{"id":88753,"date":"2019-04-19T00:00:50","date_gmt":"2019-04-23T04:03:31","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/88753\/"},"modified":"2019-04-23T12:03:33","modified_gmt":"2019-04-23T04:03:33","slug":"1d78007a4d","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/88753\/","title":{"rendered":"\u3010\u9ed8\u6c99\u4e1cPD-1\u62db\u52df\u809d\u764c\u3011\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u4ed1\u4f10\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\uff1a\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u3001III\u671f\u4e34\u5e8a\u7814\u7a76"},"content":{"rendered":"
\n

\u70b9\u51fb\"\u3010\u9ed8\u6c99\u4e1cPD-1\u62db\u52df\u809d\u764c\u3011\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u4ed1\u4f10\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\uff1a\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u3001III\u671f\u4e34\u5e8a\u7814\u7a76\"<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/span>\"\u3010\u9ed8\u6c99\u4e1cPD-1\u62db\u52df\u809d\u764c\u3011\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u4ed1\u4f10\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\uff1a\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u3001III\u671f\u4e34\u5e8a\u7814\u7a76\"<\/span><\/strong><\/strong><\/strong><\/strong><\/span><\/strong>\u9a6c\u4e0a\u5165\u7ec4\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/strong><\/span><\/p>\n

\u516c\u4f17\u53f7\uff1ashiyan589<\/span><\/p>\n

\n
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\u6297\u764c\u6307\u5357\u70b9\u51fb\u4e0b\u65b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u2193\u2193\u2193<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u3010\u9ed8\u6c99\u4e1cPD-1\u62db\u52df\u809d\u764c\u3011\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u4ed1\u4f10\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\uff1a\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u3001III\u671f\u4e34\u5e8a\u7814\u7a76\"<\/a><\/section>\n<\/section>\n<\/section>\n
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\"\u3010\u9ed8\u6c99\u4e1cPD-1\u62db\u52df\u809d\u764c\u3011\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u4ed1\u4f10\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\uff1a\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u3001III\u671f\u4e34\u5e8a\u7814\u7a76\"<\/a><\/section>\n<\/section>\n<\/section>\n
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\"\u3010\u9ed8\u6c99\u4e1cPD-1\u62db\u52df\u809d\u764c\u3011\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u4ed1\u4f10\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\uff1a\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u3001III\u671f\u4e34\u5e8a\u7814\u7a76\"<\/a><\/p>\n<\/section>\n

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\"\u3010\u9ed8\u6c99\u4e1cPD-1\u62db\u52df\u809d\u764c\u3011\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u4ed1\u4f10\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\uff1a\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u3001III\u671f\u4e34\u5e8a\u7814\u7a76\"<\/a><\/p>\n<\/section>\n

\u5165\u7ec4\u62a5\u540d\u65b9\u5f0f\u89c1\u6587\u672b<\/span><\/strong><\/p>\n

\u2193<\/span><\/strong>\u2193<\/span><\/strong>\u2193<\/span><\/strong>\u2193<\/span><\/strong><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n


<\/p>\n

1.  <\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/p>\n

<\/span>\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08<\/span>Pembrolizumab\uff0c<\/span><\/span>MK-3475<\/span>\uff09\u662f\u6297PD-1\u5355\u6297\u3002<\/span><\/span><\/p>\n

\u4ed1\u4f10\u66ff\u5c3c\uff08\u4e50\u4f10\u66ff\u5c3c\uff0c<\/span>E7080<\/span>\uff09\u662f<\/span>\u591a\u9776\u70b9\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c<\/span><\/span><\/p>\n

\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f\u665a\u671f\u809d\u7ec6\u80de\u764c<\/span>\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

2.      <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u65e8\u5728\u8bc4\u4ef7\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u4ed1\u4f10\u66ff\u5c3c\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u4ed1\u4f10\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u665a\u671f<\/span>HCC<\/span>\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span><\/span><\/p>\n

 <\/span><\/p>\n

3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u7c7b\uff1a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span><\/p>\n

\u8bd5\u9a8c\u5206\u671f\uff1a<\/span> III<\/span>\u671f<\/span><\/span><\/p>\n

\u8bbe\u8ba1\u7c7b\u578b\uff1a\u5e73\u884c\u5206\u7ec4<\/span><\/p>\n

\u968f\u673a\u5316\uff1a<\/span>   <\/span>\u968f\u673a\u5316<\/span><\/span><\/p>\n

\u76f2\u6cd5\uff1a<\/span>     <\/span>\u53cc\u76f2<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u8303\u56f4\uff1a\u56fd\u9645\u591a\u4e2d\u5fc3\u8bd5\u9a8c<\/span><\/p>\n

\u8bd5\u9a8c\u4eba\u6570<\/span>;  <\/span>\u603b\u4f53<\/span>750<\/span>\u4eba\uff0c\u4e2d\u56fd\u5f85\u5b9a\u4eba<\/span><\/span><\/p>\n

 <\/span><\/p>\n

4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u6709\u7ecf\u5f71\u50cf\u5b66\u3001\u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\u8bc1\u5b9e\u7684<\/span>HCC<\/span>\u8bca\u65ad\uff08\u7ea4\u7ef4\u677f\u5c42\u548c\u6df7\u5408\u578b\u809d\u7ec6\u80de<\/span>\/<\/span>\u80c6\u7ba1\u764c\u4e9a\u578b\u4e0d\u7b26\u5408\u5165\u9009\u6807\u51c6\uff09\u3002<\/span><\/span><\/p>\n

2  <\/span>\u6839\u636e\u5df4\u585e\u7f57\u90a3\u4e34\u5e8a\u809d\u764c\uff08<\/span>BCLC<\/span>\uff09\u5206\u671f\u7cfb\u7edf\u5f52\u4e3a<\/span>C<\/span>\u671f\u7684\u809d\u764c\u53d7\u8bd5\u8005\uff0c\u6216\u4e0d\u9002\u5408\u5c40\u90e8\u6cbb\u7597\u6216\u5c40\u90e8\u6cbb\u7597\u96be\u6cbb\uff0c\u4e14\u4e0d\u9002\u5408\u91c7\u7528\u6839\u6cbb\u6027\u6cbb\u7597\u7684<\/span>BCLC<\/span>\u5f52\u4e3a<\/span>B<\/span>\u671f\u7684\u809d\u764c\u53d7\u8bd5\u8005\u3002<\/span><\/span><\/p>\n

3  <\/span>\u5728\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>7<\/span>\u5929\u5185<\/span>Child-Pugh<\/span>\u809d\u529f\u80fd\u8bc4\u5206\u4e3a<\/span>A<\/span>\u7ea7\u3002<\/span><\/span><\/p>\n

4  <\/span>\u9884\u8ba1\u5bff\u547d<\/span>>3<\/span>\u4e2a\u6708\u3002<\/span><\/span><\/p>\n

5  BICR<\/span>\u57fa\u4e8e<\/span>RECIST 1.1<\/span>\u6807\u51c6\u786e\u8ba4\u81f3\u5c11\u5177\u6709\u4e00\u4e2a\u53ef\u6d4b\u91cf\u75c5\u7076\u3002<\/span><\/span><\/p>\n

6  <\/span>\u5728\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>7<\/span>\u5929\u5185\uff0c\u7f8e\u56fd\u4e1c\u90e8\u80bf\u7624\u534f\u4f5c\u7ec4\uff08<\/span>ECOG<\/span>\uff09\u7684\u4f53\u529b\u72b6\u6001\uff08<\/span>PS<\/span>\uff09\u8bc4\u5206\u4e3a<\/span>0-1<\/span>\u5206\u3002<\/span><\/span><\/p>\n

7  <\/span>\u53d7\u8bd5\u8005\u662f\u7537\u6027\u6216\u5973\u6027\u3002<\/span><\/span><\/p>\n

8  <\/span>\u53d7\u8bd5\u8005\u5728\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\u65f6\u5e74\u9f84\u2265<\/span>18<\/span>\u5c81\u3002<\/span><\/span><\/p>\n

9  <\/span>\u7537\u6027\u53d7\u8bd5\u8005\u5fc5\u987b\u540c\u610f\u5728\u6cbb\u7597\u671f\u95f4\u53ca\u6700\u540e\u4e00\u6b21\u7814\u7a76\u836f\u7269\u7ed9\u836f\u540e\u81f3\u5c11<\/span>120<\/span>\u5929\u5185\u91c7\u53d6\u907f\u5b55\u63aa\u65bd\uff0c\u5e76\u4e14\u5728\u6b64\u671f\u95f4\u4e0d\u80fd\u6350\u732e\u7cbe\u5b50\u3002<\/span><\/span><\/p>\n

10  <\/span>\u5973\u6027\u53d7\u8bd5\u8005\u5982\u679c\u4e0d\u5728\u598a\u5a20\u671f\uff0c\u4e0d\u5728\u54fa\u4e73\u671f\uff0c\u800c\u4e14\u81f3\u5c11\u7b26\u5408\u4ee5\u4e0b\u4e00\u79cd\u60c5\u51b5\uff0c\u5219\u53ef\u4ee5\u53c2\u52a0\u7814\u7a76\uff1a\u4e0d\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u6216\u8005\u540c\u610f\u5728\u6cbb\u7597\u671f\u95f4\u53ca\u6700\u540e\u4e00\u6b21\u7814\u7a76\u836f\u7269\u7ed9\u836f\u540e\u81f3\u5c11<\/span>120<\/span>\u5929\u5185\u6309\u7167\u65b9\u6848\u8981\u6c42\u91c7\u53d6\u907f\u5b55\u63aa\u65bd\u7684\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u3002<\/span><\/span><\/p>\n

11  <\/span>\u53d7\u8bd5\u8005\uff08\u6216\u6cd5\u5b9a\u4ee3\u8868\uff0c\u5982\u9002\u7528\uff09\u63d0\u4f9b\u53c2\u52a0\u7814\u7a76\u7684\u77e5\u60c5\u540c\u610f\u4e66\u3002<\/span><\/span><\/p>\n

12  <\/span>\u65e2\u5f80\u6216\u6301\u7eed\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08<\/span>HCV<\/span>\uff09\u611f\u67d3\u7684\u53d7\u8bd5\u8005\u5c06\u6709\u8d44\u683c\u53c2\u52a0\u8be5\u7814\u7a76\u3002\u63a5\u53d7\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u5fc5\u987b\u5728\u5f00\u59cb\u7814\u7a76\u6cbb\u7597\u524d\u81f3\u5c11<\/span>1<\/span>\u4e2a\u6708\u5b8c\u6210\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

13  <\/span>\u5df2\u63a7\u7684\u4e59\u578b\u809d\u708e\u53d7\u8bd5\u8005\u53ea\u8981\u7b26\u5408\u4ee5\u4e0b\u6807\u51c6\uff0c\u5c31\u6709\u8d44\u683c\u53c2\u52a0\u7814\u7a76\uff1a\uff1f<\/span>HBV<\/span>\u6297\u75c5\u6bd2\u6cbb\u7597\u5fc5\u987b\u7ed9\u4e88\u81f3\u5c11<\/span>4<\/span>\u5468\uff0c\u4e14\u5728\u9996\u6b21\u7814\u7a76\u836f\u7269\u7ed9\u836f\u4e4b\u524d\u7684<\/span>HBV<\/span>\u75c5\u6bd2\u8f7d\u91cf\u5fc5\u987b\u5c0f\u4e8e<\/span>100 IU\/mL<\/span>\u3002\u5bf9\u4e8e\u75c5\u6bd2\u8f7d\u91cf\u4f4e\u4e8e<\/span>100 IU\/mL<\/span>\u7684\u6b63\u5728\u63a5\u53d7\u6297<\/span>HBV<\/span>\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u5e94\u5728\u6574\u4e2a\u7814\u7a76\u6cbb\u7597\u671f\u95f4\u4fdd\u6301\u76f8\u540c\u7684\u6cbb\u7597\u3002\uff1f\u6297\u4e59\u578b\u809d\u708e\u6838\u5fc3\u6297\u4f53<\/span>HBc<\/span>\u9633\u6027\u3001\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\uff08<\/span>HBsAg<\/span>\uff09\u9634\u6027\u3001\u6297\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u4f53\uff08<\/span>HBs<\/span>\uff09\u9634\u6027\u6216\u9633\u6027\uff0c\u4e14<\/span>HBV<\/span>\u75c5\u6bd2\u8f7d\u91cf\u4f4e\u4e8e<\/span>100 IU\/mL<\/span>\u7684\u53d7\u8bd5\u8005\u4e0d\u9700\u8981\u6297<\/span>HBV<\/span>\u9884\u9632\u6027\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

14  <\/span>\u4f7f\u7528\u6216\u4e0d\u4f7f\u7528\u6297\u9ad8\u8840\u538b\u836f\u7269\u5145\u5206\u63a7\u5236\u7684\u8840\u538b\uff08<\/span>BP<\/span>\uff09\uff0c\u5b9a\u4e49\u4e3a\u7b5b\u9009\u65f6<\/span>BP <\/span>\u2264<\/span>150\/90 mm Hg<\/span>\uff0c\u5e76\u4e14\u5728\u7b2c<\/span>1<\/span>\u5468\u671f\u7b2c<\/span>1<\/span>\u5929\u524d<\/span>1<\/span>\u5468\u5185\u6297\u9ad8\u8840\u538b\u836f\u7269\u6ca1\u6709\u53d8\u5316\u3002\u6ce8\uff1a\u53c2\u52a0\u7814\u7a76\u524d\u63a5\u53d7\u2265<\/span>4<\/span>\u79cd\u6297\u9ad8\u8840\u538b\u836f\u7269\u7684\u53d7\u8bd5\u8005\u7684\u8d44\u683c\u5c06\u9700\u8981\u7533\u529e\u65b9\u8fdb\u884c\u6279\u51c6\u3002<\/span><\/span><\/p>\n

15  <\/span>\u5177\u5907\u5145\u5206\u7684\u5668\u5b98\u529f\u80fd\u3002\u6807\u672c\u5fc5\u987b\u5728\u5f00\u59cb\u7814\u7a76\u6cbb\u7597\u524d<\/span>7<\/span>\u5929\u5185\u91c7\u96c6\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u5728\u8fc7\u53bb<\/span>6<\/span>\u4e2a\u6708\u5185\u66fe\u53d1\u751f\u8fc7\u98df\u7ba1\u6216\u80c3\u9759\u8109\u66f2\u5f20\u51fa\u8840\u3002\u9664\u975e\u5728\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d\u7684<\/span>12<\/span>\u4e2a\u6708\u5185\u8fdb\u884c\u8fc7\u98df\u7ba1\u9759\u8109\u66f2\u5f20\u7b5b\u67e5\uff0c\u5426\u5219\u6240\u6709\u53d7\u8bd5\u8005\u90fd\u5c06\u63a5\u53d7\u98df\u7ba1\u9759\u8109\u66f2\u5f20\u7b5b\u67e5\u3002\u5982\u679c\u5b58\u5728\u9759\u8109\u66f2\u5f20\uff0c\u5219\u53d7\u8bd5\u8005\u5e94\u5728\u5f00\u59cb\u7814\u7a76\u6cbb\u7597\u524d\u6309\u7167\u673a\u6784\u6807\u51c6\u8fdb\u884c\u6cbb\u7597\uff1b\u5728\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>28<\/span>\u5929\u5185\u9700\u8981\u4ecb\u5165\u6cbb\u7597\u98df\u7ba1\u6216\u80c3\u9759\u8109\u66f2\u5f20\u7684\u53d7\u8bd5\u8005\u6392\u9664\u3002<\/span><\/span><\/p>\n

2  <\/span>\u5b58\u5728\u51fa\u8840\u6216\u8840\u6813\u6027\u75be\u75c5\u6216\u4f7f\u7528\u9700\u8981\u76d1\u6d4b\u56fd\u9645\u6807\u51c6\u5316\u6bd4\u503c\uff08<\/span>INR<\/span>\uff09\u7684<\/span>X<\/span>\u56e0\u5b50\u6291\u5236\u5242\u6216\u6297\u51dd\u5242\uff0c\u5982\u534e\u6cd5\u6797\u6216\u7c7b\u4f3c\u836f\u7269\u3002\u5141\u8bb8\u4f7f\u7528\u4f4e\u5206\u5b50\u91cf\u809d\u7d20\u6cbb\u7597\u3002\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u7981\u6b62\u4f7f\u7528\u6297\u8840\u5c0f\u677f\u836f\u7269\u3002<\/span><\/span><\/p>\n

3  <\/span>\u67e5\u4f53\u65f6\u53d1\u73b0\u4e0d\u53d7\u836f\u7269\u63a7\u5236\u7684\u7684\u4e34\u5e8a\u663e\u8457\u8179\u6c34\u3002\uff08\u6ce8\uff1a\u4ec5\u80fd\u901a\u8fc7\u5f71\u50cf\u5b66\u68c0\u67e5\u53d1\u73b0\u7684\u8179\u6c34\u5141\u8bb8\u53c2\u4e0e\u7814\u7a76\u3002\uff09<\/span><\/span><\/p>\n

4  <\/span>\u6839\u636e\u5f71\u50cf\u5b66\u68c0\u67e5\uff0c\u95e8\u9759\u8109\u4e3b\u5e72\uff08<\/span>Vp4<\/span>\uff09\u5904\u6709\u764c\u6813\u4fb5\u72af\u3001\u4e0b\u8154\u9759\u8109\u6216\u5fc3\u810f\u53d7\u7d2f\u3002<\/span><\/span><\/p>\n

5  <\/span>\u5728\u8fc7\u53bb<\/span>6<\/span>\u4e2a\u6708\u5185\u66fe\u88ab\u4e34\u5e8a\u8bca\u65ad\u4e3a\u809d\u6027\u8111\u75c5\u3002\u4f7f\u7528\u5229\u798f\u6614\u660e\u6216\u4e73\u679c\u7cd6\u63a7\u5236\u7684\u809d\u6027\u8111\u75c5\u53d7\u8bd5\u8005\u4e0d\u5141\u8bb8\u53c2\u4e0e\u7814\u7a76\u3002<\/span><\/span><\/p>\n

6  <\/span>\u5408\u5e76\u6709\u4e0d\u80fd\u63a5\u53d7\u4efb\u4f55\u9020\u5f71\u589e\u5f3a\u6210\u50cf\u68c0\u67e5\uff08<\/span>CT<\/span>\u6216<\/span>MRI<\/span>\uff09\u7684\u533b\u5b66\u7981\u5fcc\u75c7\u3002<\/span><\/span><\/p>\n

7  <\/span>\u80c3\u80a0\u9053\u5438\u6536\u4e0d\u826f\u3001\u80c3\u80a0\u9053\u543b\u5408\u672f\u6216\u4efb\u4f55\u5176\u4ed6\u53ef\u80fd\u5f71\u54cd\u4ed1\u4f10\u66ff\u5c3c\u5438\u6536\u7684\u60c5\u51b5\u3002<\/span><\/span><\/p>\n

8  <\/span>\u73b0\u6709\u2265<\/span>3<\/span>\u7ea7\u80c3\u80a0\u9053\u6216\u975e\u80c3\u80a0\u9053\u7618\u3002<\/span><\/span><\/p>\n

9  <\/span>\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>2<\/span>\u5468\u5185\uff0c\u4efb\u4f55\u539f\u56e0\u7684\u4e34\u5e8a\u663e\u8457\u7684\u54af\u8840\u6216\u80bf\u7624\u51fa\u8840\u3002<\/span><\/span><\/p>\n

10  <\/span>\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>12<\/span>\u4e2a\u6708\u5185\u7684\u91cd\u5927\u5fc3\u8840\u7ba1\u635f\u5bb3\uff1a\u5982\u7ebd\u7ea6\u5fc3\u810f\u534f\u4f1a\uff08<\/span>NYHA<\/span>\uff09<\/span>II<\/span>\u7ea7\u4ee5\u4e0a\u7684\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u75c5\u53f2\u3001\u4e0d\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u3001\u5fc3\u808c\u6897\u6b7b\u6216\u8111\u8840\u7ba1\u610f\u5916\u5352\u4e2d\uff0c\u6216\u4e0e\u8840\u6d41\u52a8\u529b\u5b66\u4e0d\u7a33\u5b9a\u76f8\u5173\u7684\u5fc3\u5f8b\u5931\u5e38\u3002<\/span><\/span><\/p>\n

11  <\/span>\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>4<\/span>\u5468\u5185\u8fdb\u884c\u8fc7\u809d\u810f\u5927\u624b\u672f\u3002\uff08\u6ce8\uff1a\u5982\u679c\u53d7\u8bd5\u8005\u66fe\u505a\u8fc7\u5927\u624b\u672f\uff0c\u5fc5\u987b\u5728\u5f00\u59cb\u7814\u7a76\u6027\u6cbb\u7597\u4e4b\u524d\uff0c\u5df2\u4ece\u6cbb\u7597\u6bd2\u6027\u548c<\/span>\/<\/span>\u6216\u5e76\u53d1\u75c7\u4e2d\u5145\u5206\u6062\u590d\u3002\uff09<\/span><\/span><\/p>\n

12  <\/span>\u7814\u7a76\u836f\u7269\u9996\u6b21\u6cbb\u7597\u524d\uff08\u7b2c<\/span>1<\/span>\u5468\u671f\u7b2c<\/span>1<\/span>\u5929\uff09<\/span>7<\/span>\u5929\u5185\u8fdb\u884c\u8fc7\u5c0f\u624b\u672f\uff08\u5373\u5355\u7eaf\u5207\u9664\u672f\uff09\u3002<\/span><\/span><\/p>\n

13  <\/span>\u60a3\u6709\u4e25\u91cd\u7684\u672a\u6108\u5408\u4f24\u53e3\u3001\u6e83\u75a1\u6216\u9aa8\u6298\u3002<\/span><\/span><\/p>\n

14  <\/span>\u53d7\u8bd5\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7\u4efb\u4f55\u5168\u8eab\u5316\u7597\uff0c\u5305\u62ec\u6297<\/span>VEGF<\/span>\u6cbb\u7597\uff0c\u6216\u4efb\u4f55\u7cfb\u7edf\u6027\u8bd5\u9a8c\u7528\u6297\u764c\u836f\u7269\u6cbb\u7597\u665a\u671f<\/span>\/<\/span>\u4e0d\u53ef\u5207\u9664<\/span>HCC<\/span>\u3002\uff08\u6ce8\uff1a\u63a5\u53d7\u8fc7\u809d\u810f\u5c40\u90e8\u6ce8\u5c04\u5316\u7597\u7684\u53d7\u8bd5\u8005\u7b26\u5408\u8d44\u683c\u3002\uff09<\/span><\/span><\/p>\n

15  <\/span>\u65e2\u5f80\u63a5\u53d7\u8fc7\u6297<\/span>PD-1<\/span>\u3001\u6297<\/span>-PD-L1<\/span>\u6216\u6297<\/span>PD-L2<\/span>\u836f\u7269\u7684\u6cbb\u7597\u6216\u4f5c\u7528\u4e8e\u53e6\u4e00\u79cd\u523a\u6fc0\u6027\u6216\u5171\u6291\u5236\u6027<\/span>T<\/span>\u7ec6\u80de\u53d7\u4f53\u7684\u836f\u7269\uff08\u4f8b\u5982<\/span>CTLA-4<\/span>\u3001<\/span>OX-40<\/span>\u6216<\/span>CD137<\/span>\uff09\u7684\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

16  <\/span>\u5728\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>4<\/span>\u5468\u5185\u63a5\u53d7\u8fc7\u809d\u810f\u5c40\u90e8\u6cbb\u7597\uff08\u7ecf\u5bfc\u7ba1\u5316\u7597\u6813\u585e\u672f\u3001\u7ecf\u5bfc\u7ba1\u6813\u585e\u672f\u3001\u809d\u52a8\u8109\u704c\u6ce8\u3001\u653e\u7597\u3001\u653e\u5c04\u6813\u585e\u672f\u6216\u6d88\u878d\u672f\uff09\u3002\u6ce8\u91ca\uff1a\u53d7\u8bd5\u8005\u5fc5\u987b\u5728\u5c40\u90e8\u6cbb\u7597\u540e\u663e\u793a\u75be\u75c5\u8fdb\u5c55\u7684\u8bc1\u636e\uff0c\u624d\u80fd\u53c2\u52a0\u3002<\/span><\/span><\/p>\n

17  <\/span>\u5728\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>2<\/span>\u5468\u5185\u63a5\u53d7\u8fc7\u975e\u809d\u810f\u533a\u57df\u7684\u65e2\u5f80\u653e\u7597\u3002\u53d7\u8bd5\u8005\u5fc5\u987b\u5df2\u7ecf\u4ece\u6240\u6709\u653e\u7597\u76f8\u5173\u6bd2\u6027\u4e2d\u6062\u590d\uff0c\u4e0d\u9700\u8981\u76ae\u8d28\u7c7b\u56fa\u9187\uff0c\u800c\u4e14\u6ca1\u6709\u53d1\u751f\u8fc7\u653e\u5c04\u6027\u80ba\u708e\u3002\u975e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08<\/span>CNS<\/span>\uff09\u75be\u75c5\u7684\u59d1\u606f\u6027\u653e\u7597\uff08\u2264<\/span>2<\/span>\u5468\u7684\u653e\u7597\uff09\u5141\u8bb8\u6709<\/span>2<\/span>\u5468\u7684\u6d17\u8131\u671f\u3002<\/span><\/span><\/p>\n

18  <\/span>\u5728\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>30<\/span>\u5929\u5185\u63a5\u79cd\u8fc7\u6d3b\u75ab\u82d7\u3002\u6d3b\u75ab\u82d7\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u4ee5\u4e0b\uff1a\u9ebb\u75b9\u3001\u816e\u817a\u708e\u3001\u98ce\u75b9\u3001\u6c34\u75d8<\/span>\/<\/span>\u5e26\u72b6\u75b1\u75b9\uff08\u6c34\u75d8\uff09\u3001\u9ec4\u70ed\u75c5\u3001\u72c2\u72ac\u75c5\u3001\u5361\u4ecb\u82d7\uff08<\/span>BCG<\/span>\uff09\u548c\u4f24\u5bd2\u75ab\u82d7\u3002\u7531\u4e8e\u6ce8\u5c04\u7528\u5b63\u8282\u6027\u6d41\u611f\u75ab\u82d7\u901a\u5e38\u662f\u706d\u6d3b\u75c5\u6bd2\u75ab\u82d7\uff0c\u56e0\u6b64\u5141\u8bb8\u4f7f\u7528\uff1b\u4f46\u662f\uff0c\u9f3b\u5185\u7528\u6d41\u611f\u75ab\u82d7\uff08\u4f8b\u5982\uff0c<\/span>FluMist<\/span>\uff1f\uff09\uff09\u4e3a\u51cf\u6bd2\u6d3b\u75ab\u82d7\uff0c\u56e0\u6b64\u4e0d\u5141\u8bb8\u4f7f\u7528\u3002<\/span><\/span><\/p>\n

19  <\/span>\u5f53\u524d\u6b63\u5728\u53c2\u4e0e\u6216\u5148\u524d\u53c2\u4e0e\u8fc7\u8bd5\u9a8c\u7528\u836f\u7269\u7814\u7a76\uff0c\u6216\u8005\u5728\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>4<\/span>\u5468\u5185\u4f7f\u7528\u8fc7\u8bd5\u9a8c\u6027\u5668\u68b0\u3002\u6ce8\uff1a\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u968f\u8bbf\u671f\u7684\u53d7\u8bd5\u8005\u53ef\u4ee5\u53c2\u4e0e\u672c\u9879\u8bd5\u9a8c\uff0c\u6761\u4ef6\u662f\u5728\u524d\u4e00\u79cd\u8bd5\u9a8c\u7528\u836f\u7269\u672b\u6b21\u7ed9\u836f<\/span>4<\/span>\u5468\u540e\u3002<\/span><\/span><\/p>\n

20  <\/span>\u8bca\u65ad\u4e3a\u514d\u75ab\u7f3a\u9677\u6216\u5728\u7814\u7a76\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>7<\/span>\u5929\u5185\u6b63\u5728\u63a5\u53d7\u957f\u671f\u5168\u8eab\u7c7b\u56fa\u9187\u6cbb\u7597\uff08\u6bcf\u65e5\u5242\u91cf\u8d85\u8fc7<\/span>10 mg<\/span>\u6cfc\u5c3c\u677e\u7b49\u6548\u7269\uff09\u6216\u4efb\u4f55\u5f62\u5f0f\u7684\u514d\u75ab\u6291\u5236\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

21  <\/span>\u5df2\u77e5\u6709\u53e6\u4e00\u79cd\u6076\u6027\u80bf\u7624\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u5c55\uff0c\u6216\u8fc7\u53bb<\/span>3<\/span>\u5e74\u5185\u66fe\u9700\u8981\u79ef\u6781\u6cbb\u7597\u3002\u6ce8\uff1a\u5141\u8bb8\u5df2\u63a5\u53d7\u53ef\u80fd\u6cbb\u6108\u6027\u6cbb\u7597\u7684\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\u3001\u76ae\u80a4\u9cde\u72b6\u7ec6\u80de\u764c\u6216\u539f\u4f4d\u764c\uff08\u4f8b\u5982\uff0c\u4e73\u817a\u764c\u3001\u539f\u4f4d\u5bab\u9888\u764c\uff09\u7684\u53d7\u8bd5\u8005\u3002<\/span><\/span><\/p>\n

22  <\/span>\u6839\u636e\u5f53\u5730\u7814\u7a76\u4e2d\u5fc3\u7814\u7a76\u8005\u7684\u8bc4\u4f30\uff0c\u6709\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08<\/span>CNS<\/span>\uff09\u8f6c\u79fb\u548c<\/span>\/<\/span>\u6216\u764c\u6027\u8111\u819c\u708e\u7684\u5df2\u77e5\u75c5\u53f2\u6216\u4efb\u4f55\u8bc1\u636e\u3002<\/span><\/span><\/p>\n

23  <\/span>\u5bf9\u7814\u7a76\u5e72\u9884\u548c<\/span>\/<\/span>\u6216\u5176\u4efb\u4f55\u8f85\u6599\u4e25\u91cd\u8fc7\u654f\u8005\uff08\u2265<\/span>3<\/span>\u7ea7\uff09\u3002<\/span><\/span><\/p>\n

24  <\/span>\u5728\u8fc7\u53bb<\/span>2<\/span>\u5e74\u5185\u60a3\u6709\u9700\u8981\u5168\u8eab\u6027\u6cbb\u7597\u7684\u6d3b\u52a8\u6027\u81ea\u8eab\u514d\u75ab\u75be\u75c5\uff08\u5373\uff0c\u514d\u75ab\u8c03\u8282\u836f\u7269\u3001\u76ae\u8d28\u6fc0\u7d20\u7c7b\u836f\u7269\u6216\u514d\u75ab\u6291\u5236\u6027\u836f\u7269\uff09\u3002\u66ff\u4ee3\u6cbb\u7597\uff08\u4f8b\u5982\uff0c\u7532\u72b6\u817a\u7d20\u3001\u80f0\u5c9b\u7d20\u6216\u56e0\u80be\u4e0a\u817a\u6216\u5782\u4f53\u529f\u80fd\u4e0d\u5168\u800c\u63a5\u53d7\u7684\u751f\u7406\u6027\u76ae\u8d28\u7c7b\u56fa\u9187\u66ff\u4ee3\u6cbb\u7597\uff09\u4e0d\u88ab\u89c6\u4f5c\u5168\u8eab\u6cbb\u7597\uff0c\u5141\u8bb8\u4f7f\u7528\u3002<\/span><\/span><\/p>\n

25  <\/span>\u6709\u9700\u8981\u7c7b\u56fa\u9187\u6cbb\u7597\u7684\uff08\u975e\u611f\u67d3\u6027\uff09\u80ba\u708e\u75c5\u53f2\u6216\u5f53\u524d\u60a3\u6709\u80ba\u708e\u3002<\/span><\/span><\/p>\n

26  <\/span>\u5c3f\u8bd5\u7eb8\u68c0\u6d4b\u86cb\u767d\u5c3f<\/span>>1+<\/span>\u7684\u53d7\u8bd5\u8005\u5c06\u63a5\u53d7<\/span>24<\/span>\u5c0f\u65f6\u5c3f\u6db2\u6536\u96c6\u4ee5\u5b9a\u91cf\u8bc4\u4f30\u86cb\u767d\u5c3f\u3002\u5c3f\u86cb\u767d\u2265<\/span>1g\/24 h<\/span>\u7684\u53d7\u8bd5\u8005\u4e0d\u7b26\u5408\u8d44\u683c\u3002<\/span><\/span><\/p>\n

27  <\/span>\u6821\u6b63<\/span>QT<\/span>\uff08<\/span>QTc<\/span>\uff09\u95f4\u671f\u5ef6\u957f<\/span>>480ms(Fridericia<\/span>\u516c\u5f0f\u6821\u6b63<\/span>)<\/span>\u3002<\/span><\/span><\/p>\n

28  <\/span>\u901a\u8fc7\u591a\u95e8\u63a7\u91c7\u96c6\u626b\u63cf\uff08<\/span>MUGA<\/span>\uff09\u6216\u8d85\u58f0\u5fc3\u52a8\u56fe\uff08<\/span>ECHO<\/span>\uff09\u6d4b\u5b9a\u7684\u5de6\u5fc3\u5ba4\u5c04\u8840\u5206\u6570\uff08<\/span>LVEF<\/span>\uff09\u4f4e\u4e8e\u673a\u6784\u6b63\u5e38\u8303\u56f4\u3002<\/span><\/span><\/p>\n

29  <\/span>\u60a3\u6709\u9700\u8981\u5168\u8eab\u6cbb\u7597\u7684\u6d3b\u52a8\u6027\u611f\u67d3\uff0c<\/span>HBV<\/span>\u3001<\/span>HCV<\/span>\u9664\u5916\u3002<\/span><\/span><\/p>\n

30  <\/span>\u5df2\u77e5\u6709\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08<\/span>HIV<\/span>\uff09\u611f\u67d3\u75c5\u53f2\u3002\u4e0d\u9700\u8981\u5f00\u5c55<\/span>HIV<\/span>\u68c0\u6d4b\uff0c\u9664\u975e\u5f53\u5730\u536b\u751f\u673a\u6784\u5f3a\u5236\u8981\u6c42\u3002<\/span><\/span><\/p>\n

31  <\/span>\u7814\u7a76\u5165\u7ec4\u65f6\u6709\u53cc\u91cd\u6d3b\u52a8\u6027<\/span>HBV<\/span>\u611f\u67d3\uff08<\/span>HBsAg<\/span>\uff08<\/span>+<\/span>\uff09\u548c<\/span>\/<\/span>\u6216\u53ef\u68c0\u6d4b\u7684<\/span>HBV DNA<\/span>\uff09\u548c<\/span>HCV<\/span>\u611f\u67d3\uff08\u6297<\/span>HCV Ab<\/span>\uff08<\/span>+<\/span>\uff09\u548c\u53ef\u68c0\u6d4b\u7684<\/span>HCV RNA<\/span>\uff09\u3002<\/span><\/span><\/p>\n

32  <\/span>\u7814\u7a76\u5165\u7ec4\u65f6\u6709\u53cc\u91cd\u6d3b\u52a8\u6027<\/span>HBV<\/span>\u611f\u67d3\u548c<\/span>HDV<\/span>\u611f\u67d3\u3002<\/span><\/span><\/p>\n

33  <\/span>\u6709\u6d3b\u52a8\u6027\u7ed3\u6838\uff08\u7ed3\u6838\u6746\u83cc<\/span>[Bacillustuberculosis]<\/span>\uff09\u75c5\u53f2\u3002<\/span><\/span><\/p>\n

34  <\/span>\u6709\u53ef\u80fd\u5e72\u6270\u8bd5\u9a8c\u7ed3\u679c\u3001\u59a8\u788d\u53d7\u8bd5\u8005\u5168\u7a0b\u53c2\u4e0e\u7814\u7a76\u7684\u75be\u75c5\u53f2\u6216\u75be\u75c5\u8bc1\u636e\u3001\u6cbb\u7597\u6216\u5b9e\u9a8c\u5ba4\u503c\u5f02\u5e38\uff0c\u6216\u7814\u7a76\u8005\u8ba4\u4e3a\u53c2\u52a0\u7814\u7a76\u4e0d\u7b26\u5408\u53d7\u8bd5\u8005\u7684\u6700\u5927\u5229\u76ca\u3002<\/span><\/span><\/p>\n

35  <\/span>\u5df2\u77e5\u7684\u7cbe\u795e\u75be\u75c5\u6216\u836f\u7269\u6ee5\u7528\u60c5\u51b5\u4f1a\u59a8\u788d\u53d7\u8bd5\u8005\u914d\u5408\u7814\u7a76\u8981\u6c42\u7684\u80fd\u529b\u3002<\/span><\/span><\/p>\n

36  <\/span>\u5728\u7814\u7a76\u671f\u95f4\u5373\u4ece\u7b5b\u9009\u8bbf\u89c6\u5f00\u59cb\u76f4\u81f3\u8bd5\u9a8c\u6cbb\u7597\u7684\u672b\u6b21\u7ed9\u836f\u540e<\/span>120<\/span>\u5929\u5185\uff0c\u6000\u5b55\u6216\u5904\u4e8e\u54fa\u4e73\u671f\uff0c\u6216\u8ba1\u5212\u6000\u5b55\u6216\u6210\u4e3a\u7236\u4eb2\u3002<\/span><\/span><\/p>\n

37  <\/span>\u63a5\u53d7\u8fc7\u540c\u79cd\u5f02\u4f53\u7ec4\u7ec7<\/span>\/<\/span>\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u7684\u53d7\u8bd5\u8005\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

6.       <\/span><\/span>\u533b\u9662\u548c\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u5e8f\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u673a\u6784\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u7814\u7a76\u8005 <\/span><\/p>\n<\/td>\n

\n

\u56fd\u5bb6 <\/span><\/p>\n<\/td>\n

\n

\u7701\uff08\u5dde\uff09 <\/span><\/p>\n<\/td>\n

\n

\u57ce\u5e02 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u4eba\u6c11\u89e3\u653e\u519b\u7b2c\u516b\u4e00\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u79e6\u53d4\u9035 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6c5f\u82cf <\/span><\/p>\n<\/td>\n

\n

\u5357\u4eac <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2 <\/span><\/p>\n<\/td>\n

\n

\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5b5f\u5fd7\u5f3a <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77 <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

3 <\/span><\/p>\n<\/td>\n

\n

\u56db\u5ddd\u5927\u5b66\u534e\u897f\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u738b\u8f9b <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u56db\u5ddd <\/span><\/p>\n<\/td>\n

\n

\u6210\u90fd <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

4 <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u90dd\u7eaf\u6bc5 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

5 <\/span><\/p>\n<\/td>\n

\n

\u54c8\u5c14\u6ee8\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u767d\u7389\u8d24 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u9ed1\u9f99\u6c5f <\/span><\/p>\n<\/td>\n

\n

\u54c8\u5c14\u6ee8 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

6 <\/span><\/p>\n<\/td>\n

\n

\u897f\u5b89\u4ea4\u901a\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u8096\u83ca\u9999 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u9655\u897f <\/span><\/p>\n<\/td>\n

\n

\u897f\u5b89 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

7 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u4eba\u6c11\u89e3\u653e\u519b\u8054\u52e4\u4fdd\u969c\u90e8\u961f\u7b2c\u4e5dOO\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u9648\u66e6 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u798f\u5efa <\/span><\/p>\n<\/td>\n

\n

\u798f\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

8 <\/span><\/p>\n<\/td>\n

\n

\u5e7f\u4e1c\u7701\u4eba\u6c11\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u9648\u6653\u660e <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5e7f\u4e1c <\/span><\/p>\n<\/td>\n

\n

\u5e7f\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

9 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u4e09\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u66f9\u57f9\u56fd <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6e56\u5357 <\/span><\/p>\n<\/td>\n

\n

\u957f\u6c99 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

10 <\/span><\/p>\n<\/td>\n

\n

\u6e56\u5357\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u8bb8\u82e5\u624d <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6e56\u5357 <\/span><\/p>\n<\/td>\n

\n

\u957f\u6c99 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

11 <\/span><\/p>\n<\/td>\n

\n

\u5b89\u5fbd\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u987e\u5eb7\u751f <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5b89\u5fbd <\/span><\/p>\n<\/td>\n

\n

\u5408\u80a5 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

12 <\/span><\/p>\n<\/td>\n

\n

\u590d\u65e6\u5927\u5b66\u4e2d\u5c71\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u4efb\u6b63\u521a <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77 <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

13 <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u65b9\u7ef4\u4f73 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f <\/span><\/p>\n<\/td>\n

\n

\u676d\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

14 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u4eba\u6c11\u89e3\u653e\u519b\u7b2c\u56db\u519b\u533b\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\uff08\u897f\u4eac\u533b\u9662\uff09 <\/span><\/p>\n<\/td>\n

\n

\u97e9\u56fd\u5b8f <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u9655\u897f <\/span><\/p>\n<\/td>\n

\n

\u897f\u5b89 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

15 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u8d75\u5b8f <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

16 <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5e94\u6770\u513f <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f <\/span><\/p>\n<\/td>\n

\n

\u676d\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

17 <\/span><\/p>\n<\/td>\n

\n

\u5357\u65b9\u533b\u79d1\u5927\u5b66\u5357\u65b9\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u90ed\u4e9a\u5175 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5e7f\u4e1c <\/span><\/p>\n<\/td>\n

\n

\u5e7f\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

18 <\/span><\/p>\n<\/td>\n

\n

\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u534f\u548c\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5f20\u6d9b <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6e56\u5317 <\/span><\/p>\n<\/td>\n

\n

\u6b66\u6c49 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

19 <\/span><\/p>\n<\/td>\n

\n

\u65b0\u7586\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u4e01\u4f1f <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u65b0\u7586 <\/span><\/p>\n<\/td>\n

\n

\u4e4c\u9c81\u6728\u9f50 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

20 <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u90b5\u9038\u592b\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u6f58\u5b8f\u94ed <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f <\/span><\/p>\n<\/td>\n

\n

\u676d\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n

\n
\n
\n
\u4e34\u5e8a\u8bd5\u9a8c\u62a5\u540d\u65b9\u5f0f<\/span><\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

<\/section>\n

\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\uff0c\u56de\u590d\u201c\u5165\u7ec4\u201d\u5373\u53ef<\/strong><\/span><\/span><\/p>\n

\u2193<\/strong>\u2193<\/strong>\u2193<\/strong>\u2193<\/strong><\/strong><\/span><\/span><\/p>\n

\"\u3010\u9ed8\u6c99\u4e1cPD-1\u62db\u52df\u809d\u764c\u3011\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u4ed1\u4f10\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\uff1a\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u3001III\u671f\u4e34\u5e8a\u7814\u7a76\"<\/p>\n


<\/p>\n

\"\u3010\u9ed8\u6c99\u4e1cPD-1\u62db\u52df\u809d\u764c\u3011\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u4ed1\u4f10\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\uff1a\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u3001III\u671f\u4e34\u5e8a\u7814\u7a76\"\u70b9\u51fb\u201c<\/span>\u9605\u8bfb\u539f\u6587<\/span>\u201d\u67e5\u770b\u8be6\u60c5<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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