{"id":8805,"date":"2018-06-11T01:00:00","date_gmt":"2018-07-27T09:34:29","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e5%be%ae%e8%b5%84%e8%ae%af%ef%bc%9a%e7%ac%ac%e5%8d%81%e4%ba%94%e5%b1%8aqs%e4%b8%96%e7%95%8c%e5%a4%a7%e5%ad%a6%e6%8e%92%e5%90%8d%e5%8f%91%e5%b8%83%ef%bc%8c%e6%b8%85%e5%8d%8e%e3%80%81%e5%8c%97%e5%a4%a7\/"},"modified":"2018-07-27T17:34:30","modified_gmt":"2018-07-27T09:34:30","slug":"%e5%be%ae%e8%b5%84%e8%ae%af%ef%bc%9a%e7%ac%ac%e5%8d%81%e4%ba%94%e5%b1%8aqs%e4%b8%96%e7%95%8c%e5%a4%a7%e5%ad%a6%e6%8e%92%e5%90%8d%e5%8f%91%e5%b8%83%ef%bc%8c%e6%b8%85%e5%8d%8e%e3%80%81%e5%8c%97%e5%a4%a7","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/8805\/","title":{"rendered":"\u5fae\u8d44\u8baf\uff1a\u7b2c\u5341\u4e94\u5c4aQS\u4e16\u754c\u5927\u5b66\u6392\u540d\u53d1\u5e03\uff0c\u6e05\u534e\u3001\u5317\u5927\u6392\u4f4d\u9f50\u5347 | \u4e2d\u79d1\u9662\u4f4d\u52172018\u81ea\u7136\u6307\u6570\u699c\u5355\u5168\u7403\u5341\u5927\u79d1\u7814\u673a\u6784\u9996\u4f4d"},"content":{"rendered":"
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\u200d<\/span>\u200d<\/span>\u200d\"\u5fae\u8d44\u8baf\uff1a\u7b2c\u5341\u4e94\u5c4aQS\u4e16\u754c\u5927\u5b66\u6392\u540d\u53d1\u5e03\uff0c\u6e05\u534e\u3001\u5317\u5927\u6392\u4f4d\u9f50\u5347<\/a><\/span><\/a><\/p>\n


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\u4f5c\u4e3a\u4e16\u754c\u6743\u5a01\u5927\u5b66\u6392\u540d\u4e4b\u4e00\u7684\u300aQS\u4e16\u754c\u5927\u5b66\u6392\u540d\u300b\uff0c\u672c\u6b21\u6392\u51fa\u4e86\u4e16\u754c\u524d1000\u4f4d\u5927\u5b66\uff0c\u6db5\u76d6\u4e8685\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u3002\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u7f8e\u56fd\u9ebb\u7701\u7406\u5de5\u5927\u5b66\u8fde\u7eed\u7b2c\u4e03\u5e74\u6392\u4f4d\u4e16\u754c\u7b2c\u4e00\uff0c\u4e9a\u6d32\u6392\u540d\u6700\u9876\u5c16\u5927\u5b66\u5219\u7531\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u6458\u53d6\uff0c\u540d\u5217\u7b2c11\u540d\u3002\u4e2d\u56fd\u9999\u6e2f7\u6240\u3001\u4e2d\u56fd\u6fb3\u95e81\u6240\u3001\u4e2d\u56fd\u53f0\u6e7e17\u6240\u5927\u5b66\u699c\u4e0a\u6709\u540d\uff0c\u5171\u670940\u6240\u4e2d\u56fd\u5927\u5b66\u540d\u5217\u5168\u7403500\u5f3a\u3002<\/span><\/p>\n


<\/p>\n

http:\/\/news.sciencenet.cn\/htmlnews\/2018\/6\/414006.shtm<\/span><\/p>\n

https:\/\/www.topuniversities.com\/university-rankings\/world-university-rankings\/2019<\/span><\/p>\n<\/blockquote>\n<\/section>\n


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\u30106\u67087\u65e5\u3011\u4e2d\u79d1\u9662\u4f4d\u52172018\u81ea\u7136\u6307\u6570\u699c\u5355\u5168\u7403\u5341\u5927\u79d1\u7814\u673a\u6784\u9996\u4f4d<\/span><\/strong><\/p>\n


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\u8fd1\u65e5\uff0c2018\u81ea\u7136\u6307\u6570\u5e74\u5ea6\u699c\u5355\uff08Nature Index 2018 Annual Tables\uff09\u6b63\u5f0f\u53d1\u5e03\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u4f4d\u5217\u8be5\u699c\u5355\u5168\u7403\u5341\u5927\u79d1\u7814\u673a\u6784\u9996\u4f4d\u3002\u6b64\u524d\uff0c\u4e2d\u79d1\u9662\u5df2\u8fde\u7eed6\u5e74\u4f4d\u5217\u81ea\u7136\u6307\u6570\u5168\u7403\u9996\u4f4d\u3002<\/span><\/p>\n


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\u636e\u6089\uff0c\u8be5\u699c\u5355\u8fd8\u5217\u51fa\u4e86\u81ea\u7136\u6307\u6570\u5168\u7403\u5341\u5927\u4f01\u4e1a\u79d1\u7814\u673a\u6784\uff0c\u5206\u522b\u662f\u745e\u58eb\u970d\u592b\u66fc\u2022\u7f57\u6c0f\u516c\u53f8\u3001\u7f8e\u56fdIBM\u516c\u53f8\u3001\u745e\u58eb\u8bfa\u534e\u516c\u53f8\u3001\u7f8e\u56fd\u9ed8\u514b\u516c\u53f8\u3001\u82f1\u56fd\u963f\u65af\u5229\u5eb7\u516c\u53f8\u3001\u7f8e\u56fd\u8f89\u745e\u516c\u53f8\u3001\u82f1\u56fd\u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\u3001\u65b0\u897f\u5170GNS Science\u3001\u97e9\u56fd\u4e09\u661f\u96c6\u56e2\u3001\u7f8e\u56fd\u5b89\u8fdb\u516c\u53f8\u3002<\/span><\/p>\n


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\u81ea\u7136\u6307\u6570\u7531\u65bd\u666e\u6797\u683c\u2022\u81ea\u7136\uff08Springer Nature\uff09\u65d7\u4e0b\u81ea\u7136\u79d1\u7814\uff08Nature Research\uff09\u7f16\u5236\uff0c\u4e8e2014\u5e7411\u6708\u9996\u6b21\u53d1\u5e03\uff0c\u901a\u8fc7\u8ffd\u8e2a\u9ad8\u8d28\u91cf\u81ea\u7136\u79d1\u5b66\u671f\u520a\u6240\u53d1\u8868\u7684\u79d1\u7814\u8bba\u6587\u7684\u4f5c\u8005\u4fe1\u606f\uff0c\u4e3a\u79d1\u7814\u5171\u540c\u4f53\u63d0\u4f9b\u6709\u5173\u5168\u7403\u79d1\u7814\u72b6\u51b5\u548c\u51fa\u7248\u8d8b\u52bf\u7684\u4fe1\u606f\u3002\u81ea2018\u5e746\u6708\u8d77\uff0c\u7eb3\u5165\u81ea\u7136\u6307\u6570\u7684\u671f\u520a\u6570\u91cf\u5df2\u7531\u539f\u5148\u768468\u672c\u589e\u81f382\u672c\u3002\u81ea\u7136\u6307\u6570\u76ee\u524d\u91c7\u7528\u4e24\u79cd\u8ba1\u7b97\u8bba\u6587\u4ea7\u51fa\u7684\u65b9\u6cd5\uff0c\u5176\u4e2d\u8bba\u6587\u8ba1\u6570 (AC) \u6307\u4e0d\u8bba\u4e00\u7bc7\u6587\u7ae0\u6709\u4e00\u4e2a\u8fd8\u662f\u591a\u4e2a\u4f5c\u8005\uff0c\u6bcf\u4f4d\u4f5c\u8005\u6240\u5728\u7684\u56fd\u5bb6\u6216\u673a\u6784\u90fd\u83b7\u5f971\u4e2aAC\u5206\u503c\uff1b\u5206\u6570\u5f0f\u8ba1\u91cf\uff08FC\uff09\u5219\u8003\u8651\u4e86\u6bcf\u4f4d\u8bba\u6587\u4f5c\u8005\u7684\u76f8\u5bf9\u8d21\u732e\u3002<\/span><\/p>\n


<\/p>\n

http:\/\/www.cas.cn\/yw\/201806\/t20180607_4648861.shtml<\/span><\/p>\n

https:\/\/www.natureindex.com\/annual-tables\/2018<\/span><\/p>\n<\/blockquote>\n<\/section>\n


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\u636e\u4e86\u89e3\uff0c\u8be5\u4e2d\u5fc3\u662f\u5317\u4eac\u5927\u5b66\u201c\u53cc\u4e00\u6d41\u201d\u5efa\u8bbe\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u5c06\u7acb\u8db3\u5317\u4eac\u5927\u5b66\u4f18\u8d28\u7684\u57fa\u7840\u5b66\u79d1\u4f53\u7cfb\uff0c\u8054\u5408\u56fd\u5185\u5916\u9ad8\u6c34\u5e73\u5927\u5b66\uff0c\u7387\u5148\u5efa\u6210\u4e16\u754c\u4e00\u6d41\u7684\u751f\u6001\u5b66\u79d1\uff0c\u6210\u4e3a\u56fd\u5185\u5916\u6709\u91cd\u8981\u5f71\u54cd\u7684\u751f\u6001\u5b66\u7814\u7a76\u673a\u6784\u548c\u653f\u7b56\u667a\u5e93\u3002<\/span><\/p>\n


<\/p>\n

http:\/\/news.sciencenet.cn\/htmlnews\/2018\/6\/413978.shtm<\/span><\/p>\n

http:\/\/pkunews.pku.edu.cn\/xwzh\/2018-06\/06\/content_303167.htm<\/span><\/p>\n<\/blockquote>\n<\/section>\n


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\u65e5\u524d\uff0c\u6211\u56fd\u79d1\u5b66\u5bb6\u5728\u5b66\u672f\u671f\u520a\u300a\u81ea\u7136\u2014\u7ec6\u80de\u751f\u7269\u5b66\u300b\uff08Nature Cell Biology<\/em>\uff09\u5728\u7ebf\u53d1\u8868\u7814\u7a76\u8bba\u6587\uff0c\u5728\u56fd\u9645\u4e0a\u9996\u6b21\u4ece\u5355\u7ec6\u80de\u5206\u8fa8\u7387\u548c\u5168\u8f6c\u5f55\u7ec4\u6c34\u5e73\uff0c\u5168\u9762\u3001\u7cfb\u7edf\u3001\u6df1\u5165\u5730\u9610\u660e\u4e86\u98df\u9053\u3001\u80c3\u3001\u5c0f\u80a0\u548c\u5927\u80a0\u8fd94\u79cd\u5668\u5b98\u5728\u4eba\u7c7b\u80da\u80ce\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u7684\u57fa\u56e0\u8868\u8fbe\u56fe\u8c31\u53ca\u5176\u4fe1\u53f7\u8c03\u63a7\u673a\u5236\uff0c\u63ed\u793a\u4e86\u8fd94\u79cd\u5668\u5b98\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e4b\u95f4\u7684\u7cbe\u51c6\u53d1\u80b2\u8def\u5f84\u548c\u57fa\u56e0\u8868\u8fbe\u7279\u5f81\uff0c\u5e76\u8fdb\u4e00\u6b65\u8be6\u7ec6\u89e3\u6790\u4e86\u5927\u80a0\u4ece\u80ce\u513f\u5230\u6210\u4eba\u7684\u53d1\u80b2\u3001\u6210\u719f\u8def\u5f84\u548c\u5173\u952e\u751f\u7269\u5b66\u7279\u5f81\u3002\u8fd9\u662f\u6211\u56fd\u79d1\u5b66\u5bb6\u9996\u6b21\u7cfb\u7edf\u63ed\u793a\u4eba\u7c7b\u6d88\u5316\u9053\u53d1\u80b2\u7ec6\u80de\u56fe\u8c31\u3002<\/span><\/p>\n

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<\/p>\n

http:\/\/paper.people.com.cn\/rmrb\/html\/2018-06\/07\/nw.D110000renmrb_20180607_2-11.htm#<\/span><\/p>\n

https:\/\/www.nature.com\/articles\/s41556-018-0105-4<\/span><\/p>\n<\/blockquote>\n<\/section>\n


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\u30106\u67087\u65e5\u3011\u8f89\u745e\u65b0\u836fTalazoparib\u83b7\u7f8e\u56fdFDA\u4f18\u5148\u5ba1\u8bc4\uff0c\u7528\u4e8e\u665a\u671f\u4e73\u817a\u764c\u6cbb\u7597<\/span><\/strong><\/p>\n


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\u8fd1\u65e5\uff0c\u5168\u7403\u533b\u836f\u5de8\u5934\u8f89\u745e\uff08Pfizer\uff09\u5ba3\u5e03\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u63a5\u53d7\u5176\u7814\u53d1\u7684Talazoparib\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\uff0c\u5e76\u6388\u4e88\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u3002\u8be5NDA\u7684\u63d0\u4ea4\u662f\u57fa\u4e8e\u4e34\u5e8a\u8bd5\u9a8cEMBRACA\u7684\u7ed3\u679c\u3002\u8be5\u8bd5\u9a8c\u8bc4\u4f30\u4e86Talazoparib\u4e0e\u5316\u7597\u76f8\u6bd4\uff0c\u5728\u79cd\u7cfb\uff08\u9057\u4f20\u6027\uff09BRCA\u7a81\u53d8\uff08gBRCAm\uff09\u7684HER2\u9634\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08MBC\uff09\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u4e5f\u63a5\u53d7\u4e86Talazoparib\u7684\u8425\u9500\u6388\u6743\u7533\u8bf7\uff08MAA\uff09\u3002<\/span><\/p>\n


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Talazoparib\u662f\u4e00\u6b3e\u5728\u7814\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684PARP\u6291\u5236\u5242\uff0c\u6709\u671b\u4e3a\u8fd9\u7c7b\u4e73\u817a\u764c\u60a3\u8005\u5e26\u6765\u6cbb\u7597\u5e0c\u671b\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0cTalazoparib\u5177\u6709\u9ad8\u6548\u529b\u4e14\u5177\u6709\u53cc\u91cd\u4f5c\u7528\u673a\u5236\uff0c\u6709\u6f5c\u529b\u901a\u8fc7\u963b\u65adPARP\u9176\u6d3b\u6027\uff0c\u5e76\u5c06PARP\u6355\u83b7\u5728DNA\u635f\u4f24\u90e8\u4f4d\uff0c\u6765\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002\u5e76\u4e14\uff0cTalazoparib\u4e0e\u5316\u7597\u76f8\u6bd4\u5177\u6709\u66f4\u4f18\u8d8a\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002<\/span><\/p>\n


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https:\/\/www.pfizer.com\/news\/press-release\/press-release-detail\/u_s_fda_and_european_medicines_agency_accept_regulatory_submissions_for_review_of_talazoparib_for_metastatic_breast_cancer_patients_with_an_inherited_brca_mutation-0<\/span><\/p>\n<\/blockquote>\n<\/section>\n


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\u4e2d\u56fd\u822a\u5929\u79d1\u6280\u96c6\u56e2\u6c22\u80fd\u5de5\u7a0b\u6280\u672f\u7814\u53d1\u4e2d\u5fc3\u8868\u793a\uff0c\u5c06\u5728\u56fd\u5bb6\u76f8\u5173\u653f\u7b56\u6307\u5f15\u4e0b\uff0c\u8054\u5408\u56fd\u5185\u4f18\u52bf\u5355\u4f4d\uff0c\u5b8c\u6210\u6c22\u80fd\u5229\u7528\u4ea7\u4e1a\u94fe\u7684\u519b\u6c11\u7528\u5171\u6027\u5173\u952e\u6280\u672f\u653b\u5173\uff0c\u5f62\u6210\u5b8c\u5168\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\uff0c\u5efa\u7acb\u6c22\u80fd\u4ea7\u4e1a\u94fe\u6280\u672f\u3001\u6807\u51c6\u4f53\u7cfb\uff0c\u5b9e\u73b0\u6c22\u80fd\u5229\u7528\u6280\u672f\u5728\u56fd\u9632\u548c\u6c11\u7528\u9886\u57df\u5e7f\u6cdb\u5e94\u7528\uff0c\u628a\u8be5\u4e2d\u5fc3\u6253\u9020\u6210\u4e3a\u56fd\u9645\u77e5\u540d\u7684\u6c22\u80fd\u5de5\u7a0b\u6280\u672f\u7814\u53d1\u4e2d\u5fc3\u3002<\/span><\/p>\n


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http:\/\/www.chinanews.com\/gn\/2018\/06-06\/8531985.shtml<\/span><\/p>\n<\/blockquote>\n<\/section>\n


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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a X\u4e00MOL\u8d44\u8baf <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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