{"id":85802,"date":"2019-04-13T00:00:50","date_gmt":"2019-04-18T07:52:44","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/85802\/"},"modified":"2019-04-18T15:52:47","modified_gmt":"2019-04-18T07:52:47","slug":"b5d559396a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/85802\/","title":{"rendered":"\u6052\u745e\u533b\u836f\uff0c\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u6279\u4e0a\u5e02 | Insight \u6bcf\u65e5\u65b0\u95fb"},"content":{"rendered":"
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\u70b9\u51fb\u4e0a\u65b9\u7684<\/span>  \u25b2<\/span> \u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/p>\n


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\u4eca\u65e5\u65b0\u95fb\u6982\u8981<\/strong><\/span><\/h3>\n

1.<\/span><\/strong>  \u963f\u65af\u5229\u5eb7\u4e00\u836f\u54c1\u5728\u6b27\u76df\u83b7\u6279\u6cbb\u7597\u665a\u671f\u4e73\u817a\u764c<\/span><\/p>\n

2.<\/span><\/span><\/strong>  <\/span>Keytruda \u83b7\u6279\u65b0\u9002\u5e94\u75c7<\/span><\/p>\n

3.<\/span><\/strong>  <\/span>\u4f17\u751f\u836f\u4e1a\u7b2c\u4e8c\u4e2a\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\uff08NASH\uff09\u521b\u65b0\u836f\u83b7\u6279\u4e34\u5e8a<\/span><\/p>\n

4.<\/span><\/strong>  <\/span>\u6c5f\u897f\u8ddf\u8fdb 4+7 \u4e0a\u62a5\u91c7\u8d2d\u91cf<\/span><\/p>\n

5.<\/span><\/strong>  <\/span><\/span>\u6c5f\u82cf\u6052\u745e\u66f2\u7f8e\u4ed6\u55ea\u83b7\u6279\u4e0a\u5e02<\/span><\/p>\n<\/section>\n<\/section>\n


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\"\u6052\u745e\u533b\u836f\uff0c\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u6279\u4e0a\u5e02<\/p>\n

\u963f\u65af\u5229\u5eb7 Lynparza \u5728\u6b27\u76df\u83b7\u6279\u6cbb\u7597\u665a\u671f\u4e73\u817a\u764c<\/strong><\/p>\n


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\u8fd1\u65e5\uff0c\u963f\u65af\u5229\u5eb7\u548c\u9ed8\u6c99\u4e1c\u5ba3\u5e03\uff0c\u6b27\u76df\u59d4\u5458\u4f1a\u6279\u51c6\u4e86 olaparib\uff08\u5965\u62c9\u5e15\u5229\uff0c\u5546\u54c1\u540d\uff1aLynparza\uff09\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\u751f\u6b96\u7cfb BRCA1\/2 \u57fa\u56e0\u7a81\u53d8\uff08gBRCAm\uff09\u4ee5\u53ca\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53 2\uff08HER2\uff09\u9634\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\uff0c\u8fd9\u4e5f\u662f\u6b27\u76df\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u4eba\u7fa4\u6279\u51c6\u7684\u7b2c\u4e00\u6b3e PARP \u6291\u5236\u5242\u3002<\/span><\/p>\n


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\u6b64\u6b21\u6279\u51c6\u589e\u52a0\u4e86\u8be5\u836f\u7269\u5728\u5375\u5de2\u764c\u4e2d\u73b0\u6709\u7684\u4e24\u79cd\u8bb8\u53ef\u7528\u9014\uff08\u665a\u671f\u75be\u75c5\u548c\u7ef4\u6301\u6cbb\u7597\uff09\uff0c\u8fd9\u662f\u7ee7\u8be5\u836f 2018 \u5e74\u5728\u7f8e\u56fd\u83b7\u5f97\u76f8\u4f3c\u6279\u51c6\u540e\uff0c\u9762\u5411\u5168\u7403\u8303\u56f4\u5185\u66f4\u5e7f\u60a3\u8005\u7fa4\u4f53\u7684\u518d\u4e00\u6b21\u6269\u5c55\u3002<\/span><\/p>\n


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\"\u6052\u745e\u533b\u836f\uff0c\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u6279\u4e0a\u5e02<\/p>\n

Keytruda \u83b7\u6279\u65b0\u9002\u5e94\u75c7\uff0c\u5355\u836f\u4e00\u7ebf\u6cbb\u7597\u80ba\u764c<\/strong><\/p>\n


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\u4eca\u65e5\uff0cFDA \u5ba3\u5e03\uff0c\u6279\u51c6\u9ed8\u6c99\u4e1c\u516c\u53f8\u5f00\u53d1\u7684\u91cd\u78c5\u6297 PD-1 \u7597\u6cd5 Keytruda\uff08pembrolizumab\uff09\u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\uff0c\u4e00\u7ebf\u6cbb\u7597 PD-L1 \u9633\u6027\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u3002<\/span>\u8fd9\u4e9b\u60a3\u8005\u7684\u80bf\u7624\u4e0d\u643a\u5e26 EGFR \u6216 ALK \u57fa\u56e0\u53d8\u5f02\uff0c\u5e76\u4e14\u7ecf FDA \u6279\u51c6\u7684\u68c0\u6d4b\u8868\u660e PD-L1 \u8868\u8fbe\u80bf\u7624\u6bd4\u4f8b\u8bc4\u5206\uff08TPS\uff09\u8d85\u8fc7 1%\u3002<\/span><\/p>\n


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\"\u6052\u745e\u533b\u836f\uff0c\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u6279\u4e0a\u5e02<\/p>\n


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\u8fd9\u662f\u7ee7 Keytruda \u4e0e\u5316\u7597\u7ec4\u5408\u5728\u4e2d\u56fd\u5927\u9646\u83b7\u6279\u4e00\u7ebf\u6cbb\u7597 NSCLC \u4e4b\u540e\uff0c\u518d\u5ea6\u8fbe\u5230\u7684\u4e00\u4e2a\u91cc\u7a0b\u7891\u3002<\/span>\u672c\u6b21\u6279\u51c6\u5c06\u663e\u8457\u589e\u52a0 Keytruda \u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\uff0c\u4e00\u7ebf\u6cbb\u7597 NSCLC \u60a3\u8005\u7684\u9002\u7528\u8303\u56f4\u3002<\/span>\u5bf9\u4e8e PD-L1 \u9633\u6027\u7684 NSCLC \u60a3\u8005\u6765\u8bf4\uff0c\u5b83\u53ef\u80fd\u6210\u4e3a\u6700\u4f73\u6cbb\u7597\u9009\u62e9\u4e4b\u4e00\u3002<\/span>
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\"\u6052\u745e\u533b\u836f\uff0c\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u6279\u4e0a\u5e02<\/p>\n

\u4f17\u751f\u836f\u4e1a\u7b2c\u4e8c\u4e2a\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\uff08NASH\uff09\u521b\u65b0\u836f\u83b7\u6279\u4e34\u5e8a<\/strong><\/p>\n


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4 \u6708 11 \u65e5\uff0c\u5e7f\u4e1c\u4f17\u751f\u836f\u4e1a\u53d1\u5e03\u516c\u544a\uff0c\u5176\u63a7\u80a1\u5b50\u516c\u53f8\u4f17\u751f\u777f\u521b\u751f\u7269\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6838\u53d1\u7684\u300a\u4e34\u5e8a\u8bd5\u9a8c\u901a\u77e5\u4e66\u300b\uff0c\u516c\u53f8\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u521b\u65b0\u836f ZSP0678 \u83b7\u6279\u4e34\u5e8a\uff0c\u8fd9\u662f\u8be5\u516c\u53f8\u7b2c\u4e8c\u4e2a NASH \u521b\u65b0\u836f\u3002<\/span>
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\"\u6052\u745e\u533b\u836f\uff0c\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u6279\u4e0a\u5e02<\/p>\n


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\"\u6052\u745e\u533b\u836f\uff0c\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u6279\u4e0a\u5e02<\/p>\n

\u6c5f\u897f\u8ddf\u8fdb 4+7\uff0c\u5f00\u59cb\u4e0a\u62a5\u91c7\u8d2d\u91cf<\/strong><\/strong><\/strong><\/p>\n


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\u8fd1\u65e5\uff0c\u6c5f\u897f\u7701\u533b\u7597\u4fdd\u969c\u5c40\u8054\u5408\u6c5f\u897f\u7701\u536b\u5065\u59d4\u53d1\u5e03\u901a\u77e5\uff0c\u8981\u6c42\u5168\u7701\u5404\u516c\u7acb\u533b\u7597\u536b\u751f\u673a\u6784\u586b\u62a5 25 \u79cd\u56fd\u5bb6\u5e26\u91cf\u91c7\u8d2d\u4e2d\u9009\u836f\u54c1\u7684\u5e74\u5ea6\u8ba1\u5212\u91c7\u8d2d\u91cf\uff0c\u4e14\u5f3a\u8c03\u8be5\u91c7\u8d2d\u91cf\u6709\u53ef\u80fd\u4f5c\u4e3a\u672c\u673a\u6784\u5e26\u91cf\u91c7\u8d2d\u8bd5\u70b9\u7684\u6570\u91cf\u7ea6\u5b9a\u3002\u8fd9\u8868\u660e\uff0c\u6c5f\u897f\u7701\u5f00\u59cb\u8ddf\u8fdb 4+7\u3002<\/span><\/p>\n


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\"\u6052\u745e\u533b\u836f\uff0c\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u6279\u4e0a\u5e02<\/p>\n


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\"\u6052\u745e\u533b\u836f\uff0c\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u6279\u4e0a\u5e02<\/p>\n

\u6c5f\u82cf\u6052\u745e\u300c\u76d0\u9178\u66f2\u7f8e\u4ed6\u55ea\u7f13\u91ca\u7247\u300d\u83b7\u6279\u4e0a\u5e02<\/strong>
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4 \u6708 12 \u65e5\uff0c\u6c5f\u82cf\u6052\u745e\u7684\u300c\u76d0\u9178\u66f2\u7f8e\u4ed6\u55ea\u7f13\u91ca\u7247\u300d\u88ab\u6536\u5f55\u5230\u300a\u4e0a\u5e02\u836f\u54c1\u76ee\u5f55\u96c6\u300b\uff0c\u8be5\u836f\u6309\u7167\u65b0\u6ce8\u518c\u5206\u7c7b 4 \u7c7b\u7533\u62a5\uff0c\u83b7\u6279\u4e0a\u5e02\u7684\u540c\u65f6\u89c6\u540c\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u3002<\/span><\/p>\n


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\u66f2\u7f8e\u4ed6\u55ea\u4e34\u5e8a\u9002\u7528\u4e8e\u4e00\u7ebf\u6297\u5fc3\u7ede\u75db\u7597\u6cd5\u63a7\u5236\u6216\u65e0\u6cd5\u8010\u53d7\u7684\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u3002<\/span>\u8be5\u4ea7\u54c1\u901a\u8fc7\u8c03\u8282\u5fc3\u808c\u80fd\u91cf\u4ee3\u8c22\uff0c\u53ef\u6709\u6548\u6539\u5584\u5fc3\u7ede\u75db\u60a3\u8005\u5fc3\u808c\u7f3a\u8840\u75c7\u72b6\u3001\u663e\u8457\u9884\u9632\u5fc3\u7ede\u75db\u590d\u53d1\u3002<\/span>\u4ea7\u54c1\u8010\u53d7\u6027\u597d\u3001\u5b89\u5168\u6027\u9ad8\u3001\u60a3\u8005\u4f9d\u5b58\u6027\u826f\u597d\uff0c\u76ee\u524d\u5df2\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e34\u5e8a\u3002<\/span>\u66f2\u7f8e\u4ed6\u55ea\u7f13\u91ca\u7247\u5df2\u88ab\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff082017 \u7248\uff09\u3002<\/span><\/p>\n


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Insight \u6570\u636e\u5e93\uff08https:\/\/db.dxy.cn\/v5\uff09\u663e\u793a\uff0c\u76ee\u524d\u66f2\u7f8e\u4ed6\u55ea\u5df2\u7ecf\u83b7\u6279\u4e0a\u5e02\u7684\u5242\u578b\u6709 3 \u7c7b\uff0c\u5176\u4e2d\u7247\u5242\u6700\u591a\uff0c\u5df2\u7ecf\u6709 11 \u4e2a\u4e0a\u5e02\u6279\u6587\uff1b<\/span>\u666e\u901a\u80f6\u56ca\u5242\u6709 2 \u4e2a\u4e0a\u5e02\u6279\u6587\uff1b<\/span>\u7f13\u91ca\u7247\u5171 3 \u4e2a\u6279\u6587\uff0c\u5206\u522b\u662f\u65bd\u7ef4\u96c5\u5236\u836f\u3001\u9f50\u9c81\u5236\u836f\u548c\u6c5f\u82cf\u6052\u745e<\/strong>\u3002<\/span><\/p>\n


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\"\u6052\u745e\u533b\u836f\uff0c\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u6279\u4e0a\u5e02<\/p>\n


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\u6587\u7ae0\u4fe1\u606f\u6e90<\/span>\u4e8e\u516c\u4f17\u53f7<\/span><\/span>\uff0c<\/span>\u767b<\/span>\u8f7d\u8be5\u6587\u7ae0\u76ee\u7684\u4e3a\u66f4\u5e7f\u6cdb\u7684\u4f20\u9012\u884c\u4e1a\u4fe1\u606f\uff0c\u4e0d\u4ee3\u8868\u8d5e\u540c\u5176\u89c2\u70b9\u6216\u5bf9\u5176\u771f\u5b9e\u6027\u8d1f\u8d23\u3002\u6587\u7ae0\u7248\u6743\u5f52\u539f\u4f5c\u8005\u53ca\u539f\u51fa\u5904\u6240\u6709\uff0c\u6587\u7ae0\u5185\u5bb9\u4ec5\u4f9b\u53c2\u8003\u3002\u672c\u7f51\u62e5\u6709\u5bf9\u6b64\u58f0\u660e\u7684\u6700\u7ec8\u89e3\u91ca\u6743\uff0c\u82e5\u65e0\u610f\u4fb5\u72af\u7248\u6743\uff0c\u8bf7\u8054\u7cfb\u5c0f\u7f16\u5220\u9664\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span><\/p>\n

\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u6052\u745e\u533b\u836f\uff0c\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u6279\u4e0a\u5e02<\/p>\n


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\u6bcf\u65e5\u66f4\u65b0 \u6b22\u8fce\u8ba2\u9605+<\/span><\/p>\n

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\"\u6052\u745e\u533b\u836f\uff0c\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u6279\u4e0a\u5e02<\/p>\n<\/section>\n


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\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u4e0a\u65b9\u7684  \u25b2 \u6dfb\u52a0\u5173\u6ce8 \u4eca\u65e5\u65b0\u95fb\u6982\u8981 1.  \u963f\u65af\u5229\u5eb7\u4e00 […]<\/p>\n","protected":false},"author":1,"featured_media":85803,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85802"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=85802"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85802\/revisions"}],"predecessor-version":[{"id":85815,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/85802\/revisions\/85815"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/85803"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=85802"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=85802"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=85802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}