{"id":9048,"date":"2018-06-12T01:00:00","date_gmt":"2018-07-27T09:36:01","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e9%80%9f%e9%80%92-os%e5%bb%b6%e9%95%bf7-9%e4%b8%aa%e6%9c%88%ef%bc%8c%e5%ae%89%e8%bf%9b%e9%aa%a8%e9%ab%93%e7%98%a4%e6%96%b0%e8%8d%af%e8%a1%a5%e5%85%85%e4%b8%8a%e5%b8%82%e7%94%b3%e8%af%b7%e8%8e%b7\/"},"modified":"2018-07-27T17:36:02","modified_gmt":"2018-07-27T09:36:02","slug":"%e9%80%9f%e9%80%92-os%e5%bb%b6%e9%95%bf7-9%e4%b8%aa%e6%9c%88%ef%bc%8c%e5%ae%89%e8%bf%9b%e9%aa%a8%e9%ab%93%e7%98%a4%e6%96%b0%e8%8d%af%e8%a1%a5%e5%85%85%e4%b8%8a%e5%b8%82%e7%94%b3%e8%af%b7%e8%8e%b7","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9048\/","title":{"rendered":"\u901f\u9012 | OS\u5ef6\u957f7.9\u4e2a\u6708\uff0c\u5b89\u8fdb\u9aa8\u9ad3\u7624\u65b0\u836f\u8865\u5145\u4e0a\u5e02\u7533\u8bf7\u83b7\u6279"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong style=\"white-space: normal;font-size: 15px;color: rgb(62, 62, 62);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4eca\u65e5\uff0c\u5b89\u8fdb(Amgen)\u516c\u53f8\u5ba3\u5e03\u7f8e\u56fdFDA\u6279\u51c6\u8be5\u516c\u53f8\u4e3aKYPROLIS(carfilzomib)\u9012\u4ea4\u7684\u8865\u5145\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7(supplemental New Drug Application, sNDA)\uff0c\u5141\u8bb8\u5b89\u8fdb\u516c\u53f8\u5c06\u5728\u540d\u4e3aASPIRE\u7684\u4e34\u5e8a3\u671f\u8bd5\u9a8c\u4e2d\u83b7\u5f97\u7684\u79ef\u6781\u603b\u751f\u5b58\u671f(overall survival, OS)\u6570\u636e\u52a0\u5165carfilzomib\u7684\u7f8e\u56fd\u5904\u65b9\u4fe1\u606f\u4e2d\u3002<strong>\u5728\u8fd9\u9879\u4e34\u5e8a3\u671f\u8bd5\u9a8c\u4e2d\uff0ccarfilzomib\u4e0elenalidomide\u548cdexamethasone\u6784\u6210\u7684\u7ec4\u5408\u7597\u6cd5(KRd)\u4e0elenalidomide\u548cdexamethasone\u6784\u6210\u7684\u7ec4\u5408\u7597\u6cd5(Rd)\u76f8\u6bd4\uff0c\u80fd\u591f\u5c06\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e21%\uff0c\u5e76\u4e14\u5c06OS\u5ef6\u957f7.9\u4e2a\u6708\u3002<\/strong><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><br  \/><\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532684162.jpg\" alt=\"\u901f\u9012 | OS\u5ef6\u957f7.9\u4e2a\u6708\uff0c\u5b89\u8fdb\u9aa8\u9ad3\u7624\u65b0\u836f\u8865\u5145\u4e0a\u5e02\u7533\u8bf7\u83b7\u6279\" title=\"\u901f\u9012 | OS\u5ef6\u957f7.9\u4e2a\u6708\uff0c\u5b89\u8fdb\u9aa8\u9ad3\u7624\u65b0\u836f\u8865\u5145\u4e0a\u5e02\u7533\u8bf7\u83b7\u6279\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u591a\u53d1\u6027\u9aa8\u9ad3\u7624(multiple myeloma, MM)\u662f\u4e00\u79cd\u7531\u4e8e\u9aa8\u9ad3\u4e2d\u7684\u6d46\u7ec6\u80de\u764c\u53d8\u5bfc\u81f4\u7684\u7f55\u89c1\u4f46\u662f\u5371\u53ca\u751f\u547d\u7684\u8840\u764c\uff0c\u5360\u764c\u75c7\u603b\u6570\u76842%\u5de6\u53f3\u3002\u5b83\u7684\u4e00\u4e2a\u91cd\u8981\u7279\u5f81\u662f\u4f1a\u53cd\u590d\u51fa\u73b0\u7f13\u89e3\u548c\u590d\u53d1\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7ec6\u80de\u5185\u7684\u86cb\u767d\u9176\u4f53(proteasomes)\u80fd\u591f\u5206\u89e3\u53d7\u635f\u6216\u4e0d\u518d\u9700\u8981\u7684\u86cb\u767d\uff0c\u5b83\u5bf9\u7ec6\u80de\u7684\u6b63\u5e38\u529f\u80fd\u548c\u751f\u957f\u90fd\u6709\u91cd\u8981\u7684\u4f5c\u7528\u3002Carfilzomib\u662f\u5b89\u8fdb\u516c\u53f8\u5f00\u53d1\u7684\u7b2c\u4e8c\u4ee3\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\uff0c\u5b83\u901a\u8fc7\u963b\u65ad\u86cb\u767d\u9176\u4f53\u5206\u89e3\u86cb\u767d\u7684\u529f\u80fd\uff0c\u5bfc\u81f4\u7ec6\u80de\u5185\u86cb\u767d\u7684\u8fc7\u5ea6\u79ef\u7d2f\u3002\u5728\u6709\u4e9b\u7ec6\u80de\u4e2d\uff0ccarfilzomib\u4f1a\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\u3002<strong>\u7531\u4e8e\u9aa8\u9ad3\u7624\u7ec6\u80de\u4e2d\u542b\u6709\u5927\u91cf\u5f02\u5e38\u86cb\u767d\uff0c\u56e0\u6b64carfilzomib\u5f15\u53d1\u9aa8\u9ad3\u7624\u7ec6\u80de\u6b7b\u4ea1\u7684\u6548\u679c\u5c24\u5176\u660e\u663e\u3002<\/strong>Carfilzomib\u5df2\u7ecf\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\uff0c\u53ef\u4ee5\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u6216\u8005\u4e0edexamethasone\u6216dexamethasone + lenalidomide\u6784\u6210\u7ec4\u5408\u7597\u6cd5\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027MM\u60a3\u8005\u3002\u5b83\u540c\u65f6\u4e5f\u5728\u6fb3\u5927\u5229\u4e9a\u3001\u52a0\u62ff\u5927\u3001\u9999\u6e2f\u3001\u65e5\u672c\u3001\u97e9\u56fd\u3001\u745e\u58eb\u3001\u4fc4\u7f57\u65af\u7b49\u56fd\u5bb6\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\u3002\u81ea\u4ece\u83b7\u5f97\u6279\u51c6\u4ee5\u6765\uff0c\u5168\u7403\u6709\u63a5\u8fd18\u4e07\u540d\u60a3\u8005\u5df2\u7ecf\u63a5\u53d7\u8fc7carfilzomib\u7684\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532684162.png\" alt=\"\u901f\u9012 | OS\u5ef6\u957f7.9\u4e2a\u6708\uff0c\u5b89\u8fdb\u9aa8\u9ad3\u7624\u65b0\u836f\u8865\u5145\u4e0a\u5e02\u7533\u8bf7\u83b7\u6279\" title=\"\u901f\u9012 | OS\u5ef6\u957f7.9\u4e2a\u6708\uff0c\u5b89\u8fdb\u9aa8\u9ad3\u7624\u65b0\u836f\u8865\u5145\u4e0a\u5e02\u7533\u8bf7\u83b7\u6279\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u540d\u4e3aASPIRE\u7684\u5f00\u653e\u6807\u7b7e\uff0c\u591a\u4e2d\u5fc3\uff0c\u968f\u673a\u4e34\u5e8a3\u671f\u8bd5\u9a8c\u4e2d\uff0c792\u540d\u590d\u53d1\u6216\u96be\u6cbb\u6027MM\u60a3\u8005\u63a5\u53d7\u4e86KRd\u6216Rd\u7684\u6cbb\u7597\u3002\u8fd9\u4e9b\u60a3\u8005\u5df2\u7ecf\u63a5\u53d7\u8fc71-3\u79cd\u5176\u5b83\u7597\u6cd5\u7684\u6cbb\u7597\u3002<strong>\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\u63a5\u53d7KRd\u7597\u6cd5\u60a3\u8005\u7ec4\u7684\u5e73\u5747OS\u4e3a48.3\u4e2a\u6708\uff0c\u63a5\u53d7Rd\u7597\u6cd5\u60a3\u8005\u7ec4\u7684\u5e73\u5747OS\u4e3a40.4\u4e2a\u6708\u3002KRd\u7597\u6cd5\u80fd\u591f\u5c06OS\u5ef6\u957f7.9\u4e2a\u6708(p=0.0091)\u3002<\/strong>\u5728\u53ea\u63a5\u53d7\u8fc7\u4e00\u6b21\u5176\u5b83\u7597\u6cd5\u6cbb\u7597\u7684\u60a3\u8005\u4e9a\u7fa4\u4e2d\uff0cKRd\u7597\u6cd5\u7684\u7597\u6548\u66f4\u597d\uff0c\u4e0eRd\u7597\u6cd5\u76f8\u6bd4\u80fd\u591f\u5c06\u5e73\u5747OS\u5ef6\u957f11.4\u4e2a\u6708\u3002\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(progression free survival, PFS)\u6570\u636e\u5df2\u7ecf\u5728\u53bb\u5e74\u53d1\u8868\uff0cKRd\u4e0eRd\u7597\u6cd5\u76f8\u6bd4\u80fd\u591f\u5c06PFS\u5ef6\u957f8.7\u4e2a\u6708(p=0.0001)\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u5b89\u8fdb\u516c\u53f8\u4e13\u6ce8\u4e8e\u63a8\u52a8\u6539\u53d8\u60a3\u8005\u75be\u75c5\u540e\u679c\u7684\u7597\u6cd5\uff0c\u201d\u5b89\u8fdb\u516c\u53f8\u8f6c\u5316\u79d1\u5b66\u4e0e\u80bf\u7624\u5b66\u9ad8\u7ea7\u526f\u603b\u88c1David M. Reese\u535a\u58eb\u8bf4\uff1a\u201c<strong>ASPIRE\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5305\u542bcarfilzomib\u7684\u7ec4\u5408\u7597\u6cd5\u80fd\u591f\u663e\u8457\u5ef6\u957f\u590d\u53d1\u6216\u96be\u6cbb\u6027MM\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002<\/strong>\u8fd9\u9879\u6279\u51c6\u4e4b\u540e\uff0ccarfilzomib\u7684\u7f8e\u56fd\u5904\u65b9\u4fe1\u606f\u4e2d\u5305\u542b\u4e86\u4e24\u9879\u4e34\u5e8a3\u671f\u8bd5\u9a8c\u4e2d\u4ea7\u751f\u7684\u79ef\u6781\u603b\u751f\u5b58\u671f\u6570\u636e\u3002\u8fd9\u51f8\u663e\u51fa\u6291\u5236\u86cb\u767d\u9176\u4f53\u5728\u6cbb\u7597MM\u65b9\u9762\u7684\u91cd\u8981\u4f5c\u7528\u3002\u201d<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] FDA Approves Addition Of Positive Overall Survival Data From Phase 3 ASPIRE Trial To KYPROLIS\u00ae (carfilzomib) Label<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] About Multiple Myeloma<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[3] Improvement in Overall Survival With Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma<br  \/><\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[4] Carfilzomib-lenalidomide-dexamethasone vs lenalidomide-dexamethasone in relapsed multiple myeloma by previous treatment.<\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532684162.gif\" alt=\"\u901f\u9012 | OS\u5ef6\u957f7.9\u4e2a\u6708\uff0c\u5b89\u8fdb\u9aa8\u9ad3\u7624\u65b0\u836f\u8865\u5145\u4e0a\u5e02\u7533\u8bf7\u83b7\u6279\" title=\"\u901f\u9012 | OS\u5ef6\u957f7.9\u4e2a\u6708\uff0c\u5b89\u8fdb\u9aa8\u9ad3\u7624\u65b0\u836f\u8865\u5145\u4e0a\u5e02\u7533\u8bf7\u83b7\u6279\"  \/><\/p>\n<\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u660e\u5eb7\u5fb7                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u4eca\u65e5\uff0c\u5b89\u8fdb(Amgen)\u516c\u53f8\u5ba3\u5e03\u7f8e\u56fdFDA\u6279\u51c6\u8be5\u516c\u53f8\u4e3aKYPROLIS(carfilzomi [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9049,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9048"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9048"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9048\/revisions"}],"predecessor-version":[{"id":9053,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9048\/revisions\/9053"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9049"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9048"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}