{"id":8582,"date":"2018-06-13T01:00:00","date_gmt":"2018-07-27T09:33:11","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e5%af%b9%e6%98%a0%e9%80%89%e6%8b%a9%e6%80%a7%e7%9a%84%e8%84%b1%e6%b0%a2%e4%ba%a4%e5%8f%89%e5%81%b6%e8%81%94%e5%8f%8d%e5%ba%94%e5%90%88%e6%88%90%e5%a4%9a%e5%8f%96%e4%bb%a3%e7%9a%84%e5%9b%9b%e6%b0%a2\/"},"modified":"2018-07-27T17:33:13","modified_gmt":"2018-07-27T09:33:13","slug":"%e5%af%b9%e6%98%a0%e9%80%89%e6%8b%a9%e6%80%a7%e7%9a%84%e8%84%b1%e6%b0%a2%e4%ba%a4%e5%8f%89%e5%81%b6%e8%81%94%e5%8f%8d%e5%ba%94%e5%90%88%e6%88%90%e5%a4%9a%e5%8f%96%e4%bb%a3%e7%9a%84%e5%9b%9b%e6%b0%a2","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/8582\/","title":{"rendered":"\u5bf9\u6620\u9009\u62e9\u6027\u7684\u8131\u6c22\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u5408\u6210\u591a\u53d6\u4ee3\u7684\u56db\u6c22\u5421\u5583"},"content":{"rendered":"
\n

\u200d\u200d<\/span>\u200d\"\u5bf9\u6620\u9009\u62e9\u6027\u7684\u8131\u6c22\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u5408\u6210\u591a\u53d6\u4ee3\u7684\u56db\u6c22\u5421\u5583\"<\/a><\/span><\/a><\/p>\n


<\/p>\n

\u56db\u6c22\u5421\u5583\uff08THPs\uff09\u662f\u8bb8\u591a\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u5929\u7136\u4ea7\u7269\u5206\u5b50\u548c\u836f\u7269\u5206\u5b50\u4e2d\u7684\u91cd\u8981\u7ed3\u6784\uff0c\u5f97\u5230\u8bb8\u591a\u6709\u673a\u5316\u5b66\u5bb6\u7684\u5173\u6ce8\u3002\u76ee\u524d\uff0c\u4eba\u4eec\u5df2\u53d1\u5c55\u4e86\u8bb8\u591a\u7acb\u4f53\u9009\u62e9\u6027\u6784\u5efa\u8be5\u7c7b\u7ed3\u6784\u7684\u65b9\u6cd5\uff0c\u5305\u62ecPrins\u73af\u5316\u3001\u6742Diels-Alder\u53cd\u5e94\u548c\u5206\u5b50\u5185\u4eb2\u6838\u5171\u8f6d\u52a0\u6210\u7b49\u3002\u5728\u8fd9\u4e9b\u5df2\u7ecf\u5efa\u7acb\u7684\u65b9\u6cd5\u4e2d\uff0c\u5bf9\u6620\u9009\u62e9\u6027\u7684\u63a7\u5236\u901a\u5e38\u96c6\u4e2d\u5728\u5171\u8f6d\u52a0\u6210\u6216\u70ef\u80fa\/\u4e9a\u80fa\u4e2d\u95f4\u4f53\u7684\u6d3b\u5316\u9636\u6bb5\uff0c\u8fd9\u4e24\u79cd\u7b56\u7565\u4e5f\u5e7f\u6cdb\u5730\u7528\u4e8e\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\u4e2d\u3002\u7f8e\u56fd\u897f\u5317\u5927\u5b66\u5316\u5b66\u7cfb<\/strong>\u7684Karl Scheidt<\/strong>\u8bfe\u9898\u7ec4\u957f\u671f\u81f4\u529b\u4e8e\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u53ca\u751f\u7269\u6d3b\u6027\u5c0f\u5206\u5b50\u7684\u7814\u7a76\u3002\u6700\u8fd1\uff0c\u4ed6\u4eec\u62a5\u9053\u4e86\u5728\u6784\u5efa\u591a\u53d6\u4ee3\u56db\u6c22\u5421\u5583\u65b9\u9762\u7684\u65b0\u8fdb\u5c55\uff0c\u9996\u6b21\u5b9e\u73b0\u4e86\u975e\u5b98\u80fd\u5316\u919a\u7c7b\u5e95\u7269\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7684\u4ea4\u53c9\u8131\u6c22\u5076\u8054\u53cd\u5e94<\/strong>\uff08cross-dehydrogenative coupling\uff0cCDC\uff09\u3002\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u6d89\u53ca\u4eb2\u6838\u8bd5\u5242\u7684\u539f\u4f4dLewis\u9178\u6d3b\u5316\u548c\u77ac\u6001\u6c27\u9393\u4eb2\u7535\u8bd5\u5242\u7684\u5f62\u6210\uff0c\u9664\u4e86\u5408\u6210\u7b80\u5355\u7684\u5206\u5b50\uff0c\u8fd8\u53ef\u7528\u4e8e\u6784\u5efa\u590d\u6742\u5929\u7136\u4ea7\u7269\u5206\u5b50\u4e2d\u7684\u56db\u6c22\u5421\u5583\u7ed3\u6784<\/strong>\u3002\u76f8\u5173\u5de5\u4f5c\u53d1\u8868\u5728<\/span>J. Am. Chem. Soc. <\/strong><\/em><\/span>\u4e0a\u3002<\/span><\/p>\n

\"\u5bf9\u6620\u9009\u62e9\u6027\u7684\u8131\u6c22\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u5408\u6210\u591a\u53d6\u4ee3\u7684\u56db\u6c22\u5421\u5583\"<\/p>\n

\u56fe1. CDC\u7684\u57fa\u672c\u6982\u5ff5\u548c\u672c\u6587\u5de5\u4f5c\u7684\u8bbe\u8ba1\u601d\u8def\u3002\u56fe\u7247\u6765\u6e90\uff1aJ. Am. Chem. Soc.<\/em><\/span><\/p>\n


<\/p>\n

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<\/p>\n

\u4f5c\u8005\u9996\u5148\u4ee5\u03b2-\u916e\u916f1a<\/strong>\u4f5c\u4e3a\u6a21\u677f\u5e95\u7269\u5bf9\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u4e86\u7b5b\u9009\uff0c\u6700\u7ec8\u4ee510 mol%\u7684L3<\/strong>-Cu(OTf)<\/span>2<\/sub><\/span>\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cDDQ\u4f5c\u4e3a\u6c27\u5316\u5242\uff0c\u53cd\u5e94\u5728CH<\/span>2<\/sub><\/span>Cl<\/span>2<\/sub><\/span>\u4e2d-70 \u2103\u7684\u6761\u4ef6\u4e0b\u8fdb\u884c12 h\uff0c\u80fd\u4ee583%\u7684\u6536\u7387\u548c95:5\u7684er\u503c\u5f97\u5230\u76ee\u6807\u4ea7\u72692a<\/strong>\uff0c\u5e76\u901a\u8fc7X\u5c04\u7ebf\u5355\u6676\u884d\u5c04\u5206\u6790\u786e\u5b9a\u4e86\u5176\u7ed3\u6784\u548c\u7acb\u4f53\u5316\u5b66\u3002<\/span><\/p>\n

\"\u5bf9\u6620\u9009\u62e9\u6027\u7684\u8131\u6c22\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u5408\u6210\u591a\u53d6\u4ee3\u7684\u56db\u6c22\u5421\u5583\"<\/p>\n

\u56fe2. \u53cd\u5e94\u6761\u4ef6\u7684\u7b5b\u9009\u3002\u56fe\u7247\u6765\u6e90\uff1aJ. Am. Chem. Soc<\/em>.<\/span><\/p>\n


<\/p>\n

\u6709\u4e86\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\uff0c\u4f5c\u8005\u5bf9\u5e95\u7269\u7684\u9002\u7528\u8303\u56f4\u8fdb\u884c\u8003\u5bdf\u3002\u03b2-\u916e\u916f\u4e2d\u7684R\u57fa\u53ef\u4ee5\u662f\u53d6\u4ee3\u7684\u82ef\u4e59\u70ef\u57fa\u6216\u8005\u82ef\u57fa\uff0c\u82ef\u73af\u4e0a\u53ef\u4ee5\u4fee\u9970\u70f7\u57fa\u3001\u70f7\u6c27\u57fa\u548c\u5364\u7d20\u7b49\uff0c\u82ef\u73af\u4e5f\u53ef\u4ee5\u6362\u4f5c\u8418\u73af\u3001\u5432\u54da\u6216\u8005\u567b\u5429\u7b49\uff0c\u4e0d\u540c\u53d6\u4ee3\u57fa\u5747\u8868\u73b0\u51fa\u826f\u597d\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\uff0c\u5341\u51e0\u79cd\u5e95\u7269\u4e5f\u90fd\u53d6\u5f97\u4e86\u826f\u597d\u7684\u4ea7\u7387\u548c\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u3002<\/span><\/p>\n

\"\u5bf9\u6620\u9009\u62e9\u6027\u7684\u8131\u6c22\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u5408\u6210\u591a\u53d6\u4ee3\u7684\u56db\u6c22\u5421\u5583\"<\/p>\n

\u56fe3. \u5e95\u7269\u9002\u7528\u6027\u7684\u8003\u5bdf\u3002\u56fe\u7247\u6765\u6e90\uff1aJ. Am. Chem. Soc.<\/em><\/span><\/p>\n


<\/p>\n

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\"\u5bf9\u6620\u9009\u62e9\u6027\u7684\u8131\u6c22\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u5408\u6210\u591a\u53d6\u4ee3\u7684\u56db\u6c22\u5421\u5583\"<\/p>\n

\u56fe4. CDC\u53cd\u5e94\u7684\u8fdb\u4e00\u6b65\u62d3\u5c55\u3002\u56fe\u7247\u6765\u6e90\uff1aJ. Am. Chem. Soc.<\/em><\/span><\/p>\n


<\/p>\n

\u4f5c\u8005\u8fd8\u63d0\u51fa\u4e86\u8be5CDC\u53cd\u5e94\u7684\u8fc7\u6e21\u6001\u6a21\u578b\uff0c\u6c27\u5316\u5e95\u7269\u901a\u8fc7\u53cc\u9f7f\u87af\u5408\u4f5c\u7528\u4e0eCu(II)\u4e2d\u5fc3\u7edc\u5408\uff0cL3<\/strong>\u2022Cu(II)\u7edc\u5408\u7269\u5e9e\u5927\u7684\u53d4\u4e01\u57fa\u57fa\u56e2\u5c4f\u853d\u4e86\u7ed3\u5408\u5e95\u7269\uff08Si\u9762\uff09\u7684\u9876\u9762\uff0c\u77ac\u6001\u6c27\u9393\u79bb\u5b50\u4ece\u5e95\u7269\u7684Re\u9762\u9760\u8fd1\u3002\u53cd\u5e94\u8fc7\u7a0b\u4e2d\uff0c\u91d1\u5c5e\u952e\u5408\u7684\u70ef\u9187\u5f0f\u4e2d\u95f4\u4f53\u901a\u8fc7\u5047\u6905\u5f0f\u6784\u8c61\u8fdb\u653b\u6c27\u9393\u79bb\u5b50\u7684Re\u9762\uff0c\u5f97\u5230C1’\u4f4d\u5177\u6709S\u6784\u578b\u7684\u4ea7\u72692a<\/strong>\uff0c\u4e0e\u5b9e\u9a8c\u89c2\u5bdf\u5230\u7684\u7acb\u4f53\u5316\u5b66\u4e00\u81f4\u3002<\/span><\/p>\n

\"\u5bf9\u6620\u9009\u62e9\u6027\u7684\u8131\u6c22\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u5408\u6210\u591a\u53d6\u4ee3\u7684\u56db\u6c22\u5421\u5583\"<\/p>\n

\u56fe5. CDC\u53cd\u5e94\u7684\u7acb\u4f53\u5316\u5b66\u6a21\u578b\u3002\u56fe\u7247\u6765\u6e90\uff1aJ. Am. Chem. Soc.<\/em><\/span><\/p>\n


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\u56fe7. \u5149\u8bf1\u5bfc\u7684CDC\u53cd\u5e94\u3002\u56fe\u7247\u6765\u6e90\uff1aJ. Am. Chem. Soc.<\/em><\/span><\/p>\n


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\u603b\u7ed3<\/span><\/strong><\/span><\/p>\n


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Karl Scheidt\u8bfe\u9898\u7ec4\u53d1\u5c55\u4e86\u624b\u6027Lewis\u9178\u50ac\u5316\u03b2-\u916e\u916f\u7684\u5206\u5b50\u5185\u4ea4\u53c9\u8131\u6c22\u5076\u8054\uff08CDC\uff09\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u5229\u7528\u975e\u5b98\u80fd\u5316\u7684\u8d77\u59cb\u539f\u6599\uff0c\u4ee5\u4f18\u5f02\u7684\u6536\u7387\u548c\u7acb\u4f53\u9009\u62e9\u6027\u5f97\u5230\u4e86\u624b\u60272-\u53d6\u4ee3\u7684\u56db\u6c22\u5421\u5583\uff0c\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\uff0c\u4ea7\u7269\u8fd8\u53ef\u4ee5\u8fdb\u884c\u591a\u6837\u6027\u884d\u751f\u5316\u3002\u4f5c\u8005\u8fd8\u5c06\u7ee7\u7eed\u62d3\u5c55\u5e95\u7269\u7684\u9002\u7528\u8303\u56f4\uff0c\u5e76\u7814\u7a76\u53ef\u89c1\u5149\u8bf1\u5bfc\u7684\u4e0d\u5bf9\u79f0CDC\u53cd\u5e94\u3002\u53ef\u4ee5\u9884\u89c1\uff0cCDC\u53cd\u5e94\u4e00\u5b9a\u4f1a\u4ee5\u66f4\u6e29\u548c\u7684\u6761\u4ef6\u548c\u66f4\u597d\u7684\u5e95\u7269\u9002\u7528\u6027\u5c06\u5728\u5408\u6210\u4e2d\u5f97\u5230\u66f4\u591a\u7684\u5e94\u7528\u3002<\/span><\/p>\n


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\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n

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An Enantioselective Cross-Dehydrogenative Coupling Catalysis Approach to Substituted Tetrahydropyrans<\/span><\/p>\n

J. Am. Chem. Soc.<\/span><\/em>, 2018<\/strong>, 140<\/em>, 6212, DOI: 10.1021\/jacs.8b03063<\/span><\/p>\n


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\u5bfc\u5e08\u4ecb\u7ecd<\/span><\/p>\n

Karl Scheidt<\/span><\/p>\n

http:\/\/www.x-mol.com\/university\/faculty\/396<\/span><\/p>\n


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\u672c\u6587\u7248\u6743\u5c5e\u4e8eX-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/span><\/p>\n


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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a X\u4e00MOL\u8d44\u8baf <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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