{"id":9021,"date":"2018-06-13T01:00:00","date_gmt":"2018-07-27T09:35:45","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e9%80%9f%e9%80%92-3%e6%9c%9f%e6%95%b0%e6%8d%ae%e6%9b%b4%e6%96%b0%ef%bc%8c%e5%9f%ba%e5%9b%a0%e7%96%97%e6%b3%95%e8%ae%a9%e7%9c%bc%e7%97%85%e6%82%a3%e8%80%85%e7%9c%8b%e5%88%b0%e4%ba%86%e5%85%89\/"},"modified":"2018-07-27T17:35:46","modified_gmt":"2018-07-27T09:35:46","slug":"%e9%80%9f%e9%80%92-3%e6%9c%9f%e6%95%b0%e6%8d%ae%e6%9b%b4%e6%96%b0%ef%bc%8c%e5%9f%ba%e5%9b%a0%e7%96%97%e6%b3%95%e8%ae%a9%e7%9c%bc%e7%97%85%e6%82%a3%e8%80%85%e7%9c%8b%e5%88%b0%e4%ba%86%e5%85%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9021\/","title":{"rendered":"\u901f\u9012 | 3\u671f\u6570\u636e\u66f4\u65b0\uff0c\u57fa\u56e0\u7597\u6cd5\u8ba9\u773c\u75c5\u60a3\u8005\u770b\u5230\u4e86\u5149\u660e"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong style=\"max-width: 100%;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span 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border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 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style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"           style=\"width: 558px;height: 201px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532684146.jpeg\" alt=\"\u901f\u9012 | 3\u671f\u6570\u636e\u66f4\u65b0\uff0c\u57fa\u56e0\u7597\u6cd5\u8ba9\u773c\u75c5\u60a3\u8005\u770b\u5230\u4e86\u5149\u660e\" title=\"\u901f\u9012 | 3\u671f\u6570\u636e\u66f4\u65b0\uff0c\u57fa\u56e0\u7597\u6cd5\u8ba9\u773c\u75c5\u60a3\u8005\u770b\u5230\u4e86\u5149\u660e\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">LHON\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u6bcd\u7cfb\u9057\u4f20\u7684\u7ebf\u7c92\u4f53\u9057\u4f20\u75c5\uff0c\u8868\u73b0\u4e3a\u89c6\u7f51\u819c\u795e\u7ecf\u8282\u7ec6\u80de\u53d8\u6027\uff0c\u5bfc\u81f4\u4e0d\u53ef\u9006\u7684\u89c6\u529b\u4e27\u5931\uff0c\u751a\u81f3\u5931\u660e<\/span><\/strong><span style=\"font-size: 15px;\">\u3002\u8be5\u75be\u75c5\u4e3b\u8981\u5f71\u54cd\u9752\u5c11\u5e74\u548c\u5e74\u8f7b\u4eba\u3002LHON\u60a3\u8005\u901a\u5e38\u4f1a\u7a81\u7136\u51fa\u73b0\u4e2d\u5fc3\u89c6\u529b\u4e27\u5931\uff0c\u7136\u540e\u53e6\u4e00\u53ea\u773c\u775b\u53d7\u635f\u3002\u5b83\u662f\u4e00\u79cd\u5bf9\u79f0\u6027\u75be\u75c5\uff0c\u529f\u80fd\u6027\u89c6\u89c9\u6062\u590d\u5dee\u300297\uff05\u7684\u60a3\u8005\u4f1a\u5728\u4e0d\u52301\u5e74\u7684\u65f6\u95f4\u91cc\u4e27\u5931\u53cc\u773c\u89c6\u529b\uff0c25\uff05\u7684\u60a3\u8005\u7684\u53cc\u773c\u89c6\u529b\u4f1a\u540c\u65f6\u4e27\u5931\u3002\u636e\u4f30\u8ba1\uff0cLHON\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u6bcf\u5e74\u7ea6\u9020\u62101400\u81f31500\u540d\u65b0\u60a3\u8005\u5931\u660e\u3002\u4ed6\u4eec\u6025\u9700\u6709\u6548\u7684\u6cbb\u7597\u6765\u7f13\u89e3\u75be\u75c5\uff0c\u63d0\u9ad8\u751f\u6d3b\u8d28\u91cf\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7531GenSight\u5e26\u6765\u7684GS010\u901a\u8fc7\u5229\u7528\u5176\u7ebf\u7c92\u4f53\u9776\u5411\u5e8f\u5217\uff08MTS\uff09\u4e13\u6709\u6280\u672f\u5e73\u53f0\uff0c\u6765\u6cbb\u7597LHON\u3002\u8be5\u5e73\u53f0\u6765\u81ea\u4e8e\u5df4\u9ece\u7814\u7a76\u6240Institut de la Vision\u7684\u7814\u7a76\u5de5\u4f5c\uff0c<strong>\u5b83\u4f7f\u7528\u817a\u76f8\u5173\u75c5\u6bd2\uff08AAV\uff09\u8f7d\u4f53\uff0c\u6765\u7279\u5f02\u6027\u89e3\u51b3\u7ebf\u7c92\u4f53\u5185\u90e8\u7684\u7f3a\u9677<\/strong>\u3002\u76f8\u5173\u57fa\u56e0\u4f1a\u88ab\u8f6c\u79fb\u5230\u5f85\u8868\u8fbe\u7684\u7ec6\u80de\u4e2d\uff0c\u4ea7\u751f\u529f\u80fd\u6027\u86cb\u767d\u8d28\uff0c\u7136\u540e\u901a\u8fc7\u7279\u5b9a\u7684\u6838\u82f7\u9178\u5e8f\u5217\u7a7f\u68ad\u81f3\u7ebf\u7c92\u4f53\uff0c\u4ee5\u6062\u590d\u7f3a\u5931\u6216\u7f3a\u9677\u7684\u7ebf\u7c92\u4f53\u529f\u80fd\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8be5\u7814\u7a76\u4e8e4\u6708\u4efd\u53d1\u8868\u7684\u9876\u7ebf\u7ed3\u679c\u663e\u793a\uff0c\u5176\u62b5\u8fbe\u4e86\u7531\u5149\u8c31\u57df\u5149\u5b66\u76f8\u5e72\u5c42\u6790\u6210\u50cf\uff08SD-OCT\uff09\u53c2\u6570\u5b9a\u4e49\u7684\u6b21\u8981\u7ec8\u70b9\u3002\u5177\u4f53\u4e3a\u4ece\u57fa\u7ebf\u5230\u7b2c48\u5468\u65f6\u6d4b\u91cf\u7684\u795e\u7ecf\u8282\u7ec6\u80de\u5c42\u9ec4\u6591\u4f53\u79ef\u53d8\u5316\u548c\u89c6\u7f51\u819c\u795e\u7ecf\u7ea4\u7ef4\u5c42\u989e\u8c61\u9650\u539a\u5ea6\u6539\u53d8\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c<strong>GS010\u5bf9\u4e0eLHON\u76f8\u5173\u7684\u89e3\u5256\u7ed3\u6784\u6709\u76f4\u63a5\u7684\u751f\u7269\u5b66\u548c\u751f\u7406\u5b66\u5f71\u54cd<\/strong>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532684146.jpeg\" alt=\"\u901f\u9012 | 3\u671f\u6570\u636e\u66f4\u65b0\uff0c\u57fa\u56e0\u7597\u6cd5\u8ba9\u773c\u75c5\u60a3\u8005\u770b\u5230\u4e86\u5149\u660e\" title=\"\u901f\u9012 | 3\u671f\u6570\u636e\u66f4\u65b0\uff0c\u57fa\u56e0\u7597\u6cd5\u8ba9\u773c\u75c5\u60a3\u8005\u770b\u5230\u4e86\u5149\u660e\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;\"><\/span><span style=\"color: rgb(0, 112, 192);\"><strong><span style=\"font-size: 14px;\">\u25b2\u5728\u8fd9\u4e00\u75be\u75c5\u4e2d\uff0cGS010\u53ef\u4ee5\u6062\u590d\u7ebf\u7c92\u4f53\u56e0\u4e3a<em>ND4<\/em>\u57fa\u56e0\u7a81\u53d8\u5bfc\u81f4\u7684\u529f\u80fd\u7f3a\u9677\uff08\u56fe\u7247\u6765\u6e90\uff1aGenSight Biologics\u5b98\u65b9\u7f51\u7ad9\uff09<\/span><\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u73b0\u5728\u8fdb\u4e00\u6b65\u7684\u5206\u6790\u8868\u660e\uff0c\u5c3d\u7ba1\u4e00\u4e9b\u6b21\u8981\u7ec8\u70b9\u6ca1\u6709\u663e\u793a\u51fa\u663e\u8457\u6216\u6709\u610f\u4e49\u7684\u53d8\u5316\uff0c\u4f46\u4e0e\u5bf9\u7167\u7ec4\uff08sham-treated eyes\uff09\u76f8\u6bd4\uff0c<strong>\u7531Pelli-Robson\u4f4e\u89c6\u529b\u6d4b\u8bd5\u786e\u5b9a\u7684\u5bf9\u6bd4\u654f\u611f\u5ea6\u5728GS010\u6cbb\u7597\u7684\u773c\u775b\u4e2d\u51e0\u4e4e\u589e\u52a0\u4e86\u4e00\u500d<\/strong>\u3002\u6cbb\u7597\u7ec4\u5728\u5f00\u59cb\u65f6\u7684\u5e73\u5747\u5bf9\u6bd4\u654f\u611f\u5ea6\u4f4e\u4e8e\u5bf9\u7167\u7ec4\uff080.25 LogCS vs. 0.35 LogCs\uff09\u3002\u4f46\u5728\u7b2c48\u5468\uff0c\u6cbb\u7597\u7ec4\u7684\u5bf9\u6bd4\u654f\u611f\u5ea6\u5e73\u5747\u589e\u52a0+0.20 LogCS\uff0c\u800c\u5bf9\u7167\u7ec4\u4fdd\u6301\u7a33\u5b9a\uff08\u5e73\u5747+0.08 LogCS\uff09\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6b64\u5916\uff0c\u4e8b\u540e\u5206\u6790\uff08post hoc analyses\uff09\u8d8b\u52bf\u8868\u660e\uff0c<strong>GS010\u53ef\u80fd\u5bf9\u75be\u75c5\u7a0b\u5ea6\u76f8\u5bf9\u8f83\u4f4e\u7684\u60a3\u8005\u7684\u89c6\u654f\u5ea6\uff08visual acuity\uff09\u5177\u6709\u8f83\u5927\u7684\u79ef\u6781\u5f71\u54cd<\/strong>\uff1a<\/span><\/p>\n<p><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5165\u7ec4\u65f6\u6709\u8f83\u597d\u89c6\u529b\u7684\u60a3\u8005\u503e\u5411\u4e8e\u6709\u66f4\u597d\u7684\u4e34\u5e8a\u7ed3\u679c<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u89c6\u529b\u4e27\u5931\u5c11\u4e8e9\u4e2a\u6708\u7684\u60a3\u8005\u503e\u5411\u4e8e\u6709\u66f4\u597d\u7684\u4e34\u5e8a\u7ed3\u679c<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5165\u7ec4\u65f6\u5e74\u9f84\u8f83\u5c0f\uff08&lt;21\u5c81\uff09\u7684\u53d7\u8bd5\u8005\u503e\u5411\u4e8e\u6709\u66f4\u597d\u7684\u4e34\u5e8a\u7ed3\u679c<\/span><\/p>\n<p><br  \/><\/p>\n<\/li>\n<\/ul>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201cREVERSE\u7684\u7ed3\u679c\u6574\u4f53\u8868\u660e\uff0c<strong>\u8fd9\u79cd\u7597\u6cd5\u53ef\u80fd\u4e3a\u6211\u4eec\u7684\u53d7\u8bd5\u8005\u63d0\u4f9b\u6709\u610f\u4e49\u7684\u53cc\u4fa7\u89c6\u529b\u6539\u5584\uff0c\u8fd9\u662f\u4e0d\u80fd\u4ece\u8be5\u75be\u75c5\u7684\u81ea\u7136\u53f2\u4e2d\u9884\u671f\u5230\u7684<\/strong>\u3002\u6211\u4eec\u8ba1\u5212\u5bf9REVERSE\u7684\u60a3\u8005\u8fdb\u884c\u968f\u8bbf\uff0c\u76d1\u6d4b\u4ed6\u4eec\u5728\u968f\u540e\u4e00\u5e74\u4e2d\u7684\u53cc\u4fa7\u6301\u7eed\u6539\u5584\u60c5\u51b5\uff0c\u201dGenSight\u9996\u5e2d\u533b\u5b66\u5b98Barrett 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Gilly\u535a\u58eb\u8bc4\u8bba\u9053\uff1a\u201c\u6211\u4eec\u73b0\u5728\u5c06\u4e0e\u76d1\u7ba1\u90e8\u95e8\u8ba8\u8bba\u5168\u9762\u7684\u7ed3\u679c\uff0c\u4ee5\u4fbf\u80fd\u591f\u5728\u786e\u5b9a\u7684\u65f6\u95f4\u8868\u5185\u4f7fGS010\u7684\u4e0a\u5e02\u4e0e\u73b0\u6709\u76843\u671f\u8ba1\u5212\u76f8\u4e00\u81f4\u3002\u201d<\/span><\/p>\n<p><br  \/><\/p>\n<h1 style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/h1>\n<h1 style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] GenSight Biologics Reports Positive Additional Data from REVERSE Phase III Clinical Trial of GS010 for Treatment of Leber Hereditary Optic Neuropathy (LHON)<\/span><\/h1>\n<h1 style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] GenSight Biologics\u5b98\u65b9\u7f51\u7ad9<\/span><\/h1>\n<p><br  \/><\/p>\n<p style=\"white-space: normal;\"><img class=\"__bg_gif\"      width=\"auto\" style=\"color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532684146.gif\" alt=\"\u901f\u9012 | 3\u671f\u6570\u636e\u66f4\u65b0\uff0c\u57fa\u56e0\u7597\u6cd5\u8ba9\u773c\u75c5\u60a3\u8005\u770b\u5230\u4e86\u5149\u660e\" title=\"\u901f\u9012 | 3\u671f\u6570\u636e\u66f4\u65b0\uff0c\u57fa\u56e0\u7597\u6cd5\u8ba9\u773c\u75c5\u60a3\u8005\u770b\u5230\u4e86\u5149\u660e\"  \/><\/p>\n<p style=\"white-space: normal;\">\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u660e\u5eb7\u5fb7                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 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