{"id":85259,"date":"2019-04-16T00:00:50","date_gmt":"2019-04-17T03:19:25","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/85259\/"},"modified":"2019-04-17T11:19:25","modified_gmt":"2019-04-17T03:19:25","slug":"bb6d9b132a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/85259\/","title":{"rendered":"\u901f\u9012 | \u8bfa\u534e\u52a8\u7528\u4f18\u5148\u5ba1\u8bc4\u5238\u9012\u4ea4AMD\u65b0\u836f\u7533\u8bf7\uff0c\u4eca\u5e74\u6709\u671b\u4e0a\u5e02"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\u4eca\u65e5\uff0c\u8bfa\u534e\uff08Novartis\uff09\u516c\u53f8\u5ba3\u5e03\uff0c\u4e3a\u6cbb\u7597\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08AMD\uff09\u7684brolucizumab\u5411\u7f8e\u56fdFDA\u9012\u4ea4\u4e86\u751f\u7269\u5236\u5242\u8bb8\u53ef\u7533\u8bf7\u3002\u4e3a\u4e86\u5c06\u8fd9\u6b3e\u65b0\u836f\u66f4\u5feb\u9001\u5230\u60a3\u8005\u624b\u4e2d\uff0c\u8bfa\u534e\u516c\u53f8\u4f7f\u7528\u4e86\u4f18\u5148\u5ba1\u8bc4\u5238\u6765\u52a0\u5febFDA\u7684\u5ba1\u8bc4\u8fc7\u7a0b<\/strong>\uff0c\u5982\u679c\u83b7\u5f97FDA\u7684\u6279\u51c6\uff0c\u8bfa\u534e\u9884\u8ba1\u57282019\u5e74\u672b\u80fd\u591f\u63a8\u51fa\u8fd9\u6b3e\u521b\u65b0\u7597\u6cd5<\/strong>\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

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\u6e7f\u6027AMD\u662f65\u5c81\u4ee5\u4e0a\u4eba\u7fa4\u4e2d\u5bfc\u81f4\u4e25\u91cd\u89c6\u529b\u4e27\u5931\u7684\u9996\u8981\u539f\u56e0\uff0c\u5b83\u5927\u7ea6\u5f71\u54cd\u5168\u74032000-2500\u4e07\u4eba\u7684\u751f\u6d3b\u3002\u6e7f\u6027AMD\u662f\u7531\u4e8e\u9ec4\u6591\u4e0b\u51fa\u73b0\u5f02\u5e38\u8840\u7ba1\u589e\u751f\u800c\u9020\u6210\u7684\uff0c\u8fd9\u4e9b\u8840\u7ba1\u975e\u5e38\u8106\u5f31\uff0c\u4f1a\u6e17\u51fa\u6db2\u4f53\uff0c\u635f\u574f\u6b63\u5e38\u7684\u89c6\u7f51\u819c\u7ed3\u6784\uff0c\u5e76\u4e14\u6700\u7ec8\u5bfc\u81f4\u9ec4\u6591\u53d7\u635f\u3002<\/span><\/p>\n


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Brolucizumab\u662f\u4e00\u6b3e\u4eba\u6e90\u5316\u5355\u94fe\u6297\u4f53\u53ef\u53d8\u533a\u7247\u6bb5<\/span><\/strong>\u3002\u5b83\u80fd\u591f\u4ee5\u9ad8\u4eb2\u548c\u529b\u4e0e\u6240\u6709VEGF-A\u4e9a\u578b\u76f8\u7ed3\u5408\uff0c\u5e76\u4e14\u6291\u5236\u5b83\u4eec\u7684\u529f\u80fd\u4ee5\u53caVEGF\u53d7\u4f53\u7684\u6fc0\u6d3b\u3002\u6291\u5236VEGF\u4fe1\u53f7\u901a\u8def\u53ef\u4ee5\u6291\u5236\u65b0\u751f\u8840\u7ba1\u75c5\u53d8\u7684\u589e\u957f\uff0c\u6e05\u9664\u89c6\u7f51\u819c\u6c34\u80bf\uff0c\u5e76\u4e14\u6539\u5584\u60a3\u8005\u7684\u89c6\u529b\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\u25b2<\/strong>Brolucizumab\u4e0e\u5176\u5b83\u6e7f\u6027AMD\u7597\u6cd5\u5206\u5b50\u91cf\u7684\u6bd4\u8f83\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[2]\uff09<\/span><\/strong><\/p>\n


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\u8fd9\u4e00\u7533\u8bf7\u662f\u57fa\u4e8e\u4ece\u540d\u4e3aHAWK\u548cHARRIER\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u83b7\u5f97\u7684\u6570\u636e\u3002\u5728\u8fd9\u4e24\u9879\u8bd5\u9a8c\u4e2d\uff0cBrolucizumab\u4e0e\u83b7\u6279\u7597\u6cd5aflibercept\u76f8\u6bd4\uff0c\u5728\u6539\u5584\u60a3\u8005\u89c6\u529b\u65b9\u9762\u8fbe\u5230\u975e\u52a3\u6548\u6027\u6807\u51c6\u3002<\/strong>\u800c\u4e14\uff0c\u5728\u5173\u952e\u6027\u6b21\u8981\u7ec8\u70b9\u65b9\u9762\uff0c\u63a5\u53d7brolucizumab\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u75be\u75c5\u6d3b\u52a8\u7684\u60a3\u8005\u6bd4\u4f8b\u663e\u8457\u5c11\u4e8e\u5bf9\u7167\u7ec4<\/strong>\uff0823.5%\u6bd433.5%\uff0c HAWK\u8bd5\u9a8c\uff1b21.9%\u6bd431.4%\uff0c HARRIER\u8bd5\u9a8c\uff0cp=0.0022\uff09\u3002\u540c\u65f6\uff0c\u63a5\u53d7brolucizumab\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u89c6\u7f51\u819c\u6db2\u4f53\u663e\u8457\u5c11\u4e8e\u5bf9\u7167\u7ec4\u3002<\/span><\/p>\n


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\u201c\u8fbe\u5230\u8fd9\u4e00\u91cc\u7a0b\u7891\u662f\u6211\u4eec\u6539\u53d8\u6e7f\u6027AMD\u60a3\u8005\u6cbb\u7597\u5386\u7a0b\u7684\u91cd\u8981\u4e00\u6b65\uff0c\u201d\u8bfa\u534e\u5236\u836f\u516c\u53f8\uff08Novartis Pharmaceuticals Corporation\uff09\u603b\u88c1Fabrice Chouraqui\u5148\u751f\u8bf4\uff1a\u201c\u6211\u4eec\u671f\u5f85\u770b\u5230\u8fd9\u6b3e\u65b0\u6cbb\u7597\u9009\u62e9\u5728\u6e7f\u6027AMD\u60a3\u8005\u4e2d\u5c55\u73b0\u5b83\u7684\u6f5c\u529b\u3002\u201d<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/span><\/p>\n

[1] Novartis announces FDA filing acceptance and Priority Review of <\/span>brolucizumab<\/span> (RTH258) for patients with wet AMD. Retrieved April 15, 2019, from https:<\/span>\/\/www.novartis.com\/news\/media-releases\/novartis-announces-fda-filing-acceptance-and-priority-review-brolucizumab-rth258-patients-wet-amd<\/span><\/p>\n

[2] A Novel Compound for Treatment of Wet AMD. Retrieved October 29, 2018, from http:\/\/retinatoday.com\/2016\/06\/a-novel-compound-for-treatment-of-wet-amd\/<\/span><\/p>\n

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\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


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\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u4eca\u65e5\uff0c\u8bfa\u534e\uff08Novartis\uff09\u516c\u53f8\u5ba3\u5e03\uff0c\u4e3a\u6cbb\u7597\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08AMD\uff09\u7684broluc […]<\/p>\n","protected":false},"author":1,"featured_media":85260,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85259"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=85259"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85259\/revisions"}],"predecessor-version":[{"id":85263,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85259\/revisions\/85263"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/85260"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=85259"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=85259"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=85259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}