{"id":85899,"date":"2019-04-16T00:00:50","date_gmt":"2019-04-18T07:53:37","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/85899\/"},"modified":"2019-04-18T15:53:39","modified_gmt":"2019-04-18T07:53:39","slug":"4442468302","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/85899\/","title":{"rendered":"\u5e72\u8d27|\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u7684\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size: 16px;\">\n<p style=\"line-height: 27px;text-indent: 2em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 15px;caret-color: 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32px;line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">2015\u5e74\u4ee5\u6765\uff0cAS\u7684\u6cbb\u7597\u7ba1\u7406\u53d6\u5f97\u4e86\u663e\u7740\u8fdb\u5c55\u3002\u88681\u603b\u7ed3\u4e86\u76ee\u524d\u6cbb\u7597\u76f8\u5173\u7684\u836f\u7269\u53ca\u5176\u4f5c\u7528\u673a\u5236\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/2-1555574019.jpg\" alt=\"\u5e72\u8d27|\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u7684\u7814\u7a76\u8fdb\u5c55\" title=\"\u5e72\u8d27|\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u7684\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<p style=\"line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><strong>\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u6291\u5236\u5242<\/strong><\/span><\/p>\n<p style=\"text-indent: 32px;line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u6291\u5236\u5242\uff08TNFis\uff09\u662f\u7b2c\u4e00\u6279\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u6297\u98ce\u6e7f\u7c7b\u7684\u836f\u7269\uff0c\u7531\u4e8e\u836f\u7269\u7684\u4e13\u5229\u671f\u9650\u5230\u671f\u95ee\u9898\uff0c\u8bb8\u591a\u5236\u836f\u516c\u53f8\u90fd\u96c6\u4e2d\u4e8e\u5f00\u53d1\u66f4\u5b9e\u60e0\u7684\u836f\u7269\u3002CT-P13\u662f\u82f1\u592b\u5229\u6614\u5355\u6297\u751f\u7269\u4eff\u5236\u836f\uff0cBenepali\uff08SB4\uff09\u662f\u4f9d\u90a3\u666e\u5229\u751f\u7269\u4eff\u5236\u836f\uff0c\u7814\u7a76\u53d1\u73b0\uff0cCT-P13\u548c\u82f1\u592b\u5229\u6614\u5355\u6297\u5177\u6709\u76f8\u4f3c\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u4e0d\u4ec5\u9002\u7528\u4e8eAS\u60a3\u8005\uff0c\u4e5f\u9002\u7528\u4e8e\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u60a3\u8005\uff08RA\uff09\u3002\u800cBenepali\uff08SB4\uff09\uff0c\u5176\u529f\u6548\u548c\u5b89\u5168\u6027\u7814\u7a76\u5df2\u5728RA\u60a3\u8005\u4e2d\u8fdb\u884c\uff0c\u4e0e\u4f7f\u7528Enbrel\u80fd\u83b7\u5f97\u76f8\u4f3c\u7684\u7ed3\u679c\u3002\u5c31\u6cbb\u7597\u8f6c\u6362\u800c\u8a00\uff0cRA\u60a3\u8005\u4eceEnbrel\u8f6c\u4e3aBenepali\u540e\u4ecd\u4fdd\u6301\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u76ee\u524d\u5fb7\u56fd\u6b63\u5728\u8bc4\u4f30AS\u60a3\u8005\u6cbb\u7597\u8f6c\u6362\u7684\u6548\u679c\u3002<\/span><\/p>\n<p style=\"line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><strong>\u767d\u7ec6\u80de\u4ecb\u7d20\u6291\u5236\u5242<\/strong><\/span><\/p>\n<p style=\"text-indent: 32px;line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u82cf\u91d1\u5355\u6297\uff0c\u4e00\u79cd\u80fd\u591f\u4e2d\u548cIL-17A\u7684\u5b8c\u5168\u4eba\u5355\u514b\u9686\u6297\u4f53\uff0c\u60a3\u6709AS\u7684\u60a3\u8005\u5177\u6709\u9ad8\u6c34\u5e73\u7684\u767d\u7ec6\u80de\u4ecb\u7d20\uff0c\u548cAS\u53d1\u75c5\u673a\u7406\u5bc6\u5207\u76f8\u5173\uff0c\u7814\u7a76\u62a5\u9053\u663e\u793a\u82cf\u91d1\u5355\u6297\u5177\u6709\u8f83\u597d\u7684\u5b89\u5168\u6027\uff0c\u80fd\u663e\u8457\u6539\u5584AS\u60a3\u8005\u7684\u6d3b\u52a8\uff0c\u6301\u7eed\u65f6\u95f4\u57282\u5e74\u4ee5\u4e0a\uff0c\u4e14\u6ca1\u6709\u53d1\u73b0\u91cd\u5927\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u662f\u6cbb\u7597AS\u7684\u91cd\u5927\u8fdb\u5c55\u3002\u88681\u8fd8\u7ed9\u51fa\u4e86\u51e0\u79cd\u767d\u7ec6\u80de\u4ecb\u7d20\u6291\u5236\u5242\uff0c\u5176\u90fd\u5728\u7814\u7a76\u5f53\u4e2d\uff0c\u5176\u4e2dCOVA32274\u662f\u4e00\u79cd\u5373\u80fd\u591f\u7ed3\u5408TNF-\u03b1\u548cIL-17A\u7684\u878d\u5408\u86cb\u767d\u6297\u4f53\uff0c\u5b83\u88ab\u8ba4\u4e3a\u662fAS\u6cbb\u7597\u65b9\u6cd5\u4e2d\u5177\u6709\u8f83\u597d\u524d\u666f\u7684\u7597\u6cd5\uff0c\u7136\u800c\u7531\u4e8e\u94f6\u5c51\u75c5\u5173\u8282\u708e\u8bd5\u9a8c\u4e2d\u7684\u5b89\u5168\u95ee\u9898\uff0c\u8be5\u836f\u7269\u8fd8\u5728\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u5f53\u4e2d\u3002<\/span><\/p>\n<p style=\"line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><strong>Janus<\/strong><strong>\u6fc0\u9176\u6291\u5236\u5242<\/strong><\/span><\/p>\n<p style=\"text-indent: 32px;line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">Tofacitinib\u662f\u4e00\u79cdJanus\u6fc0\u9176\uff08JAK\uff09\u6291\u5236\u5242\uff0c\u80fd\u591f\u5728IL-17\u3001IL-21\u548cIL-23\u7684\u708e\u75c7\u7ea7\u8054\u53cd\u5e94\u4e2d\u53d1\u6325\u4f5c\u7528\uff0c\u636e\u62a5\u9053\u4e0e\u4f7f\u7528\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u5728\u6bcf\u5929\u4e24\u6b215mg\u4f4e\u5242\u91cf\u7684\u60c5\u51b5\u4e0b\uff0c\u5206\u522b\u670963\uff05\u548c40\uff05\u7684\u60a3\u8005\u572812\u5468\u540e\u8fbe\u5230ASAS20\u3002<\/span><\/p>\n<p style=\"line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><strong>\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\uff08<\/strong><strong>NSAID<\/strong><strong>\uff09<\/strong><\/span><\/p>\n<p style=\"text-indent: 32px;line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u7814\u7a76\u62a5\u9053\u4e86\u4e00\u9879\u65b0\u7684\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\uff08NSAID\uff09\uff0cB-D-\u7518\u9732\u7cd6\u919b\u9178\u7684\u968f\u673a\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\u7ed3\u679c\uff0c12\u5468\u7684ASAS\u53cd\u5e94\u4e0e\u8418\u666e\u751f\u76f8\u4f3c\uff0c\u5b89\u5168\u6027\u8f83\u597d\uff0c\u6ca1\u6709\u80be\u810f\u526f\u4f5c\u7528\uff0c\u4e14\u80c3\u80a0\u9053\u8010\u53d7\u6027\u826f\u597d\u3002<\/span><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">\u68c0\u6d4b\u65b9\u6cd5<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 27px;text-indent: 2em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 15px;caret-color: red;\">\u4e00\u822c\u8d77\u75c5\u6bd4\u8f83\u9690\u533f\uff0c\u65e9\u671f\u53ef\u65e0\u4efb\u4f55\u4e34\u5e8a\u75c7\u72b6\uff0c\u6709\u4e9b\u75c5\u4eba\u5728\u65e9\u671f\u53ef\u8868\u73b0\u51fa\u8f7b\u5ea6\u7684\u5168\u8eab\u75c7\u72b6\uff0c\u5982\u4e4f\u529b\u3001\u6d88\u7626\u3001\u6216\u95f4\u65ad\u4f4e\u70ed\u3001\u538c\u98df\u3001\u8f7b\u5ea6\u8d2b\u8840\u7b49\u3002\u7531\u4e8e\u75c5\u60c5\u8f83\u8f7b\uff0c\u75c5\u4eba\u5927\u591a\u4e0d\u80fd\u65e9\u671f\u53d1\u73b0\uff0c\u81f4\u4f7f\u75c5\u60c5\u5ef6\u8bef\uff0c\u5931\u53bb\u6cbb\u7597\u65f6\u673a\u3002\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u5b9e\u9a8c\u5ba4\u67e5\u770b\u51fa\u73b0\u53cd\u5e38\u7684\u76ee\u6807\u4e0d\u591a\uff0c\u800c\u4e14\u65e0\u7279\u5f02\u6027\uff0c\u7f3a\u4e4f\u786e\u8bca\u542b\u4e49\uff0c\u4e00\u822c\u91c7\u7528\u7ed3\u5408\u75c5\u53f2+\u5e38\u89c4\u68c0\u67e5+\u5f71\u50cf\u5b66\u68c0\u67e5\u6765\u5224\u5b9a\u3002<\/span><br  \/><\/p>\n<p style=\"line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><strong>\u751f\u7269\u6807\u5fd7\u7269<\/strong><\/span><\/p>\n<p style=\"text-indent: 32px;line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">C-\u53cd\u5e94\u86cb\u767d\uff08CRP\uff09\u548c\u7ea2\u7ec6\u80de\u6c89\u964d\u7387\uff08ESR\uff09\u662f\u4e24\u79cd\u6025\u6027\u671f\u53cd\u5e94\u7269\uff0c\u5e38\u5e38\u7528\u4e8e\u8bc4\u4f30\u60a3\u8005\u662f\u5426\u5b58\u5728\u708e\u75c7\uff0c\u4f46\u7531\u4e8e\u8fd9\u4e24\u79cd\u4e0d\u5c5e\u4e8e\u7279\u5f02\u6027\u751f\u7269\u6807\u5fd7\u7269\uff0c\u6240\u4ee5\u7075\u654f\u5ea6\u8f83\u4f4e\uff0c\u8bb8\u591a\u7814\u7a76\u5c1d\u8bd5\u627e\u5230\u80fd\u591f\u9884\u6d4bAS\u4e34\u5e8a\u7ed3\u679c\u6216\u75be\u75c5\u6d3b\u52a8\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5176\u4e2d\u4ee3\u8868\u6027\u7684\u662fCalprotectin\uff0c\u5b83\u662f\u4e00\u79cd\u9499\u7ed3\u5408\u86cb\u767d\u7684\u4e8c\u805a\u4f53\uff0c\u4f5c\u4e3a\u80a0\u9053\u708e\u75c7\u7684\u66ff\u4ee3\u6807\u5fd7\u7269\uff0c\u5176\u4e3b\u8981\u5e94\u7528\u662f\u76d1\u6d4b\u708e\u6027\u80a0\u75c5\uff08IBD\uff09\u7684\u75be\u75c5\u6d3b\u52a8\uff0c\u708e\u6027\u80a0\u75c5\uff08IBD\uff09\u4e3b\u8981\u5305\u62ec\u514b\u7f57\u6069\u75c5(CD)\u548c\u6e83\u75a1\u6027\u7ed3\u80a0\u708e(UC)\uff0c\u800c\u514b\u7f57\u6069\u75c5\u548c\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u90fd\u4e0eAS\u6709\u5173\u3002<\/span><\/p>\n<p style=\"line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><strong>\u9aa8\u9abc\u53d7\u7d2f<\/strong><\/span><\/p>\n<p style=\"text-indent: 32px;line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">AS\u7684\u5178\u578b\u7279\u5f81\u662f\u9aa8\u5f62\u6210\u4e0e\u9aa8\u5438\u6536\u5171\u5b58\uff0c\u7531\u4e8e\u9aa8\u5f62\u6210\u548c\u9aa8\u5438\u6536\u8fc7\u7a0b\u4e4b\u95f4\u4e0d\u5e73\u8861\uff0c\u5bfc\u81f4AS\u60a3\u8005\u51fa\u73b0\u4e0b\u80eb\u8153\u9aa8\u548c\u9aa8\u4fb5\u8680\u3002\u7814\u7a76\u53d1\u73b0\uff0cIL-17\u4e3b\u8981\u4fc3\u8fdb\u7834\u9aa8\u7ec6\u80de\u751f\u6210\uff0c\u53ef\u4ee5\u4e0eTNF-\u03b1\u8054\u7528\u7528\u6765\u6cbb\u7597AS\uff0cTNF-\u03b1\u5206\u5b50\u901a\u8fc7RANK-RANK\u914d\u4f53\uff08RANK-RANKL\uff09\u7cfb\u7edf\u89e6\u53d1\u9aa8\u7834\u574f\uff0c\u5e76\u901a\u8fc7Dickkopf\u76f8\u5173\u86cb\u767d1\uff08DKK1\uff09\u7684\u8fc7\u8868\u8fbe\u6291\u5236\u9aa8\u5f62\u6210\u3002\u6b64\u5916\u6709\u62a5\u9053\u5de8\u566c\u7ec6\u80de\u79fb\u52a8\u6291\u5236\u56e0\u5b50\uff08MIF\uff09\u4e5f\u80fd\u591f\u4f5c\u7528\u4e8e\u6210\u9aa8\u7ec6\u80de\uff0c\u4fc3\u8fdb\u708e\u75c7\u548c\u65b0\u9aa8\u5f62\u6210\u3002\u4ed6\u4eec\u8fd8\u63d0\u51fa\u4ea7\u751fMIF\u7684\u7ec6\u80de\u7684\u4e3b\u8981\u6765\u6e90\u662f\u80a0\u9053\uff0c\u67d0\u4e9b\u75c5\u539f\u4f53\u53ef\u8bf1\u5bfc\u5176\u91ca\u653e\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u7814\u7a76\u4eba\u5458\u4e5f\u53d1\u73b0IL-22\u5728\u708e\u75c7\u4f9d\u8d56\u6027\u73af\u5883\u4e2d\u8c03\u8282\u95f4\u5145\u8d28\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u80fd\u8bf1\u5bfc\u5176\u589e\u6b96\u3001\u8fc1\u79fb\u548c\u6210\u9aa8\uff0c\u6709\u7ed3\u679c\u663e\u793aIL-32\u03b3\u5728AS\u60a3\u8005\u7684\u5173\u8282\u548c\u7ec4\u7ec7\u4e2d\u5347\u9ad8\uff0c\u5e76\u4e14\u80fd\u591f\u8bf1\u5bfc\u6210\u9aa8\u7ec6\u80de\u5206\u5316\u548c\u5f62\u6210\u975e\u5178\u578b\u7684\u65b0\u9aa8\u3002<\/span><\/p>\n<p style=\"line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><strong>\u6210\u50cf<\/strong><\/span><\/p>\n<p style=\"text-indent: 32px;line-height: 27px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u7ed3\u6784\u635f\u4f24\u7684\u8bc4\u4f30\u5bf9AS\u60a3\u8005\u5341\u5206\u91cd\u8981\u3002\u6539\u826f\u7684\u65af\u6258\u514b\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u810a\u67f1\u8bc4\u5206\uff08m&nbsp;SASSS\uff09\uff08\u7531\u4fa7\u89c6\u56fe\u4e2d\u7684\u8170\u690e\u548c\u9888\u690e\u7684\u5f97\u5206\u4e4b\u548c\u7ec4\u6210\uff0c\u8303\u56f4\u4ece0\u523072\uff09\u662f\u7528\u4e8e\u68c0\u6d4b\u5e73\u7247\u7684\u53d8\u5316\u7684\u5e38\u7528\u65b9\u6cd5\u3002\u7136\u800c\uff0cX\u5c04\u7ebf\u4e0d\u662f\u4e00\u79cd\u975e\u5e38\u654f\u611f\u7684\u5de5\u5177\uff0c\u5b83\u4eec\u65e0\u6cd5\u6b63\u786e\u533a\u5206\u9885\u8111\u7684\u5e73\u65b9\u503c\u3002&nbsp;Kim\u7b49\u7814\u7a76\u4eba\u5458\u91c7\u7528Ralston\u7b49\u4eba\u63d0\u51fa\u7684\u65b9\u6cd5\u8bc4\u4f30\u4e86\u7b2c\u4e00\u9ab6\u690e\uff08S1\uff09\u7684\u5e73\u65b9\u503c\uff0c\u8be5\u5e73\u65b9\u503c\u4e0em&nbsp;SASSS\u548c\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u7684\u53d8\u5316\u76f8\u5173\uff0c\u53ef\u7528\u4e8e\u9884\u6d4b\u810a\u67f1\u65e9\u671f\u8f74\u5411\u53d7\u7d2f\u3002<\/span><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">\u603b\u7ed3<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 27px;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u5728\u8fc7\u53bb\u4e09\u5e74\u4e2d\uff0cAS\u7684\u6cbb\u7597\u53d6\u5f97\u4e86\u5f88\u5927\u7684\u8fdb\u5c55\uff0c\u4f46\u75be\u75c5\u7684\u6f5c\u5728\u53d1\u75c5\u673a\u5236\u5c1a\u672a\u5b8c\u5168\u4e86\u89e3\uff0c\u6240\u4ee5\u5728\u672a\u6765\u5e94\u5bf9AS\u53d1\u75c5\u673a\u5236\u8fdb\u884c\u6df1\u523b\u7684\u7814\u7a76\uff0c\u4ee5\u5f00\u53d1\u5236\u5b9a\u65b0\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u4ece\u800c\u6539\u5584AS\u60a3\u8005\u7684\u8d28\u91cf\u5bff\u547d\u3002<\/span><\/p>\n<p style=\"line-height: 27px;\"><strong><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/strong><\/p>\n<p style=\"line-height: 27px;text-align: left;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 10px;\"><\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 12px;\"><\/span><\/p>\n<p style=\"line-height: 27px;text-align: left;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 10px;\"><\/span><\/p>\n<p style=\"line-height: 27px;text-align: left;\"><span style=\"font-size: 12px;\">(1)&nbsp;Garcia-Montoya&nbsp;L,&nbsp;Gul&nbsp;H&nbsp;and&nbsp;EmeryP.&nbsp;Recent&nbsp;advances&nbsp;in&nbsp;ankylosing&nbsp;spondylitis:<\/span><span style=\"font-size: 12px;\">&nbsp;understanding&nbsp;the&nbsp;diseaseandmanagement.First&nbsp;published:<\/span><span style=\"font-size: 12px;\">&nbsp;21&nbsp;Sep&nbsp;2018,&nbsp;7(F1000&nbsp;Faculty&nbsp;Rev):<\/span><span style=\"font-size: 12px;\">1512&nbsp;(doi:<\/span><span style=\"font-size: 12px;\">10.12688\/f1000research.14956.1)<\/span><\/p>\n<p style=\"line-height: 27px;text-align: left;\"><span style=\"font-size: 12px;\">(2)Watad&nbsp;A,&nbsp;Bridgewood&nbsp;C,&nbsp;Russell&nbsp;T,Marzo-Ortega&nbsp;H,&nbsp;Cuthbert&nbsp;R,&nbsp;Mc&nbsp;Gonagle&nbsp;D.&nbsp;TheEarly&nbsp;Phases&nbsp;of&nbsp;Ankylosing&nbsp;Spondylitis:<\/span><span style=\"font-size: 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