{"id":85214,"date":"2019-04-17T00:00:50","date_gmt":"2019-04-17T03:18:55","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/85214\/"},"modified":"2019-04-17T11:18:56","modified_gmt":"2019-04-17T03:18:56","slug":"f9d6e6b7b7","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/85214\/","title":{"rendered":"\u901f\u9012 | \u6548\u679c\u4f18\u4e8e\u83b7\u6279\u7597\u6cd5\uff0c\u521b\u65b0\u6212\u70df\u836f2\u671f\u4e34\u5e8a\u7ed3\u679c\u79ef\u6781"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\u4eca\u65e5\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u65b0\u7597\u6cd5\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u533b\u836f\u516c\u53f8Axsome Therapeutics\u5ba3\u5e03\uff0c\u5176\u5728\u7814\u6212\u70df\u836f\u7269AXS-05\uff0c\u4e0e\u5b89\u975e\u4ed6\u916e\uff08bupropion\uff09\u76f8\u6bd4\uff0c\u5728\u6212\u70df\u7684\u7597\u7a0b\u4e2d\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9<\/strong>\u3002AXS-05\u663e\u8457\u51cf\u5c11\u4e86\u6bcf\u65e5\u5438\u70df\u6570\u76ee\u3002<\/span><\/p>\n

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\"\u901f\u9012<\/p>\n


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\u70df\u8349\u4f9d\u8d56\u662f\u4e00\u79cd\u6162\u6027\u9ad8\u590d\u53d1\u6027\u75be\u75c5\u3002\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u5df2\u5c06\u70df\u8349\u4f9d\u8d56\u4f5c\u4e3a\u4e00\u79cd\u75be\u75c5\u5217\u5165\u56fd\u9645\u75be\u75c5\u5206\u7c7b\uff0c\u786e\u8ba4\u70df\u8349\u4f9d\u8d56\u662f\u76ee\u524d\u4eba\u7c7b\u5065\u5eb7\u7684\u6700\u5927\u5a01\u80c1\u4e4b\u4e00\u3002\u7f8e\u56fd\u7ea6\u67094000\u591a\u4e07\u70df\u6c11\uff0c\u6bcf\u5e74\u7ea6\u670943\u591a\u4e07\u4eba\u6b7b\u4e8e\u4e0e\u5438\u70df\u76f8\u5173\u7684\u75c5\u75c7\uff0c\u6bcf5\u4f8b\u6b7b\u4ea1\u5c31\u6709\u4e00\u4f8b\u662f\u5438\u70df\u5bfc\u81f4\u7684\u3002\u5438\u70df\u5f80\u5f80\u662f\u4e00\u79cd\u8d85\u8d8a\u4e60\u60ef\u7684\u5c3c\u53e4\u4e01\u6210\u763e\u8868\u73b0\u3002\u5728\u5438\u70df\u540e\uff0c\u5c3c\u53e4\u4e01\u8fc5\u901f\u4f5c\u7528\u4f4d\u4e8e\u8111\u8179\u4fa7\u88ab\u76d6\u533a\u7684\u03b14\u03b22\u53d7\u4f53\uff0c\u53d7\u4f53\u88ab\u6fc0\u6d3b\u5e76\u91ca\u653e\u80fd\u8ba9\u4eba\u8111\u4ea7\u751f\u5404\u79cd\u6109\u60a6\u611f\u53d7\u7684\u591a\u5df4\u80fa\u4ee5\u53ca\u5176\u5b83\u795e\u7ecf\u9012\u8d28\u3002\u591a\u5df4\u80fa\u7f3a\u5c11\u65f6\u5219\u4f1a\u4ea7\u751f\u70e6\u8e81\u3001\u4e0d\u9002\u3001\u6076\u5fc3\u3001\u5934\u75db\u7b49\u75c7\u72b6\uff0c\u5e76\u6e34\u671b\u518d\u6b21\u8865\u5145\u5c3c\u53e4\u4e01\u3002\u5c3c\u53e4\u4e01\u4f9d\u8d56\u662f\u4e00\u79cd\u5fc3\u7406\u6027\u75be\u75c5\u3002\u6212\u70df\u7597\u6cd5\uff0c\u53ef\u5206\u4e3a\u5c3c\u53e4\u4e01\u66ff\u4ee3\u7597\u6cd5\u548c\u975e\u5c3c\u53e4\u4e01\u6212\u70df\u836f\u4e24\u5927\u7c7b\u3002<\/span>
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\"\u901f\u9012<\/p>\n

\u25b2\u5728\u7f8e\u56fd\uff0c\u670970%\u7684\u70df\u6c11\u8bd5\u56fe\u6212\u70df\uff0c\u590d\u5438\u7387\u7ea6\u4e3a80%\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong>Axsome\u5b98\u7f51\uff09<\/span><\/strong><\/span>
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\u4f5c\u4e3a\u4e00\u6b3e\u975e\u5c3c\u53e4\u4e01\u7c7b\u6212\u70df\u836f\u7269\uff0cAXS-05\u662f\u4e00\u79cd\u521b\u65b0\u7684\u53e3\u670dNMDA\u53d7\u4f53\u62ee\u6297\u5242<\/strong>\u3002\u7531\u53f3\u7f8e\u6c99\u82ac\uff08dextromethorphan\uff09\u548c\u5b89\u975e\u4ed6\u916e\u6784\u6210\uff0c\u5e76\u4e14\u4f7f\u7528\u4e86Axsome\u516c\u53f8\u7684\u4ee3\u8c22\u6291\u5236\u6280\u672f\u3002\u53f3\u7f8e\u6c99\u82ac\u662f\u4e00\u79cd\u975e\u7ade\u4e89\u6027NMDA\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u5b83\u540c\u65f6\u4e5f\u662fsigma-1\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u70df\u78b1\u578b\u4e59\u9170\u80c6\u78b1\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u548c5-\u7f9f\u8272\u80fa\u548c\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u8f6c\u8fd0\u86cb\u767d\u7684\u6291\u5236\u5242\u3002\u5b89\u975e\u4ed6\u916e\u80fd\u591f\u63d0\u9ad8\u53f3\u7f8e\u6c99\u82ac\u7684\u751f\u7269\u5229\u7528\u5ea6\uff0c\u540c\u65f6\u4e5f\u662f\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u548c\u591a\u5df4\u80fa\u518d\u6444\u53d6\u6291\u5236\u5242\uff0c\u548c\u70df\u78b1\u578b\u4e59\u9170\u80c6\u78b1\u53d7\u4f53\u62ee\u6297\u5242\u3002\u4f5c\u4e3a\u4e00\u6b3e\u6cbb\u7597\u91cd\u5ea6\u6291\u90c1\u75c7\uff08MDD\uff09\u7684\u521b\u65b0\u7597\u6cd5\uff0cAXS-05\u66fe\u83b7\u5f97\u4e86FDA\u6388\u4e88\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u3002\u6b64\u5916\uff0cAXS-05\u7684\u6f5c\u5728\u9002\u5e94\u75c7\u8fd8\u5305\u62ec\u963f\u5179\u6d77\u9ed8\u75c7\uff08AD\uff09\u60a3\u8005\u7684\u6fc0\u52a8\u75c7\u72b6\uff0c\u53ca\u96be\u6cbb\u578b\u5fe7\u90c1\u75c7\uff08TRD\uff09\u3002<\/span><\/p>\n


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\u5728\u675c\u514b\u5927\u5b66\u6212\u70df\u4e2d\u5fc3\u8fdb\u884c\u7684\u4e3a\u671f3\u5468\u7684\u6212\u70df\u7597\u7a0b\u4e2d\uff0cAXS-05\u7ec4\uff08\u5e73\u5747\u6bcf\u65e5\u5c11\u54388.49\u652f\u70df\uff09\u4e0e\u5b89\u975e\u4ed6\u916e\u7ec4\uff08\u5e73\u5747\u6bcf\u65e5\u5c11\u54386.79\u652f\u70df\uff09\u76f8\u6bd4\uff0c\u5c06\u6bcf\u65e5\u5438\u70df\u652f\u6570\u989d\u5916\u964d\u4f4e\u4e8625%\u3002<\/strong><\/span><\/p>\n

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\"\u901f\u9012<\/p>\n

\u25b2Axsome\u7684\u7814\u53d1\u7ba1\u7ebf\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong>Axsome\u5b98\u7f51\uff09<\/span><\/strong><\/span>
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\u675c\u514b\u5927\u5b66\u6212\u70df\u4e2d\u5fc3\u533b\u5b66\u4e3b\u4efbJames Davis\u535a\u58eb\u8868\u793a\uff1a\u201c\u5b89\u975e\u4ed6\u916e\u662f\u4e00\u79cd\u83b7\u6279\u7684\u6212\u70df\u7597\u6cd5\u3002\u4e0e\u5b89\u975e\u4ed6\u916e\u76f8\u6bd4\uff0cAXS-05\u6240\u53d6\u5f97\u4e86\u66f4\u9ad8\u7684\u6212\u70df\u7597\u6548\u662f\u4ee4\u4eba\u77a9\u76ee\u7684\u3002\u5728\u672c\u6b21\u8bd5\u9a8c\u4e2d\u6240\u89c2\u5bdf\u5230\u7684AXS-05\u76f8\u5bf9\u4e8e\u5b89\u975e\u4ed6\u916e\u7684\u6539\u5584\u5e45\u5ea6\uff0c\u7b49\u540c\u4e8e\u5728\u7c7b\u4f3c\u7684\u8bd5\u9a8c\u8bbe\u8ba1\u4e0b\uff0c\u9152\u77f3\u9178\u4f10\u5c3c\u514b\u5170\u7247\uff08\u53e6\u4e00\u79cd\u83b7\u6279\u7684\u975e\u5c3c\u53e4\u4e01\u7c7b\u6212\u70df\u836f\uff09\u76f8\u5bf9\u4e8e\u5b89\u6170\u5242\u7684\u6539\u5584\u7a0b\u5ea6\u3002\u201d<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1]. <\/span>Axsome’s<\/span> AXS-05 Helps Patients Quit Smoking Significantly in Phase II Trial. Retrieved April\uff0c16, 2019, from https:<\/span>\/\/www.biospace.com\/article\/axsome-s-smoking-cessation-drug-positive-in-phase-ii-clinical-trial\/<\/span><\/p>\n

[2]. \u901f\u9012 | \u9776\u5411NMDA\u53d7\u4f53\uff0c\u91cd\u5ea6\u6291\u90c1\u75c7\u65b0\u836f\u83b7FDA\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a. Retrieved April\uff0c16, 2019, from https:<\/span>\/\/mp.weixin.qq.com\/s\/0ipMG7X7TX0LVfRvLO3Row<\/span><\/p>\n

[3]. Neal L. Benowitz., (2010), Nicotine Addiction, N Engl J Med, DOI:<\/span> 10.1056\/NEJMra0809890<\/span><\/span><\/p>\n

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\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


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\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u4eca\u65e5\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u65b0\u7597\u6cd5\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u533b\u836f\u516c\u53f8Axsome T […]<\/p>\n","protected":false},"author":1,"featured_media":85215,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85214"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=85214"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85214\/revisions"}],"predecessor-version":[{"id":85219,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85214\/revisions\/85219"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/85215"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=85214"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=85214"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=85214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}