{"id":8663,"date":"2018-06-12T01:00:00","date_gmt":"2018-07-27T09:33:41","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e9%92%af%e5%82%ac%e5%8c%96%e7%83%af%e5%9f%ba%e5%86%85%e9%85%b0%e8%83%ba%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e6%8e%a5%e5%8a%9bheck%e5%8d%95%e8%8a%b3%e5%9f%ba%e5%8c%96%e5%8f%8d%e5%ba%94\/"},"modified":"2018-07-27T17:33:43","modified_gmt":"2018-07-27T09:33:43","slug":"%e9%92%af%e5%82%ac%e5%8c%96%e7%83%af%e5%9f%ba%e5%86%85%e9%85%b0%e8%83%ba%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e6%8e%a5%e5%8a%9bheck%e5%8d%95%e8%8a%b3%e5%9f%ba%e5%8c%96%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/8663\/","title":{"rendered":"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;\"><span style=\"line-height: 0px;\">\u200d\u200d<\/span><span style=\"font-size: 18.018px;line-height: 0px;\">\u200d<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657590253&amp;idx=1&amp;sn=af64055348b35e9185b67c634d7ef95c&amp;chksm=80f7b23db7803b2bc868baa456f16ab2329ba355b97bce33703e32440ef4260a6f34c1ea970a&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-align: center;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532684022.gif\" alt=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\" title=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\"  \/><\/a><\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 18px;\">\u624b\u6027\u5185\u9170\u80fa<\/span><\/strong><span style=\"font-size: 18px;\">\u7ed3\u6784\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\u548c\u5177\u6709\u5e7f\u8c31\u751f\u7269\u6d3b\u6027\u7684\u5206\u5b50\u4e2d\uff0c\u56e0\u6b64\u53ef\u4ee5\u8bf4\u8be5\u7ed3\u6784\u662f\u4e00\u4e2a\u660e\u661f\u9aa8\u67b6\u3002\u4f8b\u5982\u56fe1\u4e2d\u7684\u4e24\u4e2a\u5185\u9170\u80fa\u5316\u5408\u7269\uff0c<strong>A<\/strong>\u662fCGRP\u53d7\u4f53\u62ee\u6297\u5242\uff0c<strong>B<\/strong>\u662fNK1\u53d7\u4f53\u62ee\u6297\u5242\u3002\u7531\u4e8e\u8be5\u7c7b\u7ed3\u6784\u7684\u91cd\u8981\u6027\uff0c\u76f8\u5173\u5316\u5408\u7269\u7684\u5408\u6210\u5f15\u8d77\u4e86\u4f17\u591a\u5316\u5b66\u5bb6\u7684\u5173\u6ce8\u548c\u7814\u7a76\uff0c\u5982\u94dc\u50ac\u5316\u7684aza-Diels-Alder\u53cd\u5e94\u3001\u6c2e\u6742\u73af\u5361\u5bbe\uff08NHC\uff09\u50ac\u5316\u4e0d\u9971\u548c\u7fb0\u57fa\u5316\u5408\u7269\u4e0e\u4e9a\u80fa\u7684\u73af\u5316\u53cd\u5e94\u4ee5\u53ca\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316<em>N<\/em>-\u82b3\u57fa\u4e9a\u80fa\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u53cd\u5e94\uff0c\u4ee5\u4e0a\u65b9\u6cd5\u90fd\u662f\u6784\u5efa\u8be5\u7c7b\u5316\u5408\u7269\u7684\u6709\u6548\u65b9\u6cd5\u3002\u6700\u8fd1\uff0c<strong>\u7f8e\u56fd\u72b9\u4ed6\u5927\u5b66<\/strong>\u7684<strong>Matthew S. Sigman<\/strong>\u6559\u6388\u56e2\u961f\u8bbe\u60f3\u901a\u8fc7<strong>\u63a5\u529bHeck\u53cd\u5e94\u7684\u7b56\u7565\u6784\u5efa\u624b\u6027\u5185\u9170\u80fa<\/strong>\u3002\u4f20\u7edf\u7684Heck\u53cd\u5e94\u5f97\u5230\u7684\u662f\u591a\u82b3\u57fa\u5316\u7684\u4ea7\u7269\uff0c\u800cSigman\u6559\u6388\u56e2\u961f\u53d1\u5c55\u7684\u63a5\u529bHeck\u53cd\u5e94\u53ef\u5b9e\u73b0\u4e0d\u5bf9\u79f0\u5355\u53d6\u4ee3\u7684\u82b3\u57fa\u5316\u8fc7\u7a0b\u3002\u4ed6\u4eec\u4ee5\u70ef\u57fa\u5185\u9170\u80fa\u4f5c\u4e3a\u5e95\u7269\uff0c\u901a\u8fc7<strong>Pd\u50ac\u5316\u7684\u5bf9\u6620\u9009\u62e9\u6027\u82b3\u57fa\u5316\u53cd\u5e94\u5b9e\u73b0\u4e86\u624b\u6027\u03b1,\u03b2-\u4e0d\u9971\u548c\u03b4-\u5185\u9170\u80fa\u7ed3\u6784\u7684\u6784\u5efa<\/strong>\uff0c\u8fd9\u79cd\u65b9\u6cd5\u540c\u6837\u53ef\u7528\u4e8e\u5305\u542b\u6c2e\u53d6\u4ee3\u5b63\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u03b4-\u5185\u9170\u80fa\u4ee5\u53ca7-\u82b3\u57fa\u03b1,\u03b2-\u4e0d\u9971\u548c\u0511-\u5185\u9170\u80fa\u5316\u5408\u7269\u7684\u5408\u6210\u3002\u76f8\u5173\u5de5\u4f5c\u53d1\u8868\u5728<\/span><span style=\"font-size: 16px;\"><em><strong>J. Am. Chem. Soc.&nbsp;<\/strong><\/em><\/span><span style=\"font-size: 18px;\">\u4e0a\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532684022.jpeg\" alt=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\" title=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe1. \u82b3\u57fa\u53d6\u4ee3\u03b4-\u5185\u9170\u80fa\u7684\u5408\u6210\u7b56\u7565\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u70ef\u57fa\u5185\u9170\u80fa\u4e2d\u7684\u53cc\u952e\u662f\u4e00\u7c7b\u6781\u5316\u7684\u70ef\u57fa\u53cc\u952e\uff0c\u53d1\u751f\u53cd\u5e94\u65f6\u901a\u5e38\u4e0d\u5b58\u5728\u533a\u57df\u9009\u62e9\u6027\u95ee\u9898\u3002\u4ece\u56fe1B\u53ef\u4ee5\u770b\u51fa\uff0c\u73af\u72b6\u70ef\u70c3\u5185\u9170\u80fa\u53ef\u8fdb\u884c\u9009\u62e9\u6027\u82b3\u57fa\u5316\u53cd\u5e94\u5f97\u5230\u4e2d\u95f4\u4f53<strong>C<\/strong>\uff0c<strong>C<\/strong>\u518d\u8fdb\u884c\u03b2-H\u6d88\u9664\u53cd\u5e94\u5f97\u5230\u4e2d\u95f4\u4f53<strong>D<\/strong>\uff0c\u4e2d\u95f4\u4f53<strong>D<\/strong>\u6709\u53ef\u80fd\u901a\u8fc7\u4f20\u7edf\u7684Heck\u53cd\u5e94\u9014\u5f84\u5f97\u5230\u76f8\u5e94\u7684\u70ef\u70c3\uff0c\u6216\u91cd\u65b0\u8fc1\u79fb\u63d2\u5165\u3001\u518d\u8fdb\u884c\u03b2-H\u6d88\u9664\u5f97\u5230\u70ed\u529b\u5b66\u66f4\u52a0\u7a33\u5b9a\u7684\u5316\u5408\u7269<strong>2<\/strong>\uff08\u56fe1\uff09\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u4f5c\u8005\u6839\u636e\u4ee5\u5f80\u5de5\u4f5c\u7684\u57fa\u7840\uff0c\u76f4\u63a5\u9009\u62e9Pd(CH<\/span><span style=\"font-size: 14px;\"><sub>3<\/sub><\/span><span style=\"font-size: 18px;\">CN)<\/span><span style=\"font-size: 14px;\"><sub>2<\/sub><\/span><span style=\"font-size: 18px;\">(OTs)<\/span><span style=\"font-size: 14px;\"><sub>2<\/sub><\/span><span style=\"font-size: 18px;\">\/PyrOx\u50ac\u5316\u4f53\u7cfb\u7b5b\u9009\u82b3\u57fa\u787c\u9178\u7684\u7528\u91cf\u5bf9\u53cd\u5e94\u7ed3\u679c\u7684\u5f71\u54cd\uff0c\u6700\u7ec8\u6743\u8861\u4ea7\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\uff0c\u53cd\u5e94\u4f7f\u75282\u5f53\u91cf\u7684\u82b3\u57fa\u787c\u9178\u53ef\u4ee5\u5f97\u5230\u6700\u597d\u7684\u7ed3\u679c\uff0c\u4ee578%\u7684\u4ea7\u7387\u548c&gt; 99:1\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4ea7\u7269<strong>2a<\/strong>\u3002\u4f5c\u8005\u63a5\u7740\u8003\u5bdf\u70ef\u57fa\u5185\u9170\u80fa\u6c2e\u53d6\u4ee3\u57fa\u5bf9\u53cd\u5e94\u7ed3\u679c\u7684\u5f71\u54cd\uff0c\u4e0d\u7ba1\u662f\u5bf9\u7532\u82ef\u78fa\u9170\u57fa\u53d6\u4ee3\u57fa\u3001\u70f7\u57fa\u53d6\u4ee3\u57fa\uff0c\u8fd8\u662f\u65e0\u53d6\u4ee3\u57fa\u7684\u5e95\u7269\u53c2\u4e0e\u53cd\u5e94\uff0c\u90fd\u80fd\u5f97\u5230\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\uff08\u56fe2\uff09\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532684022.jpeg\" alt=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\" title=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe2. \u53cd\u5e94\u6761\u4ef6\u7684\u7b5b\u9009\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc<\/em>.<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u5728\u6700\u4f73\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u5e95\u7269\u7684\u9002\u7528\u8303\u56f4\u8fdb\u884c\u4e86\u8003\u5bdf\uff0c\u4e3b\u8981\u63a2\u7a76\u70ef\u57fa\u5185\u9170\u80fa\u7684R\u53d6\u4ee3\u57fa\u548c\u4e0d\u540c\u82b3\u57fa\u787c\u9178\u5bf9\u53cd\u5e94\u7ed3\u679c\u7684\u5f71\u54cd\u3002\u4ed6\u4eec\u9996\u5148\u56fa\u5b9aR\u4e3aBoc\u53d6\u4ee3\u57fa\uff0c\u82b3\u57fa\u787c\u9178\u82ef\u73af\u7684\u95f4\u4f4d\u6216\u5bf9\u4f4d\u4fee\u9970\u53d6\u4ee3\u57fa\u65f6\uff0c\u53d6\u4ee3\u57fa\u7684\u7535\u6027\u5bf9\u53cd\u5e94\u7684\u5f71\u54cd\u8f83\u5c0f\uff0c\u53cd\u5e94\u90fd\u80fd\u4ee5\u4f18\u79c0\u7684\u4ea7\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76ee\u6807\u4ea7\u7269\u3002\u800c\u5f53\u82ef\u73af\u7684\u90bb\u4f4d\u4fee\u9970\u53d6\u4ee3\u57fa\u65f6\uff0c\u53cd\u5e94\u53ea\u80fd\u4ee588%\u7684\u4ea7\u7387\u548c87:13\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4ea7\u7269<strong>2k<\/strong>\u3002\u5f53R\u4e3a\u82c4\u57fa\u53d6\u4ee3\u57fa\u6216Boc\u53d6\u4ee3\u57fa\uff0c\u53cd\u5e94\u4f7f\u7528\u6742\u82b3\u57fa\u787c\u9178\u4f5c\u4e3a\u5e95\u7269\u65f6\uff0c\u4ea7\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u90fd\u51fa\u73b0\u4e86\u8f83\u5927\u5e45\u5ea6\u7684\u4e0b\u964d\uff08\u56fe3\uff09\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress9-1532684022.jpeg\" alt=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\" title=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe3. \u5e95\u7269\u9002\u7528\u8303\u56f4\u7684\u8003\u5bdf\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u4f5c\u8005\u63a5\u7740\u8003\u5bdf\u4e03\u5143\u73af\u70ef\u57fa\u5185\u9170\u80fa\u7684\u53cd\u5e94\u60c5\u51b5\uff0c\u4ea7\u7387\u7a0d\u6709\u4e0b\u964d\uff0c\u4f46\u662f\u4ea7\u7269<strong>4a-4c<\/strong>\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4f9d\u7136\u975e\u5e38\u4f18\u79c0\uff08\u56fe4\uff09\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress7-1532684022.jpeg\" alt=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\" title=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe4. \u4e03\u5143\u73af\u72b6\u70ef\u57fa\u5185\u9170\u80fa\u7684\u5e95\u7269\u9002\u7528\u6027\u8003\u5bdf\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u4f5c\u8005\u63a5\u7740\u8003\u5bdf\u4e86\u4e09\u53d6\u4ee3\u70ef\u57fa\u5185\u9170\u80fa\u7684\u53cd\u5e94\u60c5\u51b5\uff0c\u4ea7\u7269\u7684\u5bf9\u6620\u9009\u62e9\u6027\u975e\u5e38\u4f18\u79c0\uff0c\u4ea7\u7387\u540c\u6837\u51fa\u73b0\u4e86\u8f83\u5927\u5e45\u5ea6\u7684\u4e0b\u964d\uff08\u56fe5\uff09\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532684022.jpeg\" alt=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\" title=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe5. \u4e09\u53d6\u4ee3\u70ef\u57fa\u5185\u9170\u80fa\u7684\u5e95\u7269\u9002\u7528\u6027\u8003\u5bdf\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u4e3a\u4e86\u8bc1\u660e\u53cd\u5e94\u7684\u5b9e\u7528\u6027\uff0c\u4f5c\u8005\u8bbe\u8ba1\u4e86\u514b\u91cf\u7ea7\u89c4\u6a21\u7684\u53cd\u5e94\u548c\u884d\u751f\u5316\u5b9e\u9a8c\u3002\u8d77\u59cb\u539f\u6599<strong>1d<\/strong>\u7684\u53cd\u5e94\u89c4\u6a21\u653e\u6269\u5927\u52301.3 g\u65f6\u4f9d\u7136\u80fd\u4ee593%\u7684\u4ea7\u7387\u548c96:4\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u624b\u6027\u5355\u82ef\u57fa\u5316\u7684\u4ea7\u7269<strong>2d<\/strong>\u3002<strong>2d<\/strong>\u53ef\u4ee5\u901a\u8fc7\u6c22\u5316\/\u8fd8\u539f\u4e24\u6b65\u53cd\u5e94\u4ee590%\u7684\u603b\u6536\u7387\u548c96:4\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u54cc\u5576\u4ea7\u7269<strong>7<\/strong>\uff0c\u4ea7\u7269<strong>2d<\/strong>\u4e5f\u53ef\u901a\u8fc7\u94d1\u50ac\u5316\u82ef\u787c\u9178\u7684\u5171\u8f6d\u52a0\u6210\u53cd\u5e94\u5f97\u5230\u5316\u5408\u7269<strong>8<\/strong>\u3002\u6b64\u5916\uff0c\u5316\u5408\u7269<strong>2a<\/strong>\u53ef\u901a\u8fc7\u6c22\u5316\/Boc\u4fdd\u62a4\u57fa\u6d88\u9664\u4e24\u6b65\u53cd\u5e94\uff0c\u9ad8\u4ea7\u7387\u548c\u9ad8\u624b\u6027\u4fdd\u6301\u5730\u5f97\u5230\u975e\u5e38\u91cd\u8981\u7684\u6e38\u79bb\u5185\u9170\u80fa\u5408\u6210\u780c\u5757<strong>10<\/strong>\uff0c<strong>10<\/strong>\u53ef\u7528\u4e8e\u9ad8\u6548\u8f6c\u5316\u4e3a\u91cd\u8981\u7684\u6d3b\u6027\u5316\u5408\u7269CGRP\u53d7\u4f53\u62ee\u6297\u5242<strong>A<\/strong>\u548cTNF\u03b1\u4fe1\u53f7\u901a\u8def\u8c03\u8282\u5242<strong>F<\/strong>\uff08\u56fe6\uff09\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress2-1532684023.jpeg\" alt=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\" title=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe6. \u514b\u91cf\u7ea7\u89c4\u6a21\u7684\u53cd\u5e94\u548c\u884d\u751f\u5316\u5b9e\u9a8c\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u4f5c\u8005\u5c06\u5e95\u7269<strong>11<\/strong>\u7f6e\u4e8e\u6807\u51c6\u6761\u4ef6\u4e0b\u8fdb\u884c\u53cd\u5e94\uff0c\u4ec5\u5f97\u5230\u4e86\u4e24\u79cdHeck\u4ea7\u7269\uff0c\u6ca1\u6709\u5f97\u5230\u03b1,\u03b2-\u4e0d\u9971\u548c\u03b4-\u5185\u9170\u80fa\u4ea7\u7269<strong>2c<\/strong>\uff0c\u8868\u660e\u5f62\u6210<strong>2c<\/strong>\u7684\u8fc7\u7a0b\u4e2d\u53d1\u751f\u4e86\u201c\u94fe\u884c\u8d70\u201d\u673a\u7406\uff0c\u7531\u6b64\u5bfc\u81f4\u5f02\u6784\u5316\u8fc7\u7a0b\uff08\u56fe7\uff09\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532684023.jpeg\" alt=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\" title=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe7. \u53cd\u5e94\u673a\u7406\u7684\u7814\u7a76\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><strong><span style=\"font-size: 18px;\">\u603b\u7ed3<\/span><\/strong><\/p>\n<p style=\"text-align: center;line-height: normal;\"><strong><span style=\"font-size: 18px;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">Matthew S. Sigman\u6559\u6388\u5229\u7528\u63a5\u529bHeck\u53cd\u5e94\u7684\u7b56\u7565\uff0c\u5b9e\u73b0\u4e86\u94af\u50ac\u5316\u82b3\u57fa\u787c\u9178\u4e0e\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u82b3\u57fa\u5316\u53cd\u5e94\uff0c\u4ee5\u9ad8\u4ea7\u7387\u548c\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4e86\u624b\u60276-\u82b3\u57fa\u03b1,\u03b2-\u4e0d\u9971\u548c\u03b4-\u5185\u9170\u80fa\u4ea7\u7269\u3002\u8fd9\u79cd\u65b9\u6cd5\u540c\u6837\u53ef\u7528\u4e8e\u5305\u542b\u6c2e\u53d6\u4ee3\u5b63\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u03b4-\u5185\u9170\u80fa\u4ee5\u53ca7-\u82b3\u57fa\u03b1,\u03b2-\u4e0d\u9971\u548c\u0511-\u5185\u9170\u80fa\u5316\u5408\u7269\u7684\u5408\u6210\u3002\u6b64\u5916\uff0c\u8be5\u53cd\u5e94\u8fd8\u53ef\u6269\u5927\u5230\u514b\u91cf\u7ea7\u89c4\u6a21\u3002\u4f5c\u8005\u5c06\u8fdb\u4e00\u6b65\u7814\u7a76\u6742\u82b3\u57fa\u787c\u9178\u53c2\u4e0e\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u8fc7\u7a0b\uff0c\u4ee5\u62d3\u5c55\u8be5\u7c7b\u65b9\u6cd5\u5728\u4e0d\u5bf9\u79f0\u5355\u82b3\u57fa\u5316\u53cd\u5e94\u4e2d\u7684\u5e94\u7528\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n<p><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress2-1532684023-1.jpeg\" alt=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\" title=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing \u03b1, \u03b2-Unsaturated \u03b4-Lactams<\/span><\/p>\n<p><em><span style=\"font-size: 14px;\">J. Am. Chem. Soc.,<\/span><\/em><span style=\"font-size: 14px;\"> <strong>2018<\/strong>, DOI: 10.1021\/jacs.8b02752<\/span><\/p>\n<p><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u5bfc\u5e08\u4ecb\u7ecd<\/span><\/p>\n<p><span style=\"font-size: 14px;\">Matthew S. Sigman<\/span><\/p>\n<p><span style=\"font-size: 14px;\">http:\/\/www.x-mol.com\/university\/faculty\/1749<\/span><\/p>\n<p><br  \/><\/p>\n<section style=\"white-space: normal;\">\n<section class=\"Powered-by-XIUMI V5\" >\n<section class=\"\">\n<section class=\"\">\n<p style=\"text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532684023.jpeg\" alt=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\" title=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 25.6px;text-align: center;\"><img      style=\"font-size: 18px;background-color: rgb(255, 255, 255);line-height: 25.6px;width: 556px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532684023.png\" alt=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\" title=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\"  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section class=\"\" style=\"height: 16px;box-sizing: border-box;\">\n<section style=\"height: 15.9961px;width: 24px;float: left;border-top: 6px solid rgb(9, 158, 206);border-left: 6px solid rgb(9, 158, 206);border-right-color: rgb(9, 158, 206);border-bottom-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"height: 15.9961px;width: 24px;float: right;border-top: 6px solid rgb(9, 158, 206);border-right: 6px solid rgb(9, 158, 206);border-bottom-color: rgb(9, 158, 206);border-left-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;color: transparent;clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<section class=\"\" style=\"margin: -13px 3px;padding: 12px;border-width: 1px;border-style: solid;border-color: rgb(9, 158, 206);border-radius: 6px;word-wrap: break-word;box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 18px;\">\u672c\u6587\u7248\u6743\u5c5e\u4e8e<span style=\"color: rgb(9, 158, 206);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">X-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 18px;\"><span style=\"color: rgb(9, 158, 206);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u957f\u6309<\/strong><\/span>\u4e0b\u56fe<strong style=\"box-sizing: border-box;\">\u8bc6\u522b\u56fe\u4e2d\u4e8c\u7ef4\u7801<\/strong>\uff0c\u8f7b\u677e\u5173\u6ce8\u6211\u4eec\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<p style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\"><img class=\"\"     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532684023.jpeg\" alt=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\" title=\"\u94af\u50ac\u5316\u70ef\u57fa\u5185\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u63a5\u529bHeck\u5355\u82b3\u57fa\u5316\u53cd\u5e94\"  \/><\/p>\n<\/section>\n<\/section>\n<section class=\"\" style=\"height: 16px;box-sizing: border-box;\">\n<section style=\"height: 15.9961px;width: 24px;float: left;border-bottom: 6px solid rgb(9, 158, 206);border-left: 6px solid rgb(9, 158, 206);border-top-color: rgb(9, 158, 206);border-right-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"height: 15.9961px;width: 24px;float: right;border-bottom: 6px solid rgb(9, 158, 206);border-right: 6px solid rgb(9, 158, 206);border-top-color: rgb(9, 158, 206);border-left-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"white-space: normal;\">\n<section >\n<section>\n<section>\n<section>\n<section >\n<section>\n<section>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;line-height: 25.6px;font-size: 18.018px;max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u70b9\u51fb\u201c<span style=\"max-width: 100%;color: rgb(0, 122, 170);\">\u9605\u8bfb\u539f\u6587<\/span>\u201d\uff0c\u67e5\u770b&nbsp;<strong>\u5316\u5b66 \u2022 \u6750\u6599&nbsp;<\/strong>\u9886\u57df<span style=\"max-width: 100%;background-color: rgb(255, 218, 81);\">\u6240\u6709\u6536\u5f55\u671f\u520a<\/span><\/span><\/p>\n<p style=\"white-space: normal;line-height: 25.6px;font-size: 18.018px;max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         X\u4e00MOL\u8d44\u8baf                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u200d\u200d\u200d \u624b\u6027\u5185\u9170\u80fa\u7ed3\u6784\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\u548c\u5177\u6709\u5e7f\u8c31\u751f\u7269\u6d3b\u6027\u7684\u5206\u5b50\u4e2d\uff0c\u56e0\u6b64\u53ef\u4ee5\u8bf4\u8be5\u7ed3\u6784\u662f\u4e00\u4e2a\u660e\u661f\u9aa8\u67b6\u3002\u4f8b\u5982\u56fe1\u4e2d [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8664,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/8663"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=8663"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/8663\/revisions"}],"predecessor-version":[{"id":8677,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/8663\/revisions\/8677"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/8664"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=8663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=8663"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=8663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}