{"id":85313,"date":"2019-04-13T00:00:50","date_gmt":"2019-04-17T03:20:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/85313\/"},"modified":"2019-04-17T11:20:06","modified_gmt":"2019-04-17T03:20:06","slug":"2d6a71b851","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/85313\/","title":{"rendered":"\u901f\u9012 | \u8054\u5408\u7d22\u9a6c\u9c81\u80bd\u6cbb\u7597NASH\uff0c\u8bfa\u548c\u8bfa\u5fb7\u4e0e\u5409\u5229\u5fb7\u79d1\u5b66\u8fbe\u6210\u5408\u4f5c"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\u4eca\u65e5\uff0c\u5409\u5229\u5fb7\u79d1\u5b66\uff08Gilead Sciences\uff09\u548c\u8bfa\u548c\u8bfa\u5fb7\uff08Novo Nordisk\uff09\u516c\u53f8\u5ba3\u5e03\uff0c\u53cc\u65b9\u5c06\u6c47\u96c6\u5404\u81ea\u836f\u7269\u7814\u53d1\u7ba1\u7ebf\u4e2d\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u7684\u5728\u7814\u7597\u6cd5\uff0c\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u68c0\u9a8c\u8bfa\u548c\u8bfa\u5fb7\u7684\u7d22\u9a6c\u9c81\u80bd\uff08semaglutide\uff09\u4e0e\u5409\u5229\u5fb7\u79d1\u5b66\u7684cilofexor\u548cfirsocostat \u8054\u7528\uff0c\u6cbb\u7597NASH\u60a3\u8005\u7684\u6548\u679c<\/strong>\u3002\u4e24\u5bb6\u516c\u53f8\u540c\u65f6\u5c06\u63a2\u7d22\u8054\u5408\u8fdb\u884c\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u589e\u8fdb\u5bf9NASH\u75c5\u7406\u7406\u89e3\u7684\u53ef\u80fd\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

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NASH\u662f\u4e00\u79cd\u6162\u6027\u8fdb\u884c\u6027\u809d\u75c5\uff0c\u662f\u7531\u4e8e\u809d\u810f\u4e2d\u7684\u8102\u80aa\u79ef\u7d2f\uff0c\u5bfc\u81f4\u809d\u810f\u51fa\u73b0\u708e\u75c7\u3002\u5b83\u53ef\u4ee5\u5bfc\u81f4\u809d\u810f\u7ea4\u7ef4\u5316\uff0c\u5982\u679c\u4e0d\u52a0\u4ee5\u6cbb\u7597\uff0cNASH\u60a3\u8005\u53ef\u80fd\u4f1a\u51fa\u73b0\u809d\u786c\u5316\uff0c\u809d\u529f\u80fd\u8870\u7aed\uff0c\u809d\u764c\u5e76\u4e14\u9700\u8981\u809d\u810f\u79fb\u690d\u3002\u636e\u4f30\u8ba1\uff0c\u52302020\u5e74\uff0cNASH\u5c06\u6210\u4e3a\u7f8e\u56fd\u5bfc\u81f4\u809d\u810f\u79fb\u690d\u624b\u672f\u7684\u9996\u8981\u539f\u56e0<\/strong>\u3002<\/span><\/p>\n

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\u76ee\u524d\uff0c\u6ca1\u6709\u83b7\u6279\u7597\u6cd5\u6cbb\u7597NASH\uff0c\u4f17\u591a\u533b\u836f\u516c\u53f8\u5728\u7814\u53d1\u6cbb\u7597NASH\u7684\u6709\u6548\u7597\u6cd5\uff0c\u5176\u4e2d\u5305\u62ec<\/span>Intercept Pharmaceuticals<\/a>\uff0c<\/span>NGM Biopharmaceuticals<\/a>\uff08\u4e0e\u9ed8\u6c99\u4e1c\u5408\u4f5c\uff09\u3001<\/span>Genfit<\/a>\u3001<\/span>Metacrine<\/a>\u3001<\/span>\u4e0a\u6d77\u62d3\u81fb\u751f\u7269\u751f\u7269\u79d1\u6280<\/a>\uff08Terns\uff09\u7b49\u7b49\u3002FDA\u4e5f\u8ba4\u8bc6\u5230\u5f00\u53d1NASH\u7597\u6cd5\u7684\u91cd\u8981\u6027\uff0c\u4e3a\u4e86\u52a0\u5febNASH\u7597\u6cd5\u7684\u7814\u53d1\uff0c\u62df\u9881\u5e03<\/span>\u5bf9NASH\u4e34\u5e8a\u8bd5\u9a8c\u66ff\u4ee3\u7ec8\u70b9\u7684\u6307\u5357<\/a>\u3002<\/span><\/p>\n

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\u8bfa\u548c\u8bfa\u5fb7\u548c\u5409\u5229\u5fb7\u79d1\u5b66\u7684\u7b56\u7565\u662f\u901a\u8fc7\u7ec4\u5408\u7597\u6cd5\uff0c\u540c\u65f6\u9776\u5411\u5bfc\u81f4NASH\u7684\u591a\u79cd\u4fe1\u53f7\u901a\u8def\uff0c\u4ee5\u6c42\u63d0\u9ad8\u6cbb\u7597NASH\u7684\u6548\u679c\u3002<\/span>\u7d22\u9a6c\u9c81\u80bd\u662f\u4e00\u6b3e\u4eba\u7c7b\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\uff08GLP-1\uff09\u7684\u7c7b\u4f3c\u7269\uff0c\u80fd\u8d77\u5230GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7684\u4f5c\u7528<\/span><\/strong>\u3002\u5b83\u5df2\u7ecf<\/span>\u83b7\u5f97\u6279\u51c6<\/span><\/a>\u5e2e\u52a92\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u63a7\u5236\u8840\u7cd6\u3002\u53e3\u670d\u7d22\u9a6c\u9c81\u80bd\u7684\u65b0\u836f\u7533\u8bf7\u4e5f\u4e8e<\/span><\/span>\u8fd1\u65e5\u9012\u4ea4<\/span><\/a>\u3002<\/span>2\u578b\u7cd6\u5c3f\u75c5\u548c\u80a5\u80d6\u75c7\u662f\u5bfc\u81f4NASH\u7684\u91cd\u8981\u98ce\u9669\u56e0\u7d20\u3002\u6839\u636e\u8bfa\u548c\u8bfa\u5fb7\u7684\u4f30\u8ba1\uff0c40%\u7684NASH\u60a3\u8005\u4e5f\u60a3\u6709\u7cd6\u5c3f\u75c5\uff0c80%\u7684\u60a3\u8005\u60a3\u6709\u80a5\u80d6\u75c7\u3002<\/span>\u7d22\u9a6c\u9c81\u80bd\u4e0d\u4f46\u80fd\u591f\u523a\u6fc0\u80f0\u5c9b\u7d20\u7684\u5206\u6ccc\uff0c\u8fd8\u53ef\u4ee5\u6539\u5584\u809d\u810f\u7684\u8461\u8404\u7cd6\u4ee3\u8c22\u548c\u63d0\u9ad8\u8102\u80aa\u9178\u6c27\u5316<\/span><\/strong>\u3002\u56e0\u6b64\uff0c\u5b83\u5bf9\u6cbb\u7597NASH\u53ef\u80fd\u8d77\u5230\u91cd\u8981\u7684\u8f85\u52a9\u4f5c\u7528\u3002<\/span><\/p>\n


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\u5409\u5229\u5fb7\u79d1\u5b66\u7684cilofexor\u662f\u4e00\u6b3e\u6cd5\u5c3c\u9187X\u53d7\u4f53\uff08FXR\uff09\u6fc0\u52a8\u5242<\/strong>\uff0cFXR\u5728\u809d\u810f\u8102\u80aa\u4ee3\u8c22\u4e2d\u8d77\u5230\u91cd\u8981\u4f5c\u7528\uff0c\u662f\u591a\u5bb6\u533b\u836f\u516c\u53f8NASH\u7597\u6cd5\u7684\u9776\u6807\u3002<\/span>Firsocostat\u662f\u4e00\u79cd\u4e59\u9170\u8f85\u9176A\u7fa7\u5316\u9176\uff08ACC\uff09\u6291\u5236\u5242<\/span><\/strong>\uff0cACC\u662f\u8102\u80aa\u4ece\u5934\u5408\u6210\u8fc7\u7a0b\u4e2d\u7684\u9650\u901f\u9176\u3002\u6628\u65e5\uff0c\u5409\u5229\u5fb7\u79d1\u5b66\u521a\u521a\u5728\u56fd\u9645\u809d\u810f\u5927\u4f1a\u516c\u5e03\u4e86\u8fd9\u4e24\u79cd\u836f\u7269\u6784\u6210\u7684\u7ec4\u5408\u7597\u6cd5\u6cbb\u7597NASH\u60a3\u8005\u7684<\/span>\u6982\u5ff5\u9a8c\u8bc1\u7ed3\u679c<\/span><\/a>\u3002\u8fd9\u4e00\u7ec4\u5408\u7597\u6cd5\u80fd\u591f\u8ba974%\u60a3\u8005\u7684\u809d\u810f\u8102\u80aa\u6c34\u5e73\u964d\u4f4e\u81f3\u5c1130%<\/strong>\u3002\u540c\u65f6\u8840\u6e05\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08ALT\uff09\u6c34\u5e73\u5e73\u5747\u4e0b\u964d37%\uff08p<0.001\uff09\uff0c\u03b3-\u8c37\u6c28\u9170\u8f6c\u79fb\u9176\uff08GGT\uff09\u6c34\u5e73\u5e73\u5747\u4e0b\u964d32%\uff08p<0.001\uff09\u3002<\/span><\/p>\n


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\u201cNASH\u662f\u4e00\u79cd\u7ecf\u5e38\u56f0\u6270\u7cd6\u5c3f\u75c5\u548c\u4ee3\u8c22\u7efc\u5408\u5f81\u60a3\u8005\u7684\u590d\u6742\u75be\u75c5\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u591f\u4e0e\u8bfa\u548c\u8bfa\u5fb7\u8fbe\u6210\u8fd9\u4e00\u91cd\u8981\u5408\u4f5c\uff0c\u7ed3\u5408\u8bfa\u548c\u8bfa\u5fb7\u5728\u7cd6\u5c3f\u75c5\u548c\u65b0\u9648\u4ee3\u8c22\u65b9\u9762\uff0c\u4ee5\u53ca\u5409\u5229\u5fb7\u79d1\u5b66\u5728\u809d\u810f\u75be\u75c5\u548c\u7ec4\u5408\u7597\u6cd5\u65b9\u9762\u7684\u4e13\u957f\uff0c\u201d\u5409\u5229\u5fb7\u79d1\u5b66\u9996\u5e2d\u79d1\u5b66\u5b98\u517c\u7814\u53d1\u8d1f\u8d23\u4ebaJohn McHutchison\u535a\u58eb\u8bf4\uff1a\u201c\u6211\u4eec\u671f\u5f85\u4e0e\u8bfa\u548c\u8bfa\u5fb7\u5408\u4f5c\u63a2\u7d22\u6cbb\u7597NASH\u7684\u521b\u65b0\u7597\u6cd5\u3002\u201d<\/span><\/p>\n


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\u201c\u6211\u4eec\u975e\u5e38\u770b\u597d\u4e0e\u5409\u5229\u5fb7\u79d1\u5b66\u5408\u4f5c\u7684\u6f5c\u529b\uff0c\u5229\u7528\u4e24\u5bb6\u516c\u53f8\u884c\u4e1a\u9886\u5148\u7684\u5206\u5b50\u79d1\u5b66\u548c\u4e34\u5e8a\u7814\u7a76\u4e13\u957f\uff0c\u6211\u4eec\u671f\u5f85\u5f00\u53d1\u521b\u65b0\u6709\u6548\u7684\u7ec4\u5408\u7597\u6cd5\uff0c\u4e3aNASH\u60a3\u8005\u9020\u798f\u3002\u201d\u8bfa\u5fb7\u8bfa\u5fb7\u516c\u53f8\u9996\u5e2d\u79d1\u5b66\u5b98\u517c\u6267\u884c\u526f\u603b\u88c1Mads Krogsgaard Thomsen\u535a\u58eb\u8865\u5145\u9053\u3002<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] A blockbuster cocktail?<\/span> Gilead slides Novo Nordisk\u2019s <\/span>semaglutide<\/span> into new NASH triple therapy. Retrieved April 12, 2019, from https:<\/span>\/\/endpts.com\/a-blockbuster-cocktail-gilead-slides-novo-nordisks-semaglutide-into-new-nash-triple-therapy\/<\/span><\/p>\n

[2] Gilead Sciences and Novo Nordisk Announce Intent to Initiate a Clinical Collaboration in NASH. Retrieved April 12, 2019, from https:<\/span>\/\/www.businesswire.com\/news\/home\/20190412005104\/en\/<\/span><\/span><\/p>\n


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\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


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