{"id":85230,"date":"2019-04-17T00:00:50","date_gmt":"2019-04-17T03:19:07","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/85230\/"},"modified":"2019-04-17T11:19:08","modified_gmt":"2019-04-17T03:19:08","slug":"3f9348a576","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/85230\/","title":{"rendered":"\u901f\u9012 | \u6297\u751f\u7d20\u6cbb\u7597\u963f\u5179\u6d77\u9ed8\u75c5\uff1f\u65b0\u9510\u62dfIPO\u52df\u8d448600\u4e07\u7f8e\u5143"},"content":{"rendered":"
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\u521b\u9274\u6c47 \/ \u62a5\u9053<\/span><\/p>\n


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\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u52a0\u5dde\u65e7\u91d1\u5c71\u5e02\u5357\u90e8\u7684Cortexyme\u8fd1\u65e5\u9012\u4ea4\u4e868600\u4e07\u7f8e\u5143\u7684IPO\u7533\u8bf7<\/strong>\uff0c\u8fd9\u5bb6\u79c1\u4eba\u63a7\u80a1\u7684\u4e34\u5e8a\u9636\u6bb5\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u963f\u5179\u6d77\u9ed8\u75c5\u548c\u5176\u4ed6\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u6cbb\u7597\u7684\u836f\u7269\u7814\u53d1\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c2018\u5e746\u6708\uff0c\u8be5\u516c\u53f8\u83b7\u5f97\u4e86\u7531\u8f89\u745e\uff08Pfizer\uff09<\/strong>\u3001\u7ea2\u6749\u8d44\u672c<\/strong>\u3001\u6b66\u7530\u98ce\u9669\u6295\u8d44<\/strong>\u7b49\u77e5\u540d\u673a\u6784\u6295\u8d44\u7684<\/span>7600\u4e07\u7f8e\u5143B\u8f6e\u878d\u8d44<\/span><\/a>\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

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\u963f\u5179\u6d77\u9ed8\u75c5\u662f\u5168\u7403\u5f71\u54cd\u6700\u5e7f\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002\u968f\u7740\u4e16\u754c\u4eba\u53e3\u8001\u9f84\u5316\uff0c\u963f\u5179\u6d77\u9ed8\u75c5\u7684\u53d1\u75c5\u7387\u8fc5\u901f\u589e\u52a0\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u4eba\u8fdb\u5165\u8fd9\u4e00\u4e0e\u5e74\u9f84\u6709\u5173\u7684\u75be\u75c5\u7684\u4e3b\u8981\u98ce\u9669\u671f\u3002\u636e\u4f30\u8ba1\uff0c\u76ee\u524d\u5168\u7403\u6709\u8d85\u8fc74000\u4e07\u60a3\u8005<\/strong>\uff0c\u52302050\u5e74\uff0c\u5168\u4e16\u754c\u53d7\u5f71\u54cd\u7684\u4eba\u6570\u5c06\u53ef\u80fd\u589e\u52a0\u5230\u60ca\u4eba\u76841\u4ebf<\/strong>\u3002\u7136\u800c\uff0c\u5173\u4e8e\u963f\u5179\u6d77\u9ed8\u75c5\u7684\u53d1\u75c5\u539f\u56e0\u81f3\u4eca\u5c1a\u672a\u660e\u786e\uff0c\u4e5f\u6ca1\u6709\u53ef\u4ee5\u6709\u6548\u51cf\u7f13\u75be\u75c5\u8fdb\u7a0b\u7684\u836f\u7269\u3002\u9488\u5bf9\u963f\u5179\u6d77\u9ed8\u75c5\u7684\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u5931\u8d25\u7387\u8d85\u8fc799%<\/span>\uff0c\u6210\u4e3a\u4e86\u6574\u4e2a\u751f\u7269\u533b\u836f\u9886\u57df\u6700\u5177\u6311\u6218\u6027\u7684\u8bfe\u9898\u4e4b\u4e00<\/span>\u3002<\/span>
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Cortexyme\u8bbe\u8ba1\u4e86\u4e00\u6b3e\u201cfirst-in-class\u201d\u7684\u836f\u7269COR388<\/span><\/strong>\uff0c\u8fd9\u6b3e\u5168\u65b0\u7684\u6cbb\u7597\u9776\u70b9\u836f\u7269\u7531Cortexyme\u8054\u5408\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u79d1\u5b66\u5b98Stephen Dominy\u535a\u58eb\u53d1\u73b0\u3002Stephen Dominy\u535a\u58eb\u66fe\u662f\u4e00\u540d\u7cbe\u795e\u79d1\u533b\u751f\uff0c\u572820\u4e16\u7eaa90\u5e74\u4ee3\uff0c\u4ed6\u5c31\u5f00\u59cb\u5bf9\u963f\u5179\u6d77\u9ed8\u75c5\u53ef\u80fd\u5177\u6709\u4f20\u67d3\u6027\u7684\u60f3\u6cd5\u4ea7\u751f\u4e86\u5174\u8da3\u3002\u5f53\u4ed6\u6cbb\u7597\u827e\u6ecb\u75c5\u60a3\u8005\u65f6\uff0c\u610f\u5916\u7684\u53d1\u73b0\uff0c\u4e00\u4e9b\u60a3\u6709\u827e\u6ecb\u75c5\u7684\u963f\u5179\u6d77\u9ed8\u75c5\u60a3\u8005\u5728\u670d\u7528\u6297\u75c5\u6bd2\u836f\u7269\u540e\uff0c\u75c7\u72b6\u5f97\u5230\u4e86\u7f13\u89e3\u3002\u4ed6\u89c2\u5bdf\u5230\uff0c\u963f\u5179\u6d77\u9ed8\u75c5\u53ef\u80fd\u4e0e\u7259\u9f88\u535f\u5549\u5355\u80de\u83cc\u6709\u5173\u3002<\/span><\/p>\n

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\"\u901f\u9012<\/p>\n

<\/span>\u25b2<\/span>Cortexyme\u8054\u5408\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u79d1\u5b66\u5b98Stephen Dominy\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong>\u516c\u53f8\u5b98\u7f51\uff09<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u901a\u8fc7\u7814\u7a76\uff0c\u73b0\u5728Cortexyme\u56e2\u961f\u53d1\u73b0\u5e76\u8bc1\u5b9e<\/span>\uff0c\u5728\u5df2\u6545\u963f\u5179\u6d77\u9ed8\u75c5<\/span>\u60a3\u8005\u7684\u8111\u5207\u7247\u4e2d\u786e\u5b9e\u5b58\u5728\u7259\u9f88\u535f\u5549\u5355\u80de\u83cc<\/span>\uff0c\u540c\u65f6\u8fd8\u5728\u60a3\u8005\u7684\u810a\u9ad3\u6db2\u4e2d\u4e5f\u68c0\u6d4b\u5230\u4e86\u7259\u9f88\u535f\u5549\u5355\u80de\u83ccDNA\u7684\u5b58\u5728\u3002\u6709\u8d85\u8fc790\uff05\u963f\u5179\u6d77\u9ed8\u75c5<\/span>\u60a3\u8005<\/span>\u7684\u5927\u8111<\/span>\u5207\u7247\u6837\u672c\u90fd\u88ab\u53d1\u73b0\u5b58\u5728gingipains\u9176\u7684\u75d5\u8ff9\uff0c\u8fd9\u79cd\u9176\u7531\u7259\u9f88\u535f\u5549\u5355\u80de\u83cc\u5206\u6ccc\uff0c\u5177\u6709\u6bd2\u6027\u3002<\/span><\/span><\/span><\/p>\n


<\/p>\n

gingipains\u9176\u8d8a\u591a\uff0c\u5927\u8111\u5207\u7247\u4e2d\u7684\u963f\u5179\u6d77\u9ed8\u75c5<\/span>\u76f8\u5173\u86cb\u767dtau\u548c\u6cdb\u80bd\u6c34\u5e73\u5c31\u8d8a\u9ad8\u3002\u975e\u963f\u5179\u6d77\u9ed8\u75c5<\/span>\u60a3\u8005\u5927\u8111\u5207\u7247\u5219\u5177\u6709\u8f83\u4f4e\u6c34\u5e73\u7684gingipains\u9176\uff0c\u963f\u5179\u6d77\u9ed8\u75c5<\/span>\u76f8\u5173\u86cb\u767d\u4e5f\u66f4\u5c11\u3002\u6b64\u9879\u7814\u7a76\u53d1\u8868\u57281\u670823\u65e5<\/span>\u7684\u300aScience Advances\u300b\u671f\u520a\u4e0a\uff0c\u7259\u9f88\u535f\u5549\u5355\u80de\u83cc\u53ef\u80fd\u5c31\u662f\u963f\u5179\u6d77\u9ed8\u75c5<\/span>\u7684\u7f6a\u9b41\u7978\u9996<\/span><\/strong>\u3002<\/span><\/span><\/span><\/p>\n


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Cortexyme\u8bbe\u8ba1\u7684COR388\u836f\u7269\u662f\u9488\u5bf9\u8fd9\u4e00\u75c5\u539f\u4f53\u7684\u7279\u5f02\u6027\u7ec6\u83cc\u86cb\u767d\u9176\u6291\u5236\u5242\u3002<\/span>\u5b83\u5bf9\u6297\u75c5\u539f\u4f53\u65b9\u5f0f\u4e0d\u540c\u4e8e\u5176\u4ed6\u5e7f\u8c31\u6297\u83cc\u7d20\uff0c\u907f\u514d\u4e86\u7ec6\u83cc\u6bd2\u6027\u5bf9\u795e\u7ea7\u5143\u7684\u635f\u4f24\uff0c\u963b\u6b62\u60a3\u8005\u8ba4\u77e5\u80fd\u529b\u7684\u4e0b\u964d\u548c\u5931\u80fd<\/span><\/strong>\u3002\u76ee\u524d\uff0cCOR388\u5df2\u7ecf\u5b8c\u6210\u4e861b\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8be5\u8bd5\u9a8c\u5bf920\u5c81\u81f370\u5c81\u5e74\u9f84\u6bb5\u7684\u963f\u5179\u6d77\u9ed8\u75c5<\/span>\u60a3\u8005\u8fdb\u884c\u4e86\u836f\u7269\u8bd5\u9a8c\uff0c\u8bd5\u9a8c\u8bc1\u660eCOR388\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u5e76\u4e14\u53e3\u670d\u65f6\u5177\u6709\u826f\u597d\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u3002\u6b64\u6b21Cortexyme\u7533\u8bf7IPO\uff0c\u52df\u96c6\u7684\u8d44\u91d1\u4e5f\u5c06\u63a8\u8fdbCOR388\u836f\u7269\u8fdb\u51652\/3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/span><\/p>\n


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\u867d\u7136\u963f\u5179\u6d77\u9ed8\u75c5\u836f\u7269\u7684\u7814\u53d1\u9053\u8def\u5145\u6ee1\u4e86\u6311\u6218\u548c\u4e0d\u786e\u5b9a\u6027\uff0c\u4f46\u662f\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684\u533b\u836f\u4eba\u59cb\u7ec8\u6ca1\u6709\u653e\u5f03\uff0c\u4e00\u76f4\u5728\u575a\u6301\uff0c\u76f8\u4fe1\u4eba\u7c7b\u4e00\u5b9a\u53ef\u4ee5\u653b\u514b\u8fd9\u79cd\u75be\u75c5\u3002\u6211\u4eec\u8877\u5fc3\u795d\u613f\uff0c\u5728\u8d44\u672c\u7684\u52a9\u529b\u4e0b\uff0c\u8fd9\u6b3e\u65b0\u836f\u7684\u7814\u53d1\u987a\u5229\uff0c\u65e9\u65e5\u4e3a\u60a3\u8005\u5e26\u6765\u6cbb\u7597\u798f\u97f3\uff01<\/span>
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\u76f8\u5173\u9605\u8bfb\uff1a<\/span>\u6cbb\u7597\u963f\u5179\u6d77\u9ed8\u75c5\uff0c\u6211\u4eec\u8fd8\u5e94\u8be5\u505a\u4e9b\u4ec0\u4e48\uff1f<\/span><\/a><\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1]Early Alzheimer’s biotech, late-stage heart drug company gun for $86M IPOs Retrieved Apr 15, 2019 from https:\/\/www.fiercebiotech.com\/biotech\/early-alzheimer-s-biotech-and-late-stage-heart-drug-company-both-gun-for-86m-ipo<\/span><\/p>\n

[2]http:\/\/advances.sciencemag.org\/content\/5\/1\/eaau3333 DOI\uff1a10.1126 \/ sciadv.aau3333<\/span><\/p>\n

[3]Cortexyme announces publication of foundational data for groundbreaking approach to treating Alzheimer’s disease in Science Advances Retrieved on Jan 24 2019 from Cortexyme<\/span>\u5b98\u7f51<\/span><\/p>\n


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\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


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\u70ed\u95e8\u9605\u8bfb\uff1a<\/span><\/strong>
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\u8d85\u7ea7\u7ec6\u83cc\u7684\u514b\u661f\uff0c\u7ec6\u80de\u5185\u6eb6\u7d20\u5148\u9a71\u83b73000\u4e07\u6b27\u5143\u878d\u8d44<\/span><\/strong><\/a><\/p>\n

\u643a\u624b\u9ed8\u6c99\u4e1c\uff0c\u53c8\u4e00NASH\u809d\u75c5\u9886\u822a\u8005\u62dfIPO\u52df\u8d441\u4ebf\u7f8e\u5143<\/span><\/strong><\/a><\/p>\n

\u7ed3\u5408\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u7684\u7ec6\u83cc\u7597\u6cd5\u4eae\u76f8\uff0c\u65b0\u9510A\u8f6e\u878d\u8d445000\u4e07\u7f8e\u5143<\/span><\/strong><\/a><\/p>\n

2018\u5e74\u4e2d\u56fd\u521b\u65b0\u836f\u4f01\u4e1a\u8c01\u6700\u201c\u5438\u91d1\u201d\uff1f<\/span><\/strong><\/a>
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\u4e70\u4e70\u4e70\uff01<\/span><\/strong>2018\u5e74\u751f\u7269\u533b\u836f\u884c\u4e1a\u8d8510\u4ebf\u7f8e\u91d1\u7684\u5927\u5e76\u8d2d\u6709\u51e0\u591a\uff1f<\/span><\/strong><\/a>
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\u521a\u521a\uff01<\/span><\/strong>\u8bfa\u534e\u5ba3\u5e0321\u4ebf\u7f8e\u5143\u6536\u8d2dEndocyte\uff0c\u52a0\u901f\u5f00\u53d1\u764c\u75c7\u653e\u5c04\u6027\u7597\u6cd5<\/span><\/strong><\/a>
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\u524d\u7f57\u6c0f\u7814\u53d1\u603b\u88c1\u4efbCEO\uff0c\u8868\u89c2\u8f6c\u5f55\u7ec4\u5b66\u65b0\u9510\u6210\u7acb\uff0cA\u8f6e5400\u4e07\u7f8e\u5143<\/span><\/strong><\/a><\/p>\n

3.2\u4ebf\u7f8e\u5143\u521b\u4e1a\u57fa\u91d1\u6210\u7acb\uff0c\u4ee8\u5927\u5496\u9886\u8854\uff0c\u4e13\u6ce8\u751f\u547d\u79d1\u5b66\u9886\u57df<\/span><\/strong><\/a><\/p>\n

\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u521b\u9274\u6c47 \/ \u62a5\u9053 \u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u52a0\u5dde\u65e7\u91d1\u5c71\u5e02\u5357\u90e8\u7684Cortexyme\u8fd1\u65e5\u9012\u4ea4\u4e868600\u4e07\u7f8e\u5143\u7684IPO\u7533\u8bf7\uff0c\u8fd9\u5bb6\u79c1 […]<\/p>\n","protected":false},"author":1,"featured_media":85231,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85230"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=85230"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85230\/revisions"}],"predecessor-version":[{"id":85234,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85230\/revisions\/85234"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/85231"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=85230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=85230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=85230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}