{"id":90094,"date":"2019-04-21T00:00:50","date_gmt":"2019-04-23T04:15:50","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/90094\/"},"modified":"2019-04-23T12:15:54","modified_gmt":"2019-04-23T04:15:54","slug":"62690ffbe7","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/90094\/","title":{"rendered":"\u6db2\u4f53\u6d3b\u68c0\u65b0\u7a81\u7834 \u80f0\u817a\u764c\u68c0\u51fa\u7387\u63d0\u9ad820%\uff01"},"content":{"rendered":"
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\u7531\u4e8e\u65e9\u671f\u80bf\u7624\u60a3\u8005\u8840\u6db2\u603b\u4f53cfDNA\u6c34\u5e73\u8f83\u4f4e\uff0cctDNA\u68c0\u51fa\u8f83\u4e3a\u56f0\u96be\uff0c\u56e0\u6b64\u738b\u5c0f\u6797\u56e2\u961f\u7684\u4e0a\u8ff0\u65b9\u6cd5\u5bf9\u80f0\u817a\u764c\u7b49\u6076\u6027\u80bf\u7624\u7684\u65e9\u671f\u8bca\u65ad\u610f\u4e49\u5c24\u4e3a\u91cd\u5927\u3002\u6b27\u6d32\u5361\u54c8\u5c14\u7814\u7a76\u6240\u6db2\u4f53\u6d3b\u68c0\u4e13\u5bb6Julie Earl\u6559\u6388\u4e3a\u7814\u7a76\u6210\u679c\u8bba\u6587\u64b0\u5199\u4e86\u9898\u4e3a\u300a\u63d0\u9ad8cfDNA\u4f53\u7ec6\u80de\u7a81\u53d8\u68c0\u6d4b\u7075\u654f\u5ea6\u300b\uff08Towards a more sensitive detection of somatic mutations in cell-free DNA\uff09\u7684\u8ff0\u8bc4\uff0c\u5bf9\u738b\u5c0f\u6797\u56e2\u961f\u7684\u7814\u7a76\u8fdb\u884c\u4e86\u89e3\u6790\u548c\u9ad8\u5ea6\u8bc4\u4ef7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fe\u4e3acfDNA\u7684\u7814\u7a76\u8bbe\u8ba1\u4e0e\u5355\u94fe\u6587\u5e93\u5236\u5907\u3002cfDNA\u7247\u6bb5\u9996\u5148\u53d8\u6027\u4e3a\u5355\u94feDNA (ssDNA)\u7247\u6bb5\uff0c\u7136\u540e\u5c06ssDNA\u7247\u6bb5\u4e0e\u4e00\u4e2a\u552f\u4e00\u7684\u5206\u5b50\u6807\u8bc6\u7b26\u8fde\u63a5\uff0c\u5229\u7528\u6742\u4ea4\u548c\u78c1\u73e0\u6355\u83b7\u6280\u672f\u5bf9\u9884\u5e93\u8fdb\u884c\u5bcc\u96c6\uff0c\u7136\u540e\u8fdb\u884c\u9ad8\u901a\u91cf\u6d4b\u5e8f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u8be5\u7814\u7a76\u5efa\u7acb\u4e86\u4e00\u79cd\u57fa\u4e8e\u5355\u94fe\u5efa\u5e93\u7684cfDNA\u68c0\u6d4b\u65b0\u65b9\u6cd5\uff08single-strand library preparation and hybrid-capture-based cfDNA sequencing\uff0cSLHC-seq\uff09\uff0c\u5e76\u901a\u8fc7\u5927\u91cf\u4e34\u5e8a\u6837\u672c\u9a8c\u8bc1\u4e86\u5728\u6781\u4f4e\u603bcfDNA\u8d77\u59cb\u91cf\u7684\u60c5\u51b5\u4e0b\uff0cSLHC-seq\u68c0\u6d4b\u548c\u5b9a\u91cf\u57fa\u56e0\u7ec4\u4e2d\u8d85\u4f4e\u4e30\u5ea6\u7a81\u53d8\u7684\u6548\u80fd\u8fdc\u9ad8\u4e8e\u76ee\u524d\u5e02\u9762\u4e0a\u5e38\u89c4\u7684\u57fa\u4e8e\u53cc\u94fe\u7684\u5efa\u5e93\u65b9\u6cd5\u3002\u56e2\u961f\u6536\u96c6\u4e86\u4e0d\u540c\u5206\u671f\u7684\u80f0\u817a\u764c\u60a3\u8005\uff0c\u901a\u8fc7SLHC-seq\u65b9\u6cd5\u9274\u5b9a\u4e86\u80f0\u817a\u764cctDNA\u7684\u7a81\u53d8\u56fe\u8c31\u3002\u8be5\u7814\u7a76\u8fd8\u53d1\u73b0\u65e9\u671f\u80f0\u817a\u764c\u60a3\u8005\u4e2d\u666e\u904d\u5b58\u5728\u7834\u788e\u7684\u5c0fctDNA\u7a81\u53d8\u7247\u6bb5\uff0c\u8fd9\u53ef\u80fd\u6210\u4e3a\u80f0\u817a\u764c\u65e9\u671f\u68c0\u6d4b\u7684\u65b0\u7b56\u7565\u3002\u5bf9\u4e8e\u5bb6\u65cf\u6027\u80f0\u817a\u764c\u3001\u53ef\u7591\u80f0\u817a\u75c5\u53d8\u548c\u665a\u53d1\u6027\u7cd6\u5c3f\u75c5\u60a3\u8005\u7b49\u9ad8\u5371\u4eba\u7fa4\u7684\u65e9\u671f\u68c0\u6d4b\u5177\u6709\u91cd\u5927\u610f\u4e49\u3002<\/p>\n


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Julie Earl\u6559\u6388\u5728\u8ff0\u8bc4\u4e2d\u6307\u51fa\uff0c\u8be5\u7814\u7a76\u6240\u5efa\u7acb\u7684cfDNA\u68c0\u6d4b\u65b9\u6cd5\u4e5f\u9002\u7528\u4e8e\u5176\u5b83\u80bf\u7624\u7684\u6db2\u4f53\u6d3b\u68c0\u548c\u7a7f\u523a\u6d3b\u68c0\u6d4b\u5e8f\u3002\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u7684\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u6df1\u5316\u4e86\u4eba\u4eec\u5bf9cfDNA\u751f\u7269\u5b66\u7279\u5f81\u7684\u7406\u89e3\uff0c\u4e3a\u65e9\u671f\u80bf\u7624\u60a3\u8005\u8840\u6db2\u4e2d\u75d5\u91cfcfDNA\u7684\u9ad8\u6548\u68c0\u51fa\u63d0\u4f9b\u4e86\u975e\u5e38\u6709\u529b\u7684\u7406\u8bba\u4f9d\u636e\u3002Julie Earl\u6559\u6388\u8ba4\u4e3a\uff0c\u8be5\u7814\u7a76\u5177\u6709\u6781\u5f3a\u7684\u4e34\u5e8a\u8f6c\u5316\u4ef7\u503c\uff0c\u5e76\u5c06\u5bf9\u80bf\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u8bca\u7597\u4ea7\u751f\u975e\u5e38\u79ef\u6781\u7684\u5f71\u54cd\uff0c\u4e3a\u80f0\u817a\u764c\u7b49\u65e9\u8bca\u56f0\u96be\u3001\u9884\u540e\u4e0d\u826f\u6076\u6027\u80bf\u7624\u63d0\u4f9b\u66f4\u52a0\u4e2a\u6027\u5316\u7684\u8bca\u65ad\u6cbb\u7597\u65b9\u6cd5<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u66f4\u591a\u8d44\u8baf  \u70b9\u51fb\u4e0b\u65b9\u94fe\u63a5<\/span><\/span><\/strong><\/p>\n

\u52a0\u5165\u57fa\u56e0\u4ff1\u4e50\u90e8    \u6210\u5c31\u884c\u4e1a\u7cbe\u82f1<\/strong><\/strong><\/span><\/strong><\/span><\/a>
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\"\u6db2\u4f53\u6d3b\u68c0\u65b0\u7a81\u7834<\/span><\/a><\/span><\/p>\n

\"\u6db2\u4f53\u6d3b\u68c0\u65b0\u7a81\u7834<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u968f\u7740\u201c\u7cbe\u51c6\u533b\u5b66\u201d\u7684\u6982\u5ff5\u88ab\u9010\u6e10\u8fd0\u7528\u81f3\u80bf\u7624\u9886\u57df\u4e2d\uff0c\u4ee5\u6e38\u79bbDNA( cell-free DNA, cfDNA\uff09\u68c0\u6d4b\u4e3a […]<\/p>\n","protected":false},"author":1,"featured_media":90095,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/90094"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=90094"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/90094\/revisions"}],"predecessor-version":[{"id":90107,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/90094\/revisions\/90107"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/90095"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=90094"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=90094"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=90094"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}