{"id":88723,"date":"2019-04-17T00:00:50","date_gmt":"2019-04-23T04:03:22","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/88723\/"},"modified":"2019-04-23T12:03:23","modified_gmt":"2019-04-23T04:03:23","slug":"402babe0b6","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/88723\/","title":{"rendered":"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u4e00\u9879\u5728\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u7684 JNJ-61186372\u7684 I \u671f\u3001\u9996\u6b21\u7528\u4e8e\u4eba\u4f53\u3001\u5f00\u653e\u6027\u3001\u5242\u91cf\u9012\u589e\u7814\u7a76"},"content":{"rendered":"
\n

\u70b9\u51fb\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u4e00\u9879\u5728\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u7684<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/span>\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u4e00\u9879\u5728\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u7684<\/span><\/strong><\/strong><\/strong><\/strong><\/span><\/strong>\u9a6c\u4e0a\u5165\u7ec4\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/strong><\/span><\/p>\n

\u516c\u4f17\u53f7\uff1ashiyan589<\/span><\/p>\n

\n
\n
\n

\u6297\u764c\u6307\u5357\u70b9\u51fb\u4e0b\u65b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u2193\u2193\u2193<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

<\/a><\/p>\n
<\/a><\/p>\n
\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u4e00\u9879\u5728\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u7684<\/a><\/section>\n<\/section>\n<\/section>\n
<\/a><\/p>\n
<\/a><\/p>\n
\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u4e00\u9879\u5728\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u7684<\/a><\/section>\n<\/section>\n<\/section>\n
<\/a><\/p>\n
<\/a><\/p>\n

\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u4e00\u9879\u5728\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u7684<\/a><\/p>\n<\/section>\n

\n
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\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u4e00\u9879\u5728\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u7684<\/a><\/p>\n<\/section>\n

\u5165\u7ec4\u62a5\u540d\u65b9\u5f0f\u89c1\u6587\u672b<\/span><\/strong><\/p>\n

\u2193<\/span><\/strong>\u2193<\/span><\/strong>\u2193<\/span><\/strong>\u2193<\/span><\/strong><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n

<\/span>
<\/p>\n

1.       <\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/p>\n

JNJ-61186372<\/span>\u662f<\/span>EGFR<\/span>\u548c<\/span>cMET<\/span>\u4e3a\u9776\u6807\u7684\u53cc\u6297<\/span>\u3002<\/span><\/p>\n

\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f<\/span>\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/span>\u3002<\/span><\/p>\n

 <\/span><\/p>\n

2.<\/span>      <\/span> <\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/p>\n

\u672c\u7814\u7a76\u76ee\u7684\u65e8\u5728\u8bc4\u4f30<\/span> JNJ61186372 <\/span>\u5728\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/span>\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001<\/span>PK<\/span>\u3001\u63a2\u7d22<\/span>2<\/span>\u671f\u63a8\u8350\u5242\u91cf\u4ee5\u53ca\u521d\u6b65\u7597\u6548<\/span><\/p>\n

 <\/span><\/p>\n

3.<\/span>      <\/span> <\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/p>\n

\u8bd5\u9a8c\u5206\u7c7b\uff1a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span><\/p>\n

 <\/span>\u8bd5\u9a8c\u5206\u671f\uff1a<\/span> I<\/span>\u671f<\/span><\/p>\n

 <\/span>\u8bbe\u8ba1\u7c7b\u578b\uff1a\u5e73\u884c\u5206\u7ec4<\/span><\/p>\n

 <\/span>\u968f\u673a\u5316\uff1a<\/span>    <\/span>\u975e<\/span>\u968f\u673a\u5316<\/span><\/p>\n

 <\/span>\u76f2\u6cd5\uff1a<\/span>      <\/span>\u5f00\u653e<\/span><\/p>\n

 <\/span>\u8bd5\u9a8c\u8303\u56f4\uff1a\u56fd\u9645\u591a\u4e2d\u5fc3<\/span><\/p>\n

 <\/span>\u8bd5\u9a8c\u4eba\u6570\uff1a<\/span>\u603b\u4f53<\/span>180<\/span>\u4eba\uff0c<\/span>\u4e2d\u56fd<\/span>12<\/span>\u4eba<\/span><\/p>\n

 <\/span><\/p>\n

4.<\/span>      <\/span> <\/span>\u5165\u9009\u6807\u51c6<\/span><\/p>\n

1  <\/span>\u53d7\u8bd5\u8005\u5fc5\u987b\u2265<\/span>18<\/span>\u5c81\u5e76\u6ee1\u8db3\u5f00\u5c55\u7814\u7a76\u6240\u5728\u8f96\u533a\u89c4\u5b9a\u7684\u6cd5\u5b9a\u5e74\u9f84\u3002<\/span><\/p>\n

2  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 4 <\/span>\u4fee\u6539\u7684\u6807\u51c6\uff1a\u53d7\u8bd5\u8005\u5fc5\u987b\u5177\u6709\u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\u8bc1\u5b9e\u7684\u8f6c\u79fb\u6027\u6216\u4e0d\u53ef\u5207\u9664\u7684<\/span>NSCLC<\/span>\u3002\u53d7\u8bd5\u8005\u5fc5\u987b\u5728\u63a5\u53d7\u65e2\u5f80\u8f6c\u79fb\u6027\u75be\u75c5\u6cbb\u7597\u540e\u53d1\u751f\u8fdb\u5c55\uff0c\u4e0d\u9002\u5b9c\u6216\u62d2\u7edd\u6240\u6709\u5176\u4ed6\u76ee\u524d\u53ef\u7528\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/span><\/p>\n

3  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 5 <\/span>\u4fee\u6539\u7684\u6807\u51c6\uff1a\u4ec5\u5bf9\u4e8e\u7b2c<\/span> 2 <\/span>\u90e8\u5206\uff1a\u53d7\u8bd5\u8005\u8fd8\u5fc5\u987b\u5177\u6709\u65e2\u5f80\u8bca\u65ad\u4e3a\u643a\u5e26<\/span> EGFR <\/span>\u6fc0\u6d3b\u7a81\u53d8\u7684\u75be\u75c5\uff08\u5305\u62ec\u6291\u5236\u5242\u539f\u53d1\u6027\u654f\u611f\u7a81\u53d8\uff0c\u5982<\/span> 19 <\/span>\u53f7\u5916\u663e\u5b50\u7f3a\u5931\u548c<\/span> L858R<\/span>\uff3b\u961f\u5217<\/span> C<\/span>\uff3d\uff0c\u4ee5\u53ca\u5e02\u552e<\/span> TKI <\/span>\u8010\u836f\u6027\u7a81\u53d8\uff0c\u5982<\/span> 20 <\/span>\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\uff3b\u961f\u5217<\/span> C <\/span>\u548c<\/span> D<\/span>\uff3d\uff09\u3002<\/span>EGFR <\/span>\u7a81\u53d8\u9700\u8981\u901a<\/span>\u8fc7<\/span> CLIA <\/span>\u8ba4\u8bc1\u7684\u5b9e\u9a8c\u5ba4\uff08\u6216\u7b49\u6548\uff09\u68c0\u6d4b\u786e<\/span>\u8ba4\u3002<\/span><\/p>\n

4  <\/span>\u5bf9\u4e8e\u7b2c<\/span> 1 <\/span>\u90e8\u5206\uff1a\u53d7\u8bd5\u8005\u5fc5\u987b\u6709\u53ef\u8bc4\u4f30\u7684\u75be\u75c5\u3002\u5bf9\u4e8e\u7b2c<\/span> 2 <\/span>\u90e8\u5206\uff1a\u53d7\u8bd5\u8005\u5fc5\u987b\u6709\u7b26\u5408<\/span> RECIST <\/span>\u7b2c<\/span>1.1 <\/span>\u7248\u6807\u51c6\u7684\u53ef\u6d4b\u91cf\u75c5\u7076\u3002<\/span><\/p>\n

5  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 5 <\/span>\u4fee\u6539\u7684\u6807\u51c6\uff1a\u5bf9\u4e8e\u7b2c<\/span> 2 <\/span>\u90e8\u5206\uff1a\u961f\u5217<\/span> C<\/span>\uff1a\u643a\u5e26<\/span> EGFR <\/span>\u6216<\/span> cMET <\/span>\u53d8\u5f02\u6240\u4ecb\u5bfc\u7684\u5bf9\u65e2\u5f80\u7b2c\u4e09\u4ee3<\/span> TKI<\/span>\uff08\u4f8b\u5982<\/span> osimertinib<\/span>\uff09\u6cbb\u7597\u8010\u836f\u7684\u53d7\u8bd5\u8005\uff0c\u6216\u8005\u60a3\u6709\u539f\u53d1\u6027<\/span> 20 <\/span>\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u75be\u75c5\u3001\u65e2\u5f80\u4f7f\u7528\u8fc7\u5df2\u77e5\u5bf9<\/span> 20 <\/span>\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u75be\u75c5\u6709\u6548\u7684<\/span> TKI<\/span>\uff08\u4f8b\u5982\u6ce2\u9f50\u66ff\u5c3c\uff09\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u3002\u5408\u683c\u7684<\/span> EGFR <\/span>\u548c<\/span> cMET <\/span>\u53d8\u5f02\u7684\u793a\u4f8b\u89c1\u9644\u4ef6<\/span> 7<\/span>\uff0c\u8be5\u53d8\u5f02\u5fc5\u987b\u901a\u8fc7\u5148\u524d\u7684\u6d4b\u8bd5\u8bc1\u5b9e\uff08\u4f7f\u7528\u7b5b\u9009\u524d\u7b49\u6548\u80bf\u7624\u7ec4\u7ec7\u7684\u5f53\u5730\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7ed3\u679c\uff09\uff0c\u76f4\u81f3\u91c7\u7528<\/span> ctDNA <\/span>\u6216\u80bf\u7624\u7ec4\u7ec7\u7528\u4e8e\u4e2d\u5fc3\u68c0\u67e5\u7684<\/span> NGS <\/span>\u6280\u672f\u5f97\u5230\u9a8c\u8bc1\u3002\u4e00\u65e6\u4e2d\u5fc3\u68c0\u67e5\u53ef\u7528\uff0c\u5c06\u5728\u7b5b\u9009\u671f\u95f4\uff08\u6216\u4f7f\u7528\u7b5b\u9009\u524d\u7b49\u6548\u80bf\u7624\u7ec4\u7ec7\uff09\u57fa\u4e8e<\/span> EGFR <\/span>\u548c<\/span> cMET <\/span>\u8868\u5f81\u96c6\u4e2d\u8bc4\u4f30\u6240\u6709\u53d7\u8bd5\u8005\u7684\u8d44\u683c\u3002\u5728\u6700\u8fd1\u7684\u5168\u8eab\u6027\u6297\u764c\u7597\u6cd5\u6cbb\u7597\u540e\u5fc5\u987b\u68c0\u6d4b\u8be5\u57fa\u56e0\u53d8\u5f02\u3002\u961f\u5217<\/span> D<\/span>\uff1a\u53d7\u8bd5\u8005\u5fc5\u987b\u65e2\u5f80\u8bca\u65ad\u4e3a<\/span> EGFR 20 <\/span>\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u3002<\/span><\/p>\n

6  <\/span>\u53d7\u8bd5\u8005\u7684<\/span> ECOG <\/span>\u4f53\u80fd\u72b6\u6001\u8bc4\u5206\u5fc5\u987b\u4e3a<\/span> 0 <\/span>\u6216<\/span> 1<\/span>\u3002<\/span><\/p>\n

7  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 4 <\/span>\u4fee\u6539\u7684\u6807\u51c6\uff1a<\/span>7.4<\/span>\u53d7\u8bd5\u8005\u7684\u5668\u5b98\u548c\u9aa8\u9ad3\u529f\u80fd\u5fc5\u987b\u7b26\u5408\u4ee5\u4e0b\u6761\u4ef6\uff1a\u5b9e\u9a8c\u5ba4\u53c2\u6570\u8840\u7ea2\u86cb\u767d\u2265<\/span>10g\/dL<\/span>\uff0c<\/span>ANC<\/span>\u2265<\/span>1.5 <\/span>\u00d7<\/span> 109\/L<\/span>\uff0c\u8840\u5c0f<\/span>\u677f\u2265<\/span>75 <\/span>\u00d7<\/span> 109\/L<\/span>\uff0c<\/span>AST <\/span>\u548c<\/span> ALT<\/span>\u2264<\/span>3 <\/span>\u00d7<\/span> ULN<\/span>\uff0c\u603b\u80c6<\/span>\u7ea2\u7d20\u2264<\/span>1.5 <\/span>\u00d7<\/span> ULN<\/span>\uff1b\u6709<\/span> Gilbert <\/span>\u7efc\u5408\u5f81\u7684\u53d7\u8bd5\u8005\u5982\u679c\u7ed3\u5408\u80c6\u7ea2\u7d20\u5728\u6b63\u5e38\u8303\u56f4\u5185\u5219\u53ef\u5165\u7ec4\u3002\u8840\u6e05\u808c\u9150\uff1c<\/span>1.5 <\/span>\u00d7<\/span> ULN<\/span>\uff0c\u6216\u8ba1\u7b97\u6216\u6d4b\u91cf\u7684<\/span>\u808c\u9150\u6e05\u9664\u7387\uff08\u5982\u6709\uff09\uff1e<\/span>50 mL\/min\/1.73 m2<\/span>\uff0c\u53d7\u8bd5\u8005\u5fc5\u987b\u6ee1\u8db3\u4e0a\u8ff0\u5b9e\u9a8c\u5ba4\u6807\u51c6\uff0c\u4e14\u5728\u68c0\u6d4b\u65e5\u671f\u4e4b\u524d<\/span> 7 <\/span>\u5929\u5185\u6ca1\u6709\u7ea2\u7ec6\u80de\u8f93\u8840\u3001\u8840\u5c0f\u677f\u8f93\u6ce8\u6216<\/span> G-CSF<\/span>\u652f\u6301\u7684\u5386\u53f2\u3002<\/span><\/p>\n

8  <\/span>\u5728\u5165\u7ec4\u524d\uff0c\u5973\u6027\u53d7\u8bd5\u8005\u5fc5\u987b\uff1a<\/span>a. <\/span>\u65e0\u751f\u80b2\u80fd\u529b<\/span> b.<\/span>\u6709\u751f\u80b2\u80fd\u529b\u5e76\u4e14\u6839\u636e\u5f53\u5730\u5173\u4e8e\u201c\u4e34\u5e8a\u7814\u7a76\u53c2\u4e0e\u53d7\u8bd5\u8005\u4f7f\u7528\u8282\u80b2\u65b9\u6cd5\u201d\u7684\u6cd5\u89c4\u91c7\u53d6\u6709\u6548\u907f\u5b55\u65b9\u6cd5\uff0c\u5177\u4f53\u63cf\u8ff0\u5982\u4e0b\uff1a<\/span>1) <\/span>\u5b8c\u5168\u7981\u6b32<\/span> 2)<\/span>\u552f\u4e00\u7684\u6027\u4f34\u4fa3\u5df2\u63a5\u53d7\u8f93\u7cbe\u7ba1\u5207\u9664\u672f<\/span> 3)<\/span>\u91c7\u53d6<\/span> 2 <\/span>\u79cd\u907f\u5b55\u65b9\u6cd5\uff0c\u5305\u62ec\u4e00\u79cd\u9ad8\u6548\u7684\u907f\u5b55\u65b9\u6cd5\uff08\u5373\uff0c\u5e38\u89c4\u7684\u53e3\u670d\u3001\u6ce8\u5c04\u6216\u690d\u5165\u578b\u6fc0\u7d20\u7c7b\u907f\u5b55\u836f\uff1b\u653e\u7f6e\u5bab\u5185\u8282\u80b2\u5668<\/span> [IUD] <\/span>\u6216\u5bab\u5185\u8282\u80b2\u5668\u7cfb\u7edf<\/span>[IUS] <\/span>\uff09\uff0c\u4ee5\u53ca\u7b2c\u4e8c\u79cd\u65b9\u6cd5\uff08\u4f8b\u5982\uff0c\u5185\u542b\u6740\u7cbe\u6ce1\u6cab<\/span>\/<\/span>\u51dd\u80f6<\/span>\/<\/span>\u8584\u819c<\/span>\/<\/span>\u818f<\/span>\/<\/span>\u6813\u5242\u7684\u907f\u5b55\u5957\u6216\u5185\u542b\u6740\u7cbe\u6ce1\u6cab<\/span>\/<\/span>\u51dd\u80f6<\/span>\/<\/span>\u8584\u819c\u818f<\/span>\/<\/span>\u6813\u5242\u7684\u95ed\u585e\u6027\u5e3d\u72b6\u7269<\/span> [<\/span>\u9694\u819c\u6216\u5bab\u9888<\/span>\/<\/span>\u7a79\u7abf\u5e3d<\/span>] <\/span>\uff09\u3002\u53d7\u8bd5\u8005\u5fc5\u987b\u540c\u610f\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u6301\u7eed\u907f\u5b55\uff0c\u5e76\u6301\u7eed\u81f3\u7814\u7a76\u836f\u7269\u672b\u6b21\u7ed9\u836f\u540e<\/span> 6 <\/span>\u4e2a\u6708\u3002<\/span><\/p>\n

9  <\/span>\u7b5b\u9009\u65f6\uff0c\u6709\u751f\u80b2\u80fd\u529b\u5973\u6027\u7684\u8840\u6e05\u68c0\u6d4b\uff08\u4eba\u7ed2\u6bdb\u819c\u4fc3\u6027\u817a\u6fc0\u7d20<\/span>\u03b2<\/span> [<\/span>\u4eba\u7ed2\u6bdb\u819c\u4fc3\u6027\u817a\u6fc0\u7d20<\/span>\u03b2<\/span>] <\/span>\uff09\u5fc5\u987b\u4e3a\u9634\u6027\u3002<\/span><\/p>\n

10  <\/span>\u5973\u6027\u53d7\u8bd5\u8005\u5fc5\u987b\u540c\u610f\u5728\u7814\u7a76\u671f\u95f4\u548c\u7814\u7a76\u836f\u7269\u672b\u6b21\u7ed9\u836f\u540e<\/span> 6 <\/span>\u4e2a\u6708\u5185\u4e0d\u4ee5\u8f85\u52a9\u751f\u6b96\u4e3a\u76ee\u7684\u6350\u732e\u5375\u5b50\uff08\u5375\u7ec6\u80de\u548c\u5375\u6bcd\u7ec6\u80de\uff09\u3002<\/span><\/p>\n

11  <\/span>\u4e0e\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u6027\u751f\u6d3b\u6d3b\u8dc3\u7684\u7537\u6027\u5fc5\u987b\u540c\u610f\u4f7f\u7528\u5185\u542b\u6740\u7cbe\u6ce1\u6cab<\/span>\/<\/span>\u51dd\u80f6<\/span>\/<\/span>\u8584\u819c<\/span>\/<\/span>\u818f<\/span>\/<\/span>\u6813\u5242\u7684\u907f\u5b55\u5957\uff0c\u4e14\u5176\u4f34\u4fa3\u4e5f\u5fc5\u987b\u91c7\u53d6\u9ad8\u6548\u7684\u907f\u5b55\u65b9\u6cd5\uff08\u5373\uff0c\u5e38\u89c4\u7684\u53e3\u670d\u3001\u6ce8\u5c04\u6216\u690d\u5165\u578b\u6fc0\u7d20\u7c7b\u907f\u5b55\u836f\uff1b\u653e\u7f6e\u5bab\u5185\u8282\u80b2\u5668<\/span> [IUD] <\/span>\u6216\u5bab\u5185\u8282\u80b2\u5668\u7cfb\u7edf<\/span> [IUS] <\/span>\uff09\u3002\u5982\u679c\u53d7\u8bd5\u8005\u5df2\u63a5\u53d7\u8f93\u7cbe\u7ba1\u5207\u9664\u672f\uff0c\u4ecd\u5fc5\u987b\u4f7f\u7528\u907f\u5b55\u5957\uff08\u542b\u6216\u4e0d\u542b\u6740\u7cbe\u5242\uff09\uff0c\u4f46\u5176\u5973\u6027\u4f34\u4fa3\u4e0d\u9700\u8981\u4f7f\u7528\u907f\u5b55\u63aa\u65bd\u3002\u53d7\u8bd5\u8005\u5728\u672c\u7814\u7a76\u671f\u95f4\u4ee5\u53ca\u7814\u7a76\u836f\u7269\u672b\u6b21\u7ed9\u836f\u540e<\/span> 6 <\/span>\u4e2a\u6708\u5185\u4e0d\u5f97\u6350\u732e\u7cbe\u5b50\u3002<\/span><\/p>\n

12  <\/span>\u53d7\u8bd5\u8005\u5fc5\u987b\u613f\u610f\u4e14\u80fd\u591f\u9075\u5b88\u672c\u65b9\u6848\u6240\u89c4\u5b9a\u7684\u7981\u5fcc\u6216\u9650\u5236\u3002<\/span><\/p>\n

13  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 5 <\/span>\u4fee\u6539\u7684\u6807\u51c6\uff1a<\/span>13.5 .<\/span>\u53d7\u8bd5\u8005\u5fc5\u987b\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff08<\/span>ICF<\/span>\uff09\uff0c\u8868\u660e\u5176\u613f\u610f\u53c2\u52a0\u7814\u7a76\uff0c\u5e76\u7406\u89e3\u672c\u7814\u7a76\u7684\u76ee\u7684\u548c\u8981\u6c42\u8fdb\u884c\u7684\u7a0b\u5e8f\uff0c\u5305\u62ec\u63d0\u4f9b\u968f\u8bbf\u671f\u95f4\u7684\u4fe1\u606f\u3002<\/span><\/p>\n

14  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 5 <\/span>\u4fee\u6539\u7684\u6807\u51c6\uff1a<\/span>14.5 .<\/span>\u7b26\u5408\u7b2c<\/span>2<\/span>\u90e8\u5206\u6761\u4ef6\u7684\u53d7\u8bd5\u8005\u5fc5\u987b\u540c\u610f\u91c7\u96c6\u6cbb\u7597\u524d\u80bf\u7624\u6d3b\u68c0\u6837\u672c\uff08\u6216\u63d0\u4ea4\u7b49\u6548\u5b58\u6863\u6750\u6599\uff09\uff0c\u5728\u75be\u75c5\u8fdb\u5c55\u65f6\u91c7\u96c6\u80bf\u7624\u6d3b\u68c0\u6837<\/span>\u672c<\/span>\uff0c<\/span>\u4ee5<\/span>\u53ca<\/span>\u91c7<\/span>\u96c6<\/span>\u76f8<\/span>\u5e94<\/span>\u7684<\/span>\u8840<\/span>\u6db2<\/span>\u6837<\/span>\u672c<\/span>\u7528<\/span>\u4e8e<\/span>ctDNA <\/span>\u5206\u6790\u3002\u961f\u5217<\/span> C <\/span>\u7684\u53d7\u8bd5\u8005\u5fc5\u987b\u5728\u6700\u65b0\u7684\u5168\u8eab\u6027\u6297\u764c\u7597\u6cd5\u6cbb\u7597\u540e\u91c7\u96c6\u7b49\u6548\u7684\u6cbb\u7597\u524d\u80bf\u7624\u7ec4\u7ec7\u6837\u672c\u3002<\/span><\/p>\n

 <\/span><\/p>\n

5.<\/span>      <\/span> <\/span>\u6392\u9664\u6807\u51c6<\/span><\/p>\n

1  <\/span>\u53d7\u8bd5\u8005\u60a3\u6709\u65e0\u6cd5\u63a7\u5236\u7684\u95f4\u53d1\u6027\u75be\u75c5\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u63a7\u5236\u4e0d\u4f73\u7684\u9ad8\u8840\u538b\u6216\u7cd6\u5c3f\u75c5\uff0c\u6301\u7eed\u6216\u6d3b\u52a8<\/span>\u6027\u611f\u67d3\uff0c\u6216\u4f1a\u9650\u5236\u4f9d\u4ece\u6027\u7814\u7a76\u8981\u6c42\u7684\u7cbe\u795e\u75be\u75c5<\/span>\/<\/span>\u793e\u4f1a\u60c5\u51b5\u3002<\/span><\/p>\n

2  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 5 <\/span>\u4fee\u6539\u7684\u6807\u51c6<\/span>:2.5<\/span>\u53d7\u8bd5\u8005\u5728\u9996\u6b21\u7ed9\u836f\u524d<\/span> 2 <\/span>\u5468\u6216<\/span> 4 <\/span>\u4e2a\u534a\u8870\u671f\uff08\u4ee5\u8f83\u957f\u8005\u4e3a\u51c6\uff09\u4e4b\u524d\u63a5\u53d7\u8fc7\u5316\u7597\u3001\u764c\u75c7\u9776\u5411\u6cbb\u7597\u3001\u514d\u75ab\u6cbb\u7597\u6216\u8bd5\u9a8c\u6027\u6297\u764c\u836f\u7269\u6cbb\u7597\u3002\u5bf9\u4e8e\u534a\u8870\u671f\u8f83\u957f\u7684\u836f\u7269\uff0c\u8981\u6c42\u8ddd\u79bb\u672b\u6b21\u7ed9\u836f\u7684\u65f6\u95f4\u6700\u591a\u4e3a<\/span> 4 <\/span>\u5468\u3002\u65e2\u5f80<\/span>\u6297\u764c\u7597\u6cd5\u7684\u6bd2\u6027\u5e94\u8be5\u5df2\u7ecf\u51cf\u8f7b\u81f3\u57fa\u7ebf\u6c34\u5e73\u6216<\/span> 1 <\/span>\u7ea7<\/span>\u6216<\/span>\u66f4<\/span>\u4f4e<\/span>\uff08<\/span>\u4f46<\/span>\u8131<\/span>\u53d1<\/span>\uff3b<\/span>\u4efb<\/span>\u4f55<\/span>\u7b49\u7ea7\uff3d\u3001\u2264<\/span>2 <\/span>\u7ea7\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u548c\u4f7f\u7528\u6fc0\u7d20\u66ff\u4ee3\u7597\u6cd5\u53ef\u4ee5\u4fdd\u6301\u7a33\u5b9a\u7684\uff1c<\/span>2 <\/span>\u7ea7\u7684\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u9664\u5916\uff09\u3002\u961f\u5217<\/span> C<\/span>\uff1a\u65e2\u5f80\u63a5\u53d7\u8fc7\u8d85\u8fc7<\/span> 2 <\/span>\u7ebf\u7684\u7ec6\u80de\u6bd2\u6027\u5316\u7597\u6cbb\u7597\u8f6c\u79fb\u6027\u75be\u75c5\uff08\u4e0d\u5305\u62ec\u7ef4\u6301\u6cbb\u7597\uff09\u3002\u961f\u5217<\/span> D<\/span>\uff1a\u65e2\u5f80\u63a5\u53d7\u8fc7\u5bf9<\/span> EGFR 20 <\/span>\u53f7\u5916\u663e\u5b50\u63d2\u5165<\/span>\u7a81\u53d8\u6709\u6d3b\u6027\u4f5c\u7528\u7684<\/span> EGFR TKI <\/span>\u6cbb\u7597\uff08\u4f8b\u5982\uff0c\u6ce2\u9f50<\/span>\u66ff\u5c3c\uff09\u3002\u6ce8\uff1a\u5e94\u5728\u8ddd<\/span> JNJ-61186372 <\/span>\u6cbb\u7597\u5f00\u59cb\u81f3\u5c11<\/span> 7 <\/span>\u5929\u524d<\/span>\u5b8c\u6210\u4ee5\u59d1\u606f\u6cbb\u7597\u4e3a\u76ee\u7684\u7684\u5c40\u90e8\u653e\u7597\u3002<\/span><\/p>\n

3  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 4 <\/span>\u4fee\u6539\u7684\u6807\u51c6<\/span>:3.4 <\/span>\u5177\u6709\u672a\u6cbb\u7597\u8111\u8f6c\u79fb\u7684\u53d7\u8bd5\u8005\u3002\u5177\u6709\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u8f6c\u79fb\u4e14\u4e34\u5e8a\u7a33\u5b9a\u548c\u65e0\u75c7\u72b6\u81f3\u5c11<\/span>2 <\/span>\u5468\u7684\u60a3\u8005\uff0c\u5982\u679c\u5728\u7814\u7a76\u6cbb\u7597\u5f00\u59cb\u4e4b\u524d\u505c\u6b62\u6cbb\u7597\u6216\u63a5\u53d7\u4f4e\u5242\u91cf\u76ae\u8d28\u7c7b\u56fa\u9187\u6cbb\u7597\uff08\u2264<\/span>10mg <\/span>\u6cfc\u5c3c\u677e\u6216\u7b49\u6548\u836f\u7269\uff09\u81f3\u5c11<\/span> 2<\/span>\u5468\uff0c\u5219\u4e3a\u5408\u683c\u53d7\u8bd5\u8005\u3002<\/span><\/p>\n

4  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 3 <\/span>\u4fee\u6539\u7684\u6807\u51c6\uff1a<\/span>4.3 <\/span>\u53d7\u8bd5\u8005\u5728\u7b5b\u9009\u524d<\/span> 3 <\/span>\u5e74\u5185\u60a3\u6709\u9664\u7814\u7a76\u4e2d\u7684<\/span>\u75be\u75c5\u4ee5\u5916\u7684\u6076\u6027\u80bf\u7624\u75c5\u53f2\uff08\u76ae\u80a4\u9cde\u72b6\u548c\u57fa\u5e95\u7ec6\u80de\u764c\u3001\u5bab\u9888\u539f\u4f4d\u764c\uff0c\u6216\u7814\u7a76\u8005\u548c\u7533\u529e\u65b9\u533b\u5b66\u76d1\u67e5\u5458\u4e00\u81f4\u8ba4\u4e3a\u5df2\u6cbb\u6108\u4e14\u7b5b<\/span>\u9009\u524d<\/span> 1 <\/span>\u5e74\u5185\u590d\u53d1\u98ce\u9669\u6781\u4f4e\u7684\u6076\u6027\u80bf\u7624\u9664\u5916\uff09\u3002<\/span><\/p>\n

5  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 5 <\/span>\u4fee\u6539\u7684\u6807\u51c6\uff1a<\/span>5.5 <\/span>\u53d7\u8bd5\u8005\u5177\u6709\u4e34\u5e8a\u663e\u8457\u5fc3\u8840\u7ba1\u75be\u75c5\u75c5\u53f2\uff0c\u5728\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u4e4b\u524d<\/span> 1 <\/span>\u4e2a\u6708\u5185\u8bca\u65ad\u60a3\u6709\u6df1\u9759\u8109\u8840\u6813\u5f62\u6210\u6216\u80ba\u6813\u585e\uff0c\u6216\u5728\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u4e4b\u524d<\/span> 6 <\/span>\u4e2a\u6708\u5185\u7684\u4ee5\u4e0b\u4efb\u4f55<\/span>\u75c5\u53f2\uff1a\u5fc3\u808c\u6897\u6b7b\u3001\u4e0d\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u3001\u4e2d\u98ce\u3001\u77ed\u6682\u6027\u8111\u7f3a\u8840\u6027\u53d1\u4f5c\u3001\u51a0\u72b6<\/span>\/<\/span>\u5916\u5468\u52a8\u8109\u642d\u6865\u672f\u6216\u4efb\u4f55\u6025\u6027\u51a0\u8109\u7efc\u5408\u5f81\u3002\u4e34\u5e8a\u4e0a\u65e0\u610f\u4e49\u7684\u8840\u6813\u5f62\u6210\uff0c\u5982\u975e\u6897\u963b\u6027\u5bfc\u7ba1\u76f8\u5173\u51dd\u5757\uff0c\u4e0d\u662f\u6392\u9664\u6807\u51c6\u3002<\/span>QTcF <\/span>\u95f4\u671f\u5ef6\u957f\uff1e<\/span>480 msec <\/span>\u6216\u4e34\u5e8a\u663e\u8457\u5fc3\u810f\u5fc3\u5f8b\u4e0d\u9f50\u6216\u7535\u751f\u7406\u75be\u75c5\u3002\uff1b\u65e0\u6cd5\u63a7\u5236\uff08\u6301\u7eed\u6027\uff09\u7684\u9ad8\u8840\u538b\uff1a\u6536\u7f29\u538b\uff1e<\/span>180 mmHg<\/span>\uff1b\u8212\u5f20\u538b\uff1e<\/span>100 mmHg<\/span>\u3002\uff1b<\/span>NYHA III-IV <\/span>\u7ea7\u5145\u8840\u6027\u5fc3\u810f\u8870\u7aed\u6216\u5728\u7814\u7a76\u7b2c<\/span> 1 <\/span>\u5929\u524d\u7684<\/span> 6 <\/span>\u4e2a\u6708\u5185\u56e0\u5145\u8840\u6027\u5fc3\u810f\u8870\u7aed\u4f4f\u9662\u3002\uff1b\u5fc3\u5305\u708e<\/span>\/<\/span>\u4e34\u5e8a\u663e\u8457\u5fc3\u5305\u79ef\u6db2\uff1b\u5fc3\u808c\u708e<\/span><\/p>\n

6  <\/span>\u53d7\u8bd5\u8005\u60a3\u6709\u8f6f\u8111\u819c\u75be\u75c5\u3002<\/span><\/p>\n

7  <\/span>\u5df2\u77e5\u53d7\u8bd5\u8005\u6709\u8fc7\u654f\u53cd\u5e94\u3001\u8d85\u654f\u53cd\u5e94\u6216\u5bf9<\/span> JNJ-61186372<\/span>\u6216<\/span>\u5176<\/span>\u8f85<\/span>\u6599<\/span>\u4e0d<\/span>\u8010<\/span>\u53d7<\/span>\uff08<\/span>\u53c2<\/span>\u89c1<\/span>\u7814<\/span>\u7a76<\/span>\u8005<\/span>\u624b\u518c\uff09\u3002\u6ce8\uff1a\u7814\u7a76\u8005\u624b\u518c\u4e2d\u63cf\u8ff0\u7684\u8f85\u6599\u542b\u6709\u7ec4\u6c28\u9178\u3001\u8517\u7cd6\u548c\u805a\u5c71\u68a8\u916f<\/span>80<\/span>\u3002<\/span><\/p>\n

8  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 5 <\/span>\u4fee\u6539\u7684\u6807\u51c6\uff1a<\/span>8.5<\/span>\u53d7\u8bd5\u8005\u5728\u8ba1\u5212\u7684\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u4e4b\u524d<\/span>6 <\/span>\u5468<\/span>\u5185<\/span>\u66fe<\/span>\u63a5<\/span>\u53d7<\/span>\u8bd5<\/span>\u9a8c<\/span>\u836f<\/span>\u7269<\/span>\uff08<\/span>\u5305<\/span>\u62ec<\/span>\u8bd5<\/span>\u9a8c<\/span>\u75ab\u82d7\uff0c\u4f46\u4e0d\u5305\u62ec\u6297\u764c\u6cbb\u7597<\/span> [<\/span>\u53c2\u89c1\u6392\u9664\u6807\u51c6\uff03<\/span>2] <\/span>\uff09\u6216\u66fe\u4f7f\u7528\u6709\u521b\u8bd5\u9a8c\u7528\u533b\u7597\u5668\u68b0\u3002<\/span><\/p>\n

9  <\/span>\u5728\u7814\u7a76\u8fdb\u884c\u8fc7\u7a0b\u4e2d\u6216\u7814\u7a76\u836f\u7269\u672b\u6b21\u7ed9\u836f\u540e<\/span> 6 <\/span>\u4e2a\u6708\u5185\uff0c\u6000\u5b55\u6216\u5904\u4e8e\u54fa\u4e73\u671f\u6216\u8ba1\u5212\u6000\u5b55\u7684\u5973\u6027\u53d7\u8bd5\u8005\u3002<\/span><\/p>\n

10  <\/span>\u5728\u5165\u9009\u672c\u7814\u7a76\u65f6\u6216\u7814\u7a76\u836f\u7269\u672b\u6b21\u7ed9\u836f\u540e<\/span> 6 <\/span>\u4e2a\u6708\u5185\u6709\u751f\u80b2\u8ba1\u5212\u7684\u7537\u6027\u53d7\u8bd5\u8005<\/span><\/p>\n

11  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 4 <\/span>\u4fee\u6539\u7684\u6807\u51c6\uff1a<\/span>11.4 <\/span>\u53d7\u8bd5\u8005\u6709\u6216\u5c06\u6709\u4ee5\u4e0b\u4efb\u4f55\u4e00\u79cd\u60c5\u51b5\uff1a<\/span>a.<\/span>\u5728\u7b2c<\/span> 1 <\/span>\u5468\u671f\u7b2c<\/span> 1 <\/span>\u5929\u4e4b\u524d<\/span> 4 <\/span>\u5468\u5185\u63a5\u53d7\u8fdb\u5165\u4f53<\/span>\u8154\u7684\u521b\u4f24\u6027\u624b\u672f\u64cd\u4f5c\uff0c\u6216\u5728\u7b2c<\/span> 1 <\/span>\u5468\u671f\u7b2c<\/span> 1 <\/span>\u5929\u4e4b\u524d\u6ca1\u6709\u5b8c\u5168\u6062\u590d\u3002\u5bf9\u4e8e\u57fa\u7ebf\u80bf\u7624\u7ec4\u7ec7<\/span>\u6837\u672c\u7684\u80f8\u8154\u7a7f\u523a\u672f\uff08\u5982\u9700\u8981\uff09\u548c\u7ecf\u76ae\u6d3b\u68c0<\/span>\u53ef\u4ee5\u5728\u7b2c<\/span> 1 <\/span>\u5468\u671f\u7b2c<\/span> 1 <\/span>\u5929\u4e4b\u524d\uff1c<\/span>4 <\/span>\u5468\u8fdb\u884c\uff0c<\/span>\u524d\u63d0\u6761\u4ef6\u662f\uff0c\u6839\u636e\u7814\u7a76\u8005\u7684\u4e34\u5e8a\u5224\u65ad\uff0c\u5728<\/span>\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u4e4b\u524d\uff0c\u53d7\u8bd5\u8005\u5df2\u7ecf\u4ece\u8be5<\/span>\u624b\u672f\u4e2d\u5145\u5206\u6062\u590d\uff1b<\/span>b. <\/span>\u7b2c<\/span> 1 <\/span>\u5468\u671f\u7b2c<\/span> 1 <\/span>\u5929\u5f00\u59cb\u524d<\/span> 3 <\/span>\u5468\u5185\u53d1\u751f\u91cd\u5927\u5916\u4f24\u6027\u635f\u4f24\uff08\u6240\u6709\u4f24\u53e3\u5fc5\u987b\u5728\u7814\u7a76\u7b2c<\/span> 1 <\/span>\u5929\u524d<\/span>\u5b8c\u5168\u6108\u5408\uff09\uff1b<\/span>c. <\/span>\u9700\u8981\u5b8c\u597d\u521b\u4f24\u4fee\u590d\u80fd\u529b\u4e14\u5982\u679c\u521b\u4f24\u4fee\u590d\u80fd<\/span>\u529b\u5728\u670d\u7528\u8bd5\u9a8c\u836f\u7269\u671f\u95f4\u4e25\u91cd\u964d\u4f4e\u800c\u5371\u53ca\u53d7\u8bd5\u8005\u5b89\u5168\u7684\u6240\u6709\u533b\u7597\u72b6\u51b5\uff1b<\/span>d.<\/span>\u5728\u8bd5\u9a8c\u836f\u7269\u7ed9\u836f\u671f\u95f4\u6216\u7814\u7a76\u836f\u7269\u672b\u6b21\u7ed9\u836f<\/span>\u540e<\/span> 6 <\/span>\u4e2a\u6708\u5185\u8ba1\u5212\u63a5\u53d7\u91cd\u5927\u624b\u672f\u6cbb\u7597\u3002<\/span><\/p>\n

12  <\/span>\u7814\u7a76\u8005\u8ba4\u4e3a\u53d7\u8bd5\u8005\u53c2\u4e0e\u672c\u7814\u7a76\u5e76\u975e\u6700\u4f73\u9009\u62e9\uff08\u4f8b\u5982\u635f\u5bb3\u5065\u5eb7\uff09\uff0c\u6216\u8005\u53d7\u8bd5\u8005\u5b58\u5728\u5f71\u54cd\u3001\u9650\u5236\u6216\u6df7\u6dc6\u7814\u7a76\u65b9\u6848\u8bc4\u4f30\u7684\u75c5\u75c7\u3002<\/span><\/p>\n

13  <\/span>\u4efb\u4f55\u4e0e\u672c\u7814\u7a76\u76f4\u63a5\u76f8\u5173\u7684\u7814\u7a76\u4e2d\u5fc3\u5de5\u4f5c\u4eba\u5458\u3002<\/span><\/p>\n

14  <\/span>\u6309\u7167\u4fee\u6b63\u6848<\/span> 5 <\/span>\u4fee\u6539\u7684\u6807\u51c6\uff1a<\/span>14.5 <\/span>\u53d7\u8bd5\u8005\u7684\u65e2\u5f80\u4e59\u809d\u75c5\u6bd2<\/span>\u8868\u9762\u6297\u539f\uff08<\/span>HBsAg<\/span>\uff09\u6216\u4e19\u809d\u75c5\u6bd2\u6297\u4f53\uff08\u6297<\/span> HCV<\/span>\uff09\u9633\u6027\uff0c\u6216\u6709\u5176\u4ed6\u4e34\u5e8a\u6d3b\u52a8\u6027\u4f20\u67d3\u6027\u809d\u75c5\uff0c\u6216\u7b5b\u9009\u65f6<\/span> HBsAg <\/span>\u6216\u6297<\/span> HCV <\/span>\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633<\/span>\u6027\u3002\u6ce8\uff1a\u5177\u6709\u4e19\u578b\u809d\u708e\u75c5\u53f2\u3001\u5df2\u5b8c\u6210\u6297\u75c5\u6bd2\u6cbb\u7597\u5e76\u4e14\u968f\u540e\u5728\u7b5b\u9009\u671f\u672a\u53d1\u73b0\u8840\u6e05<\/span> HCV RNA <\/span>\u7684\u53d7\u8bd5<\/span>\u8005\uff0c\u53ef\u4ee5\u53c2\u4e0e\u7814\u7a76\u3002<\/span><\/p>\n

15  <\/span>\u53d7\u8bd5\u8005\u6709\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08<\/span>HIV<\/span>\uff09\u6297\u4f53\u9633\u6027\u75c5\u53f2\u6216\u7b5b\u9009\u65f6<\/span> HIV <\/span>\u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\u3002<\/span><\/p>\n

16  <\/span>\u53d7\u8bd5\u8005\u6709\u4efb\u4f55\u4e25\u91cd\u7684\u6f5c\u5728\u533b\u5b66\u6216\u7cbe\u795e\u72b6\u51b5\uff08\u4f8b\u5982\uff0c\u9152\u7cbe\u6216\u836f\u7269\u6ee5\u7528\uff09\u3001\u75f4\u5446\u6216\u7cbe\u795e\u72b6\u6001\u6539\u53d8\uff0c\u6216\u4f1a\u635f\u5bb3\u53d7\u8bd5\u8005\u5728\u7814\u7a76\u4e2d\u5fc3\u63a5\u53d7\u6216\u8010\u53d7\u8ba1\u5212\u6cbb\u7597\u3001\u7406\u89e3\u77e5\u60c5\u540c\u610f\u4e66\u7684\u80fd\u529b\u6216\u7814\u7a76\u8005\u8ba4\u4e3a\u4f1a\u5bfc\u81f4\u7ec8\u6b62\u53d7\u8bd5\u8005\u53c2\u4e0e\u7814\u7a76\u6216\u6df7\u6dc6\u7814\u7a76\u7ed3\u679c\u7684\u4efb\u4f55\u95ee\u9898\u3002<\/span><\/p>\n

 <\/span><\/p>\n

6.<\/span>      <\/span> <\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u5e8f\u53f7<\/span><\/p>\n<\/td>\n

\n

\u673a\u6784\u540d\u79f0<\/span><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u7814\u7a76\u8005<\/span><\/p>\n<\/td>\n

\n

\u56fd\u5bb6<\/span><\/p>\n<\/td>\n

\n

\u7701\uff08\u5dde\uff09<\/span><\/p>\n<\/td>\n

\n

\u57ce\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1<\/span><\/p>\n<\/td>\n

\n

\u5e7f\u4e1c\u7701\u4eba\u6c11\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u5434\u4e00\u9f99\/\u6d82\u6d77\u71d5<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd<\/span><\/p>\n<\/td>\n

\n

\u5e7f\u4e1c<\/span><\/p>\n<\/td>\n

\n

\u5e7f\u5dde<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2<\/span><\/p>\n<\/td>\n

\n

\u5409\u6797\u7701\u80bf\u7624\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u7a0b\u9896<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd<\/span><\/p>\n<\/td>\n

\n

\u5409\u6797<\/span><\/p>\n<\/td>\n

\n

\u957f\u6625<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

3<\/span><\/p>\n<\/td>\n

\n

\u6c5f\u82cf\u7701\u80bf\u7624\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u51af\u7ee7\u950b<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd<\/span><\/p>\n<\/td>\n

\n

\u6c5f\u82cf<\/span><\/p>\n<\/td>\n

\n

\u5357\u4eac<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

4<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u80bf\u7624\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u8d75\u519b<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

5<\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u7701\u80bf\u7624\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u8303\u4e91<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd<\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f<\/span><\/p>\n<\/td>\n

\n

\u676d\u5dde<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

6<\/span><\/p>\n<\/td>\n

\n

\u91cd\u5e86\u5e02\u80bf\u7624\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u8f87\u4f1f\u5947<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd<\/span><\/p>\n<\/td>\n

\n

\u91cd\u5e86<\/span><\/p>\n<\/td>\n

\n

\u91cd\u5e86<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

7<\/span><\/p>\n<\/td>\n

\n

\u56db\u5ddd\u7701\u80bf\u7624\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u674e\u5a1f<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd<\/span><\/p>\n<\/td>\n

\n

\u56db\u5ddd<\/span><\/p>\n<\/td>\n

\n

\u6210\u90fd<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

8<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5927\u5b66\u7b2c\u4e09\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u66f9\u5b9d\u5c71<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n

 <\/p>\n


<\/p>\n

\n
\n
\n
\u4e34\u5e8a\u8bd5\u9a8c\u62a5\u540d\u65b9\u5f0f<\/span><\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

<\/section>\n

\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\uff0c\u56de\u590d\u201c\u5165\u7ec4\u201d\u5373\u53ef<\/strong><\/span><\/span><\/p>\n

\u2193<\/strong>\u2193<\/strong>\u2193<\/strong>\u2193<\/strong><\/strong><\/span><\/span><\/p>\n

\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u4e00\u9879\u5728\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u7684<\/p>\n


<\/p>\n

\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u4e00\u9879\u5728\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u7684\u70b9\u51fb\u201c<\/span>\u9605\u8bfb\u539f\u6587<\/span>\u201d\u67e5\u770b\u8be6\u60c5<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u9a6c\u4e0a\u5165\u7ec4\u4e34\u5e8a\u8bd5\u9a8c \u516c\u4f17\u53f7\uff1ashiyan589 \u6297\u764c\u6307\u5357\u70b9\u51fb\u4e0b\u65b9 \u2193\u2193\u2193 \u5165\u7ec4\u62a5\u540d\u65b9\u5f0f\u89c1\u6587\u672b \u2193\u2193\u2193\u2193 1. […]<\/p>\n","protected":false},"author":1,"featured_media":88724,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/88723"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=88723"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/88723\/revisions"}],"predecessor-version":[{"id":88733,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/88723\/revisions\/88733"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/88724"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=88723"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=88723"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=88723"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}