{"id":88764,"date":"2019-04-19T00:00:50","date_gmt":"2019-04-23T04:03:35","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/88764\/"},"modified":"2019-04-23T12:03:36","modified_gmt":"2019-04-23T04:03:36","slug":"49ef2a38c8","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/88764\/","title":{"rendered":"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011D-0316\u5728EGFR\u7a81\u53d8\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c"},"content":{"rendered":"
\n

\u70b9\u51fb\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011D-0316\u5728EGFR\u7a81\u53d8\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\"<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/span>\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011D-0316\u5728EGFR\u7a81\u53d8\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\"<\/span><\/strong><\/strong><\/strong><\/strong><\/span><\/strong>\u9a6c\u4e0a\u5165\u7ec4\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/strong><\/span><\/p>\n

\u516c\u4f17\u53f7\uff1ashiyan589<\/span><\/p>\n

\n
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\u6297\u764c\u6307\u5357\u70b9\u51fb\u4e0b\u65b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u2193\u2193\u2193<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

<\/a><\/p>\n
<\/a><\/p>\n
\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011D-0316\u5728EGFR\u7a81\u53d8\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\"<\/a><\/section>\n<\/section>\n<\/section>\n
<\/a><\/p>\n
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\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011D-0316\u5728EGFR\u7a81\u53d8\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\"<\/a><\/section>\n<\/section>\n<\/section>\n
<\/a><\/p>\n
<\/a><\/p>\n

\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011D-0316\u5728EGFR\u7a81\u53d8\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\"<\/a><\/p>\n<\/section>\n

\n
\n

\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011D-0316\u5728EGFR\u7a81\u53d8\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\"<\/a><\/p>\n<\/section>\n

\u5165\u7ec4\u62a5\u540d\u65b9\u5f0f\u89c1\u6587\u672b<\/span><\/strong><\/p>\n

\u2193<\/span><\/strong>\u2193<\/span><\/strong>\u2193<\/span><\/strong>\u2193<\/span><\/strong><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n


<\/p>\n

<\/section>\n

1.       <\/span><\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/span>
<\/p>\n

D-0316<\/span>\u662f\u7b2c\u4e09\u4ee3<\/span>EGFR<\/span>\u6291\u5236\u5242\u3002<\/span><\/span><\/p>\n

\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f<\/span>\u65e2\u5f80\u4e34\u5e8a\u4f7f\u7528\u4e00\u4ee3\u6216\u4e8c\u4ee3<\/span>EGFR-TKI\u8010\u836f\u540e\u4ea7\u751f<\/span>T790M\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/span>\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

2.       <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u89c2\u5bdf\u53e3\u670dD-0316\u5728\u65e2\u5f80\u4e34\u5e8a\u4f7f\u7528\u4e00\u4ee3\u6216\u4e8c\u4ee3EGFR-TKI\u8010\u836f\u540e\u4ea7\u751fT790M\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u6574\u4f53\u7597\u6548\u3001\u5b89\u5168\u6027\u3001\u9885\u5185\u7597\u6548\u548c\u5065\u5eb7\u76f8\u5173\u7684\u751f\u6d3b\u8d28\u91cf\u3002<\/span><\/p>\n

 <\/span><\/p>\n

3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

 \u8bd5\u9a8c\u5206\u7c7b\uff1a<\/span>\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span>    <\/span><\/p>\n

   <\/span>\u8bd5\u9a8c\u5206\u671f\uff1a<\/span> II<\/span>\u671f<\/span><\/span><\/p>\n

  <\/span>\u8bbe\u8ba1\u7c7b\u578b\uff1a\u5355\u81c2\u8bd5\u9a8c<\/span><\/span><\/p>\n

 \u968f\u673a\u5316\uff1a<\/span>   <\/span>\u975e\u968f\u673a\u5316<\/span><\/span><\/p>\n

   <\/span>\u76f2\u6cd5\uff1a<\/span>     <\/span>\u5f00\u653e<\/span><\/span><\/p>\n

  <\/span>\u8bd5\u9a8c\u8303\u56f4\uff1a\u56fd\u5185\u8bd5\u9a8c<\/span><\/span><\/p>\n

  <\/span>\u8bd5\u9a8c\u4eba\u6570\uff1a<\/span> 300<\/span><\/span>\u4eba<\/span><\/span><\/p>\n

 <\/span><\/p>\n

4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n

1.<\/span>\u81ea\u613f\u7b7e\u7f72\u4e66\u9762\u77e5\u60c5\u540c\u610f\u4e66\uff0c\u80fd\u591f\u7406\u89e3\u548c\u9075\u5b88\u8bd5\u9a8c\u65b9\u6848\u8981\u6c42\u3002<\/span><\/span><\/p>\n

2.<\/span>\u5e74\u9f84\u2265<\/span>18<\/span>\u5468\u5c81\u3002<\/span><\/span><\/p>\n

3.<\/span>\u7ec4\u7ec7\u6216\u7ec6\u80de\u75c5\u7406\u5b66\u786e\u8bca\u7684\u5c40\u90e8\u665a\u671f\uff08<\/span>AJCC<\/span>\u7b2c<\/span>8<\/span>\u7248<\/span>IIIB<\/span>\u671f\u548c<\/span>IIIC<\/span>\uff09\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08<\/span>AJCC<\/span>\u7b2c<\/span>8<\/span>\u7248<\/span>IV<\/span>\u671f\uff09\uff0c\u4e14\u4e0d\u9002\u5408\u6839\u6cbb\u6027\u624b\u672f\u6216\u653e\u7597\u3002<\/span><\/span><\/p>\n

4.<\/span>\u5728\u65e2\u5f80\u4f7f\u7528\u4e00\u4ee3\u6216\u4e8c\u4ee3<\/span>EGFR-TKI<\/span>\uff08\u4f8b\u5982\uff1a\u5409\u975e\u66ff\u5c3c\u3001\u5384\u6d1b\u66ff\u5c3c\u7b49\uff09\u6cbb\u7597\u671f\u95f4\u6216\u6cbb\u7597\u540e\uff0c\u5f71\u50cf\u5b66\u786e\u8ba4\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u3002<\/span><\/span><\/p>\n

5.<\/span>\u83b7\u53d6\u672b\u6b21<\/span>EGFR-TKI<\/span>\u6cbb\u7597\u75be\u75c5\u8fdb\u5c55\u540e\u7684\u7ec4\u7ec7\uff0c\u7ecf\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u68c0\u6d4b<\/span>EGFR T790M<\/span>\u7a81\u53d8\u7684\u60a3\u8005\u3002\u5982\u65e0\u6cd5\u83b7\u5f97\u7ec4\u7ec7\uff0c\u53ef\u91c7\u7528\u8840\u6db2\u68c0\u6d4b\u3002<\/span><\/span><\/p>\n

6.ECOG<\/span>\u8bc4\u5206<\/span>0~1<\/span>\u5206\u3002<\/span><\/span><\/p>\n

7.<\/span>\u9884\u8ba1\u751f\u5b58\u671f\u4e0d\u5c11\u4e8e<\/span>12<\/span>\u5468\u3002<\/span><\/span><\/p>\n

8.<\/span>\u6839\u636e<\/span>RECIST 1.1<\/span>\uff0c\u7ecf\u5f71\u50cf\u5b66\u8bca\u65ad\u7b5b\u9009\u671f\u5b58\u5728\u81f3\u5c11\u4e00\u4e2a\u672a\u63a5\u53d7\u653e\u7597\u7684\u53ef\u6d4b\u91cf\u75c5\u7076\u3002<\/span><\/span><\/p>\n

9.<\/span>\u540c\u610f\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e<\/span>6<\/span>\u5468\u5185\u91c7\u7528\u5e38\u89c4\u8db3\u591f\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd\u3010\u5bf9\u4e8e\u5973\u6027\uff1a<\/span>1.<\/span>\u53e3\u670d\u3001\u6ce8\u5c04\u907f\u5b55\u836f\u6216\u690d\u5165\u6fc0\u7d20\u907f\u5b55\u6cd5\uff1b<\/span>2.<\/span>\u5bab\u5185\u8282\u80b2\u5668\u6216\u5bab\u5185\u8282\u80b2\u7cfb\u7edf\uff1b<\/span>3.<\/span>\u5c4f\u969c\u907f\u5b55\u6cd5\uff1a\u6709\u6740\u7cbe\u4f5c\u7528\u7684\u907f\u5b55\u5957\u6216\u963b\u585e\u5e3d\uff08\u9694\u819c\u6216\u5bab\u9888<\/span>\/<\/span>\u7a79\u9686\u5e3d\uff09\u3002\u5bf9\u4e8e\u7537\u6027\uff1a<\/span>1.<\/span>\u6709\u6740\u7cbe\u4f5c\u7528\u7684\u907f\u5b55\u5957\uff1b<\/span>2.<\/span>\u624b\u672f\u7edd\u80b2\uff08\u5982\uff1a\u53cc\u4fa7\u777e\u4e38\u5207\u9664\u3001\u53cc\u4fa7\u8f93\u7cbe\u7ba1\u5207\u9664\uff09\u3011\uff1b\u7edd\u7ecf\u524d\u6709\u751f\u80b2\u53ef\u80fd\u7684\uff08\u6ee1\u8db3\u4e0b\u8ff0\u6761\u4ef6\u8ba4\u4e3a\u6709\u7edd\u7ecf\u524d\u751f\u80b2\u53ef\u80fd\uff1a<\/span>1.<\/span>\u672a\u884c\u53cc\u4fa7\u8f93\u5375\u7ba1\u7ed3\u624e\u3001\u5b50\u5bab\u5207\u9664\u3001\u53cc\u4fa7\u5375\u5de2\u5207\u9664\uff1b<\/span>2.<\/span>\u672b\u6b21\u6708\u7ecf\u81f3\u7b5b\u9009\u65f6\uff1c<\/span>2<\/span>\u5e74\uff09\u5973\u6027\u60a3\u8005\u9700\u6392\u9664\u598a\u5a20\uff08\u5373\u598a\u5a20\u8bd5\u9a8c\u9634\u6027\uff09\uff1b\u4e14\u5904\u4e8e\u975e\u54fa\u4e73\u671f\u3002<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n

1.<\/span>\u5408\u5e76\u5176\u4ed6\u6076\u6027\u80bf\u7624\uff08\u4e34\u5e8a\u6cbb\u6108\u7684\u5bab\u9888\u539f\u4f4d\u764c\u3001\u57fa\u5e95\u7ec6\u80de\u6216\u9cde\u72b6\u4e0a\u76ae\u7ec6\u80de\u76ae\u80a4\u764c\u3001\u7532\u72b6\u817a\u4e73\u5934\u72b6\u764c\u9664\u5916\uff09\u3002<\/span><\/span><\/p>\n

2. <\/span>\u7814\u7a76\u836f\u7269\u6cbb\u7597\u524d<\/span>7<\/span>\u5929\u5185\u4f7f\u7528\u4e86\u7b2c\u4e00\u4ee3\u6216\u8005\u7b2c\u4e8c\u4ee3<\/span>EGFR-TKI<\/span>\u6cbb\u7597\uff08\u4f8b\u5982\uff1a\u5409\u975e\u66ff\u5c3c\u3001\u5384\u6d1b\u66ff\u5c3c\uff09\uff1b\u66fe\u4f7f\u7528\u7b2c<\/span>3<\/span>\u4ee3<\/span>EGFR-TKI<\/span>\uff08\u5982<\/span>AZD9291<\/span>\u3001\u827e\u7ef4\u66ff\u5c3c\u548c\u827e\u6c1f\u66ff\u5c3c\u7b49\uff09\u3002<\/span><\/span><\/p>\n

3. <\/span>\u5728\u9996\u6b21\u7ed9\u836f\u4e4b\u524d<\/span>4<\/span>\u5468\u5185\u8fdb\u884c\u4e86\u5316\u7597\u6216\u514d\u75ab\u6cbb\u7597\uff1b\u5728\u9996\u6b21\u7ed9\u836f\u524d<\/span>2<\/span>\u5468\u5185\u63a5\u53d7\u4e86\u653e\u5c04\u6cbb\u7597\u3002\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u4ee5\u53ca\u4e0a\u7cfb\u7edf\u6027\u5316\u7597\u6216\u514d\u75ab\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

4. <\/span>\u7814\u7a76\u836f\u7269\u6cbb\u7597\u524d<\/span>28<\/span>\u5929\u5185\u63a5\u53d7\u8fc7\u5916\u79d1\u624b\u672f\u8005\uff0c\u4f46\u7814\u7a76\u8005\u5224\u65ad\u4e0d\u5f71\u54cd\u53c2\u52a0\u8bd5\u9a8c\u7684\u5c0f\u624b\u672f\uff08\u4f8b\u5982\uff1a\u62d4\u7259\u7b49\uff09\u9664\u5916\uff1b\u6216\u5728\u7814\u7a76\u671f\u95f4\u8ba1\u5212\u8fdb\u884c\u5927\u624b\u672f\u7684\u60a3\u8005\u3002<\/span><\/span><\/p>\n

5. <\/span>\u7b5b\u9009\u524d<\/span>2<\/span>\u5468\u5185\u51fa\u73b0\u75c7\u72b6\u6216\u4f53\u5f81\u660e\u663e\u6076\u5316\uff08\u5982\u7b5b\u9009\u524d<\/span>2<\/span>\u5468\u5185\u51fa\u73b0\u5927\u91cf\u80f8\u6c34\uff0c\u63a7\u5236\u80f8\u6c34\u540e\u53ef\u8003\u8651\u7b5b\u9009\uff09\uff0c\u7814\u7a76\u8005\u5224\u65ad\u4e0d\u9002\u5408\u53c2\u52a0\u8bd5\u9a8c\u3002<\/span><\/span><\/p>\n

6. <\/span>\u65e2\u5f80\u6cbb\u7597\u540e\u7684\u6bd2\u6027\u53cd\u5e94\u672a\u6062\u590d\uff0c\u8bd5\u9a8c\u836f\u7269\u7ed9\u836f\u524d\u6839\u636e<\/span>CTCAE v4.03<\/span>\u5224\u65ad\u4e3a<\/span>2<\/span>\u7ea7\u6216<\/span>2<\/span>\u7ea7\u4ee5\u4e0a\uff0c\u5176\u4e2d\u8131\u53d1\u9664\u5916\u3002<\/span><\/span><\/p>\n

7. <\/span>\u5b58\u5728\u810a\u9ad3\u538b\u8feb\uff0c\u6216\u6709\u75c7\u72b6\u4e14\u5165\u7ec4\u524d<\/span>4<\/span>\u5468\u9700\u8981\u7c7b\u56fa\u9187\u6cbb\u7597\u7684\u4e0d\u7a33\u5b9a\u8111\u8f6c\u79fb\u3002\u8111\u8f6c\u79fb\u65e0\u75c7\u72b6\u6216\u7ecf\u6cbb\u7597\u540e\u7a33\u5b9a<\/span>4<\/span>\u5468\u4ee5\u4e0a\u4e14\u4e0d\u9700\u8981\u7c7b\u56fa\u9187\u6cbb\u7597\u7684\u60a3\u8005\u53ef\u4ee5\u5165\u7ec4\u3002<\/span><\/span><\/p>\n

8. <\/span>\u4efb\u4f55\u4e34\u5e8a\u8bc1\u636e\u8868\u660e\u60a3\u6709\u91cd\u5ea6\u6216\u672a\u63a7\u5236\u7684\u75be\u75c5\uff0c\u7814\u7a76\u8005\u8ba4\u4e3a\u4e0d\u9002\u5408\u53c2\u52a0\u672c\u4e34\u5e8a\u8bd5\u9a8c\u6216\u4f1a\u5f71\u54cd\u60a3\u8005\u5bf9\u7814\u7a76\u65b9\u6848\u4f9d\u4ece\u6027\u7684\u60c5\u51b5\uff0c\u4f8b\u5982\u7ecf\u836f\u7269\u6cbb\u7597\u540e\u4ecd\u4e0d\u80fd\u63a7\u5236\u7684\u9ad8\u8840\u538b\u60a3\u8005\uff08<\/span>SBP>160mmHg<\/span>\u6216<\/span>DBP>100mmHg<\/span>\uff09\u3001\u6d3b\u52a8\u6027\u6613\u51fa\u8840\u4f53\u8d28\u60a3\u8005\u3001\u6d3b\u52a8\u6027\u611f\u67d3\u60a3\u8005\uff08\u5982\u4e59\u578b\u809d\u708e\u3001\u4e19\u578b\u809d\u708e\u3001<\/span>HIV-1\/2<\/span>\u6297\u4f53\u9633\u6027\u3001\u6885\u6bd2\u87ba\u65cb\u4f53\u6297\u4f53\u9633\u6027\uff08\u6ef4\u5ea6\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9634\u6027\u8005\u9664\u5916\uff09\uff09\u3002\u6d3b\u52a8\u6027\u4e59\u578b\u809d\u708e\u5b9a\u4e49\u4e3a\u4e59\u809d\u6838\u5fc3\u6297\u4f53<\/span>(HBcAb)<\/span>\u6216\u4e59\u809d\u8868\u9762\u6297\u539f\uff08<\/span>HBsAg<\/span>\uff09\u9633\u6027\uff0c\u4e14<\/span>HBV DNA <\/span>\u2265<\/span> 2000 IU\/ml<\/span>\uff08\u76f8\u5f53\u4e8e<\/span>104<\/span>\u62f7\u8d1d<\/span>\/ml<\/span>\uff09\u3002\u6d3b\u52a8\u6027\u4e19\u578b\u809d\u708e\u5b9a\u4e49\u4e3a<\/span>HCV RNA<\/span>\u9ad8\u4e8e\u68c0\u6d4b\u4e0b\u9650\u3002<\/span><\/span><\/p>\n

9. <\/span>\u5728\u9759\u606f\u72b6\u6001\u4e0b\uff0c\u7b5b\u9009\u671f\u5fc3\u7535\u56fe\u6821\u6b63\u7684<\/span>QT<\/span>\u95f4\u671f\uff08<\/span>QTcF<\/span>\uff09\u7ed3\u679c\u5f02\u5e38\u8005\uff0c\u6bcf\u6b21\u81f3\u5c11\u95f4\u9694<\/span>4<\/span>\u5c0f\u65f6\uff0c\u590d\u6d4b<\/span>2<\/span>\u6b21\uff0c<\/span>3<\/span>\u6b21\u5fc3\u7535\u56fe\u68c0\u67e5\u7684\u5e73\u5747<\/span>QTcF>470 msec<\/span>\u3002<\/span><\/span><\/p>\n

10. <\/span>\u5404\u79cd\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5fc3\u5f8b\u3001\u4f20\u5bfc\u3001\u9759\u606f<\/span>ECG<\/span>\u5f62\u6001\u5f02\u5e38\uff0c\u4f8b\u5982\u5b8c\u5168\u6027\u5de6\u675f\u652f\u4f20\u5bfc\u963b\u6ede\u3001<\/span>III<\/span>\u5ea6\u4f20\u5bfc\u963b\u6ede\u3001<\/span>II<\/span>\u5ea6\u4f20\u5bfc\u963b\u6ede\u3001<\/span>PR<\/span>\u95f4\u671f<\/span>>250msec<\/span>\u3002<\/span><\/span><\/p>\n

11. <\/span>\u5b58\u5728\u589e\u52a0<\/span>QTc<\/span>\u5ef6\u957f\u98ce\u9669\u6216\u5fc3\u5f8b\u5931\u5e38\u4e8b\u4ef6\u98ce\u9669\u7684\u5404\u79cd\u56e0\u7d20\uff0c\u4f8b\u5982\u5fc3\u529b\u8870\u7aed\u3001\u4f4e\u94be\u8840\u75c7\u3001\u5148\u5929\u6027\u957f<\/span>QT<\/span>\u7efc\u5408\u75c7\u3001\u5bb6\u65cf\u53f2\u4e2d\u4e00\u7ea7\u4eb2\u5c5e\u6709\u957f<\/span>QT<\/span>\u7efc\u5408\u5f81\u6216\u4e0d\u5230<\/span>40<\/span>\u5c81\u5c31\u4e0d\u660e\u539f\u56e0\u731d\u6b7b\uff1b\u8bd5\u9a8c\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>1<\/span>\u5468\u6b63\u5728\u4f7f\u7528\u6216\u7814\u7a76\u671f\u95f4\u9700\u8981\u5408\u5e76\u4f7f\u7528\u5df2\u77e5\u6216\u53ef\u80fd\u8bf1\u5bfc<\/span>QT<\/span>\u95f4\u671f\u5ef6\u957f\u548c<\/span>\/<\/span>\u6216\u5c16\u7aef\u626d\u8f6c\u578b\u5ba4\u6027\u5fc3\u52a8\u8fc7\u901f\u98ce\u9669\u7684\u836f\u7269\u3002<\/span><\/span><\/p>\n

12. <\/span>\u4e25\u91cd\u547c\u5438\u7cfb\u7edf\u75be\u75c5\uff0c\u5982\u95f4\u8d28\u6027\u80ba\u75be\u75c5\u3001\u91cd\u5ea6\u54ee\u5598\u3001\u80ba\u6813\u585e\u7b49\u3002<\/span><\/span><\/p>\n

13. <\/span>\u4efb\u4f55\u5f71\u54cd\u60a3\u8005\u541e\u670d\u836f\u7269\u6216\u53e3\u670d\u5438\u6536\u969c\u788d\u7684\u60c5\u51b5\uff0c\u4f8b\u5982\uff1a\u4e25\u91cd\u6162\u6027\u80c3\u80a0\u9053\u75be\u75c5\u3001\u63a5\u53d7\u8fc7\u80c3\u80a0\u9053\u624b\u672f\u3001\u96be\u6cbb\u6027\u6076\u5fc3\u6216\u5455\u5410\u75c7\u72b6\u7b49\u3002<\/span><\/span><\/p>\n

14. <\/span>\u51fa\u73b0\u4ee5\u4e0b\u4efb\u4f55\u4e00\u9879\u5b9e\u9a8c\u5ba4\u6307\u6807\u5f02\u5e38\uff1a\u7edd\u5bf9\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\uff08<\/span>ANC<\/span>\uff09\uff1c<\/span>1.5<\/span>\u00d7<\/span>109\/L<\/span>\uff1b<\/span>    <\/span>\u8840\u5c0f\u677f\u8ba1\u6570\uff08<\/span>PLT<\/span>\uff09\uff1c<\/span>100<\/span>\u00d7<\/span>109\/L<\/span>\uff1b\u8840\u7ea2\u86cb\u767d\uff08<\/span>Hb<\/span>\uff09\uff1c<\/span>90g\/L<\/span>\uff1b\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u6c28\u9176\uff08<\/span>ALT<\/span>\uff09\u6216\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u6c28\u9176\uff08<\/span>AST<\/span>\uff09\uff1e<\/span>2.5<\/span>\u500d\u6b63\u5e38\u503c\u4e0a\u9650\uff08<\/span>ULN<\/span>\uff09\uff0c\u6216\u809d\u8f6c\u79fb\u65f6<\/span>ALT<\/span>\u6216<\/span>AST<\/span>\uff1e<\/span>5<\/span>\u500d<\/span>ULN<\/span>\uff1b<\/span>    <\/span>\u603b\u80c6\u7ea2\u7d20\uff1e<\/span>1.5<\/span>\u500d<\/span>ULN<\/span>\uff0c\u6216\u809d\u8f6c\u79fb\u65f6\uff1e<\/span>3<\/span>\u500d<\/span>ULN<\/span>\uff1b<\/span>   <\/span>\u8840\u6e05\u808c\u809d\uff08<\/span>SCr<\/span>\uff09\uff1e<\/span>1.5<\/span>\u500d<\/span>ULN<\/span>\u6216\u808c\u9150\u6e05\u9664\u7387\uff1c<\/span>50ml\/min<\/span>\uff08\u6839\u636e<\/span>Cockcroft-Gault<\/span>\u516c\u5f0f\u8ba1\u7b97\uff09\u3002<\/span><\/span><\/p>\n

15. <\/span>\u5bf9\u7814\u7a76\u836f\u7269\u53ca\u5176\u5236\u5242\u7684\u4efb\u4f55\u6210\u5206\u6709\u8fc7\u654f\u53f2\u6216\u7591\u4f3c\u8fc7\u654f\u75c7\u72b6\u3002<\/span><\/span><\/p>\n

16. <\/span>\u8bd5\u9a8c\u836f\u7269\u9996\u6b21\u7ed9\u836f\u524d<\/span>1<\/span>\u5468\u5185\u6b63\u5728\u4f7f\u7528\u6216\u7814\u7a76\u671f\u95f4\u9700\u8981\u4f7f\u7528<\/span>CYP3A4<\/span>\u3001<\/span>CYP3A5<\/span>\u3001<\/span>CYP2D6<\/span>\u548c<\/span>CYP2C8<\/span>\u5f3a\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u3002<\/span><\/span><\/p>\n

17. <\/span>\u6700\u8fd1\u4e00\u6b21\u53c2\u52a0\u5176\u4ed6\u836f\u7269\u6216\u533b\u7597\u5668\u68b0\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9996\u6b21\u7ed9\u836f\u524d\u672b\u6b21\u6cbb\u7597\u5c11\u4e8e<\/span>4<\/span>\u5468\uff0c\u6216\u8ba1\u5212\u5728\u672c\u7814\u7a76\u671f\u95f4\u53c2\u4e0e\u4efb\u4f55\u5176\u4ed6\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/span><\/p>\n

18. <\/span>\u7531\u7814\u7a76\u8005\u5224\u65ad\u7684\u4e0d\u9002\u5408\u8fdb\u5165\u672c\u7814\u7a76\u7684\u5176\u4ed6\u60c5\u51b5\u3002<\/span><\/span><\/p>\n

6.       <\/span><\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u5e8f\u53f7<\/span><\/p>\n<\/td>\n

\n

\u673a\u6784\u540d\u79f0<\/span><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u7814\u7a76\u8005<\/span><\/p>\n<\/td>\n

\n

\u56fd\u5bb6<\/span><\/p>\n<\/td>\n

\n

\u7701\uff08\u5dde\uff09<\/span><\/p>\n<\/td>\n

\n

\u57ce\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1<\/strong><\/span><\/p>\n<\/td>\n

\n
\u4e0a\u6d77\u5e02\u80f8\u79d1\u533b\u9662\uff08\u80bf\u7624\u5185\u79d1\uff09<\/span><\/section>\n<\/td>\n
\n
\u9646\u821c<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u4e0a\u6d77<\/span><\/section>\n<\/td>\n
\n
\u4e0a\u6d77<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

2<\/strong><\/span><\/p>\n<\/td>\n

\n
\u4e0a\u6d77\u5e02\u80f8\u79d1\u533b\u9662\uff08\u547c\u5438\u5185\u79d1\uff09<\/span><\/section>\n<\/td>\n
\n
\u59dc\u4e3d\u5ca9<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u4e0a\u6d77<\/span><\/section>\n<\/td>\n
\n
\u4e0a\u6d77<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

3<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5b89\u5fbd\u7701\u7acb\u533b\u9662\uff08\u547c\u5438\u79d1\uff09<\/span><\/section>\n<\/td>\n
\n
\u64cd\u4e50\u6770<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5b89\u5fbd<\/span><\/section>\n<\/td>\n
\n
\u5408\u80a5<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

4<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5b89\u5fbd\u7701\u7acb\u533b\u9662\uff08\u80bf\u7624\u5316\u7597\u79d1\uff09<\/span><\/section>\n<\/td>\n
\n
\u6f58\u8dc3\u94f6<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5b89\u5fbd<\/span><\/section>\n<\/td>\n
\n
\u5408\u80a5<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

5<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5409\u6797\u7701\u80bf\u7624\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u7a0b\u9896<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5409\u6797<\/span><\/section>\n<\/td>\n
\n
\u957f\u6625<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

6<\/strong><\/span><\/p>\n<\/td>\n

\n
\u70df\u53f0\u6bd3\u749c\u9876\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5b59\u840d<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5c71\u4e1c<\/span><\/section>\n<\/td>\n
\n
\u70df\u53f0<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

7<\/strong><\/span><\/p>\n<\/td>\n

\n
\u4e91\u5357\u7701\u80bf\u7624\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u9ec4\u4e91\u8d85<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u4e91\u5357<\/span><\/section>\n<\/td>\n
\n
\u6606\u660e<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

8<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5409\u6797\u5927\u5b66\u7b2c\u4e00\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5d14\u4e45\u5d6c<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5409\u6797<\/span><\/section>\n<\/td>\n
\n
\u957f\u6625<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

9<\/strong><\/span><\/p>\n<\/td>\n

\n
\u9996\u90fd\u533b\u79d1\u5927\u5b66\u5ba3\u6b66\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u652f\u4fee\u76ca<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5317\u4eac<\/span><\/section>\n<\/td>\n
\n
\u5317\u4eac<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

10<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5317\u4eac\u80bf\u7624\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u65b9\u5065<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5317\u4eac<\/span><\/section>\n<\/td>\n
\n
\u5317\u4eac<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

11<\/strong><\/span><\/p>\n<\/td>\n

\n
\u6d59\u6c5f\u7701\u53f0\u5dde\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5415\u51ac\u9752<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6d59\u6c5f<\/span><\/section>\n<\/td>\n
\n
\u53f0\u5dde<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

12<\/strong><\/span><\/p>\n<\/td>\n

\n
\u4e2d\u56fd\u4eba\u6c11\u89e3\u653e\u519b\u603b\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u9648\u826f\u5b89<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5317\u4eac<\/span><\/section>\n<\/td>\n
\n
\u5317\u4eac<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

13<\/strong><\/span><\/p>\n<\/td>\n

\n
\u54c8\u5c14\u6ee8\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u9648\u516c\u7430<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u9ed1\u9f99\u6c5f<\/span><\/section>\n<\/td>\n
\n
\u54c8\u5c14\u6ee8<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

14<\/strong><\/span><\/p>\n<\/td>\n

\n
\u56db\u5ddd\u5927\u5b66\u534e\u897f\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u7530\u6500\u6587<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u56db\u5ddd<\/span><\/section>\n<\/td>\n
\n
\u6210\u90fd<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

15<\/strong><\/span><\/p>\n<\/td>\n

\n
\u798f\u5efa\u7701\u80bf\u7624\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5e84\u6b66<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u798f\u5efa<\/span><\/section>\n<\/td>\n
\n
\u798f\u5dde<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

16<\/strong><\/span><\/p>\n<\/td>\n

\n
\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u738b\u51ef<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6d59\u6c5f<\/span><\/section>\n<\/td>\n
\n
\u676d\u5dde<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

17<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5929\u6d25\u533b\u79d1\u5927\u5b66\u603b\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u9648\u519b<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5929\u6d25<\/span><\/section>\n<\/td>\n
\n
\u5929\u6d25<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

18<\/strong><\/span><\/p>\n<\/td>\n

\n
\u6cb3\u5357\u7701\u4eba\u6c11\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u4ed3\u987a\u4e1c<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6cb3\u5357<\/span><\/section>\n<\/td>\n
\n
\u90d1\u5dde<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

19<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5b81\u590f\u533b\u79d1\u5927\u5b66\u603b\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u91d1\u5411\u660e<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5b81\u590f<\/span><\/section>\n<\/td>\n
\n
\u94f6\u5ddd<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

20<\/strong><\/span><\/p>\n<\/td>\n

\n
\u90d1\u5dde\u5e02\u7b2c\u4e00\u4eba\u6c11\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u90ac\u5fb7\u4e1c<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6cb3\u5357<\/span><\/section>\n<\/td>\n
\n
\u90d1\u5dde<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

21<\/strong><\/span><\/p>\n<\/td>\n

\n
\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u4e09\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u66f9\u57f9\u56fd<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6e56\u5357<\/span><\/section>\n<\/td>\n
\n
\u957f\u6c99<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

22<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5510\u5c71\u5e02\u4eba\u6c11\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u6768\u4fca\u6cc9<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6cb3\u5317<\/span><\/section>\n<\/td>\n
\n
\u5510\u5c71<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

23<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5b89\u5fbd\u533b\u79d1\u5927\u5b66\u7b2c\u4e8c\u9644\u5c5e\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u8d75\u5349<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5b89\u5fbd<\/span><\/section>\n<\/td>\n
\n
\u5408\u80a5<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

24<\/strong><\/span><\/p>\n<\/td>\n

\n
\u6e29\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u674e\u7389\u82f9<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6d59\u6c5f<\/span><\/section>\n<\/td>\n
\n
\u6e29\u5dde<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

25<\/strong><\/span><\/p>\n<\/td>\n

\n
\u6cb3\u5317\u5927\u5b66\u9644\u5c5e\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u81e7\u7231\u6c11<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6cb3\u5317<\/span><\/section>\n<\/td>\n
\n
\u4fdd\u5b9a<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

26<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5b89\u5fbd\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5b59\u56fd\u5e73<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5b89\u5fbd<\/span><\/section>\n<\/td>\n
\n
\u5408\u80a5<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

27<\/strong><\/span><\/p>\n<\/td>\n

\n
\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u534f\u548c\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u4f0d\u94a2<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6e56\u5317<\/span><\/section>\n<\/td>\n
\n
\u6b66\u6c49<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

28<\/strong><\/span><\/p>\n<\/td>\n

\n
\u8944\u9633\u5e02\u4e2d\u5fc3\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u6613\u94c1\u7537<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6e56\u5317<\/span><\/section>\n<\/td>\n
\n
\u8944\u9633<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

29<\/strong><\/span><\/p>\n<\/td>\n

\n
\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\u91d1\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u9ad8\u84d3\u8389<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u4e0a\u6d77<\/span><\/section>\n<\/td>\n
\n
\u4e0a\u6d77<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

30<\/strong><\/span><\/p>\n<\/td>\n

\n
\u4e0a\u6d77\u5e02\u7b2c\u4e00\u4eba\u6c11\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5f20\u65fb<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u4e0a\u6d77<\/span><\/section>\n<\/td>\n
\n
\u4e0a\u6d77<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

31<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5e7f\u897f\u58ee\u65cf\u81ea\u6cbb\u533a\u80bf\u7624\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u4e8e\u8d77\u6d9b<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5e7f\u897f<\/span><\/section>\n<\/td>\n
\n
\u5357\u5b81<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

32<\/strong><\/span><\/p>\n<\/td>\n

\n
\u90d1\u5dde\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5f20\u56ef\u4fca<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6cb3\u5357<\/span><\/section>\n<\/td>\n
\n
\u90d1\u5dde<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

33<\/strong><\/span><\/p>\n<\/td>\n

\n
\u9752\u5c9b\u5e02\u4e2d\u5fc3\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u9a6c\u5b66\u771f<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5c71\u4e1c<\/span><\/section>\n<\/td>\n
\n
\u9752\u5c9b<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

34<\/strong><\/span><\/p>\n<\/td>\n

\n
\u9752\u5c9b\u5927\u5b66\u9644\u5c5e\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u4e8e\u58ee<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5c71\u4e1c<\/span><\/section>\n<\/td>\n
\n
\u9752\u5c9b<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

35<\/strong><\/span><\/p>\n<\/td>\n

\n
\u91cd\u5e86\u5e02\u80bf\u7624\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u738b\u4e1c\u6797<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u91cd\u5e86<\/span><\/section>\n<\/td>\n
\n
\u91cd\u5e86<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

36<\/strong><\/span><\/p>\n<\/td>\n

\n
\u6c5f\u82cf\u7701\u4eba\u6c11\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u90ed\u4eba\u82b1<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6c5f\u82cf<\/span><\/section>\n<\/td>\n
\n
\u5357\u4eac<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

37<\/strong><\/span><\/p>\n<\/td>\n

\n
\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u80f8\u79d1\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5218\u5586<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5317\u4eac<\/span><\/section>\n<\/td>\n
\n
\u5317\u4eac<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

38<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5185\u8499\u53e4\u81ea\u6cbb\u533a\u4eba\u6c11\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u674e\u6587\u65b0<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5185\u8499\u53e4<\/span><\/section>\n<\/td>\n
\n
\u547c\u548c\u6d69\u7279<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

39<\/strong><\/span><\/p>\n<\/td>\n

\n
\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u7b2c\u56db\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u4e01\u7fe0\u654f<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6cb3\u5317<\/span><\/section>\n<\/td>\n
\n
\u77f3\u5bb6\u5e84<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

40<\/strong><\/span><\/p>\n<\/td>\n

\n
\u6cb3\u5317\u7701\u80f8\u79d1\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u8d75\u654f<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6cb3\u5317<\/span><\/section>\n<\/td>\n
\n
\u77f3\u5bb6\u5e84<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

41<\/strong><\/span><\/p>\n<\/td>\n

\n
\u8fbd\u5b81\u7701\u80bf\u7624\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u674e\u6653\u73b2<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u8fbd\u5b81<\/span><\/section>\n<\/td>\n
\n
\u6c88\u9633<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

42<\/strong><\/span><\/p>\n<\/td>\n

\n
\u4e1c\u839e\u5e02\u4eba\u6c11\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u6c5f\u51a0\u94ed<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5e7f\u4e1c<\/span><\/section>\n<\/td>\n
\n
\u4e1c\u839e<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

43<\/strong><\/span><\/p>\n<\/td>\n

\n
\u798f\u5efa\u7701\u798f\u5dde\u80ba\u79d1\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u9648\u7fa4<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u798f\u5efa<\/span><\/section>\n<\/td>\n
\n
\u798f\u5dde<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

44<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5317\u4eac\u5927\u5b66\u7b2c\u4e09\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u66f9\u5b9d\u5c71<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5317\u4eac<\/span><\/section>\n<\/td>\n
\n
\u5317\u4eac<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

45<\/strong><\/span><\/p>\n<\/td>\n

\n
\u5317\u4eac\u534f\u548c\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5f20\u529b<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u5317\u4eac<\/span><\/section>\n<\/td>\n
\n
\u5317\u4eac<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

46<\/strong><\/span><\/p>\n<\/td>\n

\n
\u6d59\u6c5f\u7701\u80bf\u7624\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5f20\u6c82\u5e73<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6d59\u6c5f<\/span><\/section>\n<\/td>\n
\n
\u676d\u5dde<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

47<\/strong><\/span><\/p>\n<\/td>\n

\n
\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5468\u5efa\u82f1<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u6d59\u6c5f<\/span><\/section>\n<\/td>\n
\n
\u676d\u5dde<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

48<\/strong><\/span><\/p>\n<\/td>\n

\n
\u4e2d\u56fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5218\u4e91\u9e4f<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u8fbd\u5b81<\/span><\/section>\n<\/td>\n
\n
\u6c88\u9633<\/span><\/section>\n<\/td>\n<\/tr>\n
\n

49<\/strong><\/span><\/p>\n<\/td>\n

\n
\u7a7a\u519b\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662<\/span><\/section>\n<\/td>\n
\n
\u5f20\u8270<\/span><\/section>\n<\/td>\n
\n
\u4e2d\u56fd<\/span><\/section>\n<\/td>\n
\n
\u9655\u897f<\/span><\/section>\n<\/td>\n
\n
\u897f\u5b89<\/span><\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


<\/p>\n

\n
\n
\n
\u4e34\u5e8a\u8bd5\u9a8c\u62a5\u540d\u65b9\u5f0f<\/span><\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

<\/section>\n

\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\uff0c\u56de\u590d\u201c\u5165\u7ec4\u201d\u5373\u53ef<\/strong><\/span><\/span><\/p>\n

\u2193<\/strong>\u2193<\/strong>\u2193<\/strong>\u2193<\/strong><\/strong><\/span><\/span><\/p>\n

\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011D-0316\u5728EGFR\u7a81\u53d8\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\"<\/p>\n


<\/p>\n

\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011D-0316\u5728EGFR\u7a81\u53d8\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\"\u70b9\u51fb\u201c<\/span>\u9605\u8bfb\u539f\u6587<\/span>\u201d\u67e5\u770b\u8be6\u60c5<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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