{"id":88235,"date":"2019-04-20T00:00:50","date_gmt":"2019-04-23T03:59:37","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/88235\/"},"modified":"2019-04-23T11:59:41","modified_gmt":"2019-04-23T03:59:41","slug":"a2eda41e4a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/88235\/","title":{"rendered":"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<h1  style=\"margin-bottom: 0.8em;font-weight: inherit;font-size: 1.7em;white-space: normal;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6628\u65e5\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\u7684\u751f\u7269\u533b\u836f\u516c\u53f8Arrakis Therapeutics\u5ba3\u5e03\u5b8c\u6210\u6570\u989d\u4e3a<\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDA5NTIxNQ==&amp;mid=2649983097&amp;idx=1&amp;sn=0fb2f2e7a854040e30d209ef1e33df31&amp;chksm=82e90ef9b59e87efe0a4485d09bb5ecd906ec0a638b71078b33c851bba56de207c3548bf26dc&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"text-decoration: underline;font-size: 15px;color: rgb(0, 112, 192);\" ><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">7500\u4e07\u7f8e\u5143\u7684B\u8f6e<\/span><\/a><span style=\"font-size: 15px;\">\u3002\u540c\u65f6\uff0c\u8be5\u516c\u53f8\u521b\u59cb\u4eba\u3001\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Michael Gilman\u535a\u58eb\u5728\u8bbf\u8c08\u4e2d\u62ab\u9732\uff0c\u8be5\u516c\u53f8\u7684\u836f\u7269\u53d1\u73b0\u5e73\u53f0\uff0c\u9488\u5bf9\u7f16\u7801\u8457\u540d\u201d\u4e0d\u53ef\u6210\u836f\u201c\u7684\u81f4\u764c\u86cb\u767dmyc\u7684mRNA\uff0c\u5df2\u7ecf\u53d6\u5f97\u51fa\u8272\u7684\u7b5b\u9009\u7ed3\u679c\u3002\u8fd9\u4e00\u65b0\u95fb\u5c06\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\u518d\u4e00\u6b21\u63a8\u5230\u4e86\u805a\u5149\u706f\u4e0b\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/5-1555991978.jpeg\" alt=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\" title=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<h1  style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(178, 178, 178);\"><span style=\"font-size: 14px;\">\u56fe\u7247\u6765\u6e90\uff1a<\/span><span style=\"font-size: 14px;\">Arrakis\u516c\u53f8\u5b98\u7f51<\/span><\/span><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\"><\/span><\/strong><\/h1>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u90a3\u4e48<strong>\u6211\u4eec\u4e3a\u4ec0\u4e48\u9700\u8981\u5f00\u53d1\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff1f<\/strong><\/span><strong><span style=\"font-size: 15px;\">\u53d1\u73b0\u548c\u5f00\u53d1\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\u9700\u8981\u6ce8\u610f\u4e9b\u4ec0\u4e48\u95ee\u9898\uff1f\u6700\u8fd1\u5728\u8fd9\u4e00\u9886\u57df\u53c8\u6709\u4ec0\u4e48\u65b0\u7684\u8fdb\u5c55\uff1f<\/span><\/strong><span style=\"font-size: 15px;\">\u4eca\u5929\u7684\u5fae\u4fe1\u56e2\u961f\u5c06\u7ed3\u5408\u516c\u5f00\u8d44\u6599\uff0c\u4e0e\u8bfb\u8005\u5171\u540c\u63a2\u7d22\u8fd9\u4e9b\u95ee\u9898\u7684\u7b54\u6848\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-align: justify;white-space: normal;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u4e3a\u4ec0\u4e48\u8981\u5f00\u53d1\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;background-color: rgb(0, 112, 192);height: 1px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5c0f\u5206\u5b50\u7597\u6cd5\u7edd\u5927\u90e8\u5206\u7684\u9776\u6807\u90fd\u662f\u86cb\u767d\u8d28\uff0c\u8fd9\u4e00\u7b56\u7565\u5728\u8fc7\u53bb\u6570\u5341\u5e74\u6765\u4e5f\u5e26\u6765\u4e86\u5927\u91cf\u597d\u836f\u548c\u65b0\u836f\uff0c\u636e\u4f30\u8ba1\uff0c\u63a5\u8fd199%\u7684\u53e3\u670d\u836f\u7269\u9776\u5411\u7684\u662f\u81f4\u75c5\u86cb\u767d\u3002\u7136\u800c\uff0c\u8fd9\u9700\u8981\u5c0f\u5206\u5b50\u836f\u7269\u80fd\u591f\u4e0e\u81f4\u75c5\u86cb\u767d\u4e2d\u7684\u7279\u5b9a\u4f4d\u70b9\u6216\u201c\u53e3\u888b\u201d\u76f8\u7ed3\u5408\uff0c\u800c\u5bf9\u4e8e\u5927\u90e8\u5206\uff08\u63a5\u8fd185%\uff09\u7684\u86cb\u767d\u6765\u8bf4\uff0c\u5b83\u4eec\u6ca1\u6709\u9002\u5408\u5c0f\u5206\u5b50\u836f\u7269\u7ed3\u5408\u7684\u4f4d\u70b9\u3002\u8fd9\u610f\u5473\u7740\u5b83\u4eec\u7528\u4f20\u7edf\u624b\u6bb5\u201c\u65e0\u6cd5\u6210\u836f\u201d\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u800c\u4e14\uff0c\u86cb\u767d\u53ea\u5360\u4e86\u57fa\u56e0\u7ec4\u4fe1\u606f\u7684\u6781\u5c11\u90e8\u5206\u3002\u4eba\u7c7b\u7684\u57fa\u56e0\u7ec4\u4e2d\uff0c\u53ea\u67091.5%\u7684\u5e8f\u5217\u7f16\u7801\u4e86\u86cb\u767d\u8d28\uff0c\u548c\u75be\u75c5\u76f8\u5173\u7684\u86cb\u767d\u66f4\u662f\u53ea\u5360\u5176\u4e2d\u768410-15%\u3002\u6beb\u65e0\u7591\u95ee\uff0c<strong>\u5982\u679c\u5c0f\u5206\u5b50\u836f\u7269\u7684\u9776\u70b9\u80fd\u8d85\u8d8a\u86cb\u767d\u8d28\uff0c\u5c06\u7ed9\u65b0\u53d1\u5e26\u6765\u65b0\u7684\u53d8\u9769\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><br  \/><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"           style=\"width: 480px;height: 831px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/1-1555991978.jpeg\" alt=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\" title=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2\u9776\u5411RNA\uff0c\u5c06\u7ed9\u6211\u4eec\u5e26\u6765\u66f4\u591a\u7684\u6210\u836f\u9009\u62e9\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u53c2\u8003\u8d44\u6599[8]\uff09<\/span><\/strong><span style=\"font-size: 15px;\"><\/span><br  \/><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: left;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: left;\"><span style=\"font-size: 15px;text-align: justify;\">RNA\u5c31\u662f\u8fd9\u6837\u4e00\u79cd\u6f5c\u5728\u7684\u9776\u70b9\u3002<\/span><span style=\"font-size: 15px;text-align: justify;\">\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\uff0cRNA\u6709\u7740\u91cd\u8981\u7684\u751f\u7406\u529f\u80fd\u2014\u2014mRNA\u643a\u5e26\u4e86\u57fa\u56e0\u7684\u9057\u4f20\u4fe1\u606f\uff0c\u6307\u5bfc\u86cb\u767d\u8d28\u7684\u5408\u6210\uff1b<\/span><span style=\"font-size: 15px;text-align: justify;\">\u975e\u7f16\u7801RNA\u5219\u8c03\u63a7\u57fa\u56e0\u7684\u8868\u8fbe\u3002<\/span><span style=\"font-size: 15px;text-align: justify;\">\u9776\u5411RNA\u6709\u7740\u591a\u79cd\u597d\u5904\uff1a<\/span><span style=\"font-size: 15px;text-align: justify;\">\u7531\u4e8e\u5904\u4e8e\u86cb\u767d\u8d28\u7684\u4e0a\u6e38\uff0c\u9776\u5411RNA\u6709\u671b\u76f4\u63a5\u5bf9\u86cb\u767d\u8d28\u7684\u7ffb\u8bd1\u6548\u7387\u8fdb\u884c\u4e0a\u8c03\u6216\u4e0b\u8c03\uff0c\u89e3\u51b3\u86cb\u767d\u201c\u4e0d\u53ef\u6210\u836f\u201d\u7684\u96be\u9898\uff1b<\/span><span style=\"font-size: 15px;text-align: justify;\">RNA\u5728\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u6781\u4e3a\u4e30\u5bcc\uff0c\u4ea7\u751f\u975e\u7f16\u7801RNA\u7684\u5e8f\u5217\u66f4\u662f\u5360\u5230\u4e86\u57fa\u56e0\u7ec4\u768470%\uff0c\u4e30\u5ea6\u6bd4\u7f16\u7801\u86cb\u767d\u8d28\u7684\u5e8f\u5217\u9ad8\u51fa\u4e00\u4e2a\u6570\u91cf\u7ea7\uff1b<\/span><span style=\"font-size: 15px;text-align: justify;\">\u800c\u8fd1\u671f\u4e00\u4e9b\u6982\u5ff5\u9a8c\u8bc1\u6027\u8bd5\u9a8c\u7684\u6210\u529f\uff0c\u4e5f\u8ba9\u6211\u4eec\u770b\u5230\u4e86\u5e0c\u671b\u3002<\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<section style=\"white-space: normal;max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u5f00\u53d1\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\u7684\u539f\u5219<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;background-color: rgb(0, 112, 192);height: 1px;overflow-wrap: break-word !important;\"><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6839\u636e\u300aNature Reviews Drug Discovery\u300b \u4e0a\u7684\u4e00\u7bc7\u7efc\u8ff0\uff0c\u76ee\u524d\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\u6839\u636e\u9776\u5411\u7684RNA\u7ed3\u6784\uff0c\u53ef\u4ee5\u88ab\u5206\u4e3a\u4e09\u5927\u7c7b\uff0c\u5b83\u4eec\u5206\u522b\u9776\u5411RNA\u4e2d\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<ol class=\"list-paddingleft-2\" style=\"list-style-type: decimal;\">\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u591a\u4e2a\u5bc6\u96c6\u87ba\u65cb\u7ed3\u6784\uff08multiple closely packed helices\uff09<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4e0d\u89c4\u5219\u7684\u4e8c\u7ea7\u7ed3\u6784\uff08irregular and usually bulge-containing secondary structures\uff09<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6216\u662f\u4e09\u8054\u4f53\u91cd\u590d\u5e8f\u5217\uff08triplet repeats\uff09<\/span><\/p>\n<\/li>\n<\/ol>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;\">\u7b2c\u4e00\u7c7b\u836f\u7269\u4e2d\u5df2\u7ecf\u51fa\u73b0\u4e86\u591a\u79cd\u5019\u9009\u5316\u5408\u7269\uff0c\u5305\u62ec\u56db\u79cd\u5206\u5b50\u2014\u2014linezolid\u3001ribocil\u3001<\/span>branaplam\u3001\u4ee5\u53caSMA-C5\u3002<\/span><strong><span style=\"font-size: 15px;\">\u8fd9\u4e9b\u5206\u5b50\u201c\u9776\u5411\u4e86\u590d\u6742\u7684RNA\u7ed3\u6784\u6a21\u5757\uff0c\u4e14\u6bcf\u4e00\u4e2a\u5747\u6709\u5f88\u9ad8\u7684QED\uff08quantitative estimate of drug-likeness\uff09\u5206\u503c\u201d\uff0c\u8868\u660e\u5176\u5177\u6709\u6f5c\u5728\u7684\u6210\u836f\u6f5c\u529b\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fd9\u4e9b\u5206\u5b50\u90fd\u662f\u901a\u8fc7\u8868\u578b\u7b5b\u9009\u627e\u5230\u7684\u7ed3\u679c\uff0c\u4e4b\u540e\u624d\u88ab\u786e\u8ba4\u5177\u6709RNA\u7ed3\u5408\u7684\u5c5e\u6027\u3002\u56e0\u6b64\uff0c\u5c3d\u7ba1\u5b83\u4eec\u5f00\u4e86\u4e00\u4e2aRNA\u9776\u5411\u65b0\u53d1\u7684\u597d\u5934\uff0c\u4f46\u6211\u4eec\u5c1a\u65e0\u6cd5\u4ece\u4e2d\u63a8\u5bfc\u51fa\u660e\u786e\u7684RNA\u9776\u5411\u65b9\u9488\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/9-1555991978.jpeg\" alt=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\" title=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2\u7b2c\u4e00\u7c7b\u836f\u7269\u4e2d\u5df2\u5f70\u663e\u51fa\u6f5c\u529b\u7684\u56db\u6b3e\u5206\u5b50\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u53c2\u8003\u8d44\u6599[8]\uff09<\/span><\/strong><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u53e6\u4e24\u7c7b\u836f\u7269\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u6700\u521d\u7684\u7b5b\u9009\u8fc7\u7a0b\uff0c\u5c31\u662f\u4e3a\u4e86\u627e\u5230\u80fd\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\u3002\u8fd9\u4e9b\u7b5b\u9009\u65b9\u6cd5\u5305\u62ec\u9ad8\u901a\u91cf\u7b5b\u9009\u3001\u4f7f\u7528\u4e13\u6ce8\u8fd9\u4e00\u65b9\u5411\u7684\u5316\u5408\u7269\u5e93\u3001\u53d7\u7ed3\u6784\u542f\u53d1\u7684\u8bbe\u8ba1\u3001\u57fa\u4e8e\u7247\u6bb5\u7684\u7b5b\u9009\u65b9\u6cd5\u3001\u4ee5\u53ca\u8ba1\u7b97\u673a\u6a21\u578b\u3002\u8fd9\u5e26\u6765\u4e86\u5927\u91cf\u4e0d\u540c\u7684\u6f5c\u5728RNA\u9776\u5411\u5206\u5b50\uff0c\u8ba9\u6211\u4eec\u5bf9\u9776\u5411RNA\u7684\u539f\u5219\u4e0e\u65b9\u9488\u6709\u4e86\u66f4\u6df1\u7684\u8ba4\u8bc6\u3002\u8fd9\u4e5f\u662f\u50cfArrakis\u7b49\u65b0\u5174\u751f\u7269\u533b\u836f\u516c\u53f8\u5f00\u53d1\u7684\u65b9\u5411\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">\u5982\u4f55\u9776\u5411RNA\uff1f<\/span><\/strong><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\"><br  \/><\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7531\u4e8eRNA\u4e0e\u86cb\u767d\u8d28\u7ed3\u6784\u4e0a\u7684\u663e\u8457\u4e0d\u540c\uff0c\u56e0\u6b64\uff0cRNA\u662f\u5426\u5177\u6709\u201c\u53ef\u6210\u836f\u6027\u201d\u662f\u4e00\u4e2a\u9700\u8981\u89e3\u51b3\u7684\u95ee\u9898\u3002\u4e0e\u86cb\u767d\u4e0d\u540c\uff0cRNA\u4e3b\u8981\u7531\u56db\u7c7b\u6838\u82f7\u9178\u7ec4\u6210\uff0c\u5e26\u6709\u5927\u91cf\u7535\u8377\uff0c\u4e5f\u6bd4\u86cb\u767d\u8d28\u66f4\u4e3a\u4eb2\u6c34\u3002\u7136\u800c\uff0c<strong>RNA\u5728\u6298\u53e0\u540e\u7684\u5177\u6709\u590d\u6742\u7684\u4e09\u7ef4\u7ed3\u6784\u3002<\/strong><\/span><strong><span style=\"font-size: 15px;\">\u8fd9\u4e9b\u590d\u6742\u7ed3\u6784\u6709\u671b\u5e26\u6765\u8db3\u591f\u7684\u6210\u836f\u6784\u8c61\uff0c\u8ba9\u5c0f\u5206\u5b50\u836f\u7269\u7ed3\u5408\u4e0e\u8bc6\u522b<\/span><\/strong><span style=\"font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/7-1555991979.jpeg\" alt=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\" title=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2\u5c0f\u5206\u5b50\u836f\u7269\u4e5f\u53ef\u8bc6\u522bRNA\u7ed3\u6784\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u53c2\u8003\u8d44\u6599[8]\uff09<\/span><\/strong><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8fc7\u53bb\u201c\u610f\u5916\u53d1\u73b0\u201d\u7684\u5c0f\u5206\u5b50RNA\u9776\u5411\u836f\u7269\u652f\u6301\u4e86\u8fd9\u4e00\u89c2\u70b9\u3002\u4e0a\u6587\u4e2d\u63d0\u5230\u7684<strong>linezolid\u548cribocil\u4ece\u4f20\u7edf\u836f\u7269\u5316\u5b66\u7684\u89d2\u5ea6\u770b\uff0c\u90fd\u662f\u975e\u5e38\u6770\u51fa\u7684\u5206\u5b50<\/strong>\u2014\u2014\u5b83\u4eec\u7b26\u5408\u7ecf\u5178\u7684\u201c\u91cc\u5bbe\u65af\u57fa\u4e94\u89c4\u5219\u201d\uff0c\u6709\u8f83\u5c0f\u7684\u6781\u6027\u603b\u8868\u9762\u79ef\uff08tPSA\uff09\uff0c\u4e5f\u6709\u8f83\u597d\u7684\u7ec6\u80de\u819c\u7a7f\u900f\u6027\u3002\u6b64\u5916\uff0c\u5b83\u4eec\u6ca1\u6709\u660e\u663e\u7684\u6bd2\u6027\u3002\u6700\u5173\u952e\u7684\u662f\uff0c\u5b83\u4eec\u80fd\u7ed3\u5408RNA\u9776\u70b9\u7ed3\u6784\u4e0a\u7684\u201c\u53e3\u888b\u201d\u3002\u8fd9\u4e0e\u8bb8\u591a\u9776\u5411\u86cb\u767d\u8d28\u7684\u5c0f\u5206\u5b50\u836f\u7269\u5982\u51fa\u4e00\u8f99\uff0c\u4e5f\u652f\u6301\u4e86\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\u7684\u7814\u53d1\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5982\u540c\u86cb\u767d\u8d28\u9776\u5411\u836f\u7269\u4e00\u6837\uff0c\u9776\u5411RNA\u7684\u836f\u7269\u4e5f\u9700\u8981\u5bf9RNA\u7ed3\u6784\u7684\u4e86\u89e3\u3002\u8be5\u7efc\u8ff0\u7684\u4f5c\u8005\u4eec\u6307\u51fa\uff0c\u826f\u597d\u7684RNA\u9776\u70b9\uff0c\u7ed3\u6784\u4e0a\u5e94\u6709\u8db3\u591f\u7684\u201c\u4fe1\u606f\u91cf\u201d\u3002\u76ee\u524d\uff0c\u5177\u6709\u6210\u836f\u6f5c\u529b\u7684\u51e0\u4e2a\u5206\u5b50\u90fd\u9776\u5411\u590d\u6742\u7684RNA\u7ed3\u6784\u3002\u800c\u5018\u82e5\u9776\u5411\u7b80\u5355\u7684RNA\u7ed3\u6784\uff0c\u53ef\u80fd\u4f1a\u5f71\u54cd\u5230\u9776\u5411\u5206\u5b50\u7684\u4eb2\u548c\u529b\u4e0e\u7279\u5f02\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"           style=\"width: 460px;height: 741px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/10-1555991979.jpeg\" alt=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\" title=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\"  \/><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2\u597d\u7684RNA\u9776\u70b9\u5e94\u6709\u8db3\u591f\u7684\u201c\u4fe1\u606f\u91cf\u201d\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u53c2\u8003\u8d44\u6599[8]\uff09<\/span><\/strong><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">\u7b5b\u9009\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\u7684\u516b\u5927\u6307\u5bfc\u65b9\u9488<\/span><\/strong><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\"><br  \/><\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u4e86\u6307\u5bfc\u672a\u6765\u7684\u65b0\u9009\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u6574\u7406\u4e86\u51e0\u5927\u65b9\u9488\uff0c\u4f9b\u540e\u4eba\u53c2\u8003\uff1a<\/span><\/p>\n<p><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: square;\">\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4e13\u6ce8\u4e8e\u5177\u6709\u8db3\u591f\u590d\u6742\u5ea6\uff0c\u7ed3\u6784\u72ec\u7279\u7684RNA\u6a21\u5757\u3002\u8fd9\u4e9b\u6a21\u5757\u6709\u671b\u5e26\u6765\u9ad8\u8d28\u91cf\u7684\u201c\u53e3\u888b\u201d\uff0c\u65b9\u4fbf\u5c0f\u5206\u5b50\u836f\u7269\u7ed3\u5408\u3002\u8fd9\u4e9b\u6a21\u5757\u5728\u5927\u578bRNA\u5206\u5b50\u4e2d\u8f83\u5e38\u89c1\u3002<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8c28\u614e\u51b3\u5b9a\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u57fa\u672c\u7ed3\u6784\u3002\u5728\u5b9a\u4e49\u8fd9\u4e9b\u7ed3\u6784\u524d\uff0c\u6211\u4eec\u8fd8\u9700\u8981\u66f4\u591a\u7684\u7814\u7a76\u3002\u8fc7\u53bb\u51e0\u5341\u5e74\u6765\uff0c\u9776\u5411\u86cb\u767d\u8d28\u7684\u7ecf\u9a8c\u6216\u8bb8\u6709\u7528\u3002<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u6838\u7cd6\u4f53RNA\u4e0a\u53d6\u5f97\u7684\u6210\u529f\uff0c\u672a\u5fc5\u80fd\u65c1\u63a8\u5230\u5176\u4ed6\u9886\u57df\u3002\u8fd9\u4e9bRNA\u5728\u7ec6\u80de\u4e2d\u9ad8\u5ea6\u5bcc\u96c6\uff0c\u9776\u5411\u5b83\u4eec\u7684\u5206\u5b50\u53ef\u80fd\u6709\u7279\u6b8a\u7684\u6027\u8d28\u3002<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5bf9\u4e8e\u90a3\u4e9b\u9ad8\u5ea6\u78b1\u6027\u3001\u5177\u6709\u63d2\u5165\u7279\u6027\u3001\u6216\u662f\u9ad8\u5ea6\u758f\u6c34\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u5bf9\u5b9e\u9a8c\u7ed3\u679c\u7684\u89e3\u8bfb\u8981\u5c24\u5176\u8c28\u614e\u3002\u8fd9\u4e9b\u5316\u5408\u7269\u53ef\u80fd\u4e0eRNA\u6709\u5f88\u9ad8\u7684\u4eb2\u548c\u529b\uff0c\u4f46\u53ef\u80fd\u4f1a\u6709\u4e25\u91cd\u7684\u8131\u9776\u6548\u5e94\u3002<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7559\u610f\u90a3\u4e9b\u80fd\u591f\u9776\u5411RNA-\u86cb\u767d\u8d28\u76f8\u4e92\u7ed3\u5408\u7684\u5206\u5b50\uff0c\u8b6c\u5982branaplam\u548cSMA-C5\u3002\u5b83\u4eec\u6709\u671b\u5e26\u6765\u51fa\u8272\u7684\u7279\u5f02\u6027\u4e0e\u4eb2\u548c\u529b\u3002<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u627e\u5230\u90a3\u4e9b\u5177\u6709\u201c\u9ad8\u4fe1\u606f\u91cf\u201d\u7684\u7ed3\u6784\u3002\u76f8\u6bd4\u86cb\u767d\u8d28\uff0cRNA\u7684\u4e00\u5927\u4f18\u52bf\u5728\u4e8e\u6211\u4eec\u6709\u8bb8\u591a\u5b9a\u91cf\u7684\u5316\u5b66\u65b9\u6cd5\u53bb\u5e2e\u52a9\u6211\u4eec\u5b8c\u6210\u8fd9\u4e9b\u5de5\u4f5c\u3002<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u73b0\u6709\u5de5\u5177\u7684\u57fa\u7840\u4e0a\uff0c\u5f00\u53d1\u5168\u65b0\u7684\u5de5\u5177\uff0c\u53bb\u66f4\u597d\u5730\u4e86\u89e3RNA\u7684\u590d\u6742\u7ed3\u6784\u3002<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u627e\u5230\u90a3\u4e9b\u5177\u6709\u660e\u786e\u6cbb\u7597\u673a\u5236\u7684\u9776\u70b9\uff0c\u5e76\u9488\u5bf9\u5b83\u4eec\u5bfb\u627e\u6f5c\u5728\u7684\u65b0\u836f\u3002<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<section style=\"white-space: normal;max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u8fd9\u4e00\u9886\u57df\u7684\u6700\u65b0\u8fdb\u5c55<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;background-color: rgb(0, 112, 192);height: 1px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6211\u4eec\u9ad8\u5174\u5730\u770b\u5230\uff0c\u8fd9\u4e00\u9886\u57df\u7684\u65b0\u5174\u751f\u7269\u533b\u836f\u516c\u53f8\u7684\u7814\u53d1\u65b9\u5411\u4e0e\u8fd9\u4e9b\u5efa\u8bae\u4e0d\u8c0b\u800c\u5408\u3002\u524d\u6587\u63d0\u5230\u7684Arrakis\u516c\u53f8\u5728\u8fc7\u53bb\u4e24\u5e74\u591a\u7684\u65f6\u95f4\u91cc\uff0c\u6784\u5efa\u4e13\u5c5e\u4e8e\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u7b5b\u9009\u548c\u4f18\u5316\u5e73\u53f0\u3002\u5b83\u5305\u62ec<strong>\u540d\u4e3aTryst\u7684RNA\u9776\u6807\u7b5b\u9009\u7cfb\u7edf\uff0c\u80fd\u591f\u9884\u6d4bRNA\u5e8f\u5217\u4e0a\u9002\u4e8e\u5c0f\u5206\u5b50\u836f\u7269\u7ed3\u5408\u7684\u4f4d\u70b9\u548c\u7ed3\u6784<\/strong>\u3002\u4ee5\u53ca\u5e2e\u52a9\u5206\u6790\u5c0f\u5206\u5b50\u836f\u7269\u4e0eRNA\u4e4b\u95f4\u7684\u7ed3\u5408\u673a\u5236\uff0c\u5e76\u4e14\u9009\u51fa\u6700\u4f73\u5019\u9009\u5316\u5408\u7269\u8fdb\u4e00\u6b65\u5f00\u53d1\u7684Pearl-seq\u7cfb\u7edf\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/5-1555991980.jpeg\" alt=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\" title=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6839\u636eMichael Gilman\u535a\u58eb\u7684\u63cf\u8ff0\uff0c\u8fd9\u4e00\u836f\u7269\u5f00\u53d1\u6280\u672f\u5e73\u53f0\u76ee\u524d\u5df2\u7ecf\u53ef\u4ee5\u5f00\u59cb\u5927\u89c4\u6a21\u5730\u9488\u5bf9\u591a\u79cd\u4e0d\u540cRNA\u8fdb\u884c\u836f\u7269\u7b5b\u9009\u3002\u8be5\u516c\u53f8\u805a\u7126\u7684\u7b2c\u4e00\u4e2aRNA\u5c31\u662f\u7f16\u7801myc\u86cb\u767d\u7684mRNA\u3002<em>Myc<\/em>\u662f\u6700\u521d\u53d1\u73b0\u7684\u81f4\u764c\u57fa\u56e0\u4e4b\u4e00\uff0c\u5728\u63a5\u8fd140\u5e74\u524d\u5c31\u88ab\u53d1\u73b0\u4e86\u3002\u5b83\u7f16\u7801\u7684\u8f6c\u5f55\u56e0\u5b50myc\u86cb\u767d\u4e0e\u591a\u79cd\u4eba\u7c7b\u764c\u75c7\u76f8\u5173\u3002Arrakis\u516c\u53f8\u5df2\u7ecf\u901a\u8fc7\u591a\u79cd\u7b5b\u9009\u624b\u6bb5\u5bfb\u627e\u4e0emyc RNA\u7ed3\u5408\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u7528Michael Gilman\u535a\u58eb\u7684\u8bdd\u6765\u8bf4\uff0c\u53d1\u73b0\u4e86\u9776\u5411\u8fd9\u4e00RNA\u7684\u4e0d\u5c11\u5947\u5999\u7684\u5316\u5408\u7269\u3002<\/span><strong><span style=\"font-size: 15px;\">Arrakis\u516c\u53f8\u9776\u5411myc RNA\u7684\u7b56\u7565\u662f\u627e\u5230\u80fd\u591f\u4e0eRNA\u7ed3\u5408\u5e76\u4e14\u963b\u6b62RNA\u7ffb\u8bd1\u751f\u6210\u86cb\u767d\u7684\u5c0f\u5206\u5b50\u836f\u7269<\/span><\/strong><span style=\"font-size: 15px;\">\u3002RNA\u5728\u4e0e\u6838\u7cd6\u4f53\u7ed3\u5408\u7ffb\u8bd1\u86cb\u767d\u65f6\uff0c\u9700\u8981\u89e3\u5f00\u6298\u53e0\u7684\u4e09\u7ea7\u7ed3\u6784\u53d8\u4e3a\u7ebf\u72b6\u7ed3\u6784\uff0c\u800c\u5982\u679c\u4f7f\u7528\u5c0f\u5206\u5b50\u836f\u7269\u5c06RNA\u7684\u4e09\u7ea7\u7ed3\u6784\u56fa\u5b9a\u4f4f\uff0c\u8ba9\u5b83\u4eec\u65e0\u6cd5\u88ab\u89e3\u5f00\uff0c\u5c31\u53ef\u4ee5\u9632\u6b62\u86cb\u767d\u7684\u4ea7\u751f\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u800c\u7531Scripps\u7814\u7a76\u6240\uff08The Scripps Research Institute\uff09 \u6559\u6388Matthew D. Disney\u535a\u58eb\u521b\u5efa\u7684Expansion Therapeutics\u516c\u53f8\uff0c\u5728\u5f00\u53d1\u9776\u5411\u4e09\u8054\u4f53\u91cd\u590d\u5e8f\u5217\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u65b9\u9762\u4e5f\u83b7\u5f97\u4e86\u51fa\u8272\u7684\u8fdb\u5c55\u3002<\/span><strong><span style=\"font-size: 15px;\">Expansion Therapeutics\u516c\u53f8\u7684\u836f\u7269\u5f00\u53d1\u5de5\u5177\u80fd\u591f\u5c06\u4e0a\u5343\u4e2a\u4e0d\u540c\u7684RNA\u7ed3\u6784\u4e0e\u5171\u4ef7\u56fa\u5b9a\u5728\u82af\u7247\u4e0a\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u5e93\u8fdb\u884c\u76f8\u4e92\u7b5b\u9009<\/span><\/strong><span style=\"font-size: 15px;\">\u3002\u8fd9\u4e00\u7b5b\u9009\u7ed3\u679c\u80fd\u591f\u53d1\u73b0\u4e0e\u7279\u5b9aRNA\u6298\u53e0\u7ed3\u6784\u7ed3\u5408\u7684\u9ad8\u8d28\u91cf\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u5b83\u4eec\u53ef\u4ee5\u88ab\u4f20\u7edf\u7684\u836f\u7269\u5316\u5b66\u624b\u6bb5\u8fdb\u4e00\u6b65\u4f18\u5316\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/7-1555991980.gif\" alt=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\" title=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<h1  style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2Expansion\u516c\u53f8\u7684\u7b5b\u9009\u5e73\u53f0\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">Expansion\u516c\u53f8\u5b98\u7f51\uff09<\/span><\/strong><span style=\"font-size: 17px;\"><\/span><\/h1>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">Matthew D. Disney\u535a\u58eb\u9886\u5bfc\u7684\u7814\u7a76\u56e2\u961f\u8fd8\u5f00\u53d1\u51fa\u4e86\u80fd\u591f\u5207\u65ad\u5bcc\u542bCUG\u4e09\u8054\u4f53\u91cd\u590d\u5e8f\u5217\u7684RNA\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u3002CUG\u91cd\u590d\u5e8f\u5217\u662f\u5bfc\u81f41\u578b\u5f3a\u76f4\u6027\u808c\u8425\u517b\u4e0d\u826f\uff08DM1\uff09\u7684\u57fa\u56e0\u53d8\u5f02\u3002DM1\u662f\u4e00\u79cd\u65e0\u6cd5\u6cbb\u6108\u7684\u795e\u7ecf\u808c\u8089\u75be\u75c5\u3002\u5728\u8fd1\u65e5\u53d1\u8868\u5728\u300aPNAS\u300b\u7684\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u8fd9\u79cd<strong>\u9776\u5411CUG\u91cd\u590d\u5e8f\u5217\u7684\u5c0f\u5206\u5b50\u836f\u7269cugamycin\uff0c\u80fd\u591f\u6709\u9009\u62e9\u6027\u5730\u9776\u5411\u5bfc\u81f4\u75be\u75c5\u7684RNA\u7ed3\u6784\uff0c\u5e76\u4e14\u5728\u4e34\u5e8a\u524d\u52a8\u7269\u8bd5\u9a8c\u4e2d\u6539\u5584\u5c0f\u9f20\u7684DM1\u75c7\u72b6\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><br  \/><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/9-1555991981.jpeg\" alt=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\" title=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u63a2\u7d22\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\u9886\u57df\u8fd8\u6709\u5176\u5b83\u65b0\u5174\u751f\u7269\u6280\u672f\u516c\u53f8\u3002\u4f8b\u5982\uff0c\u53bb\u5e74\uff0cSkyhawk Therapeutics\u5728\u9ebb\u7701\u6b63\u5f0f\u6210\u7acb\uff0c\u529b\u56fe<strong>\u5f00\u53d1\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4fee\u590dRNA\u526a\u63a5\u65f6\u51fa\u73b0\u7684\u5916\u663e\u5b50\u8df3\u8dc3\u9519\u8bef\uff0c\u6cbb\u7597\u795e\u7ecf\u75be\u75c5\u548c\u764c\u75c7<\/strong>\u3002\u8be5\u516c\u53f8\u53bb\u5e74\u4e0e\u65b0\u57fa\uff08Celgene\uff09\u516c\u53f8\u8fbe\u6210\u4e3a\u671f5\u5e74\u7684<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzIzMTU0NTM5MA==&amp;mid=2247488916&amp;idx=1&amp;sn=fd66c408d0580325deea6bf8eecad068&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;font-size: 15px;color: rgb(0, 112, 192);\" ><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">\u7814\u53d1\u5408\u4f5c\u534f\u8bae<\/span><\/a><span style=\"font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u76ee\u524d\uff0c\u8fd9\u4e9b\u7597\u6cd5\u4ecd\u7136\u5904\u4e8e\u4e34\u5e8a\u524d\u5f00\u53d1\u9636\u6bb5\uff0c\u5b83\u4eec\u4ecd\u7136\u9700\u8981\u5728\u4eba\u4f53\u4e2d\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9a8c\u8bc1\u3002\u6211\u4eec\u671f\u5f85\u8fd9\u4e00\u5929\u5c3d\u5feb\u5230\u6765\uff0c\u8ba9\u6211\u4eec\u8fdb\u4e00\u6b65\u7597\u6cd5\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\u5728\u6cbb\u7597\u4eba\u7c7b\u75be\u75c5\u65b9\u9762\u7684\u6f5c\u529b\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] Expansion Therapeutics. Retrieved April 19, 2019, from https:\/\/www.expansionrx.com\/expansion-repeat-disorders\/<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] Arrakis Therapeutics. Retrieved April 19, 2019, from http:\/\/arrakistx.com\/<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[3] Drugging the undruggable and other challenges on the road to targeting RNA with pills. Retrieved April 19, 2019, from https:\/\/www.statnews.com\/2019\/04\/19\/michael-gilman-rna-arrakis\/<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[4] Ribometrix. Retrieved April 19, 2019, from http:\/\/www.ribometrix.com\/index.html<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[5] RNA\u7814\u53d1\u70ed\uff01<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u8fd912\u5bb6\u516c\u53f8\u6b63\u5728\u63a8\u8fdb\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269. Retrieved April 19, 2019, from https:\/\/mp.weixin.qq.com\/s\/df8pOurBsAeXs57CBHuJOQ<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[6] Nature\u6df1\u5ea6\u7efc\u8ff0\uff1a<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u5c0f\u5206\u5b50\u9776\u5411RNA\uff0c\u8fd9\u4e9b\u539f\u5219\u4f60\u90fd\u77e5\u9053\u5417\uff1f<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\"> Retrieved April 19, 2019, from https:\/\/mp.weixin.qq.com\/s\/kpIoktgNTmlXNCfz_mCosQ<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[7] RNA-targeting Compound Shows Ability to Limit Muscle Damage in Early Myotonic Dystrophy Type 1 Study. Retrieved April 19, 2019, from https:\/\/musculardystrophynews.com\/2019\/04\/08\/rna-cutting-compound-shows-ability-to-limit-muscle-damage-in-myotonic-dystrophy-type-1-in-early-study\/<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[8] Warner et al., (2018). Principles for targeting RNA with drug-like small molecules. Principles for targeting RNA with drug-like small molecules. Nature Reviews Drug Discovery. https:\/\/doi.org\/10.1038\/nrd.2018.93.<\/span><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"__bg_gif\"      style=\"color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 640px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/7-1555991981.gif\" alt=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\" title=\"\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u7814\u53d1\u539f\u5219\u5168\u5728\u8fd9\u91cc\u4e86\uff01\"  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u6628\u65e5\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\u7684\u751f\u7269\u533b\u836f\u516c\u53f8Arrakis Therapeutics [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":88236,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/88235"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=88235"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/88235\/revisions"}],"predecessor-version":[{"id":88246,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/88235\/revisions\/88246"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/88236"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=88235"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=88235"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=88235"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}