{"id":88195,"date":"2019-04-18T00:00:50","date_gmt":"2019-04-23T03:59:07","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/88195\/"},"modified":"2019-04-23T11:59:08","modified_gmt":"2019-04-23T03:59:08","slug":"eaaa47e60f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/88195\/","title":{"rendered":"\u901f\u9012 | \u8bfa\u534e\u57fa\u56e0\u7597\u6cd53\u671f\u7ed3\u679c\u79ef\u6781\uff0c\u6709\u671b5\u6708\u83b7\u6279\u4e0a\u5e02"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

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\"\u901f\u9012<\/p>\n

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SMA\u662f\u4e00\u79cd\u4e25\u91cd\u795e\u7ecf\u808c\u8089\u75be\u75c5\uff0c\u60a3\u8005\u7531\u4e8e\u8fd0\u52a8\u795e\u7ecf\u5143\u6b7b\u4ea1\u800c\u5bfc\u81f4\u8fdb\u884c\u6027\u808c\u65e0\u529b\u548c\u762b\u75ea\u3002SMA\u662f\u7531\u4e8e\u7f16\u7801\u8fd0\u52a8\u795e\u7ecf\u5143\u751f\u5b58\u86cb\u767d\uff08SMN\uff09\u7684SMN1<\/em>\u57fa\u56e0\u51fa\u73b0\u7f3a\u9677\u800c\u5bfc\u81f4\u7684\u3002<\/span>SMA\u662f\u5bfc\u81f4\u5a74\u513f\u6b7b\u4ea1\u7684\u9996\u8981\u9057\u4f20\u56e0\u7d20\u4e4b\u4e00<\/span><\/strong>\u3002\u800c\u6700\u4e25\u91cd\u76841\u578bSMA\u60a3\u8005\uff0c\u901a\u5e38\u7531\u4e8e\u8fc5\u901f\u808c\u8089\u840e\u7f29\uff0c\u8d85\u8fc790%\u7684\u60a3\u8005\u5728\u51fa\u751f\u540e24\u4e2a\u6708\u5185\u6b7b\u4ea1\u6216\u8005\u9700\u8981\u6c38\u4e45\u6027\u7684\u547c\u5438\u652f\u6301<\/strong>\u3002<\/span><\/p>\n


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Zolgensma\u662f\u4e00\u79cd\u57fa\u4e8eAAV9\u75c5\u6bd2\u8f7d\u4f53\u7684\u57fa\u56e0\u7597\u6cd5\uff0c\u5b83\u5c06\u6b63\u5e38\u8868\u8fbeSMN\u86cb\u767d\u7684\u8f6c\u57fa\u56e0\u901a\u8fc7AAV9\u75c5\u6bd2\u8f7d\u4f53\u5bfc\u5165\u60a3\u8005\u4f53\u5185\u3002\u5b83\u5df2\u7ecf\u83b7\u5f97FDA\u6388\u4e88\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u548c<\/span>\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c<\/span><\/a>\uff0c\u9884\u8ba1\u5728\u4eca\u5e745\u6708\u6536\u5230FDA\u7684\u56de\u590d<\/strong>\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

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\u8fd9\u9879\u8bd5\u9a8c\u7b2c\u4e00\u6b21\u5bf9Zolgensma\u5728\u4eba\u4f53\u4e2d\u7684\u751f\u7269\u5206\u5e03\u8fdb\u884c\u4e86\u5206\u6790\u3002\u7814\u7a76\u8868\u660e\uff0c Zolgensma\u6210\u529f\u8f6c\u67d3\u4e86\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7ec4\u7ec7\uff0c\u5305\u62ec\u5927\u8111\u548c\u810a\u9ad3\u4e2d\u7684\u8fd0\u52a8\u795e\u7ecf\u5143<\/strong>\u3002\u540c\u65f6\uff0c\u63a5\u53d7Zolgensma\u6cbb\u7597\u7684\u60a3\u8005\u810a\u9ad3\u7ec4\u7ec7\u4e2d\u8fd0\u52a8\u795e\u7ecf\u5143\u6570\u76ee\u5f88\u591a\uff0c\u5e76\u4e14\u4fdd\u6301\u7740\u6b63\u5e38\u7684\u5927\u5c0f\u548c\u5f62\u72b6<\/strong>\u3002\u4e0e\u4e4b\u76f8\u6bd4\uff0c\u672a\u63a5\u53d7\u6cbb\u7597\u76841\u578bSMA\u60a3\u8005\u7ec4\u7ec7\u4e2d\u8fd0\u52a8\u795e\u7ecf\u5143\u7a00\u5c11\u3002\u8fd9\u4e9b\u6570\u636e\u652f\u6301Zolgensma\u5728\u4e34\u5e8a\u524d\u5c0f\u9f20\u548c\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u6a21\u578b\u4e2d\u663e\u793a\u7684\u4f5c\u7528\u673a\u5236\u3002<\/span><\/p>\n


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[1] AveXis data reinforce <\/span>effectiveness<\/span> of Zolgensma\u00ae in treating spinal muscular atrophy (SMA) Type 1. Retrieved April 17, 2019, from https:\/\/www.novartis.com\/news\/media-releases\/avexis-data-reinforce-effectiveness-zolgensma-treating-spinal-muscular-atrophy-sma-type-1<\/span><\/p>\n

[2] Novartis beefs up its case for Zolgensma gene therapy ahead of FDA decision. Retrieved April 17, 2019, from https:\/\/www.fiercepharma.com\/pharma\/novartis-releases-positive-sma-gene-therapy-data-as-fda-verdict-comes-into-view<\/span><\/span><\/p>\n


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\"\u901f\u9012<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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