{"id":89315,"date":"2019-04-18T00:00:50","date_gmt":"2019-04-23T04:08:32","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/89315\/"},"modified":"2019-04-23T12:08:53","modified_gmt":"2019-04-23T04:08:53","slug":"fbe22c1872","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/89315\/","title":{"rendered":"\u200b\u3010\u836f\u6e21\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001"},"content":{"rendered":"
\n

\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n


<\/p>\n

\n
\n
\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n
\n
\n
1\u7c7b\u5316\u836f\u4e34\u5e8a\u5ba1\u6279\u6982\u51b5<\/span><\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

2019\u5e743\u6708\uff0c\u5171\u670911\u4e2a\u4e2d\u56fd1\u7c7b\u5316\u836f\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u7684\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\uff0c\u5176\u4e2d2\u4e2a\u4e3a\u7279\u6b8a\u5ba1\u6279\u54c1\u79cd\u3002<\/span>\u5177\u4f53\u4fe1\u606f\u5982\u4e0b\u8868\u6240\u793a\uff1a<\/span><\/p>\n


<\/span><\/p>\n

\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n

<\/span><\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
1.WXFL50010210<\/span><\/span><\/strong><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

<\/span><\/p>\n

WXFL50010210\u7531\u9752\u5c9b\u9ec4\u6d77\u5236\u836f\u6709\u9650\u8d23\u4efb\u516c\u53f8\u7814\u53d1\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u75c5\uff08NAFLD\uff09\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u708e\uff08NASH\uff09\u3002<\/span><\/p>\n


<\/span><\/p>\n

2017\u5e747\u6708\uff0cCDE\u53d7\u7406\u672c\u54c1\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08\u5316\u836f1\u7c7b\uff09\uff0c\u5e76\u4e8e\u8be5\u6708\uff082017\u5e747\u6708\uff09\u8981\u6c42\u8fdb\u4e00\u6b65\u8865\u5145\u8d44\u6599\u3002<\/span>2019\u5e743\u6708\uff0c\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\uff0c\u4e14\u5c5e\u4e8e\u7279\u6b8a\u5ba1\u6279\u3002<\/span><\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
2.QBH-196<\/span><\/strong><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

<\/span><\/p>\n

QBH-196\u7531\u6c88\u9633\u836f\u79d1\u5927\u5b66\u7814\u53d1\uff0c\u662f\u4ee5\u5361\u535a\u66ff\u5c3c\u4e3a\u5148\u5bfc\u5316\u5408\u7269\u8bbe\u8ba1\u7684\u4e00\u79cd\u5305\u62ecc-Met\u5728\u5185\u7684\u591a\u9776\u70b9\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u80c3\u764c\u3002<\/span><\/p>\n


<\/span><\/p>\n

2018\u5e747\u6708\uff0cCDE\u53d7\u7406\u6c88\u9633\u836f\u79d1\u5927\u5b66\u63d0\u4ea4\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08\u5316\u836f1\u7c7b\uff09\u3002<\/span>2019\u5e743\u6708\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\u3002<\/span><\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
3.YG1699<\/span><\/strong><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/span><\/p>\n

YG-1699\u662f\u4e0a\u6d77\u7814\u5065\u5f00\u53d1\u7684\u4e00\u79cd\u94a0-\u8461\u8404\u7cd6\u534f\u540c\u8f6c\u8fd0\u86cb\u767d1\/\u94a0-\u8461\u8404\u7cd6\u534f\u540c\u8f6c\u8fd0\u86cb\u767d2\uff08SGLT1 \/ SGLT2\uff09\u53cc\u91cd\u6291\u5236\u5242\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u7cd6\u5c3f\u75c5\u3002<\/span>\u76ee\u524d\u5728\u6fb3\u5927\u5229\u4e9a\u5f00\u5c55\u4e34\u5e8a\u4e00\u671f\u8bd5\u9a8c\u3002<\/span>\u636e\u8868\u660e\uff0cYG1699\u5728\u6210\u836f\u6027\u65b9\u9762\u5177\u6709\u660e\u663e\u4f18\u52bf\uff0c\u4e0e\u5df2\u7ecf\u4e0a\u5e02\u7684\u5217\u51c0\u7c7b\u836f\u7269\u76f8\u6bd4\uff0cYG1699\u62e5\u6709\u66f4\u591a\u6709\u6548\u7684\u964d\u7cd6\u673a\u5236\uff0c\u80fd\u591f\u51cf\u8f7b\u5217\u51c0\u7c7b\u836f\u7269\u7684\u4e3b\u8981\u6bd2\u526f\u4f5c\u7528\uff0c\u4e14\u53ef\u80fd\u7684\u9002\u5e94\u4eba\u7fa4\u548c\u9002\u5e94\u75c7\u66f4\u5e7f\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n

<\/span><\/p>\n


<\/span><\/p>\n

\u7814\u53d1\u91cc\u7a0b\u7891<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

2019\u5e743\u6708\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u7533\u8bf7\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\u3002<\/span><\/p>\n


<\/span><\/p>\n

2019\u5e742\u6708\uff0cYG1699\u83b7FDA\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\uff0c\u5c06\u5f00\u5c55\u4e34\u5e8aI\u671f\u8bd5\u9a8c\u3002<\/span><\/p>\n


<\/span><\/p>\n

2018\u5e7412\u6708\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u672c\u54c1\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08\u5316\u836f1\u7c7b\uff09\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8be5\u836f\u7269\u4e2d\u56fd1\u7c7b\u540c\u9776\u70b9SGLT\uff08\u94a0-\u8461\u8404\u7cd6\u534f\u540c\u8f6c\u8fd0\u86cb\u767d\uff09\u836f\u7269\u5982\u4e0b\u8868\u6240\u793a\uff1a<\/span><\/p>\n


<\/span><\/p>\n

\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n

<\/span><\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
4.AZD4205<\/span><\/strong><\/span><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/span><\/p>\n

AZD4205\u662f\u7531\u963f\u65af\u5229\u5eb7\u548c\u8fea\u54f2\uff08\u6c5f\u82cf\uff09\u533b\u836f\u6709\u9650\u516c\u53f8\uff08\u963f\u65af\u5229\u5eb7\u548c\u4e2d\u56fd\u56fd\u6295\u521b\u65b0\u8054\u5408\u6295\u8d44\u521b\u7acb\u7684\u516c\u53f8\uff09\u8054\u5408\u5f00\u53d1\u7684\u4e00\u79cdJAK1\u6fc0\u9176\u6291\u5236\u5242\uff0c\u76ee\u524d\u963f\u65af\u5229\u5eb7\u6b63\u5728\u8fdb\u884c\u7528\u4e8e\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e34\u5e8a\u4e00\/\u4e8c\u671f\u8bd5\u9a8c\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n


<\/span><\/p>\n

2018\u5e7412\u6708\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u8fea\u54f2\uff08\u6c5f\u82cf\uff09\u533b\u836f\u6709\u9650\u516c\u53f8\u63d0\u4ea4\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08\u5316\u836f1\u7c7b\uff09\u3002<\/span>2019\u5e743\u6708\uff0c\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff08\u5305\u62ec\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u548c\u514b\u7f57\u6069\u75c5\u5728\u5185\u7684\u708e\u75c7\u6027\u80a0\u75c5\u7b49\uff09\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8be5\u836f\u7269\u4e2d\u56fd1\u7c7b\u540c\u9776\u70b9JAK\uff08\u916a\u6c28\u9178\u86cb\u767d\u6fc0\u9176JAK\uff09\u836f\u7269\u5982\u4e0b\u8868\u6240\u793a\uff1a<\/span><\/p>\n


<\/span><\/p>\n

\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n


<\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
5.HEC113995PA\u00b7H2O<\/span><\/strong><\/span><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

HEC113995PA\u00b7H2O\u7531\u5e7f\u4e1c\u4e1c\u9633\u5149\u836f\u4e1a\u6709\u9650\u516c\u53f8\u7814\u53d1\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u6291\u90c1\u75c7\u3002<\/span>2019\u5e741\u6708\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u672c\u54c1\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08\u5316\u836f1\u7c7b\uff09\u3002<\/span>2019\u5e743\u6708\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\u3002<\/span><\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
6.ASC-21<\/span><\/strong><\/span><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

ASC-21\uff08MIV-802\uff09\u662f\u4e00\u79cd\u4e19\u578b\u809d\u708e\u75c5\u6bd2NS5B RNA\u4f9d\u8d56\u7684RNA\u805a\u5408\u9176\u6291\u5236\u5242\uff0c\u6700\u521d\u7531Medivir AB\u7814\u53d1\uff0c2017\u5e74\u6b4c\u793c\u6536\u8d2d\u5176\u5927\u4e2d\u534e\u5730\u533a\u7684\u77e5\u8bc6\u4ea7\u6743\uff0c\u6b4c\u793c\u5f00\u59cb\u8d1f\u8d23\u8be5\u836f\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u5e76\u72ec\u5bb6\u62e5\u6709ASC-21\u5927\u4e2d\u534e\u5730\u533a\u6240\u6709\u6743\u76ca\u3002<\/span><\/p>\n


<\/span><\/p>\n

2019\u5e741\u6708\uff0cASC-21\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08\u5316\u836f1\u7c7b\uff09\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\uff0c\u5e76\u4e8e2019\u5e743\u6708\u83b7\u5f97\u9ed8\u793a\u8bb8\u53ef\uff0c\u62df\u5f00\u5c55\u9488\u5bf9\u6210\u4eba\u6162\u6027\u4e19\u578b\u809d\u708e\u7684\u7814\u7a76\uff0c\u4e0d\u5f97\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8be5\u836f\u7269\u4e2d\u56fd1\u7c7b\u540c\u9776\u70b9NS5B\u836f\u7269\u5982\u4e0b\u8868\u6240\u793a\uff1a<\/span><\/p>\n


<\/span><\/p>\n

\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
7.BPI-23314<\/span><\/strong><\/span><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

BPI-23314\u662f\u4e00\u79cd\u62df\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u7684\u6eb4\u7ed3\u6784\u57df\u548c\u8d85\u672b\u7aef\u7ed3\u6784\u86cb\u767d\uff08BET\uff09\u5bb6\u65cf\u6291\u5236\u5242\uff0c\u7531\u8d1d\u8fbe\u836f\u4e1a\u7814\u53d1\u3002<\/span>2019\u5e741\u6708\uff0c\u5728\u4e2d\u56fd\u7684IND\u7533\u8bf7\uff081\u7c7b\u5316\u836f\uff09\u83b7CDE\u53d7\u7406\uff0c\u5e76\u4e8e2019\u5e743\u6708\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\uff0c\u62df\u5f00\u5c55\u9488\u5bf9\u6076\u6027\u8840\u6db2\u7cfb\u7edf\u80bf\u7624\uff08\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u3001\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u548c\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff09\u7684\u7814\u7a76\u3002<\/span><\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
8.CS3003<\/span><\/strong><\/span><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

CS3003\u662f\u57fa\u77f3\u836f\u4e1a\u7814\u53d1\u7684\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176-6\uff08HDAC6\uff09\u6291\u5236\u5242\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u548c\u590d\u53d1\u6216\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/span>2019\u5e741\u6708\uff0c\u5728\u4e2d\u56fd\u7684IND\u7533\u8bf7\u83b7\u5f97CDE\u53d7\u7406\uff081\u7c7b\u5316\u836f\uff09\u3002<\/span>2019\u5e743\u6708\uff0cIND\u7533\u8bf7\u83b7\u5f97NMPA\u4e34\u5e8a\u8bd5\u9a8c\u9ed8\u8ba4\u8bb8\u53ef\uff0c\u62df\u5f00\u5c55\u9488\u5bf9\u665a\u671f\u5b9e\u4f53\u7624\u548c\u590d\u53d1\u6216\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u4e34\u5e8aI\u671f\u7814\u7a76\uff0c\u5c06\u5728\u4e2d\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u540c\u6b65\u8fdb\u884c\u3002<\/span><\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
9.PB-201<\/span><\/strong><\/span><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

PB-201\u7531\u8f89\u745e\u516c\u53f8\u7814\u53d1\uff0c\u66fe\u7ecf\u5904\u4e8e\u4e34\u5e8a\u4e8c\u671f\uff0c\u7528\u4e8e\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u3002<\/span>\u867d\u7136\u8f89\u745e\u5df2\u7ecf\u7ec8\u6b62\u4e86\u8be5\u9879\u76ee\u7684\u7814\u7a76\uff0c\u4f46\u662f\u57282016\u5e7412\u6708\u8be5\u836f\u7269\u88ab\u6388\u6743\u7ed9\u6d3e\u683c\u751f\u7269\u533b\u836f\uff08\u82cf\u5dde\uff09\u3002<\/span>2019\u5e741\u6708\uff0c\u6d3e\u683c\u751f\u7269\u533b\u836f\u63d0\u4ea4\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08\u5316\u836f1\u7c7b\uff09\u83b7NMPA\u53d7\u7406\uff0c\u5e76\u4e8e2019\u5e743\u6708\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8be5\u836f\u7269\u4e2d\u56fd1\u7c7b\u540c\u9776\u70b9GK\uff08\u8461\u8404\u7cd6\u6fc0\u9176\uff09\u836f\u7269\u5982\u4e0b\u8868\u6240\u793a\uff1a<\/span><\/p>\n


<\/p>\n

\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
10.ZSP0678<\/span><\/strong><\/span><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n


<\/span><\/p>\n

ZSP0678\u7531\u5e7f\u4e1c\u4f17\u751f\u836f\u4e1a\u7814\u53d1\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u3002<\/span><\/p>\n


<\/span><\/p>\n

2019\u5e741\u6708\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u5e7f\u4e1c\u4f17\u751f\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u63d0\u4ea4\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08\u5316\u836f1\u7c7b\uff09\u3002<\/span>2019\u5e743\u6708\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\u3002<\/span><\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
11.WXSH0081<\/span><\/strong><\/span><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

WXSH0081\u7531\u77f3\u5bb6\u5e84\u667a\u5eb7\u5f18\u4ec1\u65b0\u836f\u5f00\u53d1\u6709\u9650\u516c\u53f8\u7814\u53d1\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u708e\u75c7\u6027\u80a0\u75c5\u3002<\/span><\/p>\n


<\/span><\/p>\n

2019\u5e741\u6708\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u672c\u54c1\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08\u5316\u836f1\u7c7b\uff09\u3002<\/span>2019\u5e743\u6708\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\u3002<\/span><\/p>\n


<\/span><\/p>\n

\n
\n
\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n
\n
\n
1\u7c7b\u751f\u7269\u836f\u4e34\u5e8a\u5ba1\u6279\u6982\u51b5<\/span><\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

<\/span><\/p>\n

2019\u5e743\u6708\uff0c\u5171\u67096\u4e2a\u4e2d\u56fd1\u7c7b\u751f\u7269\u836f\u83b7\u5f97NMPA\u7684\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\uff0c\u5176\u4e2d2\u4e2a\u4e3a\u7279\u6b8a\u5ba1\u6279\u54c1\u79cd\u3002<\/span>\u5177\u4f53\u4fe1\u606f\u5982\u4e0b\u8868\u6240\u793a\uff1a<\/span><\/p>\n


<\/span><\/p>\n

\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
1.\u91cd\u7ec4\u8bfa\u5982\u75c5\u6bd2\u53cc\u4ef7\uff08G\u2160.1\/G\u2161.4\uff09\u75ab\u82d7\uff08\u6c49\u900a\u9175\u6bcd\uff09<\/span><\/span><\/strong><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

\u91cd\u7ec4\u8bfa\u5982\u75c5\u6bd2\u53cc\u4ef7\uff08G\u2160.1\/G\u2161.4\uff09\u75ab\u82d7\uff08\u6c49\u900a\u9175\u6bcd\uff09\u7531\u5170\u5dde\u751f\u7269\u5236\u54c1\u7814\u7a76\u6240\uff08Lanzhou Institute of Biological Products\uff09\u3001\u56fd\u836f\u4e2d\u751f\u751f\u7269\u6280\u672f\u7814\u7a76\u9662\uff08China national biotec\uff09\u548c\u5317\u4eac\u751f\u7269\u5236\u54c1\u7814\u7a76\u6240\uff08National vaccine and serum institute\uff09\u8054\u5408\u7814\u53d1\uff0c2017\u5e745\u6708\u8be5\u4ea7\u54c1\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\uff08\u9884\u9632\u7528\u751f\u7269\u5236\u54c11\u7c7b\uff09\u83b7CDE\u53d7\u7406\u3002<\/span>2019\u5e743\u6708\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\uff0c\u62df\u7528\u4e8e\u9884\u9632\u8bfa\u5982\u75c5\u6bd2\u611f\u67d3\u5f15\u8d77\u7684\u4e2d\/\u91cd\u5ea6\u80c3\u80a0\u708e\u3002<\/span><\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
2.CT032\u4eba\u6e90\u5316\u6297CD19\u81ea\u4f53CAR T\u7ec6\u80de<\/span><\/strong><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/span><\/p>\n

CT032\u4eba\u6e90\u5316\u6297CD19\u81ea\u4f53CAR T\u7ec6\u80de\u7531\u4e0a\u6d77\u79d1\u6d4e\u751f\u7269\u7814\u53d1\uff0c\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u4e00\u671f\u7814\u7a76\u9636\u6bb5\uff0c\u7528\u4e8e\u6cbb\u7597CD19\u9633\u6027\u6076\u6027B\u7ec6\u80de\u6027\u767d\u8840\u75c5\u548c\u6dcb\u5df4\u7624\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n


<\/span><\/p>\n

\u7814\u53d1\u91cc\u7a0b\u7891<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

2019\u5e743\u6708\uff0c\u8be5\u836f\u7269\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u4fb5\u88ad\u6027\u975e\u970d\u5947\u91d1B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08B-NHL\uff09\u7684\u7533\u8bf7\u83b7NMPA\u9ed8\u8ba4\u8bb8\u53ef\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n


<\/span><\/p>\n

2018\u5e744\u6708\uff0c\u8be5\u836f\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\uff08\u6cbb\u7597\u7528\u751f\u7269\u5236\u54c11\u7c7b\uff09\u83b7CDE\u53d7\u7406\u3002<\/span><\/p>\n


<\/span><\/p>\n

2016\u5e7411\u6708\uff0c\u5f00\u653e\u6807\u7b7e\u3001\u5355\u7ec4\u5206\u914d\u4e34\u5e8aI\u671f\u8bd5\u9a8c\uff08NCT02933775\uff09\u5728\u4e2d\u56fd\u542f\u52a8\uff0c\u9488\u5bf9CD19\u9633\u6027\u6076\u6027B\u7ec6\u80de\u6027\u767d\u8840\u75c5\u548c\u6dcb\u5df4\u7624\uff0c\u5f53\u65f6\u9884\u8ba1\u5c06\u4e8e2020\u5e741\u6708\u5b8c\u6210\uff0c\u521d\u6b65\u7ed3\u679c\u4e8e2018\u5e74EHA\u4f1a\u8bae\u516c\u5e03\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4e34\u5e8a\u7ed3\u679c<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

\u5bf9R\/R B-cell NHL\u7684I\u671f\u4e34\u5e8a\u521d\u6b65\u7ed3\u679c\u4e8e2018\u5e74EHA\u4f1a\u8bae\u516c\u5e03\u3002<\/span>\u622a\u6b62\u81f32018\u5e743\u6708\uff0c\u8be5\u7814\u7a76\u5171\u5165\u7ec43\u540d\u60a3\u8005\uff0c\u5176\u4e2d1\u540d\u8bca\u65ad\u4e3aMCL\uff0c2\u540d\u8bca\u65ad\u4e3aDLBCL\uff0c\u5728CAR-T\u7ec6\u80de\u8f93\u6ce8\u4e00\u4e2a\u6708\u4e4b\u540e\uff0cPET-CT\u6216\u8005CT\u626b\u63cf\u663e\u793a\uff0c\u6240\u6709\u60a3\u8005\u75c5\u60c5\u5747\u51fa\u73b0\u7f13\u89e3\uff0c\u5176\u4e2d1\u4f8b\u4e3aCR\uff0c\u672a\u89c2\u5bdf\u5230\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff0c\u800c\u4e3b\u8981\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff08II\u7ea7\uff09\u548c\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\uff08III\u81f3IV\u7ea7\uff091<\/span><\/sup>\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u878d\u8d44\u53ca\u4ea4\u6613<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

2018\u5e744\u6708\uff0c\u79d1\u6d4e\u751f\u7269\u5b8c\u62106000\u4e07\u7f8e\u5143\u7684Pre-C\u8f6e\u878d\u8d44\uff0c\u672c\u8f6e\u878d\u8d44\u7531\u5149\u91cf\u8d44\u672c\u9886\u6295\u3002<\/span><\/p>\n


<\/span><\/p>\n

2016\u5e741\u6708\uff0c\u79d1\u6d4e\u751f\u7269\u83b7\u5f973300\u4e07\u5143B\u8f6e\u878d\u8d44\uff0c\u6295\u8d44\u65b9\u4e3a\u51ef\u6cf0\u8d44\u672c\u3002<\/span><\/p>\n


<\/span><\/p>\n

2014\u5e7411\u6708\uff0c\u79d1\u6d4e\u751f\u7269\u5b8c\u6210A\u8f6e1000\u4e07\u4eba\u6c11\u5e01\u878d\u8d44\uff0c\u7531\u767e\u5965\u8d22\u5bcc\u9886\u6295\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u53c2\u8003<\/span><\/p>\n


<\/span><\/p>\n

1.THE EFFICACY AND SAFETY OF HUMANIZED CD19 CAR-T CELLS FOR RELAPSED OR REFRACTORY B-CELL NON-HODGKIN LYMPHOMA (NHL):<\/span> A PRELIMINARY REPORT, EHA Learning Center. Huang H.Jun 15, 2018 (Abstract:<\/span> PF402).<\/span><\/p>\n


<\/span><\/p>\n

<\/span><\/p>\n

\u8be5\u836f\u7269\u540c\u9776\u70b9\uff08CD19\uff09\u4e2d\u56fd1\u7c7b\u65b0\u836f\u5982\u4e0b\u8868\u6240\u793a\uff1a<\/span><\/p>\n


<\/span><\/p>\n

\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n


<\/p>\n

\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n

 <\/span>
<\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
3.CT053\u5168\u4eba\u6297BCMA\u81ea\u4f53CAR T\u7ec6\u80de<\/span><\/strong><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

\u79d1\u6d4e\u751f\u7269\u5f00\u53d1\u7684CT053\u5168\u4eba\u6297BCMA\u81ea\u4f53CAR T\u7ec6\u80de\u76ee\u524d\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff0c\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u96be\u6cbb\u6027\u6216\u590d\u53d1\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u7814\u53d1\u91cc\u7a0b\u7891<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

2018\u5e745\u6708\uff0c\u8be5\u4ea7\u54c1\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\uff08\u6cbb\u7597\u7528\u751f\u7269\u5236\u54c11\u7c7b\uff09\u83b7CDE\u53d7\u7406\uff0c\u5e76\u4e8e2019\u5e743\u6708\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\u3002<\/span><\/p>\n


<\/span><\/p>\n

2017\u5e7412\u6708\uff0c\u5bf9\u590d\u53d1\/\u96be\u6cbb\u6027MM\u7684\u5f00\u653e\u6807\u7b7e\u3001\u5355\u81c2\u3001\u8bd5\u70b9I\u671f\u7814\u7a76\uff08NCT03716856\uff09\u5728\u4e2d\u56fd\u542f\u52a8\uff0c\u5f53\u65f6\u9884\u8ba1\u5c06\u4e8e2020\u5e748\u6708\u5b8c\u6210\u3002<\/span><\/p>\n


<\/span><\/p>\n

2017\u5e7410\u6708\uff0c\u9488\u5bf9\u590d\u53d1\/\u96be\u6cbb\u6027MM\u7684\u5355\u81c2\u3001\u5f00\u653e\u6807\u7b7e\u3001\u8bd5\u70b9\u7814\u7a76\uff08NCT03380039\uff09\u5728\u4e2d\u56fd\u542f\u52a8\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4e34\u5e8a\u7ed3\u679c<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

2018\u5e7412\u6708\uff0cBCMA  CAR-T\u7ec6\u80de\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08R\/R MM\uff09\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u4e34\u5e8a\u7814\u7a76\u521d\u6b65\u7ed3\u679c\u4e8eASH\u516c\u5e03\u3002<\/span>\u622a\u6b622018\u5e747\u670812\u65e5\uff0c\u8be5\u7814\u7a76\u5171\u670917\u4f8bR\/R MM\u53d7\u8bd5\u8005\u63a5\u53d7\u5355\u5242CT053\u8f93\u6ce8\uff0c\u7ec6\u80de\u5242\u91cf\u8303\u56f4\u4e3a0.5-1.8×108<\/span><\/sup>\uff0c\u8f93\u6ce8\u540e\u89c2\u5bdf\u671f\u4e3a10-272\u5929\uff08\u4e2d\u4f4d92\u5929\uff09\uff0c14\u4f8b\u53d7\u8bd5\u8005\u83b7\u5f97\u81f3\u5c114\u5468\u7684\u6709\u6548\u6027\u8bc4\u4ef7\u3002<\/span>\u6240\u6709\u53d7\u8bd5\u8005\u5728\u63a5\u53d7CT053\u5355\u6b21\u6ce8\u5c04\u540e1-3\u5929\u5747\u5728\u5916\u5468\u8840\u68c0\u6d4b\u5230CAR-T\u7ec6\u80de\u6269\u589e\uff0c14\u4f8b\u6709\u6548\u6027\u8bc4\u4ef7\u7684\u53d7\u8bd5\u8005\u5728CT053\u8f93\u6ce8\u540e2-4\u5468\u540e\u81f3\u5c11\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\u53ca\u4ee5\u4e0a\u7597\u6548\uff0c\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u5230100%\uff0c\u975e\u5e38\u597d\u7684\u90e8\u5206\u7f13\u89e3\uff08VGPR\uff09\u53ca\u5b8c\u5168\u7f13\u89e3\uff08CR\/sCR\uff09\u7684\u6bd4\u4f8b\u4e3a78.6%\u3002<\/span>\u5b89\u5168\u6027\u6570\u636e\u663e\u793a\uff0c\u6240\u6709\u60a3\u8005\u5747\u80fd\u8010\u53d7\u8be5\u6cbb\u7597\uff0c\u67095\u4f8b\u53d7\u8bd5\u8005\u53d1\u751f\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\uff0c\u5305\u62ec4\u4f8b2\u7ea7\uff0c1\u4f8b3\u7ea7\uff0c\u4e8e\u7ec6\u80de\u8f93\u6ce8\u540e\u7b2c1-13\u5929\u5185\u53d1\u751f\uff0c\u4f7f\u7528\u6258\u73e0\u5355\u6297\u7b49\u6cbb\u7597\u540e\u5747\u4e8e3-6\u5929\u5185\u75c7\u72b6\u7f13\u89e31<\/span><\/sup>\u3002<\/span><\/span><\/p>\n


<\/span><\/strong><\/p>\n

\u878d\u8d44\u53ca\u4ea4\u6613<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

2018\u5e744\u6708\uff0c\u79d1\u6d4e\u751f\u7269\u5b8c\u62106000\u4e07\u7f8e\u5143\u7684Pre-C\u8f6e\u878d\u8d44\uff0c\u7531\u5149\u91cf\u8d44\u672c\u9886\u6295\u3002<\/span><\/p>\n


<\/span><\/p>\n

2016\u5e741\u6708\uff0c\u79d1\u6d4e\u751f\u7269\u83b7\u5f973300\u4e07\u5143B\u8f6e\u878d\u8d44\uff0c\u6295\u8d44\u65b9\u4e3a\u51ef\u6cf0\u8d44\u672c\u3002<\/span><\/p>\n


<\/span><\/p>\n

2014\u5e7411\u6708\uff0c\u79d1\u6d4e\u751f\u7269\u5b8c\u6210A\u8f6e1000\u4e07\u4eba\u6c11\u5e01\u878d\u8d44\uff0c\u7531\u767e\u5965\u8d22\u5bcc\u9886\u6295\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u53c2\u8003<\/span><\/p>\n


<\/span><\/p>\n

1. CARsgen Presents Preliminary Results of CAR-BCMAT Therapy at ASH 2018, PR Newswire, 2018\/12\/4.<\/span><\/p>\n


<\/span><\/p>\n

\u8be5\u836f\u7269\u540c\u9776\u70b9BCMA\uff08B\u7ec6\u80de\u6210\u719f\u86cb\u767d\uff09\u4e2d\u56fd1\u7c7b\u65b0\u836f\u5982\u4e0b\u8868\u6240\u793a\uff1a<\/span><\/p>\n


<\/p>\n

\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n


<\/span><\/p>\n

\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
4.TAEST16001<\/span><\/strong><\/span><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/span><\/p>\n

\u7531\u5e7f\u5dde\u547c\u5438\u75be\u75c5\u7814\u7a76\u6240\u4e0e\u9999\u96ea\u751f\u547d\u79d1\u5b66\u7814\u7a76\u4e2d\u5fc3\u3001\u5e7f\u4e1c\u9999\u96ea\u7cbe\u5bc6\u533b\u7597\u6280\u672f\u548c\u5e7f\u5dde\u9999\u96ea\u836f\u4e1a\u5408\u4f5c\u5f00\u53d1\u7684TAEST16001\uff0c\u662f\u7531TAEST\u6280\u672f\u6240\u4ea7\u751f\u9488\u5bf9\u6297\u539fNY-ESO-1\u5e76\u4e14\u53d7\u9650\u4e8eHLA-A2.1\u7684T\u7ec6\u80de\u7597\u6cd5\uff0c\u76ee\u524d\u5904\u4e8e\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u5b9e\u4f53\u7624\u7684\u4e34\u5e8a\u4e00\u671f\u7814\u7a76\u9636\u6bb5\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n


<\/span><\/p>\n

\u7814\u53d1\u91cc\u7a0b\u7891<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

2019\u5e743\u6708\uff0c\u7528\u4e8e\u6cbb\u7597\u8f6f\u7ec4\u7ec7\u8089\u7624\uff08\u7ec4\u7ec7\u57fa\u56e0\u578b\u4e3aHLA-A*02:<\/span>01\uff0c\u80bf\u7624\u6297\u539fNY-ESO-1\u8868\u8fbe\u4e3a\u9633\u6027\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7\u5f97NMPA\u9ed8\u793a\u8bb8\u53ef<\/span><\/p>\n


<\/span><\/p>\n

2018\u5e7412\u6708\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7NMPA\u53d7\u7406\u3002<\/span><\/p>\n


<\/span><\/p>\n

2018\u5e741\u6708\uff0c\u5f00\u59cb\u4e00\u9879\u5bf9\u5b9e\u4f53\u7624\u7684\u4e34\u5e8aI\u671f\u7814\u7a76\uff08NCT03159585\uff09\u3002<\/span>2018\u5e7410\u6708\uff0cTCR-T\u7ec6\u80de\u7597\u6cd5\uff08TAEST\uff09\u7684\u521d\u6b65\u4e34\u5e8a\u7ed3\u679c\u516c\u5e03\uff0c\u663e\u793a\u51fa\u9633\u6027\u4fe1\u53f7\u3002<\/span>\u5728\u7ecf\u5386\u6807\u51c6\u6cbb\u7597\u5931\u8d25\u76849\u540d\u764c\u75c7\u665a\u671f\u60a3\u8005\u4e2d,\u7814\u7a76TAEST\u6280\u672f\u4ea7\u751fTCR-T\u7ec6\u80de\u7597\u6cd5\u7684\u521d\u6b65\u7ed3\u679c\u663e\u793a\u5982\u4e0b\uff1a<\/span>\u5728\u524d\u4e09\u540d\u60a3\u8005\u4e2d\uff0c\u6d4b\u8bd5\u4e00\u540d\u60a3\u8005\u7684\u5242\u91cf\u9012\u589e\u548c\u4e24\u540d\u60a3\u8005\u7684\u5168\u5242\u91cf\uff0c\u4e09\u540d\u60a3\u8005\u5747\u8868\u73b0\u51fa\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u3002<\/span>\u5176\u4e2d\u4e24\u540d\u60a3\u8005\u8868\u73b0\u7a33\u5b9a\uff0c\u5206\u522b\u5b58\u6d3b\u4e866\u4e2a\u6708\u548c10\u4e2a\u6708\u3002<\/span>\u4e00\u540d\u60a3\u6709\u80ba\u764c\u7684\u60a3\u8005\u7ecf\u6cbb\u7597\u540e\u663e\u793a\u80bf\u7624\u4f53\u79ef\u51cf\u5c11\u3001\u75bc\u75db\u75c7\u72b6\u51cf\u8f7b\u3002<\/span>\u5728\u60a3\u80054\u81f39\u53f7\u4e2d\u5c06\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u6dfb\u52a0\u5230\u534f\u8bae\u65b9\u6848\u4e2d\u3002<\/span>\u6cbb\u7597\u8010\u53d7\u826f\u597d\u4f34\u6709\u53d1\u70e7\uff08n = 5\uff09\uff0c\u89c2\u5bdf\u5230\u5bd2\u6218\uff08n = 4\uff09\uff0c\u865a\u5f31\uff08n = 4\uff09\u548c\u8f7b\u5ea6\u76ae\u75b9\uff08n = 3\uff09\u3002<\/span>\u901a\u8fc7CT\u626b\u63cf\u6d4b\u91cf\uff0c\u4e24\u540d\u60a3\u8005\uff08\u4e00\u540d\u4e73\u817a\u764c\uff0c\u4e00\u540d\u6ed1\u819c\u8089\u7624\uff09\u7684\u80bf\u7624\u5927\u5c0f\u51cf\u5c11\u4e8640\uff05\u4ee5\u4e0a\u3002<\/span>\u60a3\u6709\u4e73\u817a\u764c\u7684\u60a3\u8005\u4e5f\u6709\u4e24\u4e2a\u76ae\u80a4\u8f6c\u79fb\u6027\u6e83\u75a1\u7684\u6108\u5408\u3002<\/span>\u53e6\u5916\u4e24\u540d\u60a3\u8005\uff08\u4e00\u540d\u60a3\u6709\u5207\u9664\u672f\u540e\u8179\u819c\u540e\u590d\u53d1\u7684\u809d\u764c\u60a3\u8005\uff0c\u4e00\u540d\u60a3\u6709\u7532\u72b6\u817a\u764c\u7684\u60a3\u8005\uff09\u8868\u73b0\u7a33\u5b9a\u3002<\/span>\u8fd9\u4e24\u540d\u60a3\u8005\u5728\u6cbb\u7597\u540e\u4e0d\u4e45\u90fd\u8868\u73b0\u51fa\u660e\u663e\u7684\u80bf\u7624\u574f\u6b7b\uff0c\u5bfc\u81f4\u80bf\u7624\u4e2d\u95f4\u5f62\u6210\u7a7a\u6d1e\uff0c\u5c40\u90e8\u75bc\u75db\u75c7\u72b6\u5f97\u4ee5\u7f13\u89e3\u3002<\/span>\u5176\u4f59\u4e24\u540d\u80ba\u764c\u60a3\u8005\u5728\u6cbb\u7597\u540e\u75c5\u60c5\u7a33\u5b9a\u8d85\u8fc760\u59291<\/span><\/sup>\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u878d\u8d44\u53ca\u4ea4\u6613<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

2018\u5e747\u6708\uff0c\u9999\u96ea\u751f\u547d\u79d1\u5b66XLifeSc\u548c\u7f8e\u56fd\u751f\u7269\u533b\u836f\u516c\u53f8Athenex\u8fbe\u6210\u534f\u8bae\uff0c\u5408\u8d44\u6210\u7acb\u540d\u4e3aAxis Therapeutics Limited\u7684\u65b0\u5408\u8d44\u4f01\u4e1a\uff0c\u5171\u540c\u5f00\u53d1TCR-T\u764c\u75c7\u514d\u75ab\u7597\u6cd5\uff0c\u9999\u96ea\u83b7\u5f97500\u4e07\u7f8e\u5143\u7684\u80a1\u7968\u4f5c\u4e3a\u9884\u4ed8\u6b3e\u3001\u9ad8\u8fbe1.1\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u6b3e\u9879\u4ee5\u53caAxis\u768445\uff05\u7684\u80a1\u6743\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u53c2\u8003<\/span><\/p>\n


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1. Athenex and Xiangxue Life Sciences Announce Preliminary Results of Patients Receiving T- Receptor Affinity Enhancing Specific T- Therapy (TAEST)Showed Encouraging Positive Clinical, BUFFALO, N.Y., 2018\/10\/15.<\/span><\/p>\n


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\n
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\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
5.\u91cd\u7ec4\u4eba\u6e90\u5316\u6297PD-1\u5355\u514b\u9686\u6297\u4f53<\/span><\/strong><\/span><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

\u5b89\u5fbd\u5b89\u79d1\u751f\u7269\u5f00\u53d1\u7684\u91cd\u7ec4\u4eba\u6e90\u5316\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\u5df2\u5411\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u9012\u4ea4\u4e86\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\uff08\u6cbb\u7597\u7528\u751f\u7269\u5236\u54c11\u7c7b\uff09\uff0c\u5e76\u4e8e2019\u5e741\u6708\u83b7\u5f97\u53d7\u7406\u3002<\/span>2019\u5e743\u6708\u88ab\u9ed8\u8ba4\u8bb8\u53ef\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80bf\u7624\uff08\u5305\u62ecNK\/T\u7ec6\u80de\u6dcb\u5df4\u7624\u3001\u4e09\u9634\u6027\u4e73\u817a\u764c\u3001\u4e0b\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u98df\u7ba1\u764c\u548c\u80ba\u764c\u7b49\uff09\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8be5\u836f\u7269\u7684\u540c\u9776\u70b9\uff08PD-1\uff09\u4e2d\u56fd1\u7c7b\u65b0\u836f\u5982\u4e0b\u8868\u6240\u793a\uff1a<\/span><\/p>\n


<\/span><\/p>\n

\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n


<\/p>\n

\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n


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\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
6.\u91cd\u7ec4\u5341\u56db\u4ef7\u4eba\u4e73\u5934\u7624\u75c5\u6bd2\u75ab\u82d7<\/span><\/strong><\/span><\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/section>\n<\/section>\n<\/section>\n
\n

\uff086,11,16,18,31,33,35,39,45,51,52,56,58,59\u578b\uff09\uff08\u6606\u866b\u7ec6\u80de\uff09<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5317\u4eac\u8bfa\u5b81\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u548c\u795e\u5dde\u7ec6\u80de\u5de5\u7a0b\u6709\u9650\u516c\u53f8\uff08Sinocelltechbiotech\uff09\u5171\u540c\u5f00\u53d1\u4e86\u91cd\u7ec4\u5341\u56db\u4ef7\u4eba\u4e73\u5934\u7624\u75c5\u6bd2\u75ab\u82d7\uff086,11,16,18,31,33,35,39,45,51,52,56,58,59\u578b\uff09\uff08\u6606\u866b\u7ec6\u80de\uff09\uff0c 2018\u5e741\u6708\uff0c\u8be5\u4ea7\u54c1\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\uff08\u9884\u9632\u7528\u751f\u7269\u5236\u54c1\u4e00\u7c7b\uff09\u83b7CDE\u53d7\u7406\uff0c2019\u5e743\u6708\u88ab\u9ed8\u8ba4\u8bb8\u53ef\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7528\u4e8e\u9884\u963218-45\u5c81\u5e74\u9f84\u7684\u5973\u5b69\u548c\u5987\u5973\u4eba\u7fa4\u4e2d\u75316,11,16,18,31,33,35,39,45,51,52,56,58,59\u578b\u4eba\u4e73\u5934\u7624\u75c5\u6bd2\uff08HPV\uff09\u611f\u67d3\u6240\u81f4\u7684\u5bab\u9888\u3001\u5916\u9634\u3001\u9634\u9053\u548c\u809b\u95e8\u75be\u75c5\u548c\u764c\u75c7\u3002<\/span><\/p>\n

\u8f6c\u81ea
<\/span><\/p>\n

\n
\n
\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u66f4\u591a\u7cbe\u5f69\u5185\u5bb9\uff1a\"\u200b\u3010\u6570\u636e\u30112019\u5e743\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001\"<\/span><\/strong><\/p>\n


<\/p>\n