1\u7b56\u7565\u662f\u901a\u8fc7\u7279\u5b9a\u751f\u7269\u6807\u5fd7\u7269\uff0c\u7b5b\u9009\u51fa\u60a3\u8005\u4e2d\u5bf9\u7597\u6cd5\u654f\u611f\u7684\u60a3\u8005\u4e9a\u7fa4\u3002<\/span><\/strong><\/span><\/p>\n


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\u5c55\u671b\u672a\u6765<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524d\uff0c\u6297CD20\u6297\u4f53\uff08\u5305\u62ecrituximab\u548cobinutuzumab\uff09\u662f\u6cbb\u7597NHL\u7684\u4e3b\u8981\u7597\u6cd5\u3002\u7136\u800c\u52302023\u5e74\uff0cpolatuzumab vedotin\uff0cMOR2018\u548cvenetoclax\u53ef\u80fd\u5df2\u7ecf\u6210\u4e3a\u83b7\u6279\u7597\u6cd5<\/strong>\u3002\u800c\u4e14\uff0cCAR-T\u7597\u6cd5\u6b63\u5728\u6210\u4e3a\u6cbb\u7597\u591a\u79cdNHL\u4e9a\u578b\u6700\u6709\u5e0c\u671b\u7684\u6cbb\u7597\u9009\u62e9<\/strong>\uff0c\u5b83\u4eec\u7684\u5b89\u5168\u6027\uff0c\u5236\u9020\u5de5\u827a\u548c\u5236\u9020\u6210\u672c\u65b9\u9762\u7684\u6539\u8fdb\u5c06\u51b3\u5b9aCAR-T\u7597\u6cd5\u7684\u5e94\u7528\u8303\u56f4\u3002<\/span><\/p>\n


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\"Nature\u6df1\u5ea6\u7efc\u8ff0\uff1a\u9488\u5bf9\u6700\u5e38\u89c1\u7684\u8840\u6db2\u764c\u75c7\uff0c\u54ea\u4e9b\u521b\u65b0\u7597\u6cd5\u503c\u5f97\u5173\u6ce8\uff1f\"<\/p>\n

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\u540c\u65f6\uff0crituximab\u7684\u751f\u7269\u7c7b\u4f3c\u836fTruxima\u548cRixathon\u5df2\u7ecf\u83b7\u5f97\u6279\u51c6\uff0c\u8fd9\u4e9b\u836f\u7269\u4e5f\u6709\u671b\u57282023\u5e74\u524d\u4e0a\u5e02\u3002\u53ef\u4ee5\u9884\u89c1\uff0c\u672a\u6765NHL\u7684\u6cbb\u7597\u624b\u6bb5\u5c06\u66f4\u4e3a\u591a\u6837\uff0c\u9664\u4e86\u5f00\u53d1\u66f4\u6709\u6548\u7684\u6cbb\u7597\u624b\u6bb5\u4ee5\u5916\uff0c\u5229\u7528\u57fa\u56e0\u7a81\u53d8\u5206\u6790\uff0c\u9009\u62e9\u5bf9\u7597\u6cd5\u654f\u611f\u7684\u60a3\u8005\u5c06\u8fdb\u4e00\u6b65\u6539\u5584\u6cbb\u7597\u540e\u679c\u5e76\u4e14\u964d\u4f4e\u6cbb\u7597\u6210\u672c\u3002<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] Chaudhari et al., (2019). Non-Hodgkin lymphoma therapy landscape.  Nature Reviews Drug Discovery, Retrieved April 16, 2019, <\/span>from https:<\/span>\/\/www.nature.com\/articles\/d41573-019-00051-6<\/span><\/p>\n

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[2] What Is Non-Hodgkin Lymphoma?<\/span> Retrieved April 16, 2019, from https:<\/span>\/\/www.cancer.org\/cancer\/non-hodgkin-lymphoma\/about\/what-is-non-hodgkin-lymphoma.html<\/span><\/p>\n

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\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


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