{"id":88176,"date":"2019-04-18T00:00:50","date_gmt":"2019-04-23T03:58:55","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/88176\/"},"modified":"2019-04-23T11:58:59","modified_gmt":"2019-04-23T03:58:59","slug":"e7fa09dafb","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/88176\/","title":{"rendered":"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<h1  style=\"margin-bottom: 0.8em;font-weight: inherit;font-size: 1.7em;white-space: normal;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\"> \u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u9886\u57df\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u548cCAR-T\u7597\u6cd5\u65e0\u7591\u662f\u6539\u53d8\u764c\u75c7\u6cbb\u7597\u6a21\u5f0f\u7684\u4e24\u5927\u7a81\u7834\u3002\u7136\u800c\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5df2\u7ecf\u53ef\u4ee5\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u7c7b\u578b\uff0c\u800cCAR-T\u7597\u6cd5\u7684\u9002\u5e94\u75c7\u5374\u5c48\u6307\u53ef\u6570\u3002CAR-T\u7597\u6cd5\u867d\u7136\u5728\u6cbb\u7597B\u7ec6\u80de\u8840\u6db2\u764c\u75c7\u65b9\u9762\u8868\u73b0\u51fa\u5353\u8d8a\u7684\u7597\u6548\uff0c\u7136\u800c\u6cbb\u7597\u5176\u5b83\u7c7b\u578b\u764c\u75c7\u7684CAR-T\u7597\u6cd5\u8fd8\u8fdf\u8fdf\u672a\u80fd\u8bde\u751f\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7a76\u5176\u6839\u6e90\uff0c<strong>CAR-T\u7597\u6cd5\u7684\u8bbe\u8ba1\u548c\u5f00\u53d1\u9700\u8981\u514b\u670d\u4e09\u5927\u6311\u6218\uff1a<\/strong><strong>\u7f3a\u5c11\u7406\u60f3\u7684\u80bf\u7624\u6297\u539f\u4f5c\u4e3a\u9776\u70b9\uff0c\u80bf\u7624\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\uff0c\u548cCAR-T\u7597\u6cd5\u7684\u4e25\u91cd\u6bd2\u526f\u4f5c\u7528\u3002<\/strong>\u90a3\u4e48\uff0c\u7528\u4ec0\u4e48\u65b9\u6cd5\u53ef\u4ee5\u514b\u670d\u8fd9\u4e09\u5927\u6311\u6218\uff0c\u63d0\u9ad8CAR-T\u7597\u6cd5\u7684\u6548\u679c\u5e76\u62d3\u5bbd\u5176\u5e94\u7528\u8303\u56f4\u5462\uff1f<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/7-1555991936.jpeg\" alt=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\" title=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u65e5\u524d\uff0c\u9ebb\u7701\u7406\u5de5\u5b66\u9662\uff08MIT\uff09\u8457\u540d\u8de8\u754c\u5b66\u8005\u5362\u51a0\u8fbe\uff08Timothy Lu\uff09\u535a\u58eb\u5728\u300aNature Reviews Cancer\u300b\u4e0a\u53d1\u8868\u6587\u7ae0\uff0c\u4ecb\u7ecd\u4e86\u4f7f\u7528\u5408\u6210\u751f\u7269\u5b66\u6784\u5efa\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u7684\u6700\u65b0\u8fdb\u5c55\u300280\u540e\u7684\u5362\u51a0\u8fbe\u535a\u58eb\u662fMIT\u7535\u5b50\u5de5\u7a0b\u3001\u8ba1\u7b97\u673a\u79d1\u5b66\u548c\u751f\u7269\u5de5\u7a0b\u7cfb\u6559\u6388\uff0c\u4e5f\u662f<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzIzMTU0NTM5MA==&amp;mid=2247488153&amp;idx=1&amp;sn=c8c24cd0d82bd732fab6346900c9b03d&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;font-size: 15px;color: rgb(0, 112, 192);\" ><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">Senti Biosciences<\/span><\/a><span style=\"font-size: 15px;\">\u3001Tango Therapeutics\u548cSynlogic\u7b49\u591a\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\u7684\u521b\u59cb\u4eba\u3002\u4eca\u5929\uff0c\u5fae\u4fe1\u56e2\u961f\u5c06\u548c\u8bfb\u8005\u4e00\u8d77\u5206\u4eab\u8fd9\u7bc7\u6587\u7ae0\u4e2d\u7684\u7cbe\u5f69\u5185\u5bb9\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-align: justify;white-space: normal;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u4f7f\u7528\u57fa\u56e0\u56de\u8def\u8ba9\u4e24\u79cd\u6297\u539f\u63a7\u5236CAR-T\u7ec6\u80de\u7684\u6fc0\u6d3b<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;background-color: rgb(0, 112, 192);height: 1px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">CAR-T\u7ec6\u80de\u7597\u6cd5\u9996\u5148\u4ece\u60a3\u8005\u4f53\u5185\u6536\u96c6T\u7ec6\u80de\uff0c\u7136\u540e\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u5728T\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\u3002\u8fd9\u662f\u4e00\u79cd\u878d\u5408\u86cb\u767d\uff0c\u5b83\u7684\u7ec6\u80de\u5916\u86cb\u767d\u57df\u662f\u4e00\u4e2a\u8bc6\u522b\u80bf\u7624\u8868\u9762\u6297\u539f\u7684\u5355\u94fe\u53ef\u53d8\u533a\u7247\u6bb5\uff08scFv\uff09\uff0c\u800c\u7ec6\u80de\u5185\u86cb\u767d\u57df\u5305\u542b\u4e86T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u548c\u76f8\u5173\u5171\u523a\u6fc0\u53d7\u4f53\u7684\u7ec6\u80de\u5185\u86cb\u767d\u57df\u3002\u8fd9\u4e9bCAR-T\u7ec6\u80de\u7136\u540e\u88ab\u8f93\u56de\u60a3\u8005\u4f53\u5185\uff0c\u5b83\u4eec\u53ef\u4ee5\u8bc6\u522b\u548c\u6d88\u706d\u8868\u8fbe\u6307\u5b9a\u6297\u539f\u7684\u80bf\u7624\u7ec6\u80de\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u76ee\u524d\uff0c\u5df2\u6709\u4e24\u79cdCAR-T\u7597\u6cd5\u83b7\u5f97FDA\u6279\u51c6\uff0c\u5b83\u4eec\u5728\u6cbb\u7597B\u7ec6\u80de\u8840\u764c\u65b9\u9762\u7597\u6548\u7a81\u51fa\u3002\u7136\u800c\uff0c\u76ee\u524d\u83b7\u6279\u7684CAR-T\u7597\u6cd5\u90fd\u53ea\u80fd\u8bc6\u522b\u4e00\u79cd\u6297\u539f<strong>\u3002<\/strong><strong>\u53d1\u73b0\u4e00\u4e2a\u80fd\u591f\u7279\u5f02\u6027\u6807\u8bb0\u80bf\u7624\u7ec6\u80de\u7684\u80bf\u7624\u8868\u9762\u6297\u539f\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u6311\u6218\uff0c\u8fd9\u4e5f\u662f\u9650\u5236CAR-T\u7597\u6cd5\u5e7f\u6cdb\u5e94\u7528\u7684\u539f\u56e0\u4e4b\u4e00\u3002<\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4f8b\u5982\uff0c\u9776\u5411CD19\u7684CAR-T\u7ec6\u80de\u80fd\u591f\u6709\u6548\u6cbb\u7597B\u7ec6\u80de\u8840\u764c\uff0c\u7136\u800c\u56e0\u4e3aCD19\u4e5f\u8868\u8fbe\u5728\u6b63\u5e38B\u7ec6\u80de\u8868\u9762\uff0c\u8fd9\u7c7b\u7597\u6cd5\u4e5f\u4f1a\u6d88\u706d\u6b63\u5e38B\u7ec6\u80de\uff0c\u4ece\u800c\u5bfc\u81f4B\u7ec6\u80de\u53d1\u80b2\u4e0d\u5168\u3002\u867d\u7136\u9776\u5411CD19\u7684CAR-T\u7597\u6cd5\u7684\u8fd9\u4e00\u526f\u4f5c\u7528\u901a\u5e38\u4e0d\u4f1a\u81f4\u547d\uff0c\u800c\u4e14\u53ef\u4ee5\u901a\u8fc7\u9759\u8109\u8f93\u5165\u514d\u75ab\u7403\u86cb\u767d\u6765\u8fdb\u884c\u6cbb\u7597\uff0c\u7136\u800c\uff0c\u5728\u9776\u5411\u5176\u5b83\u6297\u539f\u65f6\uff0c\u60a3\u8005\u53ef\u80fd\u65e0\u6cd5\u8010\u53d7CAR-T\u7ec6\u80de\u5bf9\u6b63\u5e38\u7ec6\u80de\u7684\u6740\u4f24\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5408\u6210\u5316\u5b66\u529b\u56fe\u4f7f\u7528\u5de5\u7a0b\u5b66\u7684\u7406\u8bba\u6765\u6539\u9020\u6d3b\u7ec6\u80de\uff0c\u901a\u8fc7\u5728\u7ec6\u80de\u4e2d\u52a0\u5165\u57fa\u56e0\u7535\u8def\uff08gene circuits\uff09\uff0c\u8ba9\u5b83\u4eec\u80fd\u591f\u611f\u77e5\u5916\u6765\u4fe1\u53f7\u5e76\u4e14\u4f5c\u51fa\u7b80\u5355\u7684\u903b\u8f91\u51b3\u7b56\u3002\u6bd4\u5982\uff0c\u5728\u8bbe\u8ba1\u65b0\u4e00\u4ee3CAR-T\u7ec6\u80de\u65b9\u9762\uff0c<strong>\u4f9d\u9760\u591a\u79cd\u6297\u539f\u6765\u533a\u5206\u80bf\u7624\u7ec6\u80de\u548c\u6b63\u5e38\u7ec6\u80de\uff0c\u5c06\u53ef\u4ee5<\/strong><strong><span style=\"font-size: 15px;\">\u8ba9CAR-T\u66f4\u4e3a\u7cbe\u786e\u9776\u5411\u80bf\u7624\uff0c\u5e76\u4e14\u66f4\u5177\u6709\u9002\u5e94\u6027\u3002<\/span><span style=\"font-size: 15px;\"><\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/0-1555991936.jpeg\" alt=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\" title=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\"  \/><\/p>\n<h1  style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2\u4f20\u7edfCAR\u8bbe\u8ba1\uff08a\uff09\u548c\u57fa\u4e8esynNotch\u7684CAR-T\u7ec6\u80de\u8bbe\u8ba1\uff08b\uff09\uff0csynNotch\u53d7\u4f53\u8ba9CAR-T\u7ec6\u80de\u9700\u8981\u540c\u65f6\u4e0e\u6297\u539fA\u548cB\u7ed3\u5408\u624d\u80fd\u88ab\u6fc0\u6d3b (\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/strong><span style=\"font-size: 15px;\"><\/span><\/h1>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4f8b\u5982\uff0c\u5408\u6210\u751f\u7269\u5b66\u53ef\u4ee5\u8bbe\u8ba1\u51fa\u4e00\u79cdT\u7ec6\u80de\uff0c\u5b83\u5fc5\u987b\u8bc6\u522b\u80bf\u7624\u8868\u9762\u8868\u8fbe\u7684\u4e24\u79cd\u6297\u539f\u624d\u4f1a\u88ab\u6fc0\u6d3b\u3002\u8fd9\u4e00\u8bbe\u8ba1\u53ef\u4ee5\u901a\u8fc7\u4eba\u5de5\u5408\u6210\u7684Notch\u53d7\u4f53\uff08synNotch\uff09\u6765\u5b9e\u73b0\u3002synNotch\u53d7\u4f53\u5728\u4e0e\u80bf\u7624\u8868\u9762\u7684\u7279\u5b9a\u6297\u539fA\u7ed3\u5408\u540e\uff0c\u901a\u8fc7\u91ca\u653e\u8f6c\u5f55\u56e0\u5b50\uff0c\u80fd\u591f\u6fc0\u53d1CAR-T\u7ec6\u80de\u8868\u8fbe\u9776\u5411\u7b2c\u4e8c\u4e2a\u6297\u539fB\u7684CAR\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c<strong>CAR-T\u7ec6\u80de\u53ea\u6709\u5728\u63a5\u89e6\u5230\u6297\u539fA\uff0c\u518d\u63a5\u89e6\u5230\u6297\u539fB\u7684\u65f6\u5019\u624d\u4f1a\u88ab\u6fc0\u6d3b\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8fd9\u4e00synNotch\u6280\u672f\u6700\u521d\u7531\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u7684Wendell Lim\u535a\u58eb\u7387\u9886\u7684\u56e2\u961f\u5f00\u53d1\uff0c\u5e76\u4e14\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\u5f97\u5230\u9a8c\u8bc1\u3002Lim\u535a\u58eb\u5171\u540c\u521b\u5efa\u4e86\u540d\u4e3a Design Labs\u7684\u516c\u53f8\u6765\u8f6c\u5316\u8fd9\u4e00\u6280\u672f\u3002\u57282017\u5e7412\u6708\uff0c\u5409\u5229\u5fb7\u79d1\u5b66\u65d7\u4e0b\u7684Kite Pharmaceuticals\u516c\u53f8\u4ee5\u53ef\u9ad8\u8fbe5.67\u4ebf\u7f8e\u5143\u7684\u6570\u989d\u6536\u8d2d\u4e86 Design Labs\uff0c\u5c06\u8fd9\u4e00\u6280\u672f\u7eb3\u5165\u8be5\u516c\u53f8\u7684CAR-T\u5f00\u53d1\u5e73\u53f0\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/10-1555991936.jpeg\" alt=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\" title=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\"  \/><\/p>\n<h1  style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2\u4fdd\u62a4\u6b63\u5e38\u7ec6\u80de\u4e0d\u53d7CAR-T\u653b\u51fb\u7684CAR-T\u8bbe\u8ba1\u7b56\u7565\uff0c\u6b63\u5e38\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u7684\u6297\u539fB\u4f1a\u6fc0\u6d3biCAR\uff0c\u4ece\u800c\u6291\u5236CAR-T\u7ec6\u80de\u7684\u6fc0\u6d3b\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"text-align: justify;font-size: 14px;color: rgb(0, 112, 192);\">\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/strong><\/h1>\n<p><strong><span style=\"text-align: justify;font-size: 14px;color: rgb(0, 112, 192);\"><br  \/><\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u800c\u5728\u4f4d\u4e8e\u7ebd\u7ea6\u7684\u7eaa\u5ff5\u65af\u9686-\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\uff08MSKCC\uff09\uff0cMichel Sadelain\u535a\u58eb\u9886\u5bfc\u7684\u56e2\u961f\u8bbe\u8ba1\u51fa\u4e86\u540c\u6837\u4f9d\u9760\u4e24\u79cd\u4e0d\u540c\u6297\u539f\u7684\u53e6\u4e00\u7c7bCAR-T\u7597\u6cd5\u3002<strong>\u8fd9\u4e00\u8bbe\u8ba1\u5229\u7528\u5728\u6b63\u5e38\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u7684\u6297\u539f\uff0c\u6291\u5236CAR-T\u7ec6\u80de\u7684\u529f\u80fd<\/strong>\u3002\u5728\u8fd9\u79cd\u8bbe\u8ba1\u4e2d\uff0cCAR-T\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u7740\u4e24\u79cd\u4e0d\u540c\u7684CAR\uff0c<strong>\u4e00\u79cd\u662f\u6fc0\u6d3b\u6027CAR\uff0c<\/strong>\u5b83\u4e0e\u80bf\u7624\u8868\u9762\u8868\u8fbe\u7684\u7279\u5b9a\u6297\u539fA\u7684\u7ed3\u5408\u80fd\u591f\u6fc0\u6d3bT\u7ec6\u80de\u3002<strong>\u800c\u53e6\u4e00\u79cd\u662f\u6291\u5236\u6027CAR\uff08iCAR\uff09\uff0c<\/strong>\u5b83\u5c06\u9776\u5411\u6b63\u5e38\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u7684\u6297\u539fB\u7684\u6297\u4f53\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u86cb\u767dCTLA-4\u6216PD-1\u53d7\u4f53\u7684\u7ec6\u80de\u5185\u57df\u878d\u5408\u5728\u4e00\u8d77\u3002\u8fd9\u79cdiCAR\u5728\u4e0e\u6297\u539f\u7ed3\u5408\u540e\u80fd\u591f\u6291\u5236T\u7ec6\u80de\u7684\u6fc0\u6d3b\u3002\u5f53\u8868\u8fbe\u4e24\u79cdCAR\u7684T\u7ec6\u80de\u540c\u65f6\u63a5\u89e6\u5230\u4e24\u79cd\u6297\u539f\u65f6\uff0c\u6291\u5236\u6027CAR\u4f1a\u6291\u5236\u6fc0\u6d3b\u6027CAR\u7684\u4f5c\u7528\u3002\u6240\u4ee5\uff0c<strong>\u8fd9\u79cdCAR-T\u7ec6\u80de\u53ea\u6709\u5728\u63a5\u89e6\u5230\u80bf\u7624\u7279\u5f02\u6027\u6297\u539fA\uff0c\u4f46\u662f\u4e0d\u63a5\u89e6\u5230\u6b63\u5e38\u7ec6\u80de\u4e2d\u8868\u8fbe\u7684\u81ea\u4f53\u6297\u539fB\u65f6\u624d\u4f1a\u88ab\u6fc0\u6d3b\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\"  src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/6-1555991937.jpeg\" alt=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\" title=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\"  \/><\/p>\n<h1  style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2\u53cc\u7279\u5f02\u6027CAR-T\u7ec6\u80de\u8bbe\u8ba1\uff0c\u4e24\u79cd\u4e0d\u540c\u7684scFv\u7247\u6bb5\u53ef\u4ee5\u8bc6\u522b\u80bf\u7624\u8868\u9762\u4e24\u79cd\u4e0d\u540c\u7684\u6297\u539f\uff0c\u4efb\u4f55\u4e00\u79cd\u90fd\u53ef\u4ee5\u6fc0\u6d3bCAR-T\u7ec6\u80de\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"font-size: 14px;text-align: justify;color: rgb(0, 112, 192);\">\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/strong><span style=\"font-size: 15px;text-align: justify;\"><\/span><\/h1>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u63a5\u53d7CAR-T\u7597\u6cd5\u6cbb\u7597\u7684\u80bf\u7624\u4f1a\u901a\u8fc7\u964d\u4f4e\u9776\u5411\u6297\u539f\u7684\u8868\u8fbe\u6765\u9003\u907fCAR-T\u7ec6\u80de\u7684\u653b\u51fb\u3002\u4f8b\u5982\uff0c\u5f88\u5927\u4e00\u90e8\u5206\u63a5\u53d7\u6297CD19 CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u60a3\u8005\u51fa\u73b0\u764c\u75c7\u590d\u53d1\u7684\u539f\u56e0\u662f\u80bf\u7624\u7ec6\u80de\u4e22\u5931\u4e86CD19\u6297\u539f\u7684\u8868\u8fbe\u3002\u56e0\u6b64\uff0c<strong>\u8bbe\u8ba1\u80fd\u591f\u8bc6\u522b\u5728\u80bf\u7624\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u591a\u79cd\u6297\u539f\u7684CAR-T\u7cfb\u7edf\u53ef\u80fd\u8ba9CAR-T\u7ec6\u80de\u7684\u529f\u80fd\u66f4\u4e3a\u5168\u9762\uff0c\u9632\u6b62\u56e0\u4e3a\u6297\u539f\u4e22\u5931\u5bfc\u81f4\u7684\u764c\u75c7\u590d\u53d1\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u901a\u8fc7\u6ce8\u5165\u4e24\u79cd\u9776\u5411\u4e0d\u540c\u80bf\u7624\u6297\u539f\u7684CAR-T\u7597\u6cd5\uff0c\u6216\u8005\u5728\u540c\u4e00T\u7ec6\u80de\u4e0a\u8868\u8fbe\u4e24\u79cd\u4e0d\u540cCAR\uff0c\u53ef\u4ee5\u5b9e\u73b0<span style=\"font-size: 15px;\">\u540c\u65f6<\/span><span style=\"font-size: 15px;\">\u8bc6\u522b\u80bf\u7624\u4e0a\u7684\u4e24\u79cd\u6297\u539f<\/span>\u3002<\/span><span style=\"font-size: 15px;\">\u800c\u6700\u65b0\u7684\u7814\u7a76\u65b9\u5411\u662f<strong>\u5728\u4e00\u4e2aCAR\u7684\u7ec6\u80de\u5916\u86cb\u767d\u57df\u4e2d\u7eb3\u5165\u4e24\u4e2a\u9776\u5411\u4e0d\u540c\u6297\u539f\u7684scFvs\uff0c\u751f\u6210\u4e00\u4e2a\u53cc\u7279\u5f02\u6027CAR<\/strong>\u3002<\/span><span style=\"font-size: 15px;\">\u4f8b\u5982\uff0c\u9776\u5411CD19\u548cCD20\u7684\u53cc\u7279\u5f02\u6027CAR\u5df2\u7ecf\u5728\u52a8\u7269\u8bd5\u9a8c\u4e2d\u9632\u6b62CD19\u9634\u6027\u7684\u80bf\u7624\u590d\u53d1\u3002<\/span><span style=\"font-size: 15px;\">\u800c\u9776\u5411CD19\u548cCD22\u7684\u53cc\u7279\u5f02\u6027CAR-T\u7597\u6cd5\u4e5f\u8868\u73b0\u51fa\u826f\u597d\u7684\u4e34\u5e8a\u524d\u6d3b\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<section style=\"white-space: normal;max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;\">\u4f7f\u7528\u836f\u7269\u7cbe\u786e\u8c03\u63a7CAR-T\u7ec6\u80de\u7684\u6d3b\u6027<\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;background-color: rgb(0, 112, 192);height: 1px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u76ee\u524d\uff0c<strong>\u5728\u5c06CAR-T\u7ec6\u80de\u8f93\u56de\u60a3\u8005\u4f53\u5185\u540e\uff0c\u5982\u4f55\u8c03\u63a7\u514d\u75ab\u53cd\u5e94\u7684\u5f3a\u5ea6\u662f\u4e00\u4e2a\u96be\u9898<\/strong>\u3002\u4f8b\u5982\uff0c\u4e0eCAR-T\u7597\u6cd5\u76f8\u5173\u7684\u4e25\u91cd\u526f\u4f5c\u7528\u5305\u62ec\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u548c\u795e\u7ecf\u6bd2\u6027\u3002\u8fd9\u4e9b\u6bd2\u526f\u4f5c\u7528\u4ea7\u751f\u7684\u539f\u56e0\u662f\uff0c\u5c06CAR-T\u7ec6\u80de\u8f93\u56de\u60a3\u8005\u4f53\u5185\u540e\uff0c\u6211\u4eec\u7f3a\u4e4f\u6709\u6548\u7684\u624b\u6bb5\u6765\u63a7\u5236CAR-T\u7ec6\u80de\u7684\u589e\u6b96\u3001\u6d3b\u6027\u548c\u5728\u4f53\u5185\u7684\u5206\u5e03\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"           style=\"width: 556px;height: 879px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/0-1555991937.jpeg\" alt=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\" title=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\"  \/><\/p>\n<h1  style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2\u5229\u7528\u5c0f\u5206\u5b50\u836f\u7269\u6fc0\u6d3b<span style=\"font-size: 14px;text-align: justify;\">\u80f1\u5929\u86cb\u767d\u91769\uff0c\u5bfc\u81f4CAR-T\u7ec6\u80de\u51cb\u4ea1\u7684\u201d\u5b89\u5168\u5f00\u5173\u201c\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/span><span style=\"text-align: justify;font-size: 14px;color: rgb(0, 112, 192);\">Bellicum&nbsp;Pharmaceuticals\u516c\u53f8\u5b98\u7f51\uff09<\/span><\/strong><span style=\"font-size: 15px;text-align: justify;\"><\/span><\/h1>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4e3a\u4e86\u66f4\u7cbe\u51c6\u5730\u63a7\u5236CAR-T\u7ec6\u80de\u7684\u6570\u91cf\u548c\u6d3b\u6027\uff0c<\/span><strong><span style=\"font-size: 15px;\">\u7814<\/span><span style=\"font-size: 15px;\">\u7a76\u4eba\u5458\u5df2\u7ecf\u5f00\u53d1\u51fa<\/span><\/strong><span style=\"font-size: 15px;\"><strong>\u80fd\u591f\u4fc3\u53d1CAR-T\u7ec6\u80de\u201c\u81ea\u6740\u201d\u7684\u5b89\u5168\u5f00\u5173\u3002<\/strong>\u4ee5Bellicum Pharmaceuticals\u516c\u53f8\u5f00\u53d1\u7684CaspaCIDe\u6280\u672f\u4e3a\u4f8b\uff0c\u7814\u7a76\u4eba\u5458\u5728CAR-T\u7ec6\u80de\u4e2d\u52a0\u5165\u4e86\u4e00\u4e2a\u80fd\u591f\u88ab\u540d\u4e3arimiducid\u7684\u5c0f\u5206\u5b50\u836f\u7269\u6fc0\u6d3b\u7684\u80f1\u5929\u86cb\u767d\u91769\uff08Caspase 9\uff09\u878d\u5408\u86cb\u767d\u3002\u6fc0\u6d3b\u80f1\u5929\u86cb\u767d\u91769\u80fd\u591f\u5bfc\u81f4CAR-T\u7ec6\u80de\u53d1\u751f\u7ec6\u80de\u51cb\u4ea1\uff0c\u4ece\u800c\u7ec8\u6b62\u8fc7\u5ea6\u7684CAR-T\u7ec6\u80de\u6d3b\u6027\u3002\u8fd9\u4e00\u5b89\u5168\u7cfb\u7edf\u5df2\u7ecf\u88ab\u7eb3\u5165\u8be5\u516c\u53f8\u7684\u4e3b\u6253\u901a\u7528\u578bT\u7ec6\u80de\u4ea7\u54c1rivogenlecleucel\u4e2d\u3002\u5728\u4eba\u4f53\u8bd5\u9a8c\u4e2d\uff0c<strong>\u5b83\u80fd\u591f\u5728\u6ce8\u5165\u836f\u726930\u5206\u949f\u4e4b\u5185\u5c31\u542f\u52a8\u7ec6\u80de\u51cb\u4ea1<\/strong>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/2-1555991938.jpeg\" alt=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\" title=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\"  \/><\/p>\n<h1  style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2GoCAR-T\u6280\u672f\u8ba9CAR-T\u7ec6\u80de\u53ea\u6709\u5728\u5c0f\u5206\u5b50\u836f\u7269\u5b58\u5728\u65f6\u624d\u4f1a\u88ab\u6fc0\u6d3b\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"text-align: justify;font-size: 14px;color: rgb(0, 112, 192);\">Bellicum\u516c\u53f8\u5b98\u7f51\uff09<\/span><\/strong><span style=\"font-size: 15px;text-align: justify;\"><\/span><\/h1>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u800c\u53e6\u4e00\u79cd\u901a\u8fc7\u836f\u7269\u6765\u5bf9CAR-T\u7ec6\u80de\u6d3b\u6027\u8fdb\u884c\u5fae\u8c03\u7684\u8bbe\u8ba1\u65b9\u5f0f\u662f\uff0c<strong>\u8ba9CAR\u7684\u6700\u521d\u72b6\u6001\u5904\u4e8e\u672a\u6fc0\u6d3b\u72b6\u6001\uff0c\u53ea\u6709\u5728\u6297\u539f\u548c\u5176\u5b83\u8c03\u63a7\u836f\u7269\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\u624d\u80fd\u591f\u88ab\u6fc0\u6d3b\u3002<\/strong>Bellicum\u516c\u53f8\u7684GoCAR-T\u6280\u672f\u8ba9<\/span><span style=\"font-size: 15px;\">CAR\u7684\u5171\u523a\u6fc0\u53d7\u4f53\u90e8\u5206\u53d7\u5230rimiducid\u7684\u8c03\u63a7\uff0c\u53ea\u6709\u5728CAR-T\u7ec6\u80de\u4e0e\u80bf\u7624\u6297\u539f\u86cb\u767d\u63a5\u89e6\uff0c\u5e76\u4e14\u63a5\u53d7rimiducid\u6cbb\u7597\u65f6\uff0cCAR-T\u7ec6\u80de\u624d\u80fd\u591f\u88ab\u6fc0\u6d3b\u3002\u8be5\u516c\u53f8\u76ee\u524d\u5c06\u8fd9\u4e00\u6280\u672f\u7528\u4e8e\u6cbb\u7597\u5b9e\u4f53\u7624\u7684CAR-T\u4ea7\u54c1BPX-601\u4e2d\uff0c\u76ee\u524d\u5b83\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u671f\u5f00\u53d1\uff0c\u57281\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63a5\u53d7\u68c0\u9a8c\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/2-1555991938-1.jpeg\" alt=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\" title=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<h1  style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(0, 112, 192);\"><strong><span style=\"font-size: 14px;\">\u25b2\u7528\u5c0f\u5206\u5b50\u836f\u7269\u8fde\u63a5\u5206\u6210\u4e24\u534a\u7684CAR\uff0c\u6fc0\u6d3bCAR-T\u7ec6\u80de\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"font-size: 14px;\">\u53c2\u8003\u8d44\u6599[6]<\/span><\/strong><strong><span style=\"text-align: justify;font-size: 14px;\">\uff09<\/span><\/strong><\/span><span style=\"color: rgb(217, 33, 66);\"><strong><span style=\"text-align: justify;font-size: 14px;\"><\/span><\/strong><\/span><strong><span style=\"text-align: justify;font-size: 14px;color: rgb(0, 112, 192);\"><\/span><\/strong><\/h1>\n<p><strong><span style=\"text-align: justify;font-size: 14px;color: rgb(0, 112, 192);\"><br  \/><\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u800c\u4e0a\u9762\u63d0\u5230\u8fc7\u7684UCSF\u7684Wendell Lim\u535a\u58eb\u7684\u7814\u7a76\u56e2\u961f\u91c7\u7528\u53e6\u5916\u4e00\u79cd\u8bbe\u8ba1\u7528\u836f\u7269\u6fc0\u6d3bCAR-T\u7ec6\u80de\u6d3b\u6027\u3002\u4ed6\u4eec<\/span><strong><span style=\"font-size: 15px;\">\u5c06\u4f20\u7edf\u7684\u5d4c\u5408\u6297\u539f\u53d7\u4f53<\/span><span style=\"font-size: 15px;\">\u5206\u4e3a\u4e24\u4e2a\u90e8\u5206\uff0c\u53ea\u6709\u5728\u8fd9\u4e24\u4e2a\u90e8\u5206\u88ab\u836f\u7269\u8fde\u63a5\u8d77\u6765\u540e\uff0cCAR\u624d\u80fd\u591f\u6fc0\u6d3b\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\uff0c\u5f15\u8d77\u514d\u75ab\u53cd\u5e94<\/span><\/strong><span style=\"font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<section style=\"white-space: normal;max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;\">\u514b\u670d\u80bf\u7624\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u7684\u969c\u788d<\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;background-color: rgb(0, 112, 192);height: 1px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><br  \/><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">CAR-T\u7597\u6cd5\u6cbb\u7597\u5b9e\u4f53\u7624\u9700\u8981\u514b\u670d\u7684\u4e00\u4e2a\u91cd\u8981\u6311\u6218\u662f\u80bf\u7624\u5fae\u73af\u5883\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u3002\u5b83\u53ef\u80fd\u6291\u5236T\u7ec6\u80de\u7684\u8fd0\u8f93\u548c\u6fc0\u6d3b\uff0c\u5bfc\u81f4\u867d\u7136CAR-T\u7ec6\u80de\u80fd\u591f\u8bc6\u522b\u80bf\u7624\u6297\u539f\uff0c\u4f46\u662f\u4ecd\u7136\u4e0d\u80fd\u591f\u6709\u6548\u884c\u4f7f\u5b83\u7684\u514d\u75ab\u529f\u80fd\u3002<strong>\u89e3\u51b3\u8fd9\u4e00\u6311\u6218\u7684\u7b56\u7565\u4e4b\u4e00\u662f\u4e3aCAR-T\u7ec6\u80de\u6b66\u88c5\u4e0a\u65b0\u7684\u201c\u6b66\u5668\u201d\uff0c\u4f8b\u5982\u8ba9\u5b83\u4eec\u8868\u8fbe\u514d\u75ab\u523a\u6fc0\u56e0\u5b50IL-12\uff0cIL-15\u6216\u8005CD40L\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4f8b\u5982\uff0cMSKCC\u7684Renier J. Brentjens\u535a\u58eb\u7387\u9886\u7684\u7814\u7a76\u56e2\u961f\u901a\u8fc7\u8ba9CAR-T\u7ec6\u80de\u6301\u7eed\u8868\u8fbeIL-12\uff0c\u5728\u52a8\u7269\u8bd5\u9a8c\u4e2d\u8ba9\u8fd9\u4e9b\u201c\u6b66\u88c5\u201d\u8d77\u6765\u7684CAR-T\u7ec6\u80de\u80fd\u591f\u514b\u670d\u80bf\u7624\u5fae\u73af\u5883\u7684\u6291\u5236\u4f5c\u7528\u3002\u8fd9\u4e00\u56e2\u961f\u8fd8\u8bbe\u8ba1\u51fa<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDA5NTIxNQ==&amp;mid=2649975849&amp;idx=4&amp;sn=14178578845a88546a88afe57abfb588&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;font-size: 15px;color: rgb(0, 112, 192);\" ><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">\u8868\u8fbe\u6297PD-1\u6297\u4f53\u7684CAR-T\u7ec6\u80de<\/span><\/a><span style=\"font-size: 15px;\">\uff0c\u6d88\u9664\u514d\u75ab\u68c0\u67e5\u70b9\u86cb\u767d\u5bf9CAR-T\u7ec6\u80de\u7684\u6291\u5236\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/9-1555991938.jpeg\" alt=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\" title=\"Nature\u7efc\u8ff0\uff1a\u514b\u670d\u4e09\u5927\u6311\u6218\uff0c\u65b0\u4e00\u4ee3\u201c\u667a\u80fd\u201dCAR-T\u7597\u6cd5\u88c5\u4e86\u54ea\u4e9b\u6b66\u5668\uff1f\"  \/><\/p>\n<h1  style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2synNotch\u63a7\u5236\u7684\u8868\u8fbe\u7cfb\u7edf\u53ef\u7528\u6765\u5728\u80bf\u7624\u9644\u8fd1\u8868\u8fbe\u6cbb\u7597\u6027\u86cb\u767d\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"text-align: justify;font-size: 14px;color: rgb(0, 112, 192);\">\u53c2\u8003\u8d44\u6599[7]\uff09<\/span><\/strong><span style=\"font-size: 17px;text-align: justify;\"><\/span><\/h1>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7136\u800c\uff0c\u8ba9CAR-T\u7ec6\u80de\u6301\u7eed\u8868\u8fbeIL-12\u7b49\u4fc3\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u53ef\u80fd\u5e26\u6765\u5168\u8eab\u6027\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u56e0\u4e3a\u5728\u5168\u8eab\u8840\u5faa\u73af\u4e2d\u6d41\u52a8\u7684CAR-T\u7ec6\u80de\u53ef\u4ee5\u4e0d\u65ad\u91ca\u653eIL-12\u3002\u4e3a\u4e86\u5bf9IL-12\u7684\u91ca\u653e\u8fdb\u884c\u8c03\u63a7\uff0cUCSF\u7684Wendell Lim\u535a\u58eb\u8bbe\u8ba1\u51fa\u4e86\u4f7f\u7528<strong>synNotch\u63a7\u5236\u7684\u6cbb\u7597\u7cfb\u7edf\uff0c\u901a\u8fc7synNotch\u6765\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7279\u5f02\u6027\u91ca\u653eIL-12\u7b49\u7ec6\u80de\u56e0\u5b50\uff0c\u6216\u8005\u5176\u5b83\u6cbb\u7597\u6027\u86cb\u767d<\/strong>\u3002\u8fd9\u4e9b\u624b\u6bb5\u90fd\u53ef\u4ee5\u7eb3\u5165CAR-T\u7ec6\u80de\u7684\u8bbe\u8ba1\u4e2d\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3aCAR-T\u7ec6\u80de\u514b\u670d\u80bf\u7624\u5fae\u73af\u5883\u7684\u80fd\u529b\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<section style=\"white-space: normal;max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u7ed3\u8bed<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;background-color: rgb(0, 112, 192);height: 1px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5408\u6210\u751f\u7269\u5b66\u5df2\u7ecf\u53ef\u4ee5\u901a\u8fc7\u4e3aCAR-T\u7597\u6cd5\u589e\u6dfb\u57fa\u56e0\u56de\u8def\uff0c\u6269\u5c55\u7597\u6cd5\u7684\u53ef\u63a7\u6027\u548c\u9002\u5e94\u80fd\u529b\u3002\u6211\u4eec\u4ecd\u7136\u9700\u8981\u66f4\u591a\u7684\u8bd5\u9a8c\u6765\u8bc1\u660e\u8fd9\u4e9b\u65b0\u8bbe\u8ba1\u5728\u4e34\u5e8a\u60c5\u51b5\u4e0b\u7684\u6548\u679c\u548c\u5b89\u5168\u6027\u3002\u5362\u51a0\u8fbe\u535a\u58eb\u5728\u7efc\u8ff0\u4e2d\u540c\u65f6\u6307\u51fa\uff0c\u8fd9\u4e9b\u57fa\u56e0\u56de\u8def\u7684\u590d\u6742\u6027\u610f\u5473\u7740\uff0c\u5c06\u5b83\u4eec\u5bfc\u5165\u7ec6\u80de\u5e76\u4e14\u6574\u5408\u5165\u57fa\u56e0\u7ec4\u5c06\u6210\u4e3a\u7814\u53d1\u8fc7\u7a0b\u7684\u74f6\u9888\u3002<strong>\u6211\u4eec\u9700\u8981\u66f4\u7cbe\u7b80\u7684\u57fa\u56e0\u56de\u8def\u8bbe\u8ba1\u548c\u66f4\u6709\u6548\u7684\u9012\u9001\u8f7d\u4f53\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5408\u6210\u751f\u7269\u5b66\u5728\u764c\u75c7\u6cbb\u7597\u65b9\u9762\u7684\u5e94\u7528\u4ecd\u7136\u5904\u4e8e\u521d\u7ea7\u9636\u6bb5\uff0c\u6211\u4eec\u671f\u5f85\u66f4\u591a\u7684\u57fa\u7840\u79d1\u5b66\u3001\u8f6c\u5316\u79d1\u5b66\u548c\u4e34\u5e8a\u7814\u7a76\u8ba9\u57fa\u4e8e\u57fa\u56e0\u56de\u8def\u7684\u7ec6\u80de\u7597\u6cd5\u5728\u4e34\u5e8a\u533b\u836f\u5f00\u53d1\u65b9\u9762\u5c55\u73b0\u5b83\u7684\u5a01\u529b\u3002<br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1]&nbsp;Wu&nbsp;et&nbsp;al.,&nbsp;(2019).&nbsp;Engineering&nbsp;advanced&nbsp;cancer&nbsp;therapies&nbsp;with&nbsp;synthetic&nbsp;biology.&nbsp;Nature&nbsp;Reviews&nbsp;Cancer,&nbsp;https:<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\/\/doi.org\/10.1038\/s41568-019-0121-0<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2]&nbsp;A&nbsp;suicide&nbsp;switch&nbsp;for&nbsp;CAR-T?<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">&nbsp;Retrieved&nbsp;April&nbsp;15,&nbsp;2019,&nbsp;from&nbsp;https:<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\/\/www.iqvia.com\/blogs\/2019\/01\/a-suicide-switch-for-car-t<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[3]&nbsp;Bellicum&nbsp;Pharmaceuticals.&nbsp;Retrieved&nbsp;April&nbsp;15,&nbsp;2019,&nbsp;from&nbsp;http:<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\/\/www.bellicum.com\/<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[4]&nbsp;ectis.&nbsp;Retrieved&nbsp;April&nbsp;15,&nbsp;2019,&nbsp;from&nbsp;https:<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\/\/www.cellectis.com<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[5]&nbsp;Controlling&nbsp;CAR-T:<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">&nbsp;How&nbsp;scientists&nbsp;plan&nbsp;to&nbsp;make&nbsp;the&nbsp;engineered&nbsp;T&nbsp;cell&nbsp;therapy&nbsp;<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">safer,<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">&nbsp;and&nbsp;work&nbsp;for&nbsp;more&nbsp;cancers.&nbsp;Retrieved&nbsp;April&nbsp;15,&nbsp;2019,&nbsp;from&nbsp;https:<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\/\/cen.acs.org\/pharmaceuticals\/oncology\/Controlling-CAR-T-scientists-plan\/96\/i19<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[6]&nbsp;Wu&nbsp;et&nbsp;al.,&nbsp;(2015).&nbsp;Remote&nbsp;control&nbsp;of&nbsp;therapeutic&nbsp;T&nbsp;cells&nbsp;through&nbsp;a&nbsp;small&nbsp;molecule-gated&nbsp;chimeric&nbsp;receptor.&nbsp;Science,&nbsp;<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">doi<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">:<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">&nbsp;10.1126\/science.aab4077<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[7]&nbsp;Roybal&nbsp;et&nbsp;al.,&nbsp;(2016).&nbsp;Engineering&nbsp;T&nbsp;s&nbsp;with&nbsp;Customized&nbsp;Therapeutic&nbsp;Response&nbsp;Programs&nbsp;Using&nbsp;Synthetic&nbsp;Notch&nbsp;Receptors.&nbsp;,&nbsp;https:<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\/\/doi.org\/10.1016\/j.cell.2016.09.011<\/span><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"white-space: normal;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: left;background-color: rgb(255, 255, 255);line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"white-space: normal;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);line-height: normal;\"><span 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