{"id":85338,"date":"2019-04-12T00:00:50","date_gmt":"2019-04-17T03:20:24","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/85338\/"},"modified":"2019-04-17T11:20:25","modified_gmt":"2019-04-17T03:20:25","slug":"85528e4132","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/85338\/","title":{"rendered":"\u901f\u9012 | \u663e\u8457\u589e\u52a0\u9002\u7528\u60a3\u8005\u6570\uff0cKeytruda\u83b7\u6279\u6269\u5c55\u5355\u836f\u4e00\u7ebf\u6cbb\u7597\u80ba\u764c\u9002\u5e94\u75c7\u8303\u56f4"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\u4eca\u65e5\uff0cFDA\u5ba3\u5e03\uff0c\u6279\u51c6\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u516c\u53f8\u5f00\u53d1\u7684\u91cd\u78c5\u6297PD-1\u7597\u6cd5 Keytruda\uff08pembrolizumab\uff09\u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\uff0c\u4e00\u7ebf\u6cbb\u7597PD-L1\u9633\u6027\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u3002<\/strong><\/span>\u8fd9\u4e9b\u60a3\u8005\u7684\u80bf\u7624\u4e0d\u643a\u5e26EGFR<\/em>\u6216ALK<\/em>\u57fa\u56e0\u53d8\u5f02<\/span>\uff0c<\/span><\/strong>\u5e76\u4e14\u7ecfFDA\u6279\u51c6\u7684\u68c0\u6d4b\u8868\u660e<\/span>PD-L1\u8868\u8fbe\u80bf\u7624\u6bd4\u4f8b\u8bc4\u5206\uff08TPS\uff09\u8d85\u8fc71%<\/span><\/strong>\u3002\u8fd9\u662f\u7ee7Keytruda\u4e0e\u5316\u7597\u7ec4\u5408\u5728<\/span>\u4e2d\u56fd\u5927\u9646\u83b7\u6279\u4e00\u7ebf\u6cbb\u7597NSCLC<\/span><\/a>\u4e4b\u540e\uff0c\u518d\u5ea6\u8fbe\u5230\u7684\u4e00\u4e2a\u91cc\u7a0b\u7891\u3002\u672c\u6b21\u6279\u51c6\u5c06\u663e\u8457\u589e\u52a0Keytruda\u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\uff0c\u4e00\u7ebf\u6cbb\u7597NSCLC\u60a3\u8005\u7684\u9002\u7528\u8303\u56f4\u3002\u5bf9\u4e8ePD-L1\u9633\u6027\u7684NSCLC\u60a3\u8005\u6765\u8bf4\uff0c\u5b83\u53ef\u80fd\u6210\u4e3a\u6700\u4f73\u6cbb\u7597\u9009\u62e9\u4e4b\u4e00\u3002<\/span><\/p>\n


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\u5728\u6cbb\u7597\u80ba\u764c\u65b9\u9762\uff0cKeytruda\u6700\u521d\u57282015\u5e74\u83b7\u6279\u4f5c\u4e3a2\u7ebf\u7597\u6cd5\uff0c\u6cbb\u7597\u8868\u8fbePD-L1\u7684\u665a\u671fNSCLC\u60a3\u8005\u3002\u57282016\u5e7410\u6708\u9996\u6b21\u6210\u4e3a\u4e00\u7ebf\u7597\u6cd5\uff0c\u83b7\u6279\u5355\u836f\u6cbb\u7597PD-L1\u9ad8\u8868\u8fbe\uff08TSP\u226550%\uff09\u7684\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u3002\u7136\u800c\uff0c\u5728\u80ba\u764c\u60a3\u8005\u4e2d\uff0cPD-L1\u9ad8\u8868\u8fbe\u7684\u60a3\u8005\u6570\u76ee\u53ea\u536030%\u3002\u672c\u6b21\u6279\u51c6\u5c06\u9002\u5408\u63a5\u53d7Keytruda\u6cbb\u7597\u7684\u60a3\u8005PD-L1\u8868\u8fbe\u6807\u51c6\u964d\u4f4e\u5230TPS\u22651%\uff0c\u6839\u636e\u4ee5\u5f80\u5bf9\u80ba\u764c\u60a3\u8005PD-L1\u8868\u8fbe\u6c34\u5e73\u5206\u5e03\u7684\u7814\u7a76\uff0c\u8fd9\u53ef\u80fd\u8ba9\u9002\u5408\u63a5\u53d7Keytruda\u5355\u836f\u6cbb\u7597\u7684PD-L1\u9633\u6027NSCLC\u60a3\u8005\u6570\u63d0\u9ad8\u4e00\u500d\u4ee5\u4e0a<\/strong>\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

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\u25b2Keytruda\u80ba\u764c\u9002\u5e94\u75c7\u83b7\u6279\u5386\u53f2\uff08\u5236\u56fe\uff09<\/span><\/strong><\/h1>\n


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\u8fd9\u4e00\u6279\u51c6\u662f\u57fa\u4e8eKeytruda\u5728\u8fd1\u65e5\u516c\u5e03\u7684<\/span>KEYNOTE-042\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c<\/span>\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0cPD-L1\u9633\u6027\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u63a5\u53d7\u4e86Keytruda\u6216\u5316\u7597\u7684\u6cbb\u7597\uff0c\u8fd9\u4e9b\u60a3\u8005\u4e0d\u643a\u5e26EGFR\u6216ALK\u57fa\u56e0\u7a81\u53d8\u3002\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u65e0\u8bba\u60a3\u8005PD-L1\u8868\u8fbe\u7684TPS\u226550%\uff0c\u226520%\uff0c\u6216\u22651%\uff0cKeytruda\u5355\u836f\u6cbb\u7597\u7684\u603b\u751f\u5b58\u671f\u90fd\u4f18\u4e8e\u5316\u7597\u7ec4<\/strong>\u3002\u5bf9\u4e8eTPS\u226550%\u7684\u60a3\u8005\uff0cKeytruda\u7ec4\u548c\u5316\u7597\u7ec4\u7684\u4e2d\u4f4d\u751f\u5b58\u671f\u5206\u522b\u4e3a20.0\u4e2a\u6708\u548c12.2\u4e2a\u6708\uff0cKeytruda\u7ec4\u6b7b\u4ea1\u98ce\u9669\u663e\u8457\u964d\u4f4e31%\u3002TPS\u226520%\u548cTPS\u22651%\u7684\u60a3\u8005\uff0c\u6b7b\u4ea1\u98ce\u9669\u5206\u522b\u663e\u8457\u964d\u4f4e23%\uff08\u4e2d\u4f4d\u751f\u5b58\u671f17.7\u4e2a\u6708 vs 13.0\u4e2a\u6708\uff09\u548c19%\uff0816.7\u4e2a\u6708 vs 12.1\u4e2a\u6708\uff09\u3002<\/span><\/p>\n


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\u63a2\u7d22\u6027\u5206\u6790\u663e\u793a\uff0c\u5373\u4fbf\u5728TPS\u4e3a1%-49%\u7684\u60a3\u8005\u4eba\u7fa4\u4e2d\uff0cKeytruda\u5bf9\u603b\u751f\u5b58\u671f\u7684\u6539\u5584\u4e5f\u4e0e\u5316\u7597\u76f8\u5f53\uff0c\u751a\u81f3\u8fd8\u663e\u793a\u51fa\u4e86\u4e00\u5b9a\u4f18\u52bf\uff0c\u4f46\u672a\u8fbe\u5230\u7edf\u8ba1\u5b66\u663e\u8457\u3002\u800c\u4e14\u4ece\u526f\u4f5c\u7528\u89d2\u5ea6\u770b\uff0cKeytruda\u5355\u836f\u7597\u6cd5\u4ea7\u751f\u7684\u526f\u4f5c\u7528\u5c0f\u4e8e\u5316\u7597\uff0c\u8ba9\u5b83\u53ef\u80fd\u6210\u4e3a\u66f4\u4f18\u79c0\u7684\u4e00\u7ebf\u7597\u6cd5\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\"\u901f\u9012<\/p>\n

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[1] Keytruda nabs key lung cancer nod in China. But are blockbuster sales really attainable?<\/span> Retrieved April 10, 2019, from https:<\/span>\/\/www.fiercepharma.com\/pharma-asia\/keytruda-nabs-first-line-lung-cancer-nod-china-but-blockbuster-sale-really-attainable<\/span><\/p>\n

[2] FDA Grants Priority Review to Merck\u2019s Supplemental Biologics License Application for KEYTRUDA\u00ae (pembrolizumab) Monotherapy for Third-Line Treatment of Patients with Advanced Small  Lung Cancer (SCLC). Retrieved April 10, 2019, from https:<\/span>\/\/www.businesswire.com\/news\/home\/20190220005296\/en\/FDA-Grants-Priority-Review-Merck%E2%80%99s-Supplemental-Biologics<\/span><\/p>\n

[3] AACR:<\/span> Merck’s Keytruda, up for new FDA nod, spurs lengthy responses in small cell lung cancer. Retrieved April 10, 2019, from https:<\/span>\/\/www.fiercepharma.com\/pharma\/merck-s-keytruda-awaiting-fda-nod-provokes-lengthy-responses-small-cell-lung-cancer<\/span><\/p>\n

[4] Gandhi et al., (2018) Pembrolizumab plus Chemotherapy in Metastatic Non\u2013Small- Lung Cancer. New England Journal of Medicine, DOI:<\/span> 10.1056\/NEJMoa1801005<\/span><\/p>\n

[5] Munari et al., (2017). PD-L1 expression heterogeneity in non-small cell lung cancer:<\/span> evaluation of small biopsies reliability. Oncotarget, <\/span>doi<\/span>:<\/span> 10.18632\/oncotarget.21485<\/span><\/p>\n

[6] Tony S K Mok, et al., (2019). Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial. The Lancet, 10.1016\/S0140-6736(18)32409-7<\/span><\/span><\/p>\n


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