{"id":89706,"date":"2019-04-19T00:00:50","date_gmt":"2019-04-23T04:11:57","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/89706\/"},"modified":"2019-04-23T12:12:03","modified_gmt":"2019-04-23T04:12:03","slug":"d82e0726a3","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/89706\/","title":{"rendered":"\u5b66\u79d1\u524d\u6cbf | CPU\u524d\u6cbf\uff5c\u5f20\u5a1f\u3001\u9ec4\u5f20\u5efa\u5408\u4f5c\u62a5\u9053\u6297\u4f53-\u4e00\u6c27\u5316\u6c2e\u5076\u8054\u7269\u6297\u809d\u764c\u7814\u7a76\u65b0\u8fdb\u5c55"},"content":{"rendered":"
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\u8fd1\u65e5\uff0c\u80bf\u7624\u9886\u57df\u6743\u5a01\u6742\u5fd7Cancer Research\uff08\u5f71\u54cd\u56e0\u5b50 9.130\uff09\u5728\u7ebf\u53d1\u8868\u4e86\u6211\u6821\u751f\u547d\u79d1\u5b66\u4e0e\u6280\u672f\u5b66\u9662\u5f20\u5a1f\u526f\u6559\u6388\u548c\u836f\u7269\u79d1\u5b66\u7814\u7a76\u9662\u9ec4\u5f20\u5efa\u7814\u7a76\u5458\u5408\u4f5c\u62a5\u9053\u7684\u6700\u65b0\u7814\u7a76\u6210\u679c\u2014\u2014Anti-CD24 antibody-nitric oxide conjugate (ANC) selectively and potently suppresses hepatic carcinoma\u3002\u5fae\u751f\u7269\u4e0e\u751f\u5316\u836f\u5b66\u4e13\u4e1a\u535a\u58eb\u751f\u5b59\u798f\u8c0b\u540c\u5b66\u4e3a\u672c\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\uff0c\u5f20\u5a1f\u526f\u6559\u6388\u548c\u9ec4\u5f20\u5efa\u7814\u7a76\u5458\u4e3a\u672c\u6587\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/span><\/p>\n

\u3000\u3000\u4f20\u7edf\u7684\u6297\u4f53-\u836f\u7269\u5076\u8054\u7269\uff08antibodydrug conjugate, ADC\uff09\u7531\u62e5\u6709\u5f3a\u7ec6\u80de\u6bd2\u6027\u7684\u5316\u5b66\u836f\u7269\u901a\u8fc7\u8fde\u63a5\u7269\u4e0e\u5355\u6297\u5076\u8054\u800c\u6210\uff0c\u517c\u5177\u5c0f\u5206\u5b50\u836f\u7269\u5f3a\u5927\u7684\u6740\u4f24\u529b\u548c\u5355\u6297\u9ad8\u5ea6\u7684\u9776\u5411\u6027\u7684\u4f18\u70b9\u3002\u53d7ADC\u8bbe\u8ba1\u7684\u542f\u53d1\uff0c\u5f20\u5a1f\u56e2\u961f\u548c\u9ec4\u5f20\u5efa\u56e2\u961f\u6210\u529f\u901a\u8fc7\u5355\u6297\u5b9e\u73b0\u4e86\u6c14\u4f53\u4fe1\u4f7f\u5206\u5b50\u4e00\u6c27\u5316\u6c2e\uff08NO\uff09\u7684\u9776\u5411\u9012\u9001\uff0c\u5e76\u9996\u6b21\u63d0\u51fa\u4e86\u6297\u4f53-\u4e00\u6c27\u5316\u6c2e\u5076\u8054\u7269\uff08antibody nitric oxide conjugate , ANC\uff09\u7684\u6982\u5ff5\uff0c\u4e3a\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u63d0\u4f9b\u4e00\u79cd\u5d2d\u65b0\u7684\u8bbe\u8ba1\u601d\u8def\u3002<\/span><\/p>\n

\u3000\u3000NO\u5728\u80bf\u7624\u6cbb\u7597\u4e2d\u5177\u6709\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\uff0c\u5982\u4f55\u5c06\u5176\u51c6\u786e\u5730\u9012\u9001\u81f3\u764c\u75c7\u75c5\u7076\u6210\u4e3a\u9650\u5236\u5176\u6210\u836f\u6027\u7684\u74f6\u9888\u6240\u5728\u3002ADC\u836f\u7269\u8fd1\u5e74\u6765\u5728\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u7624\u7684\u6cbb\u7597\u9886\u57df\u5747\u53d6\u5f97\u4e86\u7a81\u7834\u6027\u7684\u8fdb\u5c55\u3002\u7136\u800c\uff0c\u4f20\u7edfADC\u7684\u7814\u7a76\u5747\u96c6\u4e2d\u4e8e\u5229\u7528\u6297\u4f53\u5c06\u5fae\u7ba1\u86cb\u767d\u6291\u5236\u5242\u8fd9\u7c7b\u9ad8\u6bd2\u6027\u5c0f\u5206\u5b50\u7684\u9012\u9001\uff0c\u540c\u65f6\u4e5f\u4e0d\u514d\u5e26\u6765\u9ad8\u6bd2\u526f\u4f5c\u7528\u3002\u5f20\u5a1f\u56e2\u961f\u548c\u9ec4\u5f20\u5efa\u56e2\u961f\u62d3\u5bbd\u4e86ADC\u836f\u7269\u7684\u6982\u5ff5\uff0c\u5c06\u56e2\u961f\u81ea\u4e3b\u7814\u53d1\u7684\u6297CD24\u5355\u6297\u4e0eNO\u4f9b\u4f53\u5de7\u5999\u5730\u7ed3\u5408\u8d77\u6765\uff0c\u5229\u7528\u5728\u80bf\u7624\u75c5\u7076\u7684\u6c27\u5316\u8fd8\u539f\u73af\u5883\u4e0b\u624d\u53d1\u751f\u65ad\u88c2\u7684\u4e8c\u786b\u952e\u4e0e\u6297\u4f53\u8fde\u63a5\u83b7\u5f97\u6297\u4f53\u4e00\u6c27\u5316\u6c2e\u5076\u8054\u7269 (ANC)\u3002\u8be5ANC\u4e0e\u809d\u764c\u7ec6\u80de\u8868\u9762\u9ad8\u8868\u8fbe\u7684\u7279\u5f02\u6027\u53d7\u4f53\u5206\u5b50CD24\u9776\u5411\u7ed3\u5408\uff0c\u7531CD24\u5206\u5b50\u4ecb\u5bfc\u7684\u5185\u541e\u4f5c\u7528\u8fdb\u5165\u809d\u764c\u7ec6\u80de\uff0c\u4e8c\u786b\u952e\u65ad\u88c2\u968f\u540e\u53d1\u751f1,6-\u6d88\u9664\u53cd\u5e94\u91ca\u653e\u51fa\u9ad8\u6d53\u5ea6\u7684NO\u5206\u5b50\uff0c\u4ece\u800c\u5b9e\u73b0\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u9009\u62e9\u6027\u6740\u4f24\u3002<\/span><\/p>\n

\u3000\u3000\u8be5ANC\u5c0f\u8bd5\u751f\u4ea7\u5de5\u827a\u53ef\u63a7\uff0c\u5177\u6709\u9009\u62e9\u6027\u80bf\u7624\u9776\u5411\u3001\u4f5c\u7528\u673a\u5236\u660e\u786e\u3001\u4f53\u5185\u5faa\u73af\u7a33\u5b9a\u3001\u836f\u6548\u6548\u679c\u663e\u8457\u548c\u6bd2\u526f\u4f5c\u7528\u6781\u4f4e\u7684\u4f18\u70b9\uff0c\u4ea6\u53ef\u7528\u4e8e\u5176\u4ed6CD24\u9ad8\u8868\u8fbe\u7684\u80bf\u7624\u5982\u7ed3\u76f4\u80a0\u764c\u3001\u5934\u9888\u764c\u3001\u5375\u5de2\u764c\u7b49\u3002<\/span><\/p>\n

\u3000\u3000\u6b64\u9879\u7814\u7a76\u6210\u679c\u6269\u5c55\u4e86ADC\u7684\u8bbe\u8ba1\u7406\u5ff5\uff0c\u5e76\u9996\u6b21\u63d0\u51fa\u4e86ANC\u7684\u6982\u5ff5\uff0c\u89e3\u51b3NO\u9776\u5411\u6027\u7ed9\u836f\u7684\u96be\u9898\u3002\u8be5ANC\u7684\u8bbe\u8ba1\u7406\u5ff5\u53ef\u4ee5\u63a8\u5e7f\u81f3\u66f4\u591a\u5177\u6709\u6cbb\u7597\u6f5c\u529b\u7684\u6c14\u4f53\u5c0f\u5206\u5b50\u836f\u7269\u7684\u7814\u53d1\u4e2d\u3002\u76ee\u524d\u8be5ANC\u5df2\u7533\u8bf7\u4e2d\u56fd\u4e13\u5229\u548c\u56fd\u9645\u4e13\u5229\uff0c\u5177\u6709\u826f\u597d\u7684\u5e94\u7528\u548c\u8f6c\u5316\u524d\u666f\u3002\u6b64\u9879\u6210\u679c\u4f5c\u4e3a\u8fd1\u671f\u7814\u7a76\u70ed\u70b9\u4e5f\u88ab\u79d1\u5b66\u8bc4\u8bba\u6742\u5fd7Hepatic News<\/em>\u8bc4\u8bba\u62a5\u9053 (Volume 3.11 | Mar 29)\u3002<\/span><\/p>\n


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\u25cf <\/strong><\/span>\u60f3\u56de\u987e\u300a\u836f\u5b66\u8fdb\u5c55\u300b\u7f16\u59d4\u4f1a\u4e3b\u529e\u548c\u534f\u529e\u8fc7\u7684\u7cbe\u5f69\u6d3b\u52a8\u5417\uff1f\u8bf7\u6233\u8fd9\u91cc\uff01<\/span><\/p>\n

\u2192 <\/span>\u3010\u836f\u95fb\u5927\u5bb6\u8c08\u3011\u201c\u836f\u5b66\u670d\u52a1\u6a21\u5f0f\u521b\u65b0\u4e0e\u672a\u6765\u836f\u5e08\u4ef7\u503c\u4f53\u73b0\u9ad8\u7aef\u8bba\u575b\u201d\u9686\u91cd\u5f00\u5e55<\/a><\/span><\/p>\n


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\u2192 \u7531\u300a\u836f\u5b66\u8fdb\u5c55\u300b\u7f16\u59d4\u4f1a\u4e3b\u529e\u7684\u4fa8\u754c\u751f\u7269\u533b\u836f\u7cbe\u82f1\u4eba\u624d\u201c\u8d4b\u80fd\u4e4b\u65c5\u201d\u53d6\u5f97\u5706\u6ee1\u6210\u529f\uff01<\/a><\/span><\/p>\n


<\/p>\n

\u2192 \u949f\u5c71\u5cf0\u4f1a\uff5c11\u4e2a\u521b\u65b0\u9879\u76ee\uff0b10\u5bb6\u4e13\u4e1a\u673a\u6784\u7684\u76f8\u89c1\u6068\u665a<\/a><\/span><\/p>\n


<\/p>\n

\u2192 \u300a\u836f\u5b66\u8fdb\u5c55\u300b\u7f16\u59d4\u805a\u9996\u6e2f\u57ce\uff0c\u52a9\u529b\u8fde\u4e91\u6e2f\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u521b\u65b0\u672a\u6765\uff01<\/a><\/span><\/p>\n


<\/p>\n

\u2192 2018\u5e74\u9996\u5c4a\u201c\u949f\u5c71\u5cf0\u4f1a\u201d\u5728\u5b81\u53ec\u5f00\uff0c\u9662\u58eb\u9886\u8854\u836f\u754c\u7cbe\u82f1\u9f50\u805a\u6c5f\u5317\u65b0\u533a\uff0c\u300a\u836f\u5b66\u8fdb\u5c55\u300b\u7f16\u59d4\u6c47\u667a\u91d1\u9675\uff0c\u4e3a\u533b\u836f\u4ea7\u4e1a\u53d1\u5c55\u5efa\u8a00\u732e\u7b56\uff01<\/a><\/span><\/p>\n

\u2192 \u7fa4\u82f1\u835f\u8403\uff1a\u300a\u836f\u5b66\u8fdb\u5c55\u300b\u7f16\u59d4\u4f1a\u66a8\u201c\u7b2c\u56db\u5c4a\u836f\u5b66\u524d\u6cbf\u9ad8\u5cf0\u8bba\u575b\u201d\u7cbe\u5f69\u56de\u987e\uff08I\uff09<\/a><\/span><\/p>\n

\u2192 \u7fa4\u82f1\u835f\u8403\uff1a\u300a\u836f\u5b66\u8fdb\u5c55\u300b\u7f16\u59d4\u4f1a\u66a8\u201c\u7b2c\u56db\u5c4a\u836f\u5b66\u524d\u6cbf\u9ad8\u5cf0\u8bba\u575b\u201d\u7cbe\u5f69\u56de\u987e\uff08\u2161\uff09<\/a><\/span><\/p>\n

\u2192 \u7fa4\u82f1\u835f\u8403\uff1a\u300a\u836f\u5b66\u8fdb\u5c55\u300b\u7f16\u59d4\u4f1a\u66a8\u201c\u7b2c\u56db\u5c4a\u836f\u5b66\u524d\u6cbf\u9ad8\u5cf0\u8bba\u575b\u201d\u7cbe\u5f69\u56de\u987e\uff08III\uff09<\/a><\/span><\/p>\n


<\/p>\n

\u2192<\/span> <\/span>\u53cc\u521b\u54cd\u6c5f\u82cf\uff0c\u732e\u793c\u5341\u4e5d\u5927  |\u201c\u5065\u5eb7\u4e2d\u56fd\u201d\u751f\u7269\u533b\u836f\u521b\u65b0\u521b\u4e1a\u5927\u8d5b\u9686\u91cd\u53ec\u5f00<\/a><\/span><\/span><\/p>\n


<\/p>\n

\u2192 \u76db\u9080 | 2017\u7b2c\u4e8c\u5c4a\u521b\u65b0\u836f\u7269\u7814\u53d1\u4e0e\u5e94\u7528\u5927\u4f1a  \u70ed\u5ff1\u6b22\u8fce\u60a8\u53c2\u4f1a\uff01<\/a><\/span><\/p>\n


<\/p>\n

\u2192 <\/span>\u7531\u300a\u836f\u5b66\u8fdb\u5c55\u300b\u7f16\u59d4\u4f1a\u534f\u529e\u7684\u7b2c\u4e09\u5c4a\u201c\u57fa\u56e0\u6cbb\u7597\u4ea7\u4e1a\u53d1\u5c55\u8bba\u575b\u201d\u5728\u4eac\u6210\u529f\u4e3e\u529e\uff01<\/span><\/a><\/p>\n


<\/p>\n

\u2192<\/span> \u521b\u65b0\u521b\u4e1a\uff0c\u96c6\u7fa4\u53d1\u5c55 \u2014\u2014\u751f\u7269\u533b\u836f\u534f\u540c\u521b\u65b0\u65b0\u65b9\u5411<\/a><\/span><\/span><\/p>\n


<\/p>\n

\u2192 <\/span>\u5b64\u513f\u836f\u7684\u5fe7\u4f24\u4e0e\u66d9\u5149- \u7b2c\u4e09\u5c4a\u4e2d\u56fd\u5b64\u513f\u53d1\u8bba\u575b\u7cbe\u5f69\u56de\u987e\uff08I\uff09<\/a>
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\u2192 <\/span>\u5b64\u513f\u836f\u6295\u8d44\u8fdb\u884c\u66f2\u2014\u7b2c\u4e09\u5c4a\u4e2d\u56fd\u5b64\u513f\u53d1\u8bba\u575b\u7cbe\u5f69\u56de\u987eII<\/a>
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\u2192 <\/span>\u5b64\u513f\u53d1\u591a\u65b9\u534f\u594f\u66f2\u2014\u7b2c\u4e09\u5c4a\u4e2d\u56fd\u5b64\u513f\u53d1\u8bba\u575b\u7cbe\u5f69\u56de\u987eIII<\/a>
<\/span><\/p>\n


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\u2192<\/span><\/a> \u653e\u773c\u56fd\u9645\uff0c\u805a\u7126\u521b\u65b0\uff5c2017\u4e2d\u56fd\u533b\u53d1\u521b\u65b0\u9ad8\u5cf0\u8bba\u575b\u9686\u91cd\u53ec\u5f00\uff01<\/a><\/span><\/p>\n


<\/p>\n

\u2192<\/span><\/a> \u4f18\u79c0\u9879\u76ee\u3001\u91d1\u878d\u8d44\u672c\u3001\u4ea7\u4e1a\u5e73\u53f0\u7cbe\u51c6\u5bf9\u63a5\u2014\u2014\u201c2017 \u676d\u5dde\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u521b\u65b0\u4e0e\u6295\u8d44\u6d3d\u8c08\u4f1a\u201d\u5728\u82cf\u4e3e\u529e<\/a><\/span><\/p>\n


<\/p>\n

\u2192 <\/span>\u667a\u6c47\u6c5f\u82cf\uff0c\u5171\u521b\u672a\u6765\uff1a\u201c\u5927\u9662\u5927\u6240\u6c5f\u82cf\u884c\u201d\u751f\u7269\u533b\u836f\u4e13\u9898\u63a8\u4ecb\u4f1a\u7cbe\u5f69\u56de\u987e\uff08\u2160\uff09<\/span><\/a>
<\/p>\n

\u2192 <\/span>\u667a\u6c47\u6c5f\u82cf\uff0c\u5171\u521b\u672a\u6765\uff1a\u201c\u5927\u9662\u5927\u6240\u6c5f\u82cf\u884c\u201d\u4e4b\u8d70\u8fdb\u5357\u4eac\u751f\u7269\u533b\u836f\u8c37\u66a8\u521b\u836f\u6c47-\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u521b\u65b0\u4e0e\u6295\u878d\u8d44\u9ad8\u5cf0\u8bba\u575b\u7cbe\u5f69\u56de\u987e\uff08II\uff09<\/span><\/a>
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<\/p>\n

\u2192 <\/span>\u5e74\u4f1a\u5de1\u793c\uff1a\u300a\u836f\u5b66\u8fdb\u5c55\u300b\u7f16\u59d4\u4f1a\u66a8\u201c\u7b2c\u4e09\u5c4a\u836f\u5b66\u524d\u6cbf\u9ad8\u5cf0\u8bba\u575b\u201d\u7cbe\u5f69\u56de\u987e\uff08\u2160\uff09<\/span><\/a><\/p>\n

\u2192 <\/span><\/a><\/strong>\u5e74\u4f1a\u5de1\u793c\uff1a\u300a\u836f\u5b66\u8fdb\u5c55\u300b\u7f16\u59d4\u4f1a\u66a8\u201c\u7b2c\u4e09\u5c4a\u836f\u5b66\u524d\u6cbf\u9ad8\u5cf0\u8bba\u575b\u201d\u7cbe\u5f69\u56de\u987e\uff08\u2161\uff09<\/a><\/span><\/p>\n

\u2192 <\/span><\/a><\/strong>\u5e74\u4f1a\u5de1\u793c\uff1a\u300a\u836f\u5b66\u8fdb\u5c55\u300b\u7f16\u59d4\u4f1a\u66a8\u201c\u7b2c\u4e09\u5c4a\u836f\u5b66\u524d\u6cbf\u9ad8\u5cf0\u8bba\u575b\u201d\u7cbe\u5f69\u56de\u987e\uff08\u2162\uff09<\/a><\/span><\/p>\n

\u2192 <\/span><\/a><\/strong>\u5e74\u4f1a\u5de1\u793c\uff1a\u300a\u836f\u5b66\u8fdb\u5c55\u300b\u7f16\u59d4\u4f1a\u66a8\u201c\u7b2c\u4e09\u5c4a\u836f\u5b66\u524d\u6cbf\u9ad8\u5cf0\u8bba\u575b\u201d\u7cbe\u5f69\u56de\u987e\uff08IV\uff09<\/a><\/span><\/p>\n


<\/p>\n

\u2192 <\/span><\/a><\/strong>\u7cbe\u51c6\u533b\u7597\u65f6\u4ee3\uff0c\u8fd8\u9700\u7cbe\u51c6\u7814\u53d1\u2014\u2014\u300a\u836f\u5b66\u8fdb\u5c55\u300b-\u590d\u661f\u533b\u836f\u7b2c\u4e8c\u5c4a\u4e13\u9898\u5b66\u672f\u7814\u8ba8\u4f1a\u7eaa\u5b9e<\/a><\/span><\/p>\n


<\/p>\n

\u2192 <\/span><\/strong><\/span><\/a>\u56fd\u9645\u4eff\u5236\u836f\u53d1\u5c55\u524d\u6cbf\u4e0e\u4e00\u81f4\u6027\u8bc4\u4ef7\u5173\u952e\u6280\u672f\u9ad8\u5cf0\u8bba\u575b\u9686\u91cd\u5f00\u5e55<\/a><\/span><\/p>\n


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<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u8fd1\u65e5\uff0c\u80bf\u7624\u9886\u57df\u6743\u5a01\u6742\u5fd7Cancer Research\uff08\u5f71\u54cd\u56e0\u5b50 9.130\uff09\u5728\u7ebf\u53d1\u8868\u4e86\u6211\u6821\u751f\u547d\u79d1\u5b66\u4e0e\u6280\u672f\u5b66\u9662\u5f20 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/89706"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=89706"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/89706\/revisions"}],"predecessor-version":[{"id":89712,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/89706\/revisions\/89712"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=89706"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=89706"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=89706"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}