{"id":90426,"date":"2019-04-21T00:00:50","date_gmt":"2019-04-23T04:18:40","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/90426\/"},"modified":"2019-04-23T12:18:42","modified_gmt":"2019-04-23T04:18:42","slug":"c6c500f7d8","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/90426\/","title":{"rendered":"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/6-1555993120.gif\" alt=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\" title=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\"><\/p>\n<p><span style=\"font-size: 15px;\">\u8fd1\u65e5\uff0c\u6e05\u534e\u5927\u5b66\u836f\u5b66\u9662<strong>\u9976\u71cf<\/strong>\u8bfe\u9898\u7ec4\u4e0e\u6e05\u534e\u5927\u5b66\u533b\u5b66\u9662<strong>\u5a04\u667a\u52c7<\/strong>\u8bfe\u9898\u7ec4\u5408\u4f5c\u5728\u836f\u7269\u5316\u5b66\u6743\u5a01\u6742\u5fd7\u300aJournal of Medicinal Chemistry\u300b\u5728\u7ebf\u53d1\u8868\u9898\u4e3a\u201cDiscovery, Optimization and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors\u201d\u7684\u7814\u7a76\u5de5\u4f5c\uff0c<strong>\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\u3002<\/strong><\/span><br style=\"color: rgb(65, 64, 66);font-family: 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style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;\"><\/span><br style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;white-space: normal;\"  \/><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/8-1555993121.jpg\" alt=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\" title=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\"><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u56fe1&nbsp; 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Med. Chem. 2017, 60 (5), 1994-2005\uff09\uff0c\u5728\u7b2c\u4e00\u8f6e\u7b5b\u9009\u4e2d\u4ec5\u4ece\u4e0d\u5230200\u4e2a\u5316\u5408\u7269\u4e2d\u5c31\u786e\u8ba4\u5f97\u5230\u4e865\u4e2a\u82d7\u5934\u5316\u5408\u7269\uff0c\u7136\u540e\u7ecf\u8fc7\u4e00\u7cfb\u5217\u7684\u6784\u6548\u5173\u7cfb\u7814\u7a76\u548c\u4f18\u5316\u5f97\u5230\u4e00\u4e2a\u6d3b\u6027\u6700\u5f3a\u7684\u5206\u5b50<strong>RYL-634<\/strong>\uff08\u56fe1\uff09\u3002\u8fd9\u4e5f\u662f\u55b9\u8bfa\u916e\u7c7b\u5316\u5408\u7269\u5728\u836f\u7269\u53d1\u73b0\u4e2d\u4f5c\u4e3a\u4e00\u79cd\u4f18\u52bf\u7ed3\u6784\u7684\u4f53\u73b0\u3002\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u53d1\u73b0\uff0cRYL-634\u5bf9\u5305\u62ec\u4e19\u809d\u75c5\u6bd2\uff08HCV\uff09\u3001DENV\u3001ZIKV\u3001\u57fa\u5b54\u80af\u96c5\u75c5\u6bd2\uff08CHIKV\uff09\u3001\u80a0\u9053\u75c5\u6bd2EV71\u3001\u4eba\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08HIV\uff09\u3001\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\uff08RSV\uff09\u3001\u4e2d\u4e1c\u547c\u5438\u7efc\u5408\u75c7\u51a0\u72b6\u75c5\u6bd2\uff08MERS-CoV\uff09\u3001\u53d1\u70ed\u4f34\u8840\u5c0f\u677f\u51cf\u5c11\u7efc\u5408\u5f81\u75c5\u6bd2(SFTSV)\u3001\u6d41\u611f\u75c5\u6bd2\u7b49\u5bf9\u4eba\u81f4\u75c5\u75c5\u6bd2\u5177\u6709\u5f88\u5f3a\u6216\u8f83\u660e\u663e\u7684\u6291\u5236\u6548\u679c\uff0c\u5bf9\u5bbf\u4e3b\u7ec6\u80de\u7684\u6bd2\u6027\u4e5f\u5728\u53ef\u63a5\u53d7\u8303\u56f4\u5185\uff08\u88681\uff09\u3002RYL-634\u8fd8\u4e0e\u76ee\u524d\u6279\u51c6\u7684\u6297\u75c5\u6bd2\u836f\u7269\u8054\u7528\u5177\u6709\u534f\u540c\u6548\u5e94\u3002\u7ecf\u8fc7\u8010\u836f\u538b\u529b\u7b5b\u9009\uff0c\u672a\u53d1\u73b0\u5bf9RYL-634\u8010\u836f\u7684\u75c5\u6bd2\u682a\u4ea7\u751f\u3002\u4ee5\u4e0a\u7ed3\u679c\u663e\u793a\u4e86\u57fa\u4e8eRYL-634\u53d1\u5c55\u65b0\u578b\u6297\u75c5\u6bd2\u6cbb\u7597\u65b9\u6cd5\u5177\u6709\u5f88\u5927\u7684\u6f5c\u529b\u3002<\/span><span style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;\"><\/span><br style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;white-space: normal;\"  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/3-1555993121.png\" alt=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\" title=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\"><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u88681&nbsp; RYL-634\u7684\u5e7f\u8c31\u6297\u75c5\u6bd2\u6d3b\u6027<\/span><br style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;white-space: normal;\"  \/><br  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u4eba\u5458\u5bf9RYL-634\u7684\u4f5c\u7528\u673a\u5236\u8fdb\u884c\u4e86\u63a2\u5bfb\u3002\u7531\u4e8e\u4eba\u7c7b\u548c\u75c5\u6bd2\u4e2d\u4e0d\u542b\u6709\u8be5\u7c7b\u5206\u5b50\u5148\u524d\u7684\u4f5c\u7528\u9776\u70b9\u759f\u539f\u866b\u7684NDH2\u6216\u5176\u540c\u6e90\u86cb\u767d\uff0c\u8be5\u7c7b\u5316\u5408\u7269\u4e5f\u4ece\u672a\u88ab\u62a5\u9053\u8fc7\u6709\u6297\u75c5\u6bd2\u6d3b\u6027\uff0c\u7814\u7a76\u4eba\u5458\u91c7\u7528Activity-Based Protein Profiling (ABPP)\u7684\u65b9\u6cd5\u5728\u4e4b\u524d\u603b\u7ed3\u7684\u6784\u6548\u5173\u7cfb\u57fa\u7840\u4e0a\u8bbe\u8ba1\u5408\u6210\u4e86\u5149\u4ea4\u8054\u63a2\u9488\u8fdb\u884c\u9776\u70b9\u201c\u5782\u9493\u201d\uff08\u56fe2\uff09\uff0c\u5e76\u901a\u8fc7\u751f\u7269\u4fe1\u606f\u5b66\u7684\u5206\u6790\u53d1\u73b0RYL-634\u4f5c\u7528\u4e8e\u591a\u79cd\u751f\u7269\u5b66\u901a\u8def\uff0c\u5177\u6709\u591a\u79cd\u53ef\u80fd\u6f5c\u5728\u7684\u9776\u70b9\uff0c\u53ef\u80fd\u6027\u6700\u5927\u7684\u662f\u4f5c\u7528\u4e8e\u5bbf\u4e3b\u7684\u80de\u5185\u5206\u5b50\u4ee3\u8c22\u76f8\u5173\u901a\u8def\uff0c\u5e76\u5229\u7528\u53cd\u76f8\u5bf9\u63a5\u7684\u65b9\u6cd5\u8fdb\u4e00\u6b65\u7f29\u5c0f\u4e86\u6f5c\u5728\u9776\u70b9\u7684\u8303\u56f4\u3002<\/span><span style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;\"><\/span><br style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;white-space: normal;\"  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/10-1555993121.jpg\" alt=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\" title=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\"><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u56fe2&nbsp; \u5229\u7528ABPP\u548c\u53cd\u76f8\u5bf9\u63a5\u641c\u5bfb\u9776\u70b9<\/span><br style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;white-space: normal;\"  \/><br  \/><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">\u6700\u7ec8\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u4e00\u7cfb\u5217\u751f\u5316\u5b9e\u9a8c\u3001Drug Affinity Responsive Target Stability \uff08DARTS\uff09\u7b49\u65b9\u6cd5\u786e\u5b9a\u4e86\u4eba\u7684DHODH\u662fRYL-634\u7684\u4e00\u4e2a\u6297\u75c5\u6bd2\u9776\u70b9<\/span><\/strong><span style=\"font-size: 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style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;\"><\/span><br style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;white-space: normal;\"  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/4-1555993122.jpg\" alt=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\" title=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\"><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u56fe3&nbsp; RYL-634\u4e0eDHODH\u7684\u76f8\u4e92\u4f5c\u7528<\/span><br style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;white-space: normal;\"  \/><br  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u9976\u71cf\u8bfe\u9898\u7ec4\u548c\u5a04\u667a\u52c7\u8bfe\u9898\u7ec4\u535a\u58eb\u540e<strong>\u6768\u6bc5\u5e86\u3001\u66f9\u6797\u3001\u9ad8\u7ea2\u82f1<\/strong>\u4e3a\u672c\u5de5\u4f5c\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c<strong>\u9976\u71cf<\/strong>\u548c<strong>\u5a04\u667a\u52c7<\/strong>\u4e3a\u901a\u8baf\u4f5c\u8005\u3002<\/span><span style=\"font-size: 15px;\">\u672c\u7814\u7a76\u5f97\u5230\u4e86\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u6e05\u534e-\u5317\u5927\u751f\u547d\u8054\u5408\u4e2d\u5fc3\u4ee5\u53ca\u4e2d\u56fd\u535a\u58eb\u540e\u57fa\u91d1\u7684\u5927\u529b\u652f\u6301\u3002<\/span><br style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;white-space: normal;\"  \/><span style=\"font-size: 15px;\">&nbsp;<br style=\"color: rgb(65, 64, 66);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;text-align: start;white-space: normal;\"  \/>\u539f\u6587\u94fe\u63a5\uff1a<\/span><span style=\"font-size: 15px;\">https:\/\/pubs.acs.org.ccindex.cn\/doi\/10.1021\/acs.jmedchem.9b00091<\/span><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u6765\u6e90\uff1a\u6e05\u534e\u5927\u5b66\u836f\u5b66\u9662<br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u7f16\u8f91\uff1aipsvirus<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/4-1555993122.png\" alt=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\" title=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\"><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/9-1555993122.jpg\" alt=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\" title=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\"><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/1-1555993122.jpeg\" alt=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\" title=\"\u6e05\u534e\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u62a5\u9053\u65b0\u578b\u5e7f\u8c31\u6297\u75c5\u6bd2\u5316\u5408\u7269\u7684\u53d1\u73b0\u53ca\u5176\u9776\u70b9\u786e\u8bc1\u5de5\u4f5c\"><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd1\u65e5\uff0c\u6e05\u534e\u5927\u5b66\u836f\u5b66\u9662\u9976\u71cf\u8bfe\u9898\u7ec4\u4e0e\u6e05\u534e\u5927\u5b66\u533b\u5b66\u9662\u5a04\u667a\u52c7\u8bfe\u9898\u7ec4\u5408\u4f5c\u5728\u836f\u7269\u5316\u5b66\u6743\u5a01\u6742\u5fd7\u300aJournal of Med 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