{"id":85288,"date":"2019-04-15T00:00:50","date_gmt":"2019-04-17T03:19:46","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/85288\/"},"modified":"2019-04-17T11:19:47","modified_gmt":"2019-04-17T03:19:47","slug":"3851aea149","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/85288\/","title":{"rendered":"\u901f\u9012 | \u9776\u5411\u80fd\u91cf\u4ee3\u8c22\uff0cNASH\u521b\u65b0\u7597\u6cd52b\u671f\u4e34\u5e8a\u7ed3\u679c\u79ef\u6781"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\u65e5\u524d\uff0c\u5728\u5965\u5730\u5229\u7ef4\u4e5f\u7eb3\u4e3e\u529e\u7684\u56fd\u9645\u809d\u810f\u5927\u4f1a\u4e0a\uff0cCirius Therapeutics\u516c\u5e03\uff0c\u5176\u7528\u4e8e\u6cbb\u7597\u4f34\u6709\u7ea4\u7ef4\u5316\u75c7\u72b6\u7684\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u7684\u4e3b\u8981\u5019\u9009\u836f\u7269MSDC-0602K\uff0c\u57282b\u671fEMMINENCE\u8bd5\u9a8c\u7684\u4e2d\u671f\u5206\u6790\u4e2d\uff0c\u53d6\u5f97\u4e86\u5bf9\u63a2\u7d22\u6027\u7ec8\u70b9\u5206\u6790\u7684\u79ef\u6781\u7ed3\u679c<\/strong>\u3002Cirius\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u6cbb\u7597\u809d\u810f\u548c\u4ee3\u8c22\u75be\u75c5\u7684\u521b\u65b0\u7597\u6cd5\u7684\u5f00\u53d1\u548c\u63a8\u5e7f\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

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\u4f5c\u4e3a\u4e00\u79cd\u4e0e\u9152\u7cbe\u65e0\u5173\u7684\u5e38\u89c1\u809d\u75c5\uff0cNASH\u7684\u7279\u5f81\u662f\u8102\u80aa\u5728\u809d\u810f\u4e2d\u79ef\u805a\uff0c\u5e76\u53d1\u751f\u708e\u75c7\u548c\u7ea4\u7ef4\u5316\uff0c\u8fdb\u4e00\u6b65\u5bfc\u81f4\u809d\u786c\u5316\u548c\u809d\u529f\u80fd\u53d7\u635f\u3002\u636e\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u4ecb\u7ecd\uff0cNASH\u5f71\u54cd\u52306%\u7f8e\u56fd\u6210\u5e74\u4eba\uff0c\u662f\u5bfc\u81f4\u809d\u810f\u79fb\u690d\u53d1\u5c55\u6700\u5feb\u7684\u539f\u56e0\u4e4b\u4e00\uff0c\u4e5f\u662f\u809d\u764c\u53d1\u75c5\u7387\u589e\u52a0\u7684\u539f\u56e0\u4e4b\u4e00\u3002<\/span><\/p>\n

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MSDC-0602K\u662f\u7b2c\u4e8c\u4ee3\u567b\u5511\u70f7\u4e8c\u916e\uff08TZD\uff09\uff0c\u8bbe\u8ba1\u7528\u4e8e\u4e0e\u7ebf\u7c92\u4f53\u4e19\u916e\u9178\u8f7d\u4f53\uff08MPC\uff09\u9009\u62e9\u6027\u7ed3\u5408\uff0c\u5e76\u8c03\u8282\u4e19\u916e\u9178\u8fdb\u5165\u7ebf\u7c92\u4f53<\/span><\/strong>\u3002MPC\u662f\u4e00\u79cd\u7ebf\u7c92\u4f53\u5185\u819c\u4e2d\u7684\u86cb\u767d\u8d28\u590d\u5408\u7269\uff0c\u53ef\u4ecb\u5bfc\u4e19\u916e\u9178\u8fdb\u5165\u7ebf\u7c92\u4f53\u7684\u901f\u7387\u3002\u4e19\u916e\u9178\u662f\u78b3\u6c34\u5316\u5408\u7269\u4ee3\u8c22\u7684\u6700\u7ec8\u4ea7\u7269\uff0c\u5e76\u4e14\u662f\u7ec6\u80de\u7684\u91cd\u8981\u80fd\u91cf\u6765\u6e90\u4e4b\u4e00\u3002\u8425\u517b\u8fc7\u5269\u610f\u5473\u7740\u8fc7\u91cf\u7684\u4e19\u916e\u9178\u901a\u8fc7MPC\u63d0\u4f9b\u7ed9\u7ebf\u7c92\u4f53\uff0c\u800cMPC\u5219\u4f1a\u8fdb\u800c\u4f9d\u636e\u7ec6\u80de\u7684\u8425\u517b\u72b6\u6001\u548c\u80fd\u91cf\u9700\u6c42\uff0c\u534f\u8c03\u7ec6\u80de\u673a\u5236\uff0c\u9176\u4ee3\u8c22\u9014\u5f84\u548c\u57fa\u56e0\u8868\u8fbe\u7b49\u4e0b\u6e38\u4fe1\u53f7\u3002<\/span><\/p>\n


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\u52a8\u7269\u7814\u7a76\u663e\u793a\uff0c\u809d\u7279\u5f02\u6027\u5730\u6572\u9664MPC\uff0c\u53ef\u4ee5\u9632\u6b62\u56e0\u8425\u517b\u8fc7\u5269\u5f15\u8d77\u7684\u809d\u635f\u4f24\uff0c\u5305\u62ec\u7ea4\u7ef4\u5316\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0c\u5bf9MPC\u8fdb\u884c\u8c03\u63a7\uff0c\u53ef\u51cf\u8f7b\u8425\u517b\u8fc7\u5269\u5bf9NASH\u75c5\u7406\u5b66\uff0c\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u4ee5\u53ca2\u578b\u7cd6\u5c3f\u75c5\u7684\u5f71\u54cd<\/strong>\u3002\u76f8\u8f83\u7b2c\u4e00\u4ee3TZDs\uff0cMSDC-0602K\u867d\u7136\u4fdd\u7559\u4e86\u7c7b\u4f3c\u7684\u7ed3\u6784\uff0c\u4f46\u5176\u8bbe\u8ba1\u7406\u5ff5\u8bd5\u56fe\u6700\u5927\u9650\u5ea6\u5730\u964d\u4f4ePPAR\u03b3\uff08\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u589e\u6b96\u7269\u6d3b\u5316\u53d7\u4f53\u03b3\uff09\u7684\u76f4\u63a5\u6fc0\u52a8\u6548\u5e94\uff0c\u8fd9\u6837\u5728\u4fdd\u7559\u836f\u6548\u7684\u540c\u65f6\uff0c\u5177\u6709\u4e86\u66f4\u597d\u7684\u5b89\u5168\u6027\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\u25b2MSDC-0602K\u80fd\u591f\u5bf9\u6297\u8425\u517b\u8fc7\u5269\u7684\u4f5c\u7528\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong>Cirius\u516c\u53f8\u5b98\u7f51\uff09<\/span><\/strong><\/span><\/h1>\n


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\u4e3a\u671f12\u4e2a\u6708\uff0c\u8bc4\u4f30\u4e09\u79cd\u53e3\u670d\u5242\u91cf\u7684EMMINENCE\u8bd5\u9a8c\u5c1a\u5728\u8fdb\u884c\u4e2d\u3002\u672c\u6b21\u516c\u5e03\u76846\u4e2a\u6708\u968f\u8bbf\u7684\u4e2d\u671f\u5206\u6790\u8868\u660e\uff0c\u4e0e\u57fa\u7ebf\u76f8\u6bd4\uff0cMSDC-0602K\u7ec4\u7684\u60a3\u8005\u5728\u809d\u529f\u80fd\u548c\u80f0\u5c9b\u7d20\u62b5\u6297\u65b9\u9762\u6709\u7740\u663e\u8457\u6539\u5584\uff1a\u5728125 mg\u5242\u91cf\u7ec4\uff0cALT\u548cAST\u5206\u522b\u964d\u4f4e14.3 U\/L\uff08p<0.001\uff09\u548c7.9 U\/L\uff08p=0.012\uff09<\/strong>\uff1b\u5728250 mg\u5242\u91cf\u7ec4\uff0cALT\u548cAST\u5206\u522b\u964d\u4f4e10.6 U\/L\uff08p=0.004\uff09\u548c4.0 U\/L\uff08NS\uff09<\/strong>\u3002\u6b64\u5916\uff0c\u5728\u60a3\u67092\u578b\u7cd6\u5c3f\u75c5\u7684\u60a3\u8005\u4e2d\uff0c\u6240\u6709MSDC-0602K\u5242\u91cf\u7ec4\u90fd\u663e\u793a\u4e86\u5bf9\u8840\u7cd6\u63a7\u5236\u7684\u6807\u5fd7\u7269\u4e4b\u4e00\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff08HbA1c\uff09\u6c34\u5e73\u7684\u663e\u8457\u6539\u5584\u3002<\/span><\/p>\n


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Cirius\u516c\u53f8\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Bob Baltera\u5148\u751f\u8bf4\uff1a\u201cEMMINENCE\u662f\u5728NASH\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u542b\u6709\u914d\u5bf9\u6d3b\u7ec4\u7ec7\u68c0\u67e5\uff08paired biopsies\uff09\u7684\u6700\u5927\u89c4\u6a212b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002Cirius\u76f8\u4fe1\uff0c\u672c\u6b21\u4e2d\u671f\u7ed3\u679c\u652f\u6301MSDC-0602K\u5177\u6709\u6cbb\u7597\u6709\u7ea4\u7ef4\u5316\u75c7\u72b6\u7684NASH\u7684\u6f5c\u529b\uff0c\u5305\u62ec\u540c\u65f6\u60a3\u67092\u578b\u7cd6\u5c3f\u75c5\u7684\u60a3\u8005\u3002Cirius\u9884\u8ba1\u5c06\u5728\u4eca\u5e74\u4e0b\u534a\u5e74\u53d1\u5e03\u5b8c\u6574\u7684\u6570\u636e\u3002\u201d<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1]. <\/span>Cirius<\/span> Therapeutics Announces Presentation of Interim Data from Phase 2b Clinical Study of MSDC-0602K at The International Liver Congress 2019. Retrieved April\uff0c12, 2019, from https:<\/span>\/\/www.biospace.com\/article\/releases\/cirius-therapeutics-announces-presentation-of-interim-data-from-phase-2b-clinical-study-of-msdc-0602k-at-the-international-liver-congress-2019\/<\/span><\/p>\n

[2]. nash\u65b0\u836f2\u671f\u4e34\u5e8a\u7ed3\u679c\u79ef\u6781. Retrieved April\uff0c12, 2019, from https:<\/span>\/\/www.wuximediaglobal.com<\/span><\/span><\/p>\n


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\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


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\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u65e5\u524d\uff0c\u5728\u5965\u5730\u5229\u7ef4\u4e5f\u7eb3\u4e3e\u529e\u7684\u56fd\u9645\u809d\u810f\u5927\u4f1a\u4e0a\uff0cCirius Therapeutics\u516c […]<\/p>\n","protected":false},"author":1,"featured_media":85289,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85288"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=85288"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85288\/revisions"}],"predecessor-version":[{"id":85292,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85288\/revisions\/85292"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/85289"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=85288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=85288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=85288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}