{"id":9008,"date":"2018-06-13T01:00:00","date_gmt":"2018-07-27T09:35:38","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e9%80%9f%e9%80%92-nash%e6%96%b0%e8%8d%af%e6%8a%b5%e8%be%be%e8%8e%b7%e6%89%b9%e6%a0%87%e5%87%86%ef%bc%8c%e5%8d%b3%e5%b0%86%e5%b1%95%e5%bc%80%e5%85%b3%e9%94%ae%e8%af%95%e9%aa%8c\/"},"modified":"2018-07-27T17:35:40","modified_gmt":"2018-07-27T09:35:40","slug":"%e9%80%9f%e9%80%92-nash%e6%96%b0%e8%8d%af%e6%8a%b5%e8%be%be%e8%8e%b7%e6%89%b9%e6%a0%87%e5%87%86%ef%bc%8c%e5%8d%b3%e5%b0%86%e5%b1%95%e5%bc%80%e5%85%b3%e9%94%ae%e8%af%95%e9%aa%8c","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9008\/","title":{"rendered":"\u901f\u9012 | NASH\u65b0\u836f\u62b5\u8fbe\u83b7\u6279\u6807\u51c6\uff0c\u5373\u5c06\u5c55\u5f00\u5173\u952e\u8bd5\u9a8c"},"content":{"rendered":"
\n

\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n


<\/p>\n

\u4eca\u5929\u662f\u9996\u4e2a\u56fd\u9645\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u65e5\uff08First International NASH Day\uff09<\/span><\/strong>\u3002\u800c\u5728\u533b\u836f\u884c\u4e1a\u5185\uff0c\u4e00\u6761\u5173\u4e8eNASH\u7684\u4e34\u5e8a\u8bd5\u9a8c\u65b0\u95fb\u4e5f\u5438\u5f15\u4e86\u4e0d\u5c11\u4eba\u7684\u5173\u6ce8\uff1aGalmed Pharmaceuticals<\/span>\u5ba3\u5e03\uff0c\u5176\u53e3\u670dNASH\u7597\u6cd5Aramchol\u83b7\u5f97\u4e86\u79ef\u6781\u76842b\u671f\u4e34\u5e8a\u6570\u636e\uff0c\u6ee1\u8db3\u4e86FDA\u7684\u76d1\u7ba1\u6279\u51c6\u7ec8\u70b9\u3002<\/span><\/p>\n

<\/span><\/p>\n

\"\u901f\u9012<\/p>\n

NASH\u662f\u4e00\u7c7b\u65b0\u8fd1\u51fa\u73b0\u7684\u5168\u7403\u5065\u5eb7\u5371\u673a\uff0c\u5f71\u54cd\u4e86\u5927\u7ea62%-4%\u7684\u603b\u4eba\u53e3\u3002\u8fd9\u662f\u4e00\u79cd\u8fdb\u884c\u5f0f\u7684\u809d\u810f\u75be\u75c5\uff0c\u4f1a\u5bfc\u81f4\u809d\u786c\u5316\u4ee5\u53ca\u809d\u764c\u7b49\u4e25\u91cd\u540e\u679c\u3002\u5b83\u4e5f\u662f\u9020\u6210\u7f8e\u56fd\u809d\u764c\u6216\u809d\u79fb\u690d\u7684\u6700\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u3002\u5c3d\u7ba1\u5b83\u7ed9\u5168\u7403\u5065\u5eb7\u9020\u6210\u4e86\u5371\u673a\uff0c\u4f46\u6211\u4eec\u5c1a\u7f3a\u5c11\u6709\u6548\u6cbb\u7597\u8fd9\u4e00\u75be\u75c5\u7684\u65b9\u6cd5\u3002<\/span><\/p>\n


<\/p>\n

\u7531Galmed\u5e26\u6765\u7684Aramchol\u662f\u4e00\u7c7b\u521b\u65b0\u7684\u8102\u80aa\u9178\u548c\u80c6\u6c41\u9178\u5076\u5408\u7269\uff08fatty acid bile acid conjugate\uff09\uff0c\u80fd\u5bf9\u809d\u5185\u8102\u8d28\u4ee3\u8c22\u8d77\u5230\u6709\u76ca\u7684\u8c03\u8282\u4f5c\u7528\u3002<\/span><\/strong>\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c\u5b83\u80fd\u6709\u6548\u5730\u51cf\u5c11\u8102\u80aa\u53d8\u6027\u3001\u708e\u75c7\u3001\u4ee5\u53ca\u7ea4\u7ef4\u5316\u8fd9\u4e09\u5927NASH\u7684\u75c5\u7406\u7279\u5f81\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u4e00\u9879\u540d\u4e3aARREST\u76842b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u62db\u52df\u4e86247\u540d\u901a\u8fc7\u6d3b\u68c0\u786e\u8ba4\u60a3\u6709NASH\u7684\u60a3\u8005\uff0c\u5e76\u5c06\u4ed6\u4eec\u4ee52\uff1a2\uff1a1\u7684\u6bd4\u4f8b\u5206\u4e3a\u4e09\u7ec4\uff0c\u5206\u522b\u63a5\u53d7600mg Aramchol\u3001400mg Aramchol\u3001\u4ee5\u53ca\u5b89\u6170\u5242\u7684\u6cbb\u7597\u3002\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u662f\u809d\u810f\u7518\u6cb9\u4e09\u916f\u6bd4\u4f8b\u7684\u53d8\u5316\uff0c\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u5728NASH\u75c7\u72b6\uff08\u6307\u708e\u75c7\u548c\/\u6216\u809d\u7ec6\u80de\u6c14\u7403\u6837\u53d8\u6027\uff09\u4e0d\u6076\u5316\u7684\u60c5\u51b5\u4e0b\uff0c\u5bf9\u7ea4\u7ef4\u5316\u7a0b\u5ea6\u7684\u6539\u5584\u3002\u6b64\u5916\uff0c\u5728\u7ea4\u7ef4\u5316\u7a0b\u5ea6\u4e0d\u6076\u5316\u7684\u60c5\u51b5\u4e0b\uff0cNASH\u75c5\u60c5\u7684\u7f13\u89e3\u7a0b\u5ea6\u4e5f\u662f\u6b21\u8981\u7ec8\u70b9\u4e4b\u4e00\u3002<\/span><\/p>\n


<\/span><\/p>\n

<\/span><\/p>\n

\"\u901f\u9012<\/p>\n

<\/span><\/p>\n

\u25b2<\/span><\/strong><\/span><\/strong><\/strong><\/strong>\u8be5\u7814\u7a76\u7684\u8bd5\u9a8c\u7ed3\u679c\uff08\u56fe\u7247\u6765\u6e90\uff1aGalmed Pharmaceuticals\u5b98\u65b9\u7f51\u7ad9\uff1b\u70b9\u51fb\u56fe\u7247\u53ef\u89c2\u770b\u5927\u56fe\uff09<\/span><\/strong><\/p>\n


<\/p>\n

\u8be5\u7814\u7a76\u53d6\u5f97\u4e86\u590d\u6742\u7684\u8bd5\u9a8c\u6570\u636e\u3002\u5728\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u4e0a\uff0c400mg\u7ec4\u663e\u8457\u51cf\u5c11\u4e86\u809d\u810f\u8102\u80aa\uff08p = 0.0450\uff09\uff0c\u800c600mg\u7ec4\u672a\u80fd\u8fbe\u5230\u8fd9\u4e00\u76ee\u6807\u3002\u4f46\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c600mg\u7ec4\u4e2d\u53d6\u5f975%\u7edd\u5bf9\u6539\u5584\u7684\u60a3\u8005\u6bd4\u4f8b\u8981\u663e\u8457\u66f4\u9ad8\uff0c\u8fbe47.0%\uff08\u5bf9\u7167\u7ec4\u4e3a24.4%\uff0cp = 0.0279\uff09\u3002<\/span><\/p>\n


<\/p>\n

\u8bb8\u591a\u5206\u6790\u4eba\u5458\u6307\u51fa\uff0c\u8fd9\u9879\u8bd5\u9a8c\u7684\u4e00\u5927\u4eae\u70b9\uff0c\u5728\u4e8e\u5176\u6b21\u8981\u4e34\u5e8a\u7ec8\u70b9\u4e0a\u53d6\u5f97\u7684\u79ef\u6781\u6570\u636e\u3002<\/span><\/strong>\u7814\u7a76\u8868\u660e\uff0c600mg\u7ec4\u7684\u60a3\u8005\u5728\u7ea4\u7ef4\u5316\u60c5\u51b5\u4e0d\u6076\u5316\u7684\u60c5\u51b5\u4e0b\uff0c\u66f4\u591a\u60a3\u8005\u51fa\u73b0\u4e86NASH\u75c5\u60c5\u7684\u7f13\u89e3\uff0816.7%\u5bf95.0%\uff0cp = 0.0514\uff09\uff1b\u540c\u6837\uff0c\u5728NASH\u75c5\u60c5\u4e0d\u6076\u5316\u7684\u60c5\u51b5\u4e0b\uff0c\u4e5f\u6709\u66f4\u591a\u60a3\u8005\u7684\u7ea4\u7ef4\u5316\u7a0b\u5ea6\u6709\u6240\u6539\u5584\uff0829.5%\u5bf917.5%\uff0cp = 0.2110\uff09\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fd9\u6b63\u662f\u7f8e\u56fdFDA\u6240\u63a8\u8350\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ec8\u70b9\u3002\u8fd9\u4e5f\u8ba9\u6211\u4eec\u770b\u5230\u4e86Aramchol\u83b7\u6279\u7684\u5e0c\u671b\u3002<\/strong><\/span><\/p>\n


<\/strong><\/span><\/p>\n

<\/span><\/p>\n

\"\u901f\u9012<\/p>\n

<\/span><\/p>\n

\u25b2<\/span><\/strong><\/span><\/strong><\/strong><\/strong>\u8be5\u7814\u7a76\u8fbe\u5230\u4e86\u7f8e\u56fdFDA\u63a8\u8350\u7684\u7ec8\u70b9\u8981\u6c42\uff08\u56fe\u7247\u6765\u6e90\uff1aFDA\uff09<\/span><\/strong><\/p>\n


<\/p>\n

\u201c\u8fd9\u4e9b\u4ee4\u4eba\u5174\u594b\u7684\u7ed3\u679c\u8868\u660e600mg\u7684Aramchol\u80fd\u6539\u5584\u75be\u75c5\u7684\u7ea4\u7ef4\u5316\u7a0b\u5ea6\u548c\u809d\u786c\u5316\u8fdb\u5c55\u3002<\/strong>\u4ece\u957f\u671f\u770b\uff0c\u8fd9\u53ef\u80fd\u5e26\u6765\u6709\u610f\u4e49\u7684\u4e34\u5e8a\u6539\u5584\uff0c\u201d\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u516c\u5171\u536b\u751f\u5b66\u9662\u7684Arun Sanyal\u6559\u6388\u8bf4\u9053\uff1a\u201c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e9b\u6548\u679c\u6709\u5242\u91cf\u4f9d\u5b58\u6027\uff0c\u4e14\u8fd9\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u662f\u4e00\u9879\u5168\u7403\u7814\u7a76\u3002\u8fd9\u8868\u660e\u672c\u6b21\u8bd5\u9a8c\u53d6\u5f97\u7684\u7ed3\u679c\u6709\u53ef\u80fd\u57283\u671f\u4e34\u5e8a\u4e2d\u5f97\u5230\u91cd\u590d\u3002<\/strong>\u201d<\/span><\/p>\n


<\/p>\n

\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u770b\u5230ARREST\u7684\u8bd5\u9a8c\u7ed3\u679c\u3002\u5b83\u8ba9\u6211\u4eec\u80fd\u4e0e\u76d1\u7ba1\u90e8\u95e8\u5c3d\u5feb\u5546\u8ba8\u5173\u952e\u8bd5\u9a8c\u7684\u8bbe\u8ba1\uff0c\u201d Galmed\u7684\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Allen Baharaff\u5148\u751f\u8bf4\u9053\uff1a\u201cAramchol\u5728\u79d1\u5b66\u4e0a\u5bf9NASH\u7684\u6539\u5584\u4f9d\u636e\u80fd\u8f6c\u5316\u4e3a\u4e34\u5e8a\u7ed3\u679c\uff0c\u8fd9\u662f\u4e00\u4ef6\u975e\u5e38\u53ef\u559c\u7684\u4e8b\u60c5\u3002<\/strong>\u201d<\/span><\/p>\n


<\/p>\n

\u6211\u4eec\u671f\u5f85\u8fd9\u6b3e\u65b0\u836f\u7684\u540e\u7eed\u7814\u7a76\u80fd\u4e00\u5207\u987a\u5229\uff0c\u65e9\u65e5\u4e3a\u60a3\u8005\u5e26\u6765\u65b0\u836f\uff0c\u89e3\u51b3NASH\u8fd9\u4e00\u65e5\u8d8b\u4e25\u91cd\u7684\u5065\u5eb7\u5371\u673a\u3002<\/span><\/p>\n


<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] Galmed’s 600 mg Aramchol\u2122 Achieved a Regulatory Approvable Endpoint Showing NASH Resolution Without Worsening of Fibrosis, in NASH Patients, in the Global Phase 2b ARREST 52-Week Study<\/span><\/p>\n

[2] Galmed\u2019s stock rockets up as execs tout a mixed set of NASH data<\/span><\/p>\n

[3] Galmed Pharmaceuticals\u5b98\u65b9\u7f51\u7ad9<\/span><\/p>\n


<\/p>\n

\"\u901f\u9012<\/p>\n<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u660e\u5eb7\u5fb7 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u4eca\u5929\u662f\u9996\u4e2a\u56fd\u9645\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u65e5\uff08First International NASH Day […]<\/p>\n","protected":false},"author":1,"featured_media":9009,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9008"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9008"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9008\/revisions"}],"predecessor-version":[{"id":9014,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9008\/revisions\/9014"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9009"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9008"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9008"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9008"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}