{"id":88734,"date":"2019-04-17T00:00:50","date_gmt":"2019-04-23T04:03:26","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/88734\/"},"modified":"2019-04-23T12:03:28","modified_gmt":"2019-04-23T04:03:28","slug":"145a9f204b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/88734\/","title":{"rendered":"\u3010\u80ba\u764c-\u60a3\u8005\u62db\u52df\u3011TQB3456\u7247\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66I\u671f\u4e34\u5e8a\u7814\u7a76"},"content":{"rendered":"
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1. \u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\u786e\u8bca\u7684\u8fdb\u5c55\u6027\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff1b<\/p>\n

2. \u63a5\u53d7\u8fc7EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u5355\u836f\u6cbb\u7597\uff08\u5982\uff0c\u5409\u975e\u66ff\u5c3c\u3001\u5384\u6d1b\u66ff\u5c3c\u3001\u57c3\u514b\u66ff\u5c3c\u3001\u963f\u6cd5\u66ff\u5c3c\uff09\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\uff1b<\/span><\/p>\n

3. \u786e\u8bc1\u5b58\u5728EGFR T790M\u7a81\u53d8\uff1b<\/span><\/p>\n

4. 18~70\u5c81\uff1bECOG\u4f53\u529b\u72b6\u51b5\uff1a0~1\u5206\uff1b\u9884\u8ba1\u751f\u5b58\u671f\u8d85\u8fc73\u6708\uff1b<\/span><\/p>\n

5. \u4e3b\u8981\u5668\u5b98\u529f\u80fd\u6b63\u5e38\uff0c\u5373\u7b26\u5408\u4e0b\u5217\u6807\u51c6\uff1aa)\u8840\u5e38\u89c4\u68c0\u67e5\uff1a\u8840\u7ea2\u86cb\u767d\uff08Hb\uff09\u226580g\/L\uff0814\u5929\u5185\u672a\u8f93\u8840\uff09\uff1b\u7edd\u5bf9\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\uff08ANC\uff09\u22651.5\u00d7109\/L\uff1b\u8840\u5c0f\u677f\uff08PLT\uff09\u226590\u00d7109\/L\uff1bb)\u751f\u5316\u68c0\u67e5\uff1a\u8c37\u4e19\u8f6c\u6c28\u9176\uff08ALT\uff09\u53ca\u8c37\u8349\u8f6c\u6c28\u9176\uff08AST\uff09\u2264 2.5\u00d7ULN\uff08\u80bf\u7624\u809d\u810f\u8f6c\u79fb\u8005\uff0c\u2264 5\u00d7ULN\uff09\uff1b\u8840\u6e05\u603b\u80c6\u7ea2\u7d20\uff08TBIL\uff09\u22641.5\u00d7ULN\uff08Gilbert\u7efc\u5408\u75c7\u60a3\u8005\uff0c\u2264 3\u00d7ULN\uff09\uff1b\u8840\u6e05\u808c\u9150\uff08Cr\uff09\u22641.5\u00d7ULN\uff1b c)\u51dd\u8840\u529f\u80fd\uff1a\u6d3b\u5316\u90e8\u5206\u51dd\u8840\u6d3b\u9176\u65f6\u95f4\uff08APTT\uff09\u3001\u56fd\u9645\u6807\u51c6\u5316\u6bd4\u503c\uff08INR\uff09\u3001\u51dd\u8840\u9176\u539f\u65f6\u95f4\uff08PT\uff09\u2264 1.5\u00d7ULN\uff1bd)\u591a\u666e\u52d2\u8d85\u58f0\u8bc4\u4f30\uff1a\u5de6\u5ba4\u5c04\u8840\u5206\u6570 (LVEF)\u226550%\uff1b<\/span><\/p>\n

6. \u5973\u6027\u5fc5\u987b\u6ee1\u8db3\u4ee5\u4e0b\u6761\u4ef6\u4e4b\u4e00\uff1a\u2460 \u5df2\u884c\u624b\u672f\u7edd\u80b2\uff1b\u2461 \u5df2\u7edd\u7ecf\u8005\uff0c\u505c\u7ecf\u81f3\u5c111\u5e74\u4ee5\u4e0a\uff1b\u2462 \u5177\u6709\u751f\u80b2\u80fd\u529b\uff0c\u9700\u6ee1\u8db3\u4e0b\u5217\u6761\u4ef6\uff1b\u5165\u7ec4\u672c\u8bd5\u9a8c\u524d\u8840\u6e05\/\u5c3f\u598a\u5a20\u68c0\u67e5\u7ed3\u679c\u9634\u6027\uff1b\u4ece\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\u8d77\uff0c\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u548c\u7814\u7a76\u7ed3\u675f\u540e6\u4e2a\u6708\u5185\uff0c\u540c\u610f\u91c7\u53d6\u4e00\u79cd\u88ab\u8ba4\u53ef\u7684\u65b9\u6cd5\u907f\u5b55\uff08\u4f8b\u5982\uff1a\u53e3\u670d\u907f\u5b55\u6cd5\u3001\u6ce8\u5c04\u907f\u5b55\u6cd5\u6216\u8005\u690d\u5165\u7684\u3001\u6709\u5c4f\u969c\u4f5c\u7528\u7684\u907f\u5b55\u65b9\u6cd5\uff0c\u6740\u7cbe\u5242\u548c\u907f\u5b55\u5957\uff0c\u6216\u8005\u5bab\u5185\u907f\u5b55\u5668\uff09\uff1b\u7537\u6027\u5fc5\u987b\u6ee1\u8db3\u4ee5\u4e0b\u6761\u4ef6\u4e4b\u4e00\uff1a\u2460\u5df2\u884c\u624b\u672f\u7edd\u80b2\uff1b\u2461\u5fc5\u987b\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u548c\u7814\u7a76\u7ed3\u675f\u540e6\u4e2a\u6708\u5185\u91c7\u7528\u4e00\u79cd\u88ab\u8ba4\u53ef\u7684\u907f\u5b55\u65b9\u6cd5\uff1b<\/span><\/p>\n

7. \u60a3\u8005\u81ea\u613f\u52a0\u5165\u672c\u7814\u7a76\uff0c\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff0c\u4f9d\u4ece\u6027\u597d\u3002    <\/span><\/p>\n


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\u6392\u9664\u6807\u51c6<\/strong><\/p>\n<\/section>\n

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1. \u51fa\u73b0\u4ee5\u4e0b\u4efb\u4f55\u4e00\u9879\u76ee\u7684\u53d7\u8bd5\u8005\u5c06\u4e0d\u80fd\u5165\u7ec4\u672c\u7814\u7a76\uff1a a.\u66fe\u63a5\u53d7\u8fc7\u5965\u5e0c\u66ff\u5c3c\u3001\u6216\u5176\u4ed6\u7528\u4e8eEGFRT790M\u7a81\u53d8\u836f\u7269\u539f\u6599\u6216\u5236\u5242\u6cbb\u7597\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff1b b.\u8ddd\u60a3\u8005\u9996\u6b21\u7528\u836f\u65f6\u95f4\u95f4\u9694\uff1a4\u5468\u5185\u63a5\u53d7EGFR TKI\uff08\u5982\uff0c\u5409\u975e\u66ff\u5c3c\u3001\u5384\u6d1b\u66ff\u5c3c\u3001\u57c3\u514b\u66ff\u5c3c\u3001\u963f\u6cd5\u66ff\u5c3c\u7b49\uff09\u548c\u9776\u5411EGFR\u7684\u751f\u7269\u5236\u54c1\uff08\u5982\uff0c\u5c3c\u59a5\u73e0\u5355\u6297\u3001\u5e15\u5c3c\u5355\u6297\u548c\u897f\u59a5\u6614\u5355\u6297\u7b49\uff09\u6cbb\u7597\u7684\u60a3\u8005\uff1b c.\u8ddd\u60a3\u8005\u9996\u6b21\u7528\u836f\u65f6\u95f4\u95f4\u9694\uff1a4\u5468\u5185\u53c2\u4e0e\u8fc7\u4efb\u4f55\u5176\u4ed6\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u62164\u5468\u5185\u4f7f\u7528\u8fc7\u5176\u4ed6\u6297\u764c\u836f\u7269\uff1b d.\u8ddd\u60a3\u8005\u9996\u6b21\u7528\u836f\u65f6\u95f4\u95f4\u9694\uff1a4\u5468\u5185\u63a5\u53d7\u8fc7\u91cd\u5927\u5916\u79d1\u624b\u672f\uff1b e.\u8ddd\u60a3\u8005\u9996\u6b21\u7528\u836f\u65f6\u95f4\u95f4\u9694\uff1a7\u5929\u5185\u63a5\u53d7\u8fc7\u5c40\u90e8\u653e\u5c04\u6027\u6cbb\u7597\uff1b4\u5468\u5185\u63a5\u53d7\u8fc7\u9aa8\u9ad3\u653e\u7597\uff08\u9762\u79ef>30%\uff09\uff0c\u6216\u9614\u91ce\u653e\u7597\uff1b<\/p>\n

2. \u8fc7\u53bb2\u5e74\u66fe\u60a3\u5176\u4ed6\u6076\u6027\u80bf\u7624\uff0c\u5df2\u6cbb\u6108\u7684\u6216\u5c40\u90e8\u53ef\u6cbb\u6108\u764c\u75c7\u9664\u5916\uff0c\u4f8b\u5982\u76ae\u80a4\u57fa\u5e95\u764c\u6216\u9cde\u72b6\u7ec6\u80de\u764c\u3001\u6d45\u8868\u8180\u80f1\u764c\u3001\u5b50\u5bab\u9888\u764c\u6216\u4e73\u817a\u539f\u4f4d\u764c\uff1b<\/span><\/p>\n

3. \u5df2\u77e5\u810a\u9ad3\u538b\u8feb\u3001\u764c\u6027\u8111\u819c\u708e\u60a3\u8005\uff0c\u5df2\u77e5\u6216\u65b0\u53d1\u4e2d\u67a2\u7cfb\u7edf\u80bf\u7624\u6216\u6709\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8f6c\u79fb\u7684\u60a3\u8005\u75c7\u72b6\u63a7\u5236\u7a33\u5b9a\u5c0f\u4e8e4\u5468\u7684\u60a3\u8005\uff1b<\/span><\/p>\n

4. \u65e2\u5f80\u5b58\u5728\u95f4\u8d28\u6027\u80ba\u75c5\uff0c\u836f\u7269\u6027\u95f4\u8d28\u6027\u80ba\u75c5\uff0c\u9700\u8981\u7c7b\u56fa\u9187\u6cbb\u7597\u7684\u653e\u5c04\u6027\u80ba\u75c5\u53f2\uff0c\u6216\u4e34\u5e8a\u4e0a\u6709\u6d3b\u52a8\u95f4\u8d28\u6027\u80ba\u75c5\u8ff9\u8c61\u4e25\u91cd\u7684\u6d3b\u52a8\u6027\u611f\u67d3\uff1b<\/span><\/p>\n

5. \u4e0d\u80fd\u63a7\u5236\u7684\u9700\u8981\u53cd\u590d\u5f15\u6d41\u7684\u80f8\u8154\u79ef\u6db2\u3001\u5fc3\u5305\u79ef\u6db2\u6216\u8179\u6c34\uff1b<\/span><\/p>\n

6. \u660e\u663e\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u4f8b\u5982\u7f8e\u56fd\u7ebd\u7ea6\u5fc3\u810f\u75c5\u534f\u4f1a\uff08NYHA\uff09\u5206\u7ea7\u4e3a2\u7ea7\u53ca\u4ee5\u4e0a\u7684\u5fc3\u529b\u8870\u7aed\u3001\u65e2\u5f803\u4e2a\u6708\u5185\u7684\u5fc3\u808c\u6897\u6b7b\u3001\u4e0d\u7a33\u5b9a\u7684\u5fc3\u5f8b\u5931\u5e38\uff08\u5305\u62ecQTC\u95f4\u671f\u2265480 ms\uff09\u6216\u4e0d\u7a33\u5b9a\u7684\u5fc3\u7ede\u75db\uff1b<\/span><\/p>\n

7. \u6709\u514d\u75ab\u7f3a\u9677\u75c5\u53f2\uff0c\u5305\u62ecHIV\u68c0\u6d4b\u9633\u6027\u6216\u60a3\u6709\u5176\u5b83\u83b7\u5f97\u6027\u3001\u5148\u5929\u6027\u514d\u75ab\u7f3a\u9677\u75be\u75c5\uff0c\u6216\u6709\u5668\u5b98\u79fb\u690d\u53f2\u8005\uff1b<\/span><\/p>\n

8. \u7ecf\u4e00\u79cd\u836f\u7269\u6cbb\u7597\u4ecd\u65e0\u6cd5\u63a7\u5236\u7684\u9ad8\u8840\u538b\uff08\u6536\u7f29\u538b\u2265140 mmHg\uff0c\u8212\u5f20\u538b\u2265 90 mmHg\uff09\u60a3\u8005\uff1b<\/span><\/p>\n

9. \u7cd6\u5c3f\u75c5\u60a3\u8005\u8840\u7cd6\u63a7\u5236\u4e0d\u4f73\uff08\u7a7a\u8179\u8840\u7cd6\uff08FBG\uff09\uff1e10mmol\/L\uff09\uff1b<\/span><\/p>\n

10. \u4e59\u809d\u75c5\u6bd2\u6709\u6d3b\u8dc3\u590d\u5236\u7684\u60a3\u8005\uff08DNA\uff1e500 cps\/mL\uff09\uff0c\u6d3b\u52a8\u6027\u4e19\u578b\u809d\u708e\u60a3\u8005\uff1b<\/span><\/p>\n

11. \u9996\u6b21\u7528\u836f\u524d\u5b58\u5728\u65e2\u5f80\u6297\u80bf\u7624\u6cbb\u7597\u5f15\u8d77\u7684\u672a\u6062\u590d\u7684\u6bd2\u6027\uff08\u4e0d\u5305\u62ec\u8131\u53d1\uff09\uff1b<\/span><\/p>\n

12. \u5b58\u5728\u672a\u6108\u5408\u7684\u4f24\u53e3\u3001\u6e83\u75a1\u6216\u9aa8\u6298\uff1b<\/span><\/p>\n

13. \u5177\u6709\u5f71\u54cd\u53e3\u670d\u836f\u7269\u5438\u6536\u7684\u591a\u79cd\u56e0\u7d20\uff08\u4f8b\u5982\u65e0\u6cd5\u541e\u54bd\u3001\u6162\u6027\u8179\u6cfb\u3001\u96be\u4ee5\u63a7\u5236\u7684\u6076\u5fc3\u5455\u5410\u3001\u80c3\u80a0\u9053\u5207\u9664\u6216\u624b\u672f\u53f2\uff09\uff1b<\/span><\/p>\n

14. \u5177\u6709\u7cbe\u795e\u7c7b\u836f\u7269\u6ee5\u7528\u53f2\u4e14\u65e0\u6cd5\u6212\u9664\u6216\u6709\u7cbe\u795e\u969c\u788d\u8005\uff1b<\/span><\/p>\n

15. \u6839\u636e\u7814\u7a76\u8005\u7684\u5224\u65ad\uff0c\u6709\u4e25\u91cd\u7684\u5371\u5bb3\u60a3\u8005\u5b89\u5168\u6216\u5f71\u54cd\u60a3\u8005\u5b8c\u6210\u7814\u7a76\u7684\u4f34\u968f\u75be\u75c5\u8005\u3002    <\/span><\/p>\n


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\u4e34\u5e8a\u8bd5\u9a8c\u62a5\u540d\u65b9\u5f0f<\/span><\/section>\n

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\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\uff0c\u56de\u590d\u201c\u5165\u7ec4\u201d\u5373\u53ef<\/strong><\/span><\/span><\/p>\n

\u2193<\/strong>\u2193<\/strong>\u2193<\/strong>\u2193<\/strong><\/strong><\/span><\/span><\/p>\n

\"\u3010\u80ba\u764c-\u60a3\u8005\u62db\u52df\u3011TQB3456\u7247\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66I\u671f\u4e34\u5e8a\u7814\u7a76\"<\/p>\n


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\"\u3010\u80ba\u764c-\u60a3\u8005\u62db\u52df\u3011TQB3456\u7247\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66I\u671f\u4e34\u5e8a\u7814\u7a76\"\u70b9\u51fb\u201c<\/span>\u9605\u8bfb\u539f\u6587<\/span>\u201d\u67e5\u770b\u8be6\u60c5<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u9a6c\u4e0a\u5165\u7ec4\u4e34\u5e8a\u8bd5\u9a8c \u516c\u4f17\u53f7\uff1ashiyan589 \u6297\u764c\u6307\u5357\u70b9\u51fb\u4e0b\u65b9 \u2193\u2193\u2193 \u5165\u7ec4\u62a5\u540d\u65b9\u5f0f\u89c1\u6587\u672b \u2193\u2193\u2193\u2193 \u8bd5\u9a8c […]<\/p>\n","protected":false},"author":1,"featured_media":88735,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/88734"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=88734"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/88734\/revisions"}],"predecessor-version":[{"id":88752,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/88734\/revisions\/88752"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/88735"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=88734"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=88734"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=88734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}