{"id":85241,"date":"2019-04-16T00:00:50","date_gmt":"2019-04-17T03:19:15","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/85241\/"},"modified":"2019-04-17T11:19:16","modified_gmt":"2019-04-17T03:19:16","slug":"ace258d7c0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/85241\/","title":{"rendered":"\u901f\u9012 | 20\u5e74\u6765\u65b0\u7a81\u7834\uff0c\u6768\u68ee\u516c\u53f8\u5361\u683c\u5217\u51c0\u964d\u4f4e\u80be\u8870\u7aed\u98ce\u966930%"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\u65e5\u524d\uff0c\u5f3a\u751f\uff08Johnson & Johnson\uff09\u96c6\u56e2\u65d7\u4e0b\u6768\u68ee\uff08Janssen\uff09\u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u5f00\u53d1\u76842\u578b\u7cd6\u5c3f\u75c5\u7597\u6cd5Invokana\uff08canagliflozin\uff0c\u5361\u683c\u5217\u51c0\uff09\uff0c\u57283\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fbe\u5230\u4e3b\u8981\u590d\u5408\u7ec8\u70b9\uff0c\u5728\u60a3\u6709\u6162\u6027\u80be\u75c5\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\uff0c\u5c06\u75be\u75c5\u8fdb\u5c55\u5230\u7ec8\u672b\u671f\u80be\u529f\u80fd\u8870\u7aed\uff08ESKD\uff09\u7684\u98ce\u9669\u964d\u4f4e30%\u3002\u6839\u636e\u6768\u68ee\u7684\u65b0\u95fb\u7a3f\uff0c\u8fd9\u662f\u8fd120\u5e74\u6765\uff0c<\/strong>\u552f\u4e00\u4e00\u6b3e\u5728\u8fd9\u4e00\u60a3\u8005\u7fa4\u4e2d\u663e\u8457\u964d\u4f4e\u80be\u529f\u80fd\u8870\u7aed\u3001\u900f\u6790\u6216\u80be\u79fb\u690d\uff0c\u4ee5\u53ca\u80be\u6216\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u98ce\u9669\u7684\u7cd6\u5c3f\u75c5\u836f\u7269<\/strong>\u3002<\/span><\/p>\n


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\u7cd6\u5c3f\u75c5\u662f\u5bfc\u81f4\u80be\u529f\u80fd\u8870\u7aed\u7684\u9996\u8981\u539f\u56e0\uff0c\u5f71\u54cd\u5230\u4e16\u754c\u5404\u5730\u4e0a\u767e\u4e07\u60a3\u8005\uff0c\u7136\u800c\u76ee\u524d\u6709\u6548\u7684\u957f\u671f\u7597\u6cd5\u5374\u4e0d\u591a\u3002<\/span>Invokana\u662f\u6768\u68ee\u516c\u53f8\u5f00\u53d1\u7684\u4e00\u6b3e\u94a0\u8461\u8404\u7cd6\u5171\u8f6c\u8fd0\u86cb\u767d-2 \uff08SGLT2\uff09\u6291\u5236\u5242<\/span><\/strong>\uff0c\u901a\u8fc7\u6291\u5236SGLT2\u7684\u529f\u80fd\uff0c\u51cf\u5f31\u80be\u810f\u5bf9\u8461\u8404\u7cd6\u7684\u91cd\u5438\u6536\uff0c\u4ece\u800c\u5e2e\u52a9\u63a7\u52362\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840\u7cd6\u6c34\u5e73\u3002\u5b83\u5df2\u7ecf\u83b7\u5f97\u6279\u51c6\u4f5c\u4e3a\u8f85\u52a9\u7597\u6cd5\u63a7\u52362\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840\u7cd6\u6c34\u5e73\uff0c\u5e76\u4e14\u5e2e\u52a9\u51cf\u4f4e\u5fc3\u8840\u7ba1\u75be\u75c5\u98ce\u9669\u3002<\/span><\/p>\n


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\u540d\u4e3aCREDENCE\u7684\u968f\u673a\u53cc\u76f2\uff0c\u542b\u5b89\u6170\u5242\u5bf9\u7167\u7684\u53cc\u81c23\u671f\u4e34\u5e8a\u8bd5\u9a8c\u662f\u7b2c\u4e00\u6b3e\u4e13\u95e8\u68c0\u6d4bSGLT2\u6291\u5236\u5242\u5bf9\u80be\u529f\u80fd\u7684\u5f71\u54cd\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u603b\u8ba14401\u540d\u5904\u4e8e2\u62163\u671f\u6162\u6027\u80be\u75c5\uff08CKD\uff09\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u63a5\u53d7\u4e86\u6cbb\u7597\u3002\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5728\u4e2d\u4f4d\u968f\u8bbf\u671f\u4e3a2.62\u5e74\u65f6\uff0cInvokana\u7ec4\u60a3\u8005\u51fa\u73b0ESKD\u7684\u98ce\u9669\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\u964d\u4f4e\u4e8630%<\/strong>\uff08HR: 0.70\uff1b95% CI: 0.59-0.82, P=0.00001\uff09\u3002Invokana\u7ec4\u60a3\u8005\u7684MACE\u98ce\u9669\u540c\u65f6\u964d\u4f4e\u4e8620%<\/strong>\uff08HR: 0.80, 95% CI: 0.67-0.95, p=0.01\uff09\u3002<\/span><\/p>\n


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\u201c\u5361\u683c\u5217\u51c0\u4ee3\u8868\u7740\u8fd120\u5e74\u6765\u5728\u9ad8\u5371\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u7f13\u89e3\u6162\u6027\u80be\u75c5\u8fdb\u5c55\u65b9\u9762\u7684\u7b2c\u4e00\u4e2a\u533b\u5b66\u7a81\u7834\uff0c\u201cCREDENCE\u8bd5\u9a8c\u6307\u5bfc\u59d4\u5458\u4f1a\u8054\u5408\u4e3b\u5e2d\uff0cUNSW\u6089\u5c3c\u5206\u6821\u7684Vlado Perkovic\u535a\u58eb\u8bf4\uff1a\u201dCRECENCE\u7814\u7a76\u83b7\u5f97\u7684\u4f18\u8d8a\u7ed3\u679c\u5c06\u5bf9\u9632\u6b62\u80be\u8870\u7aed\uff0c\u6539\u5584\u4e0a\u767e\u4e07\u60a3\u6709CDK\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u5065\u5eb7\u4ea7\u751f\u91cd\u5927\u5f71\u54cd\u3002\u201c<\/span><\/p>\n


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\u6768\u68ee\u516c\u53f8\u5728\u4eca\u5e743\u6708\u5df2\u7ecf\u5411FDA\u9012\u4ea4\u8865\u5145\u65b0\u836f\u7533\u8bf7\uff0c\u57fa\u4e8e\u8fd9\u4e9b\u7ed3\u679c\u6269\u5c55Invokana\u7684\u9002\u5e94\u75c7\u8303\u56f4\u3002\u6211\u4eec\u671f\u5f85\u76d1\u7ba1\u7533\u8bf7\u65e9\u65e5\u83b7\u6279\uff0c\u4e3a\u6539\u5584\u60a3\u6709CDK\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u5065\u5eb7\u63d0\u4f9b\u65b0\u9009\u62e9\u3002<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] INVOKANA\u00ae (canagliflozin) Significantly Reduces the Risk of Renal Failure in Patients with Type 2 Diabetes and Chronic Kidney Disease in the Landmark Phase 3 CREDENCE Study. Retrieved April 15, 2019, from https:<\/span>\/\/www.prnewswire.com\/news-releases\/invokana-canagliflozin-significantly-reduces-the-risk-of-renal-failure-in-patients-with-type-2-diabetes-and-chronic-kidney-disease-in-the-landmark-phase-3-credence-study-300831777.html<\/span><\/p>\n

[2] Janssen Submits Supplemental New Drug Application to U.S. FDA for INVOKANA\u00ae (canagliflozin) for the Treatment of Chronic Kidney Disease in Patients with Type 2 Diabetes https:<\/span>\/\/www.jnj.com\/janssen-submits-supplemental-new-drug-application-to-u-s-fda-for-invokana-canagliflozin-for-the-treatment-of-chronic-kidney-disease-in-patients-with-type-2-diabetes<\/span><\/span><\/p>\n


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\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


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