{"id":9033,"date":"2018-06-13T01:00:00","date_gmt":"2018-07-27T09:35:51","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e7%9b%98%e7%82%b9-%e8%82%bf%e7%98%a4%e9%a2%86%e5%9f%9f%e8%bf%91%e6%9c%9f%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e6%b1%87%e6%80%bb%ef%bc%88%e7%ac%ac69%e6%9c%9f%ef%bc%89\/"},"modified":"2018-07-27T17:35:53","modified_gmt":"2018-07-27T09:35:53","slug":"%e7%9b%98%e7%82%b9-%e8%82%bf%e7%98%a4%e9%a2%86%e5%9f%9f%e8%bf%91%e6%9c%9f%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e6%b1%87%e6%80%bb%ef%bc%88%e7%ac%ac69%e6%9c%9f%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9033\/","title":{"rendered":"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;\"><strong style=\"max-width: 100%;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">1. \u75be\u75c5\u98ce\u9669\u9510\u51cf81%\uff01FDA\u6279\u51c6\u767d\u8840\u75c5\u65b0\u7597\u6cd5<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u827e\u4f2f\u7ef4\uff08AbbVie\uff09\u4e0e\u57fa\u56e0\u6cf0\u514b\uff08Genentech\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c<strong>\u7f8e\u56fdFDA\u5df2\u6279\u51c6\u91cd\u78c5\u836f\u7269Venclexta\uff08venetoclax\uff09\u4e0eRituxan\uff08rituximab\uff09\u8054\u5408\u4f7f\u7528\uff0c\u6cbb\u7597\u7ecf\u6cbb\u7684\u6162\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\uff08CLL\uff09\u6216\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6027\u6dcb\u5df4\u7624\uff08SLL\uff09\u60a3\u8005\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><br  \/><\/strong><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;\"><strong><img   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress2-1532684152.jpg\" alt=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09\" title=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09\"  \/><\/strong><\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6162\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\u662f\u6210\u4eba\u4e2d\u6700\u4e3a\u5e38\u89c1\u7684\u767d\u8840\u75c5\u7c7b\u578b\uff0c\u4e3b\u8981\u75c5\u53d1\u4e8e\u8840\u6db2\u548c\u9aa8\u9ad3\u3002\u636e\u4f30\u8ba1\uff0c\u7f8e\u56fd\u57282018\u5e74\u5c06\u67092\u4e07\u4f8b\u65b0\u53d1\u75c5\u4f8b\uff0c\u76ee\u524d\u5b83\u65e0\u6cd5\u5f97\u5230\u6cbb\u6108\u3002\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6027\u6dcb\u5df4\u7624\u5219\u662f\u4e00\u79cd\u7c7b\u4f3c\u4e8e\u6162\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\u7684\u75be\u75c5\uff0c\u4f46\u4e3b\u8981\u75c5\u53d1\u4e8e\u6dcb\u5df4\u7ed3\u3002\u5bf9\u4e8e\u8fd9\u4e24\u7c7b\u75be\u75c5\uff0c\u60a3\u8005\u4eec\u5c1a\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u672c\u6b21\u83b7\u6279\u7684\u8054\u5408\u7597\u6cd5\u6709\u671b\u7ed9\u60a3\u8005\u5e26\u6765\u5e0c\u671b\u3002<strong>Venclexta\u662f\u4e00\u6b3e\u9009\u62e9\u6027\u7684BCL-2\u6291\u5236\u5242\uff0c\u6291\u5236\u5728\u6162\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\u4e2d\u8fc7\u91cf\u8868\u8fbe\u7684BCL-2\u86cb\u767d\u3002<\/strong>\u8fd9\u6b3e\u86cb\u767d\u5728\u7ec6\u80de\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u7684\u8fc7\u7a0b\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\uff0c\u800c\u6291\u5236\u5b83\u6709\u671b\u91cd\u5851\u7ec6\u80de\u7684\u5173\u952e\u4fe1\u53f7\u901a\u8def\uff0c\u8ba9\u764c\u7ec6\u80de\u81ea\u6211\u6467\u6bc1\u3002<strong>Rituxan\u5219\u662f\u4e00\u6b3e\u9488\u5bf9CD20\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u6709\u6548\u5bf9\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u8fdb\u884c\u6cbb\u7597\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><br  \/><\/strong><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><img   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532684152.jpg\" alt=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09\" title=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09\"  \/><\/strong><\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u4e00\u9879\u540d\u4e3aMURANO\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8fd9\u6b3e\u8054\u5408\u7597\u6cd5\u7684\u6cbb\u7597\u6f5c\u529b\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002\u8be5\u7814\u7a76\u62db\u52df\u4e86389\u540d\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u6b21\u6cbb\u7597\u7684\u6162\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\u60a3\u8005\uff0c\u5e76\u5c06\u5176\u5206\u4e3a\u4e24\u7ec4\u3002\u5176\u4e2d\u4e00\u7ec4\u63a5\u53d7\u5316\u7597\u836f\u7269\u82ef\u8fbe\u83ab\u53f8\u6c40\uff08bendamustine\uff09\u4e0eRituxan\u7684\u6cbb\u7597\uff0c\u53e6\u4e00\u7ec4\u5219\u63a5\u53d7Venclexta\u4e0eRituxan\u7684\u6cbb\u7597\u3002<strong>\u7814\u7a76\u8868\u660e\uff0c\u76f8\u6bd4\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff0cVenclexta\u4e0eRituxan\u7684\u8054\u5408\u6cbb\u7597\u80fd\u663e\u8457\u51cf\u5c11\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u98ce\u9669\u8fbe81%<\/strong>\uff08HR=0.19\uff1b95% CI\uff1a0.13-0.28\uff1bp&lt;0.0001\uff09\u3002\u57fa\u4e8e\u8fd9\u4e9b\u826f\u597d\u7684\u6570\u636e\uff0cFDA\u6b63\u5f0f\u6279\u51c6\u5176\u4e0a\u5e02\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"color: rgb(0, 112, 192);\"><strong><span style=\"font-size: 15px;\">2. \u8f89\u745ePARP\u6291\u5236\u5242\u83b7\u4f18\u5148\u5ba1\u8bc4\uff0c\u6cbb\u7597\u665a\u671f\u4e73\u817a\u764c<\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8f89\u745e\u516c\u53f8\uff08Pfizer\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c<strong>\u7f8e\u56fdFDA\u63a5\u53d7\u4e86\u5176\u4e3atalazoparib\u9012\u4ea4\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\uff0c\u5e76\u6388\u4e88\u5b83\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u3002<\/strong>\u8be5NDA\u7684\u63d0\u4ea4\u662f\u57fa\u4e8e\u4e34\u5e8a\u8bd5\u9a8cEMBRACA\u7684\u7ed3\u679c\u3002\u8be5\u8bd5\u9a8c\u8bc4\u4f30\u4e86talazoparib\u4e0e\u5316\u7597\u76f8\u6bd4\uff0c\u5728\u79cd\u7cfb\uff08\u9057\u4f20\u6027\uff09<em>BRCA<\/em>\u7a81\u53d8\uff08gBRCAm\uff09\u7684HER2\u9634\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08MBC\uff09\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u4e5f\u63a5\u53d7\u4e86talazoparib\u7684\u8425\u9500\u6388\u6743\u7533\u8bf7\uff08MAA\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"white-space: normal;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress7-1532684152.jpg\" alt=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09\" title=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><em><span style=\"font-size: 15px;\">BRCA1<\/span><\/em><span style=\"font-size: 15px;\">\u548c<em>BRCA2<\/em>\u662f\u4ea7\u751f\u53c2\u4e0eDNA\u4fee\u590d\u7684\u86cb\u767d\u8d28\u7684\u4eba\u7c7b\u57fa\u56e0\u3002\u5f53\u5176\u53d1\u751f\u7a81\u53d8\u65f6\uff0cDNA\u4fee\u590d\u5c31\u53ef\u80fd\u65e0\u6cd5\u6b63\u5e38\u8fdb\u884c\uff0c\u4f1a\u5bfc\u81f4\u67d0\u4e9b\u7c7b\u578b\u764c\u75c7\uff08\u5982\u4e73\u817a\u764c\uff09\u7684\u53d1\u751f\u3002<em>BRCA<\/em>\u7a81\u53d8\u53ef\u4ee5\u662f\u9057\u4f20\u6027\uff08\u751f\u6b96\u7ec6\u80de\uff09\u6216\u81ea\u53d1\u6027\uff08\u4f53\u7ec6\u80de\uff09\u3002<em>BRCA1<\/em>\u548c<em>BRCA2<\/em>\u7a81\u53d8\u7ea6\u5360\u9057\u4f20\u6027\u4e73\u817a\u764c\u7ea625\uff05\u81f330\uff05\uff0c\u548c\u6240\u6709\u4e73\u817a\u764c5\uff05\u81f310\uff05\u3002\u636e\u4f30\u8ba1\uff0c\u7ea672\uff05\u7684\u5177\u6709\u9057\u4f20\u6027<em>BRCA1<\/em>\u7a81\u53d8\u7684\u4eba\uff0c\u548c\u7ea669\uff05\u7684\u5177\u6709<em>BRCA2<\/em>\u7a81\u53d8\u7684\u4eba\uff0c\u4f1a\u572880\u5c81\u524d\u60a3\u4e0a\u4e73\u817a\u764c\u3002<\/span><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">Talazoparib\u662f\u4e00\u6b3e\u5728\u7814\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684PARP\u6291\u5236\u5242\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0ctalazoparib\u5177\u6709\u9ad8\u6548\u529b\u4e14\u5177\u6709\u53cc\u91cd\u4f5c\u7528\u673a\u5236\uff0c\u6709\u6f5c\u529b\u901a\u8fc7\u963b\u65adPARP\u9176\u6d3b\u6027\uff0c\u5e76\u5c06PARP\u6355\u83b7\u5728DNA\u635f\u4f24\u90e8\u4f4d\uff0c\u6765\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">Talazoparib\u6cbb\u7597\u4e73\u817a\u764c\u7684\u7597\u6548\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u4e86\u8bc1\u5b9e\u3002EMBRACA\u8bd5\u9a8c\u5728431\u4f8b\u643a\u5e26\u9057\u4f20\u6027<em>BRCA1\/2<\/em>\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e09\u9634\u6027\uff08TNBC\uff09\u6216\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08ER+\uff09\/HER2-\u60a3\u8005\u4e2d\uff0c\u8bc4\u4f30\u4e86\u6bcf\u65e5\u4e00\u6b21talazoparib\u4e0e\u533b\u751f\u9009\u62e9\u7684\u5316\u7597\uff08\u5361\u57f9\u4ed6\u6ee8[capecitibine]\u3001\u827e\u65e5\u5e03\u6797[eribulin]\u3001\u5409\u897f\u4ed6\u6ee8[gemcitabine]\u6216\u957f\u6625\u745e\u6ee8[vinorelbine]\uff09\u76f8\u6bd4\u7684\u7597\u6548\u3002<strong>\u8be5\u7814\u7a76\u62b5\u8fbe\u4e86\u5176\u4e3b\u8981\u7ec8\u70b9\uff0c\u8bc1\u660etalazoparib\u4e0e\u5316\u7597\u76f8\u6bd4\u5177\u6709\u66f4\u4f18\u8d8a\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002<\/strong>\u5e76\u4e14PFS\u83b7\u76ca\u5728\u9884\u5148\u8bbe\u5b9a\u7684\u4e9a\u7ec4\u4e2d\u4e00\u81f4\uff0c\u5305\u62ec\u6709\u8111\u8f6c\u79fb\u53f2\u7684\u60a3\u8005\u3001\u66fe\u63a5\u53d7\u8fc7\u5316\u7597\u7684\u60a3\u8005\u3001TNBC\u60a3\u8005\u548cHR+\u60a3\u8005\u3002&nbsp;<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">3. Gilead TCR\u7597\u6cd5\u6709\u671b\u6cbb\u7597HPV\u9633\u6027\u5b9e\u4f53\u7624<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u65e5\u524d\uff0cGilead Sciences\u65d7\u4e0b\u7684Kite\u516c\u53f8\u53d1\u5e03\u4e86\u5728\u7814T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u7597\u6cd5\u6cbb\u7597HPV\u9633\u6027\u5b9e\u4f53\u7624\u7684\u4e34\u5e8a1\u671f\u8bd5\u9a8c\u7684\u65e9\u671f\u6570\u636e\u3002<strong>\u7814\u7a76\u8868\u660e\uff0c\u9776\u541116\u578bHPV(HPV-16)\u7684E7\u86cb\u767d\u7684TCR\u7597\u6cd5\u80fd\u591f\u5728\u90e8\u5206HPV-16\u9633\u6027\u764c\u75c7\u60a3\u8005\u8eab\u4e0a\u5b9e\u73b0\u80bf\u7624\u90e8\u5206\u7f13\u89e3\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><br  \/><\/strong><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;\"><strong><img   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532684152.jpeg\" alt=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09\" title=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09\"  \/><\/strong><\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">HPV\u611f\u67d3\u4e0e\u51e0\u4e4e\u6240\u6709\u7684\u5bab\u9888\u764c\u4e4b\u95f4\u5b58\u5728\u7740\u56e0\u679c\u5173\u7cfb\uff0c\u800c\u4e14\u5b83\u8fd8\u4f1a\u5bfc\u81f4\u591a\u79cd\u5934\u9888\u764c\u548c\u809b\u95e8\u751f\u6b96\u5668\u80bf\u7624\uff08anogenital malignancies\uff09\u3002HPV-16\u662f\u8fd9\u4e9b\u80bf\u7624\u4e2d\u6700\u5e38\u89c1\u7684HPV\u7c7b\u578b\u3002\u76ee\u524d\u9488\u5bf9HPV\u76f8\u5173\u80bf\u7624\u7684\u6cbb\u7597\u65b9\u6cd5\u4e0d\u4f46\u7f13\u89e3\u7387\u4f4e\uff0c\u800c\u4e14\u60a3\u8005\u7684\u7f13\u89e3\u671f\u5f88\u77ed\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">TCR\u7597\u6cd5\u662f\u4e00\u79cd\u6fc0\u6d3b\u4eba\u4f53\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u548c\u6740\u4f24\u7279\u5b9a\u80bf\u7624\u7684\u4e2a\u4f53\u5316\u514d\u75ab\u7597\u6cd5\u3002\u5b83\u6536\u96c6\u60a3\u8005\u7684T\u6dcb\u5df4\u7ec6\u80de\uff0c\u7136\u540e\u5728\u8fd9\u4e9b\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u9776\u5411\u7279\u5b9a\u80bf\u7624\u6297\u539f\u7684\u5929\u7136\u6dcb\u5df4\u7ec6\u80de\u53d7\u4f53\u3002\u7531HPV\u5bfc\u81f4\u7684\u4e0a\u76ae\u764c\u7684\u80bf\u7624\u7ec6\u80de\u4e2d\u4f1a\u8868\u8fbe\u53eb\u505aE7\u7684\u86cb\u767d\u3002\u643a\u5e26\u8fd9\u4e9b\u80bf\u7624\u7684\u60a3\u8005\u4e00\u65e6\u5728\u63a5\u53d7\u6807\u51c6\u7597\u6cd5\u540e\u764c\u75c7\u590d\u53d1\uff0c\u6216\u5bf9\u7597\u6cd5\u4ea7\u751f\u6297\u6027\uff0c\u5c31\u6ca1\u6709\u53ef\u7528\u7597\u6cd5\u80fd\u591f\u5c06\u4ed6\u4eec\u6cbb\u6108\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">Kite\u516c\u53f8\u5f00\u53d1\u7684KITE-439\u6709\u671b\u89e3\u51b3\u8fd9\u79cd\u72b6\u51b5\uff0c\u5b83\u662f\u4e00\u79cd\u9776\u5411E7\u86cb\u767d\u7684TCR\u7597\u6cd5\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u5728\u8fd9\u9879\u4ecd\u5728\u8fdb\u884c\u7684\u4e34\u5e8a1\u671f\u8bd5\u9a8c\u4e2d\uff0c8\u4f4d\u60a3\u6709\u8f6c\u79fb\u6027HPV-16\u9633\u6027\u80bf\u7624\u7684\u60a3\u8005\u63a5\u53d7\u4e86\u8868\u8fbeE7 TCR\u7684T\u7ec6\u80de\u7597\u6cd5\u3002\u8fd9\u4e9b\u60a3\u8005\u4e4b\u524d\u5df2\u7ecf\u63a5\u53d7\u8fc73\u52307\u79cd\u5168\u8eab\u6027\u764c\u75c7\u7597\u6cd5\u3002\u5728\u6700\u521d\u63a5\u53d7TCR\u7ec6\u80de\u7597\u6cd5\u76846\u4f4d\u60a3\u8005\u4e2d\uff0c\u6ce8\u5165\u7684T\u7ec6\u80de\u4e2d90-99%\u7684\u7ec6\u80de\u8868\u9762\u8868\u8fbeE7 TCR\uff0c\u800c\u4e14\u8868\u8fbeE7 TCR\u7684T\u7ec6\u80de\u5728\u63a5\u53d7\u6cbb\u7597\u540e6\u5468\u4ecd\u7136\u53ef\u4ee5\u5728\u5916\u5468\u8840\u6db2\u4e2d\u88ab\u68c0\u6d4b\u5230\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7ed3\u679c\u663e\u793a\uff0c\u57287\u540d\u53ef\u4ee5\u63a5\u53d7\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff0c\u67093\u540d\u60a3\u8005\u7684\u80bf\u7624\u83b7\u5f97\u90e8\u5206\u7f13\u89e3\uff0c2\u540d\u60a3\u8005\u7684\u80bf\u7624\u72b6\u6001\u7a33\u5b9a\u3002\u622a\u6b62\u5230\u6570\u636e\u53d1\u5e03\u65f6\uff0c\u7f13\u89e3\u671f\u6700\u957f\u53ef\u4ee5\u8fbe\u52309\u4e2a\u6708\uff0c\u83b7\u5f97\u90e8\u5206\u7f13\u89e3\u7684\u60a3\u8005\u5206\u522b\u4e3a\u5916\u9634\u764c\u3001\u53e3\u54bd\u764c\u548c\u809b\u95e8\u764c\u60a3\u8005\uff0c\u5176\u4e2d2\u540d\u60a3\u8005\u66fe\u7ecf\u63a5\u53d7\u8fc7\u6297PD1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u3002\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u6ca1\u6709\u51fa\u73b0\u9650\u5236\u7597\u6cd5\u5242\u91cf\u7684\u6bd2\u526f\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">4. PARP\u6291\u5236\u5242\u5236\u80dc\u665a\u671f\u524d\u5217\u817a\u764c\uff0c\u663e\u8457\u5ef6\u957fPFS<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u65e5\u524d\uff0c\u963f\u65af\u5229\u5eb7\uff08AstraZeneca\uff09\u548c\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u516c\u5e03\u4e86\u5176\u5408\u4f5c\u5f00\u53d1\u7684\u65b0\u836fLynparza\uff08olaparib\uff09\u6cbb\u7597\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u60a3\u8005\uff08mCRPC\uff09\u7684\u6570\u636e\u3002\u8be5\u7814\u7a76\u663e\u793a\uff0c<strong>\u4e0e\u6807\u51c6\u6cbb\u7597\u963f\u6bd4\u7279\u9f99\uff08abiraterone\uff09\u5355\u836f\u76f8\u6bd4\uff0cLynparza\u8054\u5408\u963f\u6bd4\u7279\u9f99\u53ef\u4ee5\u663e\u8457\u6539\u5584mCRPC\u60a3\u8005\u7684\u4e2d\u4f4d\u653e\u5c04\u5b66\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08rPFS\uff09\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><br  \/><\/strong><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><img   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532684152.jpg\" alt=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09\" title=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09\"  \/><\/strong><\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u524d\u5217\u817a\u764c\u662f\u7537\u6027\u7b2c\u4e8c\u5e38\u89c1\u7684\u764c\u75c7\uff0c2015\u5e74\u5168\u7403\u7ea6\u6709160\u4e07\u65b0\u8bca\u65ad\u75c5\u4f8b\uff0c\u4e14\u6b7b\u4ea1\u7387\u5f88\u9ad8\u3002\u524d\u5217\u817a\u764c\u7684\u53d1\u751f\u5f80\u5f80\u662f\u7531\u96c4\u6fc0\u7d20\uff08androgen\uff09\u9a71\u52a8\uff0c\u5305\u62ec\u777e\u916e\uff08testosterone\uff09\u3002\u5728mCRPC\u91cc\uff0c\u5c3d\u7ba1\u60a3\u8005\u5728\u4f7f\u7528\u96c4\u6fc0\u7d20\u5265\u593a\u7597\u6cd5\uff08androgen-deprivation therapy\uff09\u963b\u65ad\u96c4\u6027\u6fc0\u7d20\u7684\u4f5c\u7528\uff0c\u4f46\u524d\u5217\u817a\u764c\u4ecd\u7136\u751f\u957f\u5e76\u8513\u5ef6\u81f3\u8eab\u4f53\u7684\u5176\u4ed6\u90e8\u4f4d\u3002<strong>\u5927\u7ea610-20\uff05\u7684\u665a\u671f\u524d\u5217\u817a\u764c\u60a3\u8005\u4f1a\u57285\u5e74\u5185\u53d1\u5c55\u4e3aCRPC\uff0c\u5176\u4e2d\u81f3\u5c11\u670984\uff05\u7684\u60a3\u8005\u5728\u8bca\u65ad\u51faCRPC\u65f6\u5df2\u7ecf\u53d1\u751f\u8f6c\u79fb\u3002<\/strong>\u5728\u90a3\u4e9b\u8bca\u65adCRPC\u65f6\u672a\u53d1\u751f\u8f6c\u79fb\u7684\u7537\u6027\u4e2d\uff0c33\uff05\u7684\u60a3\u8005\u53ef\u80fd\u57282\u5e74\u5185\u53d1\u751f\u8f6c\u79fb\u3002\u5c3d\u7ba1\u9002\u5408\u8fd9\u7c7b\u60a3\u8005\u7684\u6cbb\u7597\u5728\u589e\u52a0\uff0c\u4f46\u4ed6\u4eec\u7684\u4e94\u5e74\u751f\u5b58\u7387\u4ec5\u4e3a28\uff05\u3002\u8fd9\u4e00\u9886\u57df\u8fd8\u6709\u5de8\u5927\u7684\u533b\u7597\u9700\u6c42\u672a\u88ab\u6ee1\u8db3\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">Lynparza\u662f\u79cdPARP\u6291\u5236\u5242\uff0c\u5b83\u4e5f\u662f\u9996\u4e2a\u6709\u6f5c\u529b\u5229\u7528DNA\u635f\u4f24\u5e94\u7b54\uff08DDR\uff09\u901a\u8def\u7f3a\u9677\uff08\u5982<em>BRCA<\/em>\u7a81\u53d8\uff09\uff0c\u6765\u4f18\u5148\u6740\u6b7b\u764c\u7ec6\u80de\u7684\u9776\u5411\u7597\u6cd5\u3002\u4f53\u5916\u7814\u7a76\u663e\u793a\uff0cLynparza\u8bf1\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u53ef\u80fd\u6d89\u53caPARP\u9176\u6d3b\u6027\u7684\u6291\u5236\uff0c\u548cPARP-DNA\u590d\u5408\u7269\u5f62\u6210\u7684\u589e\u52a0\uff0c\u4ece\u800c\u5bfc\u81f4DNA\u635f\u4f24\u548c\u764c\u7ec6\u80de\u6b7b\u4ea1\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6b64\u6b21\u516c\u5e03\u7684\u7814\u7a76Study 08\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc32\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6bd4\u8f83\u4e86Lynparza\u52a0\u963f\u6bd4\u7279\u9f99\u8054\u5408\u7597\u6cd5\uff08n=71\uff09\u4e0e\u963f\u6bd4\u7279\u9f99\u5355\u4e00\u7597\u6cd5\uff08n=71\uff09\uff0c\u5728\u66fe\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684mCRPC\u60a3\u8005\u4e2d\u7684\u7597\u6548\uff0c\u65e0\u8bba\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\uff08HRR\uff09\u7a81\u53d8\u72b6\u6001\u5982\u4f55\u3002\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662frPFS\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u5230\u7b2c\u4e8c\u6b21\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u65f6\u95f4\uff08PFS2\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\u548c\u4e0e\u5065\u5eb7\u76f8\u5173\u7684\u751f\u6d3b\u8d28\u91cf\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7ed3\u679c\u663e\u793a\uff0cLynparza\u52a0\u963f\u6bd4\u7279\u9f99\u8054\u5408\u7597\u6cd5\u7ec4\u7684\u4e2d\u4f4drPFS\u4e3a13.8\u4e2a\u6708\uff0c\u800c\u963f\u6bd4\u7279\u9f99\u5355\u4e00\u7597\u6cd5\u7ec4\u4e3a8.2\u4e2a\u6708\uff08HR 0.65\uff1b95\uff05CI 0.44-0.97\uff1bp=0.034\uff09\u3002\u4e2d\u4f4dPFS2\u5206\u522b\u4e3a23.3\u4e2a\u6708\u548c18.5\u4e2a\u6708\uff08HR 0.79\uff1b95\uff05CI 0.51-1.21\uff09\u3002\u4e2d\u4f4dOS\u5206\u522b\u4e3a22.7\u4e2a\u6708\u548c20.9\u4e2a\u6708\uff08HR 0.91\uff1b95\uff05CI 0.60-1.38\uff09\u3002\u9884\u5148\u6307\u5b9a\u7684\u63a2\u7d22\u6027\u4e9a\u7ec4\u5206\u6790\u663e\u793a\uff0c\u65e0\u8bbaHRR\u72b6\u6001\u5982\u4f55\uff0c\u60a3\u8005\u7684rPFS\u90fd\u6709\u6240\u6539\u5584\u3002\u6b64\u5916\uff0cLynparza\u52a0\u963f\u6bd4\u7279\u9f99\u8054\u5408\u7597\u6cd5\u7684\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e0e\u5355\u7528\u963f\u6bd4\u7279\u9f99\u76f8\u6bd4\uff0c\u5bf9\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u6ca1\u6709\u4e0d\u5229\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">5. \u603b\u751f\u5b58\u671f\u8fd13\u5e74\uff01\u8f89\u745e\u516c\u5e03\u6f5c\u529b\u4e00\u7ebf\u80ba\u764c\u65b0\u836f\u6570\u636e<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u65e5\u524d\uff0c\u8f89\u745e\u516c\u53f8\uff08Pfizer\uff09\u5ba3\u5e03\u4e86\u5176\u4e34\u5e8a\u8bd5\u9a8cARCHER 1050\u7684\u603b\u4f53\u751f\u5b58\u671f\uff08OS\uff09\u6570\u636e\u3002<strong>\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86dacomitinib\u4e00\u7ebf\u6cbb\u7597\u5177\u6709EGFR\u6fc0\u6d3b\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u7597\u6548\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">&nbsp;<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u80ba\u764c\u662f\u5168\u7403\u764c\u75c7\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u5176\u4e2dNSCLC\u7ea6\u5360\u80ba\u764c\u75c5\u4f8b\u768485\uff05\uff0c\u73b0\u4eca\u4ecd\u7136\u96be\u4ee5\u6cbb\u7597\u3002<strong>\u5927\u7ea675\uff05\u7684NSCLC\u60a3\u8005\u786e\u8bca\u65f6\u5df2\u662f\u665a\u671f\uff0c\u4e94\u5e74\u5b58\u6d3b\u7387\u4ec5\u4e3a5\uff05\u3002<\/strong>EGFR\u662f\u4e00\u79cd\u5e2e\u52a9\u7ec6\u80de\u751f\u957f\u548c\u5206\u88c2\u7684\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u86cb\u767d\uff0c\u5f53\u5b83\u53d1\u751f\u7a81\u53d8\u65f6\uff0c\u53ef\u5bfc\u81f4\u764c\u7ec6\u80de\u5f62\u6210\u3002EGFR\u7a81\u53d8\u5728\u5168\u740310\uff05\u81f335\uff05\u7684NSCLC\u4e2d\u51fa\u73b0\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7531\u8f89\u745e\u5e26\u6765\u7684dacomitinib\u5c5e\u4e8e\u7b2c\u4e8c\u4ee3EGFR TKI\uff08\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff09\u3002\u548c\u7b2c\u4e00\u4ee3\u836f\u7269\u76f8\u6bd4\uff0c\u5b83\u4e0eEGFR\u7684\u7ed3\u5408\u66f4\u4e3a\u6709\u6548\uff0c\u56e0\u6b64\u6709\u671b\u53d6\u5f97\u66f4\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6b64\u6b21\u516c\u5e03\u7684OS\u6570\u636e\u662fARCHER 1050\u7684\u7b2c\u4e8c\u4e2a\u7ec8\u70b9\uff0c\u8fd9\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u76843\u671f\u7814\u7a76\uff0c\u6bd4\u8f83\u4e86dacomitinib\u4e0egefitinib\u6cbb\u7597\u5177\u6709EGFR\u6fc0\u6d3b\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<strong>\u8be5\u7814\u7a76\u663e\u793a\uff0cdacomitinib\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a34.1\u4e2a\u6708<\/strong>\uff0895\uff05CI\uff1a29.5,37.7\uff09\uff0c<strong>\u76f8\u8f83\u5bf9\u7167\u7ec4\u768426.8\u4e2a\u6708<\/strong>\uff0895\uff05CI\uff1a23.7,32.1\uff09\uff0c<strong>\u6539\u5584\u8d85\u8fc77\u4e2a\u6708\u3002<\/strong>\u572830\u4e2a\u6708\u65f6\uff0cdacomitinib\u7ec4\u7684\u751f\u5b58\u7387\u4e3a56.2\uff05\uff0c\u800c\u5bf9\u7167\u7ec4\u4e3a46.3\uff05\u3002\u4e9a\u7ec4\u5206\u6790\u5728\u5927\u591a\u6570\u57fa\u7ebf\u7279\u5f81\u4e0a\u4e0e\u4e3b\u8981OS\u5206\u6790\u4e00\u81f4\uff0c\u5305\u62ec\u5177\u6709\u5171\u540c\u4e9a\u7a81\u53d8\u5916\u663e\u5b5019\u548c21\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u7684\u4f7f\u7528dacomitinib\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\u4e0e\u5148\u524d\u8bd5\u9a8c\u7684\u7ed3\u679c\u4e00\u81f4\u3002&nbsp;<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] Genentech Announces FDA Approval for Venclexta Plus Rituxan for People With Previously Treated Chronic Lymphocytic Leukemia<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] U.S. FDA and European Medicines Agency Accept Regulatory Submissions for Review of Talazoparib for Metastatic Breast Cancer Patients with an Inherited BRCA Mutation<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[3] Kite\u2019s TCR cell therapy offers promise for HPV-positive solid tumors<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[4] Lynparza in combination with abiraterone delayed disease progression in metastatic castration-resistant prostate cancer<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[5] Dacomitinib Shows More than Seven-Month Improvement in Overall Survival Compared to an Established Therapy in Advanced NSCLC with EGFR-Activating Mutations<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\"><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532684153.gif\" alt=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09\" title=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c69\u671f\uff09\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u660e\u5eb7\u5fb7                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 1. \u75be\u75c5\u98ce\u9669\u9510\u51cf81%\uff01FDA\u6279\u51c6\u767d\u8840\u75c5\u65b0\u7597\u6cd5 \u827e\u4f2f\u7ef4\uff08AbbVie\uff09\u4e0e\u57fa\u56e0\u6cf0\u514b\uff08Gene [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9034,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9033"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9033"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9033\/revisions"}],"predecessor-version":[{"id":9041,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9033\/revisions\/9041"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9034"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9033"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9033"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9033"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}