{"id":88808,"date":"2019-04-21T00:00:50","date_gmt":"2019-04-23T04:03:52","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/88808\/"},"modified":"2019-04-23T12:03:55","modified_gmt":"2019-04-23T04:03:55","slug":"6d327a2595","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/88808\/","title":{"rendered":"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76"},"content":{"rendered":"
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\u70b9\u51fb\"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\"<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/span>\"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\"<\/span><\/strong><\/strong><\/strong><\/strong><\/span><\/strong>\u9a6c\u4e0a\u5165\u7ec4\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/strong><\/span><\/p>\n

\u516c\u4f17\u53f7\uff1ashiyan589<\/span><\/p>\n

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\u6297\u764c\u6307\u5357\u70b9\u51fb\u4e0b\u65b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u2193\u2193\u2193<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\"<\/a><\/section>\n<\/section>\n<\/section>\n
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\"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\"<\/a><\/section>\n<\/section>\n<\/section>\n
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\"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\"<\/a><\/p>\n<\/section>\n

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\"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\"<\/a><\/p>\n<\/section>\n

\u5165\u7ec4\u62a5\u540d\u65b9\u5f0f\u89c1\u6587\u672b<\/span><\/strong><\/p>\n

\u2193<\/span><\/strong>\u2193<\/span><\/strong>\u2193<\/span><\/strong>\u2193<\/span><\/strong><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

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\u8bd5\u9a8c\u540d\u79f0<\/strong><\/p>\n<\/section>\n

\"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\" <\/p>\n

<\/section>\n<\/section>\n<\/section>\n
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\u8bc4\u4ef7HMPL-453\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u60a3\u8005\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u521d\u6b65\u6297\u80bf\u7624\u6d3b\u6027\u7684\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u7684I\/II\u671f\u4e34\u5e8a\u7814\u7a76<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u8bd5\u9a8c\u9002\u5e94\u75c7<\/strong><\/p>\n<\/section>\n

\"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\" <\/p>\n

<\/section>\n<\/section>\n<\/section>\n
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\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u60a3\u8005<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u8bd5\u9a8c\u836f\u7269<\/strong><\/p>\n<\/section>\n

\"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\" <\/p>\n

<\/section>\n<\/section>\n<\/section>\n
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HMPL-453\u9152\u77f3\u9178\u76d0<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8bd5\u9a8c\u72b6\u6001<\/strong><\/p>\n<\/section>\n

\"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\" <\/p>\n

<\/section>\n<\/section>\n<\/section>\n
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 \u8fdb\u884c\u4e2d (\u62db\u52df\u4e2d)   <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8bd5\u9a8c\u76ee\u7684<\/strong><\/p>\n<\/section>\n

\"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\" <\/p>\n

<\/section>\n<\/section>\n<\/section>\n
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  1. \n

    \u8bc4\u4ef7\u53e3\u670d\u5355\u836fHMPL-453\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002<\/p>\n<\/li>\n

  2. \n

    \u786e\u5b9aHMPL-453\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u6700\u5927\u8010\u53d7\u5242\u91cf\uff08MTD\uff09\u6216II\u671f\u4e34\u5e8a\u7814\u7a76\u63a8\u8350\u5242\u91cf\uff08RP2D\uff09\u3002<\/p>\n<\/li>\n

  3. \n

    \u5728\u5242\u91cf\u6269\u5c55\u9636\u6bb5\uff0c\u8bc4\u4ef7HMPL-453\u5728\u63a8\u8350\u5242\u91cf\u4e0b\u6cbb\u7597\u4f34\u6709FGFR\u57fa\u56e0\u5f02\u5e38\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/span><\/p>\n

    <\/span><\/p>\n

    <\/span><\/p>\n<\/li>\n<\/ol>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    <\/p>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u8bd5\u9a8c\u8bbe\u8ba1<\/strong><\/p>\n<\/section>\n

    \"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\" <\/p>\n

    <\/section>\n<\/section>\n<\/section>\n
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    \u8bd5\u9a8c\u5206\u7c7b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u5b89\u5168\u6027\u548c\u6709\u6548\u6027  <\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u8bd5\u9a8c\u5206\u671f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u5176\u5b83<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u8bbe\u8ba1\u7c7b\u578b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u5355\u81c2\u8bd5\u9a8c<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u968f\u673a\u5316<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u975e\u968f\u673a\u5316<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u76f2\u6cd5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u5f00\u653e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u8bd5\u9a8c\u8303\u56f4<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u56fd\u5185\u8bd5\u9a8c
    <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    <\/p>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    \u5165\u9009\u6807\u51c6<\/strong><\/p>\n<\/section>\n

    \"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\" <\/p>\n

    <\/section>\n<\/section>\n<\/section>\n
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    1. \u5bf9\u672c\u7814\u7a76\u5df2\u5145\u5206\u4e86\u89e3\u5e76\u81ea\u613f\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff1b<\/p>\n

    2. \u5e74\u9f84 \u2265 25\u5c81\uff1b<\/span><\/p>\n

    3. \u5242\u91cf\u9012\u589e\u9636\u6bb5\uff0c\u5165\u7ec4\u7ecf\u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\u786e\u8bca\u4e14\u6807\u51c6\u6cbb\u7597\u5931\u8d25\uff0c\u6216\u4e0d\u80fd\u8010\u53d7\u6807\u51c6\u6cbb\u7597\uff0c\u6216\u5c1a\u65e0\u6807\u51c6\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\uff1b<\/span><\/p>\n

    4. \u5728\u5242\u91cf\u6269\u5c55\u9636\u6bb5\uff0c\u5165\u7ec4\u7ecf\u7ec4\u7ec7\u5b66\u786e\u8bca\u7684\u3001\u5c40\u90e8\u665a\u671f\u6216\u8fdc\u5904\u8f6c\u79fb\u4e14\u6807\u51c6\u6cbb\u7597\u5931\u8d25\u7684\u3001\u4f34\u6709FGF\/FGFR\u57fa\u56e0\u5f02\u5e38\u7684\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u809d\u5185\u80c6\u7ba1\u764c\u548c\u5176\u4ed6\u5b9e\u4f53\u7624\u4ee5\u53ca\u4f34\u6216\u4e0d\u4f34FGF\/FGFR\u57fa\u56e0\u5f02\u5e38\u7684\u95f4\u76ae\u7624\uff1b<\/span><\/p>\n

    5. \u5728\u5242\u91cf\u9012\u589e\u9636\u6bb5\uff0c\u60a3\u8005\u5e94\u6709\u53ef\u8bc4\u4ef7\u6216\u53ef\u6d4b\u91cf\u75c5\u7076\uff08\u6839\u636eRECIST 1.1\u6807\u51c6\uff09\uff1b\u5728\u5242\u91cf\u6269\u5c55\u9636\u6bb5\uff0c\u60a3\u8005\u5e94\u6709\u53ef\u6d4b\u91cf\u75c5\u7076\uff08\u6839\u636eRECIST 1.1\u6807\u51c6\uff09\uff1b<\/span><\/p>\n

    6. \u9884\u8ba1\u751f\u5b58\u671f\u81f3\u5c1112\u5468\uff1b<\/span><\/p>\n

    7. \u4f53\u80fd\u72b6\u6001\u8bc4\u5206\uff08ECOG\uff090-1\u5206\uff1b<\/span><\/p>\n

    8. \u5973\u6027\u53d7\u8bd5\u8005\u613f\u610f\u91c7\u53d6\u907f\u5b55\u63aa\u65bd\uff08\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u81f3\u6cbb\u7597\u7ed3\u675f3\u4e2a\u6708\u5185\uff09\u3002\u53ef\u63a5\u53d7\u7684\u907f\u5b55\u65b9\u5f0f\u5305\u62ec\u8f93\u5375\u7ba1\u7ed3\u624e\u3001\u53e3\u670d\u6216\u6ce8\u5c04\u907f\u5b55\u836f\u3001\u5bab\u5185\u8282\u80b2\u5668\u3001\u914d\u5076\u4f7f\u7528\u907f\u5b55\u5957\u6216\u914d\u5076\u8f93\u7cbe\u7ba1\u7ed3\u624e\u7b49\u3002\u6240\u6709\u6fc0\u7d20\u7c7b\u907f\u5b55\u63aa\u65bd\u5fc5\u987b\u5408\u5e76\u914d\u5076\u4f7f\u7528\u907f\u5b55\u5957\u7b49\u63aa\u65bd\u3002\u5973\u6027\u53d7\u8bd5\u8005\u7981\u6b62\u5728\u7814\u7a76\u671f\u95f4\u54fa\u4e73\uff0c\u5e76\u4e14\u5728\u7ed9\u836f\u524d\u598a\u5a20\u68c0\u67e5\u4e3a\u9634\u6027\uff0c\u6216\u8005\u5177\u6709\u4ee5\u4e0b\u60c5\u51b5\u4e4b\u4e00\u4ee5\u8bc1\u5b9e\u65e0\u53d7\u5b55\u53ef\u80fd\uff1a\u7edd\u7ecf\u540e\u5987\u5973\uff08>50\u5c81\u5e76\u4e14\u505c\u7ecf\u81f3\u5c111\u5e74\u4ee5\u4e0a\uff09\uff0c\u4e14\u672a\u63a5\u53d7\u5916\u6e90\u6027\u6fc0\u7d20\u6cbb\u7597\uff1b50\u5c81\u4ee5\u4e0b\u5987\u5973\u505c\u7ecf\u81f3\u5c111\u5e74\u4ee5\u4e0a\uff0c\u672a\u63a5\u53d7\u5916\u6e90\u6027\u6fc0\u7d20\u6cbb\u7597\uff0c\u4e14LH\/FSH\u5904\u4e8e\u7edd\u7ecf\u6c34\u5e73\uff1b\u63a5\u53d7\u4e86\u4e0d\u53ef\u9006\u7684\u7edd\u80b2\u624b\u672f\uff0c\u5305\u62ec\u53cc\u4fa7\u8f93\u5375\u7ba1\u5207\u9664\u6216\u7ed3\u624e\u3001\u5168\u5b50\u5bab\u5207\u9664\u3001\u53cc\u4fa7\u5375\u5de2\u5207\u9664\u7b49\uff1b<\/span><\/p>\n

    9. \u7537\u6027\u53d7\u8bd5\u8005\u613f\u610f\u91c7\u53d6\u907f\u5b55\u63aa\u65bd\uff08\u6cbb\u7597\u671f\u95f4\u53ca\u6cbb\u7597\u7ed3\u675f3\u4e2a\u6708\u5185\uff09\u3002<\/span><\/p>\n


    <\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

    \n
    \n
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    \u6392\u9664\u6807\u51c6<\/strong><\/p>\n<\/section>\n

    \"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\" <\/p>\n

    <\/section>\n<\/section>\n<\/section>\n
    \n
    \n
    \n

    1. \u65e2\u5f80\u63a5\u53d7\u8fc7\u9009\u62e9\u6027FGFR\u6291\u5236\u5242\u6cbb\u7597\uff1b<\/p>\n

    2. \u53d7\u8bd5\u8005\u5728\u8fc7\u53bb5\u5e74\u5185\u60a3\u6709\u5176\u5b83\u6076\u6027\u80bf\u7624\uff0c\u7ecf\u8fc7\u6839\u6cbb\u6027\u6cbb\u7597\u7684\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\uff0c\u4e73\u817a\u539f\u4f4d\u764c\u548c\u5bab\u9888\u539f\u4f4d\u764c\u9664\u5916\uff1b<\/span><\/p>\n

    3. \u53d7\u8bd5\u8005\u6709\u539f\u53d1\u795e\u7ecf\u7cfb\u7edf\u80bf\u7624\u3001\u810a\u9ad3\u538b\u8feb\u6216\u8111\u8f6c\u79fb\uff1b\u9664\u975e\u53d7\u8bd5\u8005\u6ca1\u6709\u75c7\u72b6\u3001\u5904\u4e8e\u75be\u75c5\u7a33\u5b9a\u72b6\u6001\uff0c\u5e76\u4e14\u5728\u5f00\u59cb\u7814\u7a76\u6cbb\u7597\u524d\u81f3\u5c114\u5468\u4e0d\u9700\u8981\u6fc0\u7d20\u6cbb\u7597\uff1b<\/span><\/p>\n

    4. \u514d\u75ab\u529f\u80fd\u4e0d\u5168\u7684\u53d7\u8bd5\u8005\uff0c\u6bd4\u5982\u5df2\u77e5\u8840\u6e05\u5b66\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08HIV\uff09\u9633\u6027\uff1b\u5df2\u77e5\u6709\u663e\u8457\u610f\u4e49\u7684\u809d\u75c5\u75c5\u53f2\uff0c\u5305\u62ec\u75c5\u6bd2\u6027\u809d\u708e[\u6162\u6027\u4e59\u578b\u809d\u708e\u5b9a\u4e49\u4e3a\u4e59\u809d\u8868\u9762\u6297\u539f\u9633\u6027\uff1b\u5bf9\u4e8e\u4e59\u809d\u8868\u9762\u6297\u539f\u9634\u6027\uff0c\u4f46\u6838\u5fc3\u6297\u4f53\uff08HBcAb\uff09\u9633\u6027\u53d7\u8bd5\u8005\u9700\u8981\u68c0\u6d4bHBV DNA\uff0cHBV DNA\u9633\u6027\uff08>1\u00d7104\/ml\uff09\u53d7\u8bd5\u8005\u4e0d\u80fd\u5165\u7ec4\uff1b\u4e19\u578b\u809d\u708e\u5b9a\u4e49\u4e3aHCV\u6297\u4f53\u8840\u6e05\u5b66\u9633\u6027\u4e14HCV RNA\u9633\u6027\uff08>1\u00d7103\/ml\uff09]\uff0c\u6216\u5176\u5b83\u809d\u708e\uff0c\u809d\u786c\u5316\uff1b\u5728\u5242\u91cf\u6269\u5c55\u9636\u6bb5\uff0c\u4e59\u809d\u8868\u9762\u6297\u539f\u9633\u6027\u4f46HBV DNA\u9634\u6027\u7684\u60a3\u8005\u53ef\u5165\u7ec4\uff1b<\/span><\/p>\n

    5. \u8ddd\u9996\u6b21\u7814\u7a76\u7528\u836f\u524d3\u5468\u5185\u63a5\u53d7\u8fc7\u5df2\u6279\u51c6\u6216\u5728\u7814\u7684\u6297\u80bf\u7624\u6cbb\u7597\uff0c\u5305\u62ec\u5316\u7597\u3001\u514d\u75ab\u6cbb\u7597\u6216\u5176\u4ed6\u6297\u80bf\u7624\u6cbb\u7597\u3002\u4fc3\u9ec4\u4f53\u751f\u6210\u7d20\u91ca\u653e\u6fc0\u7d20\u6fc0\u52a8\u5242\uff08LHRHa\uff09\u3001\u53cc\u78f7\u9178\u76d0\u6216\u5730\u8bfa\u5355\u6297\u9664\u5916\uff1b<\/span><\/p>\n

    6. \u8ddd\u9996\u6b21\u7814\u7a76\u7528\u836f\u524d1\u5468\u5185\u63a5\u53d7\u8fc7\u7528\u4e8e\u7f13\u89e3\u75c7\u72b6\u7684\u5c40\u90e8\u653e\u5c04\u6cbb\u7597\uff0c\u62164\u5468\u5185\u66fe\u5bf930%\u4ee5\u4e0a\u9aa8\u9ad3\u8fdb\u884c\u653e\u7597\u6216\u5927\u9762\u79ef\u653e\u7597\uff1b<\/span><\/p>\n

    7. \u8ddd\u9996\u6b21\u7814\u7a76\u7528\u836f\u524d4\u5468\u5185\u63a5\u53d7\u8fc7\u9700\u8981\u4f4f\u9662\u8fdb\u884c\u7684\u91cd\u5927\u624b\u672f\uff1b<\/span><\/p>\n

    8. \u5b58\u5728\u4ee5\u4e0b\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u5f02\u5e38\uff1a\u7edd\u5bf9\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\uff08ANC\uff09\uff1c1.5\u00d7109\/L\uff1b\u8840\u7ea2\u86cb\u767d\uff1c90g\/L\uff1b\u8840\u5c0f\u677f < 100 \u00d7109\/L\uff1b<\/span><\/p>\n

    9. \u5b58\u5728\u4ee5\u4e0b\u4efb\u4e00\u809d\u80be\u529f\u80fd\u4e0d\u5168\u7684\u60c5\u51b5\uff1a\u65e0\u809d\u8f6c\u79fb\u65f6\uff0cALT\u6216AST \u9ad8\u4e8e\u6b63\u5e38\u503c\u53c2\u8003\u8303\u56f4\uff08ULN\uff09\u4e0a\u9650\u76842.5\u500d\uff1b\u6709\u809d\u8f6c\u79fb\u65f6\uff0cALT\u6216AST\u9ad8\u4e8e\u6b63\u5e38\u503c\u53c2\u8003\u8303\u56f4\u4e0a\u9650\u76845\u500d\uff1b\u8840\u6e05\u603b\u80c6\u7ea2\u7d20\u9ad8\u4e8e\u6b63\u5e38\u503c\u53c2\u8003\u8303\u56f4\u4e0a\u9650\u76841.5\u500d\uff1b\u8840\u6e05\u808c\u9150\u9ad8\u4e8e\u6b63\u5e38\u503c\u53c2\u8003\u8303\u56f4\u4e0a\u9650\u76841.5\u500d\u5408\u5e76\u5b58\u5728\u808c\u9150\u6e05\u9664\u7387 < 50 ml\/min\uff08\u4f9d\u636eCockcroft-Gault\u516c\u5f0f\u4f30\u7b97\uff09\uff1b\u6ce8\uff1a\u4ec5\u5728\u8840\u6e05\u808c\u9150\u9ad8\u4e8e\u6b63\u5e38\u503c\u53c2\u8003\u8303\u56f4\u4e0a\u9650\u76841.5\u500d\u65f6\u9700\u8981\u786e\u8ba4\u808c\u9150\u6e05\u9664\u7387\uff09\uff1b<\/span><\/p>\n

    10. \u56fd\u9645\u6807\u51c6\u5316\u6bd4\u503c\uff08INR\uff09\u9ad8\u4e8e\u6b63\u5e38\u503c\u53c2\u8003\u8303\u56f4\u4e0a\u9650\u76841.5\u500d\u6216\u90e8\u5206\u6d3b\u5316\u51dd\u8840\u9176\u539f\u65f6\u95f4\uff08aPTT\uff09\u9ad8\u4e8e\u6b63\u5e38\u503c\u53c2\u8003\u8303\u56f4\u4e0a\u9650\u76841.5\u500d\u3002\u6b63\u5728\u63a5\u53d7\u534e\u6cd5\u6797\u6297\u51dd\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5982INR\u57282-3\u9664\u5916\uff1b<\/span><\/p>\n

    11. \u5bf9\u4e8e\u5242\u91cf\u9012\u589e\u9636\u6bb5\uff0c\u53d7\u8bd5\u8005\u76ee\u524d\u6216\u65e2\u5f80\u5b58\u5728\u9499\u78f7\u4ee3\u8c22\u5f02\u5e38\uff1b\u5bf9\u4e8e\u5242\u91cf\u6269\u5c55\u9636\u6bb5\uff0c\u60a3\u8005\u57fa\u7ebf\u5b58\u5728\u9499\u78f7\u4ee3\u8c22\u5f02\u5e38\uff0c\u5982\u57fa\u7ebf\u8840\u78f7\/\u8840\u9499\u5728\u6b63\u5e38\u8303\u56f4\u4ee5\u5916\uff0c\u6709\u7532\u72b6\u65c1\u817a\u75be\u75c5\u53f2\u3001\u7532\u72b6\u65c1\u817a\u624b\u672f\u53f2\u3001\u80bf\u7624\u6eb6\u89e3\u3001\u80bf\u7624\u6837\u9499\u76d0\u6c89\u7740\u75c7\u7b49\uff1b<\/span><\/p>\n

    12. \u6b63\u5728\u670d\u7528\u53ef\u80fd\u5bfc\u81f4\u8840\u78f7\u548c\/\u6216\u8840\u9499\u5347\u9ad8\u7684\u836f\u7269\u6216\u81b3\u98df\u8865\u5145\u5242\uff08\u5982\u9499\u5242\u3001\u78f7\u5242\u3001\u7ef4\u751f\u7d20D\u3001\u7532\u72b6\u65c1\u817a\u7d20\u7b49\uff09\uff1b\u6b63\u5728\u670d\u7528\u53ef\u80fd\u5bfc\u81f4QT\u95f4\u671f\u5ef6\u957f\u6216\u5c16\u7aef\u626d\u8f6c\u6027\u5ba4\u6027\u5fc3\u5f8b\u5931\u5e38\u7684\u836f\u7269\uff08\u836f\u7269\u5217\u8868\u53c2\u8003\uff1ahttp:\/\/www.qtdrugs.org\/\uff09\uff1b<\/span><\/p>\n

    <\/span>13. \u53d7\u8bd5\u8005\u76ee\u524d\u6216\u65e2\u5f80\u5b58\u5728\u7684\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5f02\u4f4d\u9499\u5316\uff0c\u5305\u62ec\u8f6f\u7ec4\u7ec7\u9499\u5316\u3001\u80be\u810f\u9499\u5316\u3001\u80a0\u9053\u9499\u5316\u3001\u5fc3\u808c\u9499\u5316\u3001\u4e3b\u52a8\u8109\u9499\u5316\uff1b<\/span><\/p>\n

    14. \u76ee\u524d\u5b58\u5728\u7ecf\u773c\u79d1\u68c0\u67e5\u786e\u8bca\u7684\u89d2\u819c\u75c5\u53d8\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5927\u75b1\u6027\u89d2\u819c\u75c5\u53d8\u3001\u5e26\u72b6\u89d2\u819c\u53d8\u6027\u3001\u89d2\u819c\u64e6\u4f24\u3001\u89d2\u819c\u6e83\u75a1\u3001\u89d2\u819c\u708e\u7b49\uff1b\u76ee\u524d\u5b58\u5728\u7ecf\u773c\u79d1\u68c0\u67e5\u786e\u8bca\u7684\u89c6\u7f51\u819c\u8131\u843d\uff08\u4ec5\u5242\u91cf\u6269\u5c55\u9636\u6bb5\uff09\uff1b<\/span><\/p>\n

    15. \u53d7\u8bd5\u8005\u76ee\u524d\u6216\u65e2\u5f80\u5b58\u5728\u89c6\u7f51\u819c\u8131\u843d\uff1b\u60a3\u8005\u5b58\u5728\u6df1\u5ea6\u8fd1\u89c6\uff08\u57fa\u4e8e\u77eb\u6b63\u89c6\u529b0.8\u65f6\uff0c\u5c48\u5149\u5927\u4e8e600\u5ea6\uff09(\u4ec5\u5242\u91cf\u6269\u5c55\u9636\u6bb5)\uff1b<\/span><\/p>\n

    16. \u65e0\u8bba\u662f\u5426\u4f7f\u7528\u6297\u9ad8\u8840\u538b\u836f\u7269\uff0c\u6536\u7f29\u538b> 140 mmHg \u548c\/\u6216\u8212\u5f20\u538b> 90 mmHg\uff08\u4ec5\u9002\u7528\u4e8e\u5242\u91cf\u9012\u589e\u9636\u6bb5\uff09\uff1b<\/span><\/p>\n

    17. \u6b63\u5728\u4f7f\u7528\u7ec6\u80de\u8272\u7d20\u9176P450 3A4\uff08CYP3A4\uff09\u5f3a\u8bf1\u5bfc\u5242\u6216\u5f3a\u6291\u5236\u5242\uff1b<\/span><\/p>\n

    18. \u7b26\u5408\u4e0b\u5217\u4efb\u4e00\u6761\u5fc3\u810f\u76f8\u5173\u6807\u51c6\uff1a\u5404\u79cd\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5fc3\u5f8b\u5931\u5e38\u6216\u4f20\u5bfc\u5f02\u5e38\uff0c\u9700\u8981\u4e34\u5e8a\u5e72\u9884\uff1b\u9759\u606f\u72b6\u6001\u4e0b\uff0cECG\u68c0\u67e5QT\u95f4\u671f\uff08QTcF\uff09> 470 msec\uff1b\u5404\u79cd\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u5305\u62ec\u5165\u7ec4\u524d6\u4e2a\u6708\u5185\u7684\u6025\u6027\u5fc3\u808c\u6897\u6b7b\u3001\u4e25\u91cd\u6216\u4e0d\u7a33\u5b9a\u6027\u5fc3\u7ede\u75db\u3001\u51a0\u72b6\u52a8\u8109\u642d\u6865\u624b\u672f\u3001\u7ebd\u7ea6\u5fc3\u529f\u80fd\u5206\u7ea7\uff08NYHA\uff09III\/IV\u7ea7\u5145\u8840\u6027\u5fc3\u8870\u3001\u9700\u8981\u6cbb\u7597\u7684\u5ba4\u6027\u5fc3\u5f8b\u5931\u5e38\u3001\u6216\u5de6\u5fc3\u5c04\u8840\u5206\u6570\uff08LVEF\uff09< 50%\u7b49\uff1b<\/span><\/p>\n

    19. \u7ecf\u7814\u7a76\u8005\u5224\u65ad\u53d7\u8bd5\u8005\u5b58\u5728\u4efb\u4f55\u5176\u4ed6\u533b\u5b66\u72b6\u51b5\u6216\u8005\u4e34\u5e8a\u663e\u8457\u6027\u5b9e\u9a8c\u5ba4\u6307\u6807\u5f02\u5e38\uff0c\u5bfc\u81f4\u53d7\u8bd5\u8005\u4e0d\u9002\u5b9c\u53c2\u52a0\u672c\u7814\u7a76\uff1b<\/span><\/p>\n

    20. \u65e2\u5f80\u6297\u764c\u6cbb\u7597\u7684\u6bd2\u6027\u53cd\u5e94\u5c1a\u672a\u6062\u590d\u52300\u6216\u80051\u7ea7\u6c34\u5e73\uff08\u8131\u53d1\u3001\u76ae\u80a4\u8272\u7d20\u6539\u53d8\u6216\u2264 2\u7ea7\u7684\u795e\u7ecf\u6bd2\u6027\u9664\u5916\uff09\uff1b<\/span><\/p>\n

    21. \u65e0\u6cd5\u53e3\u670d\u7814\u7a76\u836f\u7269\uff1b<\/span><\/p>\n

    22. \u6000\u5b55\u6216\u54fa\u4e73\u671f\u5987\u5973\uff1b<\/span><\/p>\n

    23. \u53d7\u8bd5\u8005\u5bf9HMPL-453\u6d3b\u6027\u6210\u5206\u6216\u8f85\u6599\u6709\u8fc7\u654f\u53f2\u3002    <\/span><\/p>\n


    <\/p>\n<\/section>\n<\/section>\n<\/section>\n

    \n
    \n
    \n

    \u4e3b\u8981\u7814\u7a76\u8005\u4fe1\u606f<\/strong><\/p>\n<\/section>\n

    \"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\" <\/p>\n

    <\/section>\n<\/section>\n<\/section>\n
    \n
    \n
    \n

    \u5f90\u5efa\u660e\uff0c\u533b\u5b66\u535a\u58eb    <\/span>\u6559\u6388<\/span>    <\/span><\/p>\n

    \u4e2d\u56fd\u4eba\u6c11\u89e3\u653e\u519b\u7b2c307\u533b\u9662    <\/span><\/p>\n

    \u5317\u4eac\u5e02\u4e30\u53f0\u533a\u4e1c\u5927\u88578\u53f7\u5185\u79d1\u697c\u6d88\u5316\u80bf\u7624\u79d1   <\/span><\/p>\n

        <\/p>\n

    <\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

    \n
    \n
    \n

    \u8bd5\u9a8c\u53c2\u4e0e\u673a\u6784\u4fe1\u606f<\/strong><\/p>\n<\/section>\n

    \"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\" <\/p>\n

    <\/section>\n<\/section>\n<\/section>\n
    \n
    \n
    \"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\"<\/section>\n<\/section>\n<\/section>\n
    \n
    \n
    \n


    <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \n
    \n
    \n
    \u4e34\u5e8a\u8bd5\u9a8c\u62a5\u540d\u65b9\u5f0f<\/span><\/section>\n

    <\/section>\n<\/section>\n<\/section>\n<\/section>\n


    <\/p>\n

    <\/section>\n

    \u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\uff0c\u56de\u590d\u201c\u5165\u7ec4\u201d\u5373\u53ef<\/strong><\/span><\/span><\/p>\n

    \u2193<\/strong>\u2193<\/strong>\u2193<\/strong>\u2193<\/strong><\/strong><\/span><\/span><\/p>\n

    \"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\"<\/p>\n


    <\/p>\n

    \"\u3010\u5b9e\u4f53\u7624-\u60a3\u8005\u62db\u52df\u3011HMPL-453\u9152\u77f3\u9178\u76d0\u6cbb\u7597\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684I\/II\u671f\u7814\u7a76\"\u70b9\u51fb\u201c<\/span>\u9605\u8bfb\u539f\u6587<\/span>\u201d\u67e5\u770b\u8be6\u60c5<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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