{"id":85361,"date":"2019-04-12T00:00:50","date_gmt":"2019-04-17T03:20:39","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/85361\/"},"modified":"2019-04-17T11:20:40","modified_gmt":"2019-04-17T03:20:40","slug":"00c8f2e742","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/85361\/","title":{"rendered":"\u901f\u9012 | \u521b\u65b0\u6297\u4f53\u4f18\u5316\u5e73\u53f0\u6539\u8fdb\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0cTwist\u8fbe\u6210\u7814\u53d1\u5408\u4f5c"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\u4eca\u65e5\uff0c\u5408\u4f5c\u4f19\u4f34Twist Bioscience\u5ba3\u5e03\u4e0ePandion Therapeutics\u8fbe\u6210\u4e00\u9879\u5408\u4f5c\u534f\u8bae\uff0cPandion\u5c06\u5229\u7528Twist\u7684\u6297\u4f53\u4f18\u5316\uff08Twist Antibody Optimization\uff0cTAO\uff09\u5e73\u53f0\u4f18\u5316\u5176\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7684\u9776\u5411\u81c2<\/strong>\u3002<\/span><\/p>\n

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\"\u901f\u9012<\/p>\n

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\u4f5c\u4e3a\u4e00\u5bb6\u884c\u4e1a\u9886\u5148\u5e76\u4e14\u53d1\u5c55\u8fc5\u901f\u7684DNA\u5408\u6210\u751f\u7269\u6280\u672f\u516c\u53f8\uff0cTwist\u72ec\u7279\u7684\u57fa\u4e8e\u534a\u5bfc\u4f53\u7845\u82af\u7247\u7684DNA\u5408\u6210\u6280\u672f\u5e73\u53f0\uff0c\u80fd\u591f\u9ad8\u901a\u91cf\uff0c\u9ad8\u4fdd\u771f\u5ea6\u3001\u4f4e\u6210\u672c\u5730\u4e3a\u5ba2\u6237\u5408\u6210DNA\u548c\u57fa\u56e0\u3002\u5b83\u4eec\u53ef\u4ee5\u7528\u4e8e\u533b\u7597\u5065\u5eb7\u9886\u57df\u7684\u836f\u7269\u7814\u53d1\u548c\u5206\u5b50\u8bca\u65ad\uff0c\u5316\u5b66\u751f\u4ea7\uff0c\u519c\u4e1a\uff0c\u57fa\u7840\u79d1\u5b66\u7814\u7a76\u4ee5\u53ca\u6570\u636e\u50a8\u5b58\u7814\u7a76\u3002<\/span><\/p>\n

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Twist\u8fd8\u5efa\u7acb\u4e86TAO\u5e73\u53f0\uff0c\u5c06\u5176\u72ec\u6709\u7684DNA\u5408\u6210\u6280\u672f\u5e94\u7528\u4e8e\u4eba\u6e90\u5316\u6297\u4f53\u7684\u4eb2\u548c\u529b\u7684\u6210\u719f\u8fc7\u7a0b\u3002<\/span><\/strong>\u8fd9\u4e00\u8fc7\u7a0b\u901a\u5e38\u9700\u8981\u901a\u8fc7\u4f7f\u7528NNK\/NNS\/TRIM\u7b49\u968f\u673a\u5316\u65b9\u6848\u5728\u6297\u4f53\u7684\u4e92\u8865\u51b3\u5b9a\u533a\uff08complementarity-determining regions\uff0cCDR\uff09\u548c\u6846\u67b6\u533a\u4e2d\u8bf1\u53d1\u7a81\u53d8\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u65b9\u6848\u4f1a\u4ea7\u751f\u5927\u91cf\u4e0d\u9700\u8981\u7684\u7a81\u53d8\u4f4d\u70b9\uff0c\u5e76\u4e3a\u4e0b\u6e38\u751f\u4ea7\u9020\u6210\u8d1f\u62c5\u3002<\/span><\/p>\n


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TAO\u5e73\u53f0\u901a\u8fc7\u81ea\u5b9a\u4e49\u7b97\u6cd5\uff0c\u53c2\u7167\u5929\u7136\u4eba\u4f53\u6297\u4f53\u5e8f\u5217\u4fe1\u606f\u6784\u5efa\u4f18\u5316\u7684\u6297\u4f53\u5e93\u3002\u7136\u540e\u5229\u7528Twist\u7845\u82af\u7247DNA\u5408\u6210\u6280\u672f\u5e73\u53f0\uff0c\u53ef\u4ee5\u5feb\u901f\u548c\u7cbe\u786e\u5730\u5408\u6210\u7684\u6297\u4f53\u5e93\uff0c\u907f\u514d\u65e0\u529f\u80fd\u5e8f\u5217\u4e32\uff0c\u6c28\u57fa\u9178\u8d1f\u62c5\u548c\u5df2\u6709\u7684\u5546\u4e1aCDR\u7a7a\u95f4\u3002\u4ec5\u4ec5\u901a\u8fc7\u8868\u8fbe\u4e0e\u81ea\u7136CDR\u8c31\u7cfb\u5339\u914d\u7684\u5e8f\u5217\uff0c\u6240\u5f97\u5230\u7684\u6297\u4f53\u5e93\u4e5f\u964d\u4f4e\u4e86\u836f\u7269\u5f00\u53d1\u7ba1\u7ebf\u7684\u514d\u75ab\u539f\u6027\u98ce\u9669\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\u25b2TAO\u5e73\u53f0\u7684\u6d41\u7a0b\u548c\u5176\u6280\u672f\u4f18\u52bf\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong>Twist\u5b98\u7f51\uff09<\/span><\/strong><\/span><\/p>\n


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\u80bf\u7624\u7684\u4e00\u9879\u91cd\u8981\u80fd\u529b\u662f\u9003\u907f\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u7684\u76d1\u6d4b\u548c\u653b\u51fb\u3002Pandion\u516c\u53f8\u7684\u7814\u53d1\u7b56\u7565\u662f\u7814\u53d1\u7279\u522b\u7684\u7ec4\u7ec7\u7279\u5f02\u6027\u6297\u4f53\uff0c\u8fd9\u4e9b\u6297\u4f53\u80fd\u591f\u6a21\u62df\u80bf\u7624\u4e2d\u6291\u5236\u514d\u75ab\u7cfb\u7edf\u7684\u5206\u5b50\u7684\u80fd\u529b\uff0c\u4ece\u800c\u5728\u5c40\u90e8\u4fdd\u62a4\u7ec4\u7ec7\u6216\u5668\u5b98\u4e0d\u53d7\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u5f71\u54cd<\/strong>\u3002\u8be5\u516c\u53f8\u7684\u53cc\u7279\u5f02\u6027\uff08bi-specific\uff09\u6297\u4f53\u8ddf\u4f20\u7edf\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u4e0d\u540c\uff0c\u5b83\u7684\u5c3e\u90e8\u80fd\u591f\u4e0e\u7279\u5b9a\u7ec4\u7ec7\u6216\u5668\u5b98\u7ed3\u5408\uff0c\u4f8b\u5982\u53d7\u5230\u708e\u75c7\u75be\u75c5\u5f71\u54cd\u7684\u809d\u810f\u3001\u80be\u810f\u6216\u76ae\u80a4\u3002\u800c\u6297\u4f53\u7684\u5934\u90e8\u6784\u6210\u4e00\u4e2a\u4fdd\u62a4\u5c42\uff0c\u6291\u5236\u6fc0\u6d3b\u7684T\u7ec6\u80de\u5e76\u4e14\u6fc0\u6d3b\u8c03\u8282\u6027T\u7ec6\u80de\u3002\u8fd9\u79cd\u65b9\u6cd5\u80fd\u591f\u5c06\u514d\u75ab\u6291\u5236\u529f\u80fd\u63a7\u5236\u5728\u5c40\u90e8\u7ec4\u7ec7\uff0c\u4ece\u800c\u907f\u514d\u4e86\u5168\u8eab\u6027\u514d\u75ab\u6291\u5236\u836f\u7269\u7684\u526f\u4f5c\u7528\u3002\u4e0e\u8c03\u8282\u514d\u75ab\u6d3b\u6027\u7684\u6548\u5e94\u5206\u5b50\u7ed3\u5408\uff0c\u6062\u590d\u514d\u75ab\u7a33\u6001\u3002<\/span><\/p>\n


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Pandion\u8054\u5408\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98Anthony Coyle\u535a\u58eb\u8bf4\u3002\uff1a\u201cTwist\u7684\u751f\u7269\u5236\u836f\u90e8\u95e8\uff0c\u5177\u6709\u5bf9\u6297\u4f53\u8fdb\u884c\u9ad8\u5ea6\u5dee\u5f02\u5316\u4f18\u5316\u7684\u80fd\u529b\uff0c\u53ef\u4f18\u5316\u6297\u4f53\u7684\u5c5e\u6027\u5305\u62ec\u4eb2\u548c\u529b\uff0c\u8868\u8fbe\u6c34\u5e73\uff0c\u6eb6\u89e3\u5ea6\uff0c\u534a\u8870\u671f\uff0c\u514d\u75ab\u539f\u6027\uff0c\u53ef\u6210\u836f\u6027\u548c\u53ef\u52a0\u5de5\u6027\u3002Pandion\u671f\u5f85\u7740\u8fd9\u4e2a\u4e13\u6ce8\u4e8e\u5173\u952e\u7597\u6cd5\u9776\u70b9\u7684\u65e9\u671f\u9879\u76ee\uff0c\u53ef\u80fd\u4e3a\u9700\u8981\u65b0\u6cbb\u7597\u65b9\u6848\u7684\u60a3\u8005\u5e26\u6765\u5e0c\u671b\u3002\u201d<\/span><\/p>\n


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Twist\u8054\u5408\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98Emily M. Leproust\u535a\u58eb\u8bc4\u8bba\u9053\uff1a\u201c\u901a\u8fc7\u5728\u75be\u75c5\u90e8\u4f4d\u5c40\u90e8\u8d77\u4f5c\u7528\u7684\u6297\u4f53\u7597\u6cd5\u6765\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u548c\u708e\u75c7\u6027\u75be\u75c5\uff0cPandion\u6b63\u5728\u52aa\u529b\u6539\u53d8\u7597\u6cd5\u7684\u8f68\u8ff9\uff0c\u5229\u7528Twist\u6700\u5148\u8fdb\u7684\u6297\u4f53\u4f18\u5316\u5e73\u53f0\uff0c\u6211\u4eec\u671f\u5f85\u4e0ePandion\u5408\u4f5c\uff0c\u5f00\u53d1\u51fa\u6709\u6f5c\u529b\u6539\u5584\u7597\u6548\u7684\u4eba\u6e90\u5316\u589e\u5f3a\u6297\u4f53\u3002\u201d<\/span><\/p>\n


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[1]. Twist Bioscience Announces Antibody Optimization Agreement with Pandion Therapeutics. Retrieved April\uff0c11, 2019, from https:<\/span>\/\/www.businesswire.com\/news\/home\/20190411005229\/en\/<\/span><\/p>\n

[2]. \u795d\u8d3a\uff01<\/span>Twist Bioscience\u767b\u9646\u7eb3\u65af\u8fbe\u514b\uff0cIPO\u52df\u8d447000\u4e07\u7f8e\u5143. Retrieved April\uff0c11, 2019, from https:<\/span>\/\/mp.weixin.qq.com\/s\/skng9n8Kgknftf6VylIM6w<\/span><\/p>\n

[3]. \u795d\u8d3a!<\/span> 2018\u201c\u751f\u7269\u6280\u672f\u731b\u516c\u53f8\u201d\u63ed\u6653\uff0c\u817e\u76db\u535a\u836f\u699c\u4e0a\u6709\u540d. Retrieved April\uff0c11, 2019, from https:<\/span>\/\/mp.weixin.qq.com\/s\/NG1VkWuG8KVA3y2T9ww0Lg<\/span><\/span><\/p>\n


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\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


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\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u4eca\u65e5\uff0c\u5408\u4f5c\u4f19\u4f34Twist Bioscience\u5ba3\u5e03\u4e0ePandion Th […]<\/p>\n","protected":false},"author":1,"featured_media":85362,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85361"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=85361"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85361\/revisions"}],"predecessor-version":[{"id":85365,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85361\/revisions\/85365"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/85362"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=85361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=85361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=85361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}