{"id":88188,"date":"2019-04-18T00:00:50","date_gmt":"2019-04-23T03:59:02","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/88188\/"},"modified":"2019-04-23T11:59:04","modified_gmt":"2019-04-23T03:59:04","slug":"bf1c92bade","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/88188\/","title":{"rendered":"\u901f\u9012 | CRISPR\u6280\u672f\u9996\u6b21\u5728\u7f8e\u56fd\u6cbb\u7597\u5b9e\u4f53\u7624\u60a3\u8005\uff0cT\u7ec6\u80de\u7597\u6cd5\u542f\u52a8\u4e34\u5e8a\u8bd5\u9a8c"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\u65e5\u524d\uff0c\u7f8e\u56fd\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\uff08University of Pennsylvania\uff09\u7684\u7814\u7a76\u4eba\u5458\u5ba3\u5e03\uff0c\u4e24\u540d\u764c\u75c7\u60a3\u8005\u5df2\u7ecf\u63a5\u53d7\u4e86\u57fa\u4e8eCRISPR\u6280\u672f\u6539\u9020\u8fc7\u7684T\u7ec6\u80de\u7597\u6cd5\u7684\u6cbb\u7597\u3002\u4ed6\u4eec\u5206\u522b\u4e3a\u590d\u53d1\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u548c\u8089\u7624\u60a3\u8005\u3002\u8fd9\u662f\u9996\u6b21\u57fa\u4e8eCRISPR\u6280\u672f\u6539\u9020\u7684\u7ec6\u80de\u7597\u6cd5\u5728\u7f8e\u56fd\u60a3\u8005\u8eab\u4e0a\u63a5\u53d7\u68c0\u9a8c<\/strong>\u3002<\/span><\/p>\n


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\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7531\u7f8e\u56fd\u9876\u7ea7CAR-T\u7ec6\u80de\u7597\u6cd5\u53d1\u660e\u4ebaCarl June\u535a\u58eb\u8054\u5408\u521b\u5efa\u7684Tmunity\u516c\u53f8<\/strong>\uff0cFacebook\u521b\u59cb\u4eba\u4e4b\u4e00Sean Parker\u5148\u751f\u521b\u5efa\u7684\u5e15\u514b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7814\u7a76\u6240<\/strong>\uff0c\u548c\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u8054\u5408\u8fdb\u884c\uff0c\u5c06\u5728\u591a\u79cd\u5b9e\u4f53\u7624\u548c\u8840\u764c\u60a3\u8005\u8eab\u4e0a\u68c0\u9a8c\u7ecf\u8fc7CRISPR\u6280\u672f\u7f16\u8f91\u7684T\u7ec6\u80de\u7597\u6cd5\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u3002<\/span><\/p>\n


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\u8fd9\u6b3e\u65b0\u578bT\u7ec6\u80de\u7597\u6cd5\u79f0\u4e3aNYCE T\u7ec6\u80de\u7597\u6cd5\uff0c\u5b83\u4ece\u60a3\u8005\u4f53\u5185\u83b7\u53d6T\u7ec6\u80de\uff0c\u7136\u540e\u5c06\u9776\u5411NY-ESO-1\u6297\u539f\u7684T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u8868\u8fbe\u5728T\u7ec6\u80de\u4e2d\u3002<\/span>NY-ESO-1\u6297\u539f\u662f\u4e00\u79cd\u764c\u75c7\u777e\u4e38\u6297\u539f\uff08CTA\uff09<\/span><\/strong>\uff0c\u5b83\u901a\u5e38\u53ea\u5728\u777e\u4e38\u6216\u5375\u5de2\u7ec4\u7ec7\u4e2d\u8868\u8fbe\uff0c\u7136\u800c\u5728\u591a\u79cd\u764c\u75c7\u4e2d\uff0c\u8fd9\u79cd\u6297\u539f\u4f1a\u91cd\u65b0\u5f00\u59cb\u8868\u8fbe\u3002\u56e0\u6b64\uff0c\u5b83\u4e3aT\u7ec6\u80de\u7597\u6cd5\u63d0\u4f9b\u4e86\u4e00\u79cd\u7279\u5f02\u6027\u5f3a\uff0c\u800c\u6bd2\u526f\u4f5c\u7528\u5f31\u7684\u9776\u6807\u6297\u539f<\/strong>\u3002<\/span><\/p>\n

\"\u901f\u9012<\/p>\n


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\u8fd9\u6b3eT\u7ec6\u80de\u7597\u6cd5\u4e0e\u4f17\u4e0d\u540c\u4e4b\u5904\u5728\u4e8e\uff0c\u5728\u8868\u8fbe\u9776\u5411NY-ESO-1\u6297\u539f\u7684TCR\u540c\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528CRISPR\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u6572\u9664\u4e86T\u7ec6\u80de\u539f\u6709\u7684TCR\u548cPD-1\u53d7\u4f53<\/strong>\u3002\u6291\u5236PD-1\u86cb\u767d\u529f\u80fd\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5df2\u7ecf\u5728\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u65b9\u9762\u83b7\u5f97\u4e86\u51fa\u8272\u7684\u7597\u6548\u3002\u901a\u8fc7\u4f7f\u7528\u57fa\u56e0\u7f16\u8f91\u6572\u9664PD-1\u53d7\u4f53\uff0c\u7814\u7a76\u4eba\u5458\u5e0c\u671b\u80fd\u591f\u53bb\u6389\u6291\u5236TCR\u7ec6\u80de\u7597\u6cd5\u6d3b\u6027\u7684\u201c\u5239\u8f66\u201d\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3a\u8fd9\u6b3eTCR\u7597\u6cd5\u653b\u51fb\u764c\u75c7\u7684\u80fd\u529b\u3002<\/span><\/p>\n


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CRISPR\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5728\u79d1\u5b66\u7814\u7a76\u548c\u751f\u7269\u533b\u836f\u5f00\u53d1\u65b9\u9762\u7684\u5e94\u7528\u5df2\u7ecf\u83b7\u5f97\u4e86\u5e7f\u6cdb\u7684\u5173\u6ce8\u3002\u76ee\u524d\uff0c\u6709\u591a\u5bb6\u516c\u53f8\u5728\u5f00\u53d1\u57fa\u4e8eCRISPR\u6280\u672f\u7684\u5728\u7814\u7597\u6cd5\u3002\u5176\u4e2dCRISPR Therapeutics\u548cVertex Pharmaceuticals\u516c\u53f8\u53bb\u5e74\u5728\u5fb7\u56fd\u542f\u52a8\u4e86<\/span>1\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/a>\uff0c\u68c0\u9a8c\u57fa\u4e8eCRISPR\u7684\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u6cbb\u7597\u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u60a3\u8005\u7684\u6548\u679c\u3002\u800c\u8457\u540d\u5b66\u8005\u5f20\u950b\u521b\u5efa\u7684Editas Medicine\u4e5f\u5373\u5c06\u5f00\u59cb<\/span>1\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/a>\uff0c\u7528\u57fa\u4e8eCRISPR\u7684\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u6cbb\u7597Leber\u5148\u5929\u6027\u9ed1\u6726\u60a3\u8005\u3002<\/span><\/p>\n


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\u201c2019\u5e74\uff0c\u6211\u4eec\u5c06\u770b\u5230CRISPR\u6280\u672f\u771f\u6b63\u80fd\u591f\u4e3a\u4e16\u754c\u5e26\u6765\u54ea\u4e9b\u79ef\u6781\u7684\u76ca\u5904\u3002\u201d Altius\u751f\u7269\u533b\u5b66\u79d1\u5b66\u7814\u7a76\u6240\uff08Altius Institute for Biomedical Sciences\uff09\u7684\u57fa\u56e0\u7f16\u8f91\u79d1\u5b66\u5bb6Fyodor Urnov\u535a\u58eb\u8bf4\u3002\u6211\u4eec\u671f\u5f85\u57282019\u5e74\uff0c\u542c\u5230CRISPR\u6280\u672f\u5728\u751f\u7269\u533b\u836f\u9886\u57df\u83b7\u5f97\u79ef\u6781\u5e94\u7528\u7684\u66f4\u591a\u597d\u6d88\u606f\u3002<\/span><\/p>\n


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[1] In another CRISPR first, Penn researchers dose US cancer patients with gene-edited T cell therapy. Retrieved April 17, 2019, from https:\/\/endpts.com\/in-another-crispr-first-penn-researchers-dose-us-cancer-patients-with-gene-edited-t-cell-therapy\/<\/span><\/p>\n

[2] NY-ESO-1-redirected CRISPR (TCRendo and PD1) Edited T s (NYCE T s). Retrieved April 17, 2019, from https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03399448?term=Crispr&rank=6<\/span><\/span><\/p>\n


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\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n


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