{"id":8648,"date":"2018-06-12T01:00:00","date_gmt":"2018-07-27T09:33:36","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/nature-chem-%e8%af%b7%e4%bd%a0%e4%ba%86%e8%a7%a3%e4%b8%80%e4%b8%8b%e8%83%bd%e6%b2%bb%e6%99%ae%e9%80%9a%e6%84%9f%e5%86%92%e7%9a%84%e5%b0%8f%e5%88%86%e5%ad%90\/"},"modified":"2018-07-27T17:33:39","modified_gmt":"2018-07-27T09:33:39","slug":"nature-chem-%e8%af%b7%e4%bd%a0%e4%ba%86%e8%a7%a3%e4%b8%80%e4%b8%8b%e8%83%bd%e6%b2%bb%e6%99%ae%e9%80%9a%e6%84%9f%e5%86%92%e7%9a%84%e5%b0%8f%e5%88%86%e5%ad%90","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/8648\/","title":{"rendered":"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;\"><span style=\"line-height: 0px;\">\u200d\u200d<\/span><span style=\"font-size: 18.018px;line-height: 0px;\">\u200d<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657590253&amp;idx=1&amp;sn=af64055348b35e9185b67c634d7ef95c&amp;chksm=80f7b23db7803b2bc868baa456f16ab2329ba355b97bce33703e32440ef4260a6f34c1ea970a&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-align: center;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532684017.gif\" alt=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\" title=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\"  \/><\/a><\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657574730&amp;idx=1&amp;sn=7001a26433acb77dcdd5629f27cd8b20&amp;chksm=80f7769ab780ff8cedab5baefd9bc7a02dd18b2191cd29afb2d190e8ea149564133c9437e7d5&amp;scene=21#wechat_redirect\" target=\"_blank\"><\/a><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u770b\u5230\u6807\u9898\uff0c\u53ef\u80fd\u6709\u4eba\u5fc3\u91cc\u4f1a\u6709\u7591\u60d1\uff1a\u6bcf\u4e2a\u836f\u5e97\u90fd\u80fd\u4e70\u5230\u7684\u611f\u5192\u836f\uff0c\u8fd8\u80fd\u4e0a\u5316\u5b66\u9876\u520a\uff1f<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u7684\u786e\uff0c\u611f\u5192\u662f\u4e00\u79cd\u592a\u5e38\u89c1\u7684\u75c5\uff0c\u6bcf\u4e2a\u4eba\u90fd\u7ecf\u5386\u8fc7\uff0c\u4e5f\u5e94\u8be5\u90fd\u77e5\u9053\u611f\u5192\u7531\u75c5\u6bd2\u5f15\u8d77\u3002\u5927\u89c4\u6a21\u7684\u6d41\u884c\u6027\u611f\u5192\u7684\u75c5\u539f\u4f53\u662f\u6d41\u611f\u75c5\u6bd2\uff08influenza virus\uff09\uff0c\u800c\u666e\u901a\u611f\u5192\u7684\u75c5\u539f\u4f53\u66f4\u52a0\u591a\u6837\uff0c\u5305\u62ec\u4ee5<strong>\u9f3b\u75c5\u6bd2<\/strong>\uff08rhinoviruses\uff0cRV\uff09\u4e3a\u4e3b\u7684\u591a\u79cd\u75c5\u6bd2\u3002\u7531\u4e8e\u76ee\u524d\u8fd8\u6ca1\u6709\u7279\u522b\u6709\u6548\u7684\u836f\u7269\u80fd\u76f4\u63a5\u6291\u5236\u8fd9\u4e9b\u75c5\u6bd2\u7684\u751f\u957f\u548c\u589e\u6b96\uff0c\u5927\u591a\u6570\u60c5\u51b5\u4e0b\u611f\u5192\u7684\u6cbb\u7597\u90fd\u662f\u4e3a\u4e86\u7f13\u89e3\u75c7\u72b6\u800c\u4e0d\u662f\u6253\u51fb\u75c5\u6bd2\uff0c\u6bd4\u5982\u524d\u9762\u63d0\u5230\u7684\u836f\u5e97\u91cc\u80fd\u4e70\u5230\u7684\u975e\u5904\u65b9\u611f\u5192\u836f\uff0c\u4e00\u822c\u90fd\u5305\u62ec\u89e3\u70ed\u9547\u75db\u7c7b\u7684\u6d3b\u6027\u6210\u5206\uff0c\u4f8b\u5982\u5e03\u6d1b\u82ac\u6216\u5bf9\u4e59\u9170\u6c28\u57fa\u915a\u3002\u81f3\u4e8e\u5bf9\u6297\u75c5\u6bd2\uff0c\u8fd8\u662f\u8981\u9760\u75c5\u4eba\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u5e78\u8fd0\u7684\u662f\u611f\u5192\u4e00\u822c\u4f1a\u5728\u4e00\u4e24\u5468\u5185\u81ea\u6108\u3002\u987a\u4fbf\u79d1\u666e\u4e00\u4e0b\uff0c\u6297\u751f\u7d20\u5bf9\u75c5\u6bd2\u4e0d\u8d77\u4f5c\u7528\uff0c\u6240\u4ee5\u611f\u5192\u65f6\u4e0d\u8981\u6ee5\u7528\u6297\u751f\u7d20\uff0c\u9664\u975e\u51fa\u73b0\u7ec6\u83cc\u611f\u67d3\u7684\u5e76\u53d1\u75c7\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u770b\u5230\u8fd9\u91cc\uff0c\u8bf8\u4f4d\u6216\u8bb8\u80fd\u731c\u5230\uff0c\u5e94\u8be5\u662f\u6709\u4eba\u7814\u7a76\u51fa\u4e86\u80fd\u76f4\u63a5\u6253\u51fb\u611f\u5192\u75c5\u6bd2\u7684\u5c0f\u5206\u5b50\u4e86\u3002\u786e\u5b9e\u5982\u6b64\uff0c\u6765\u81ea<strong>\u82f1\u56fd\u5e1d\u56fd\u7406\u5de5\u5b66\u9662<\/strong>\u7684<strong>Roberto Solari<\/strong>\u548c<strong>Edward W. Tate<\/strong>\u524d\u4e0d\u4e45\u5728<\/span><span style=\"font-size: 16px;\"><em><strong>Nature Chemistry<\/strong><\/em><\/span><span style=\"font-size: 18px;\"> \u4e0a\u53d1\u8868\u6587\u7ae0\uff0c\u62a5\u9053\u4e86<strong>\u80fd\u963b\u6b62\u9f3b\u75c5\u6bd2\u590d\u5236\u7684<em>N<\/em>-\u8089\u8c46\u853b\u9170\u8f6c\u79fb\u9176<\/strong>\uff08<em>N<\/em>-myristoyltransferase\uff0cNMT\uff09<strong>\u6291\u5236\u5242IMP-1088<\/strong>\u7684\u7814\u53d1\u8fc7\u7a0b\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532684017.jpeg\" alt=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\" title=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a<em>Nat. Chem.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u54b1\u4eec\u5148\u6765\u4e86\u89e3\u4e00\u4e0bRV\u7684\u590d\u5236\u8fc7\u7a0b\u3002\u4f5c\u8005\u7ed9\u51fa\u7684\u914d\u56fe\u7b80\u6d01\u660e\u4e86\uff0cRV\u5728\u5bbf\u4e3b\u7ec6\u80de\u5185\u5408\u6210\u86cb\u767d\uff0c\u5728\u5bbf\u4e3b\u7ec6\u80deNMT\u7684\u4f5c\u7528\u4e0b\u5f62\u6210\u8863\u58f3\u524d\u4f53\uff08VP0-VP4\uff09\uff0c\u8fd9\u4e9b\u8863\u58f3\u524d\u4f53\u8fdb\u4e00\u6b65\u7ec4\u88c5\u5f62\u6210\u75c5\u6bd2\u8863\u58f3\uff0c\u75c5\u6bd2\u8863\u58f3\u5728\u6574\u5408\u4e86RNA\u540e\u6700\u7ec8\u5f62\u6210\u5177\u6709\u611f\u67d3\u6027\u7684\u75c5\u6bd2\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress2-1532684017.jpeg\" alt=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\" title=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a<em>Nat. Chem.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u4f5c\u8005\u9009\u62e9\u7684\u653b\u51fb\u9776\u6807\u5c31\u662f\u5e2e\u52a9\u5f62\u6210\u8863\u58f3\u524d\u4f53\u7684NMT\u3002\u4f5c\u8005\u5728\u524d\u671f\u8fdb\u884cNMT\u6291\u5236\u5242\u9ad8\u901a\u91cf\u7b5b\u9009\u65f6\u5f97\u5230\u4e86\u4e00\u4e2a\u6291\u5236\u80fd\u529b\u8f83\u5f31\u7684\u5316\u5408\u7269IMP-72\u3002\u901a\u8fc7\u7ed3\u5408\u6a21\u5f0f\u7684\u5206\u6790\uff0c\u4f5c\u8005\u8ba4\u4e3aIMP-72\u7684\u7ed3\u5408\u4f4d\u70b9\u548c\u4e4b\u524d\u4ed6\u4eec\u62a5\u9053\u7684\u55b9\u5549\u7c7bNMT\u6291\u5236\u5242\u6709\u6240\u4e0d\u540c\u3002\u4e3a\u6b64\uff0c\u4ed6\u4eec\u5236\u5907\u4e86\u4e00\u4e2a\u7ed3\u6784\u7b80\u5355\u7684\u55b9\u5549\u884d\u751f\u7269IMP-358\uff0c\u5e76\u5728IMP-358\u548cIMP-72\u5171\u540c\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\u68c0\u6d4b\u4e86NMT\u7684\u6d3b\u6027\u3002\u7ed3\u679c\u8868\u660e\uff0cIMP-72\u7684\u6d3b\u6027\u5927\u5e45\u63d0\u9ad8\u3002\u7531\u4e8eIMP-72\u7684\u5206\u5b50\u91cf\u6bd4\u8f83\u5c0f\uff0c\u4f5c\u8005\u5c31\u91c7\u7528\u7247\u6bb5\u7ec4\u5408\u7684\u4f18\u5316\u7b56\u7565\uff0c\u5c06IMP-72\u548c\u914d\u4f53\u6548\u7387\u66f4\u9ad8\uff0c\u6eb6\u89e3\u5ea6\u66f4\u597d\u7684\u4e09\u7532\u57fa\u5421\u5511\u8fdb\u884c\u62fc\u5408\uff0c\u5f97\u5230\u4e86\u6d3b\u6027\u63d0\u9ad8\u4e0a\u5343\u500d\u7684IMP-917\u3002\u4f5c\u8005\u53c8\u968f\u624b\u4e22\u51fa\u4e86\u8fd9\u51e0\u4e2a\u5316\u5408\u7269\u548cNMT\u7684\u5171\u6676\u7ed3\u6784\u6765\u9610\u660e\u5176\u5fae\u89c2\u4f5c\u7528\u6a21\u5f0f\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532684017.jpeg\" alt=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\" title=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a<em>Nat. Chem.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u5728\u5bf9IMP-72\u8fdb\u884c\u4f18\u5316\u7684\u65f6\u5019\u8fd8\u5f97\u5230\u4e86\u6d3b\u6027\u63d0\u9ad8\u7684\u5316\u5408\u7269IMP-994\u3002\u65e2\u7136\u662f\u7247\u6bb5\u62fc\u5408\u7684\u4f18\u5316\u7b56\u7565\uff0c\u5e72\u8106\u5c31\u4e00\u62fc\u5230\u5e95\uff0c\u6700\u7ec8\u6512\u51fa\u4e86\u6d3b\u6027\u6c34\u5e73\u8fbe\u5230\u76ae\u6469\u5c14\u7ea7\u522b\u7684\u5f3a\u529b\u6291\u5236\u5242IMP-1088\u3002\u4f5c\u8005\u4ece\u4eb2\u548c\u529b\u5e38\u6570\uff08K<\/span><span style=\"font-size: 14px;\"><sub>D<\/sub><\/span><span style=\"font-size: 18px;\">\uff09\u548c\u534a\u6570\u6291\u5236\u6d53\u5ea6\u9a8c\u8bc1\u4e86\u76ae\u6469\u5c14\u7ea7\u522b\u7684\u4f5c\u7528\u5f3a\u5ea6\uff0c\u5e76\u4f9d\u7136\u7528\u5c0f\u5206\u5b50-\u86cb\u767d\u5171\u6676\u624b\u6bb5\u9610\u660e\u4e86IMP-1088\u548cNMT\u7684\u4f5c\u7528\u65b9\u5f0f\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532684018.jpeg\" alt=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\" title=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a<em>Nat. Chem.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u8d85\u5f3aNMT\u6291\u5236\u5242IMP-1088\u88ab\u7814\u53d1\u51fa\u6765\u540e\u5c31\u8981\u5bf9\u5176\u8be6\u7ec6\u7684\u751f\u7269\u5b66\u6548\u5e94\u8fdb\u884c\u8bc4\u4ef7\u5566\u3002\u4f5c\u8005\u5229\u7528\u5316\u5b66\u86cb\u767d\u8d28\u7ec4\u5b66\u6280\u672f\u548cWestern Blot\u5b9e\u9a8c\u9a8c\u8bc1\u4e86IMP-1088\u5bf9\u5bbf\u4e3b\u7ec6\u80de\u8863\u58f3\u86cb\u767d\u7684\u8089\u8c46\u853b\u9170\u5316\u6291\u5236\u4f5c\u7528\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532684018-1.jpeg\" alt=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\" title=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a<em>Nat. Chem.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u66f4\u5389\u5bb3\u7684\u8fd8\u5728\u540e\u9762\uff0c\u4f5c\u8005\u901a\u8fc7\u5b9e\u9a8c\u8bc1\u660e\u4e86IMP-1088\u80fd\u963b\u6b62\u611f\u67d3\u75c5\u6bd2\u7684\u7ec6\u80de\u53d1\u751f\u7ec6\u80de\u75c5\u53d8\uff0c\u5e76\u4e14\u5728\u76f8\u540c\u6d4b\u8bd5\u6d53\u5ea6\u4e0b\u5bf9\u975e\u67d3\u6bd2\u7ec6\u80de\u65e0\u589e\u6b96\u6291\u5236\u4f5c\u7528\u3002\u5e76\u4e14\uff0cIMP-1088\u8fd8\u80fd\u6291\u5236\u7ec6\u80de\u5185\u611f\u67d3\u75c5\u6bd2\u7684\u751f\u6210\u3002\u8fd9\u5316\u5408\u7269\u7684\u6297\u75c5\u6bd2\u4f5c\u7528\u7b97\u662f\u88ab\u5750\u5b9e\u4e86\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532684018.jpeg\" alt=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\" title=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a<em>Nat. Chem.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u6700\u540e\u4f5c\u8005\u8fd8\u4e0d\u5fd8\u8bb0\u5c0f\u5c0f\u7684\u63a2\u8ba8\u4e00\u4e0b\u5316\u5408\u7269\u6297\u75c5\u6bd2\u7684\u673a\u5236\u3002\u6709\u522b\u4e8e\u591a\u6570\u6297\u75c5\u6bd2\u836f\u7269\uff0cIMP-1088\u65e2\u4e0d\u6291\u5236\u75c5\u6bd2RNA\u751f\u6210\u4e5f\u4e0d\u6291\u5236\u86cb\u767d\u8f6c\u5f55\uff0c\u8fd9\u5316\u5408\u7269\u6291\u5236\u7684\u662f\u975e\u6d3b\u6027\u75c5\u6bd2\u9897\u7c92\u7684\u805a\u96c6\u7ec4\u88c5\u8fc7\u7a0b\u3002\u6709\u56fe\u4e3a\u8bc1\uff1a<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532684018-1.jpeg\" alt=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\" title=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a<em>Nat. Chem.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u6587\u7ae0\u4ecb\u7ecd\u5b8c\u4e86\uff0c\u7167\u4f8b\u8c08\u8c08\u672c\u541b\u7684\u611f\u53d7\u5427\u3002\u7b2c\u4e00\u4e2a\u611f\u89c9\u662f\u8fd9\u6587\u7ae0\u600e\u4e48\u4f1a\u53d1\u5728<em>Nat. Chem.<\/em>\u4e0a\uff0c\u53d1\u5728<em>Nat. Chem. Biol.<\/em>\u4e0a\u66f4\u5408\u9002\u5427\uff0c\u6bd5\u7adf\u8fd9\u7bc7\u6587\u7ae0\u6700\u5927\u7684\u4eae\u70b9\u5728\u4e8e\u8d85\u5f3a\u7684\u4f53\u5916\u6d3b\u6027\u548c\u673a\u5236\u76f8\u5bf9\u65b0\u9896\u7684\u6297\u75c5\u6bd2\u4f5c\u7528\uff0c\u5355\u4ece\u5316\u5b66\u90e8\u5206\u6765\u8bb2\u90fd\u662f\u6807\u51c6\u64cd\u4f5c\uff0c\u6ca1\u89c1\u5230\u4ec0\u4e48\u795e\u6765\u4e4b\u7b14\u3002\u7b2c\u4e8c\u4e2a\u611f\u89c9\u5c31\u662f\u8fd9\u6587\u7ae0\u7b80\u76f4\u662f\u5168\u65b9\u4f4d\u65e0\u6b7b\u89d2\u6253\u51fb\uff0c\u7ecf\u5e38\u7528\u4e24\u79cd\u4e0d\u540c\u5b9e\u9a8c\u65b9\u6cd5\u9a8c\u8bc1\u4e00\u4e2a\u89c2\u70b9\uff0c\u903b\u8f91\u7f1c\u5bc6\uff0c\u96be\u6311\u7455\u75b5\uff0c\u53d1<em>Nat. Chem.&nbsp;<\/em>\u7edd\u5bf9\u662f\u5b9e\u529b\u4f7f\u7136\u3002\u7b2c\u4e09\u4e2a\u611f\u89c9\u6709\u70b9\u516b\u5366\uff0c\u672c\u541b\u4ece\u5fc3\u91cc\u8ba4\u4e3a\u8fd9\u4e2a\u5316\u5408\u7269\u4ee3\u53f7\u771f\u5409\u5229\u554a\uff0c\u201c1088\u201d\u2014\u201c\u836f\u7075\u53d1\u53d1\u201d\u2014\u201c\u836f\u7269\u7075\u9a8c\uff0c\u53d1\u53d1\u6587\u7ae0\u201d\u2026\u2026\u4ee5\u540e\u5927\u5bb6\u9009\u5316\u5408\u7269\u540d\u5b57\u7684\u65f6\u5019\u522b\u5fd8\u4e86\u770b\u770b\u4ee3\u53f7\u554a\uff0c\u9009\u4e2a\u5409\u5229\u70b9\u7684\u2026\u2026\u5f53\u7136\u4e86\uff0c\u82f1\u56fd\u4eba\u5ff5\u8d77\u201c1088\u201d\u6765\u5b8c\u5168\u662f\u53e6\u5916\u4e00\u7801\u4e8b\uff0c\u4f46\u4ee3\u53f7\u5409\u5229\u70b9\u603b\u4e0d\u662f\u4ec0\u4e48\u574f\u4e8b\uff0c\u5bf9\u5427\uff1f<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n<p><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532684019.jpeg\" alt=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\" title=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">Fragment-derived inhibitors of human <em>N<\/em>-myristoyltransferase block capsid assembly and replication of the common cold virus<\/span><\/p>\n<p><em><span style=\"font-size: 14px;\">Nat. Chem.<\/span><\/em><span style=\"font-size: 14px;\">, <strong>2018<\/strong>, <em>10<\/em>, 599\u2013606, DOI: 10.1038\/s41557-018-0039-2<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: right;\">\uff08\u672c\u6587\u7531<strong>\u4e50\u53ea\u541b\u5b50<\/strong>\u4f9b\u7a3f\uff09<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<section style=\"white-space: normal;\">\n<section class=\"Powered-by-XIUMI V5\" >\n<section class=\"\">\n<section class=\"\">\n<p style=\"text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532684019.jpeg\" alt=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\" title=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 25.6px;text-align: center;\"><img      style=\"font-size: 18px;background-color: rgb(255, 255, 255);line-height: 25.6px;width: 556px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532684019.png\" alt=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\" title=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\"  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section class=\"\" style=\"height: 16px;box-sizing: border-box;\">\n<section style=\"height: 15.9961px;width: 24px;float: left;border-top: 6px solid rgb(9, 158, 206);border-left: 6px solid rgb(9, 158, 206);border-right-color: rgb(9, 158, 206);border-bottom-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"height: 15.9961px;width: 24px;float: right;border-top: 6px solid rgb(9, 158, 206);border-right: 6px solid rgb(9, 158, 206);border-bottom-color: rgb(9, 158, 206);border-left-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;color: transparent;clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<section class=\"\" style=\"margin: -13px 3px;padding: 12px;border-width: 1px;border-style: solid;border-color: rgb(9, 158, 206);border-radius: 6px;word-wrap: break-word;box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 18px;\">\u672c\u6587\u7248\u6743\u5c5e\u4e8e<span style=\"color: rgb(9, 158, 206);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">X-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 18px;\"><span style=\"color: rgb(9, 158, 206);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u957f\u6309<\/strong><\/span>\u4e0b\u56fe<strong style=\"box-sizing: border-box;\">\u8bc6\u522b\u56fe\u4e2d\u4e8c\u7ef4\u7801<\/strong>\uff0c\u8f7b\u677e\u5173\u6ce8\u6211\u4eec\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<p style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\"><img class=\"\"     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532684019-1.jpeg\" alt=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\" title=\"Nature Chem.\u8bf7\u4f60\u4e86\u89e3\u4e00\u4e0b\u80fd\u6cbb\u666e\u901a\u611f\u5192\u7684\u5c0f\u5206\u5b50\"  \/><\/p>\n<\/section>\n<\/section>\n<section class=\"\" style=\"height: 16px;box-sizing: border-box;\">\n<section style=\"height: 15.9961px;width: 24px;float: left;border-bottom: 6px solid rgb(9, 158, 206);border-left: 6px solid rgb(9, 158, 206);border-top-color: rgb(9, 158, 206);border-right-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"height: 15.9961px;width: 24px;float: right;border-bottom: 6px solid rgb(9, 158, 206);border-right: 6px solid rgb(9, 158, 206);border-top-color: rgb(9, 158, 206);border-left-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"white-space: normal;\">\n<section >\n<section>\n<section>\n<section>\n<section >\n<section>\n<section>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;line-height: 25.6px;font-size: 18.018px;max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u70b9\u51fb\u201c<span style=\"max-width: 100%;color: rgb(0, 122, 170);\">\u9605\u8bfb\u539f\u6587<\/span>\u201d\uff0c\u67e5\u770b&nbsp;<strong>\u5316\u5b66 \u2022 \u6750\u6599&nbsp;<\/strong>\u9886\u57df<span style=\"max-width: 100%;background-color: rgb(255, 218, 81);\">\u6240\u6709\u6536\u5f55\u671f\u520a<\/span><\/span><\/p>\n<p style=\"white-space: normal;line-height: 25.6px;font-size: 18.018px;max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         X\u4e00MOL\u8d44\u8baf                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u200d\u200d\u200d \u770b\u5230\u6807\u9898\uff0c\u53ef\u80fd\u6709\u4eba\u5fc3\u91cc\u4f1a\u6709\u7591\u60d1\uff1a\u6bcf\u4e2a\u836f\u5e97\u90fd\u80fd\u4e70\u5230\u7684\u611f\u5192\u836f\uff0c\u8fd8\u80fd\u4e0a\u5316\u5b66\u9876\u520a\uff1f \u7684\u786e\uff0c\u611f\u5192\u662f\u4e00\u79cd\u592a\u5e38\u89c1\u7684\u75c5 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8649,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/8648"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=8648"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/8648\/revisions"}],"predecessor-version":[{"id":8662,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/8648\/revisions\/8662"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/8649"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=8648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=8648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=8648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}