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\n

\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n


<\/p>\n

\u827e\u5c14\u5efa\uff08Allergan\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u5176\u5728\u7814\u836f\u7269Atogepant\u5728\u4e34\u5e8a2b\/3\u671f\u8bd5\u9a8c\u4e2d\u53d6\u5f97\u4e86\u79ef\u6781\u7ed3\u679c\uff0c\u5728\u6240\u6709\u5242\u91cf\u65b9\u6848\u4e0a\u90fd\u8fbe\u5230\u4e86\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff0c\u5e76\u5728\u7edf\u8ba1\u5b66\u610f\u4e49\u4e0a\u663e\u8457\u51cf\u5c11\u4e86\u504f\u5934\u75db\u60a3\u8005\u7684\u95f4\u6b47\u6027\u6bcf\u6708\u53d1\u4f5c\u5929\u6570\u3002<\/strong>Atogepant\u662f\u4e00\u79cd\u65b0\u578b\u7684\u53e3\u670d\u964d\u9499\u7d20\u57fa\u56e0\u76f8\u5173\u80bd\uff08CGRP\uff09\u53d7\u4f53\u62ee\u6297\u5242\u3002<\/span><\/p>\n

 <\/span><\/p>\n

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\"\u901f\u9012<\/p>\n


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<\/p>\n

CGRP\u53ca\u5176\u53d7\u4f53\u5728\u4e0e\u504f\u5934\u75db\u75c5\u7406\u751f\u7406\u5b66\u76f8\u5173\u7684\u795e\u7ecf\u7cfb\u7edf\u533a\u57df\u8868\u8fbe\u3002CGRP\u53d7\u4f53\u62ee\u6297\u4f5c\u7528\u662f\u504f\u5934\u75db\u6025\u6027\u6cbb\u7597\u7684\u4e00\u79cd\u65b0\u7684\u4f5c\u7528\u673a\u5236\uff0c\u4e0e\u73b0\u6709\u7684\u66f2\u5766\u7c7b\uff08\u8840\u6e05\u7d201B \/ 1D\u6fc0\u52a8\u5242\uff09\u548c\u963f\u7247\u7c7b\u836f\u7269\u7684\u4f5c\u7528\u673a\u5236\u660e\u663e\u4e0d\u540c\u3002Atogepant\u662f\u827e\u5c14\u5efa\u7ee7Ubrogepant\u540e\uff0c\u5f00\u53d1\u7684\u7b2c\u4e8c\u79cdCGRP\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u80fd\u663e\u8457\u51cf\u5c11\u6025\u6027\u504f\u5934\u75db\u53d1\u4f5c\u5929\u6570\u3002<\/strong>\u827e\u5c14\u5efa\u8ba4\u4e3aCGRP\u62ee\u6297\u5242\u836f\u7269\u53ef\u4ee5\u548c\u8be5\u516c\u53f8\u7684Botox\u4e92\u8865\uff0c\u540e\u8005\u53ef\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u504f\u5934\u75db\u3002<\/span><\/p>\n


<\/p>\n

\"\u901f\u9012<\/p>\n

\u25b2CGP-MD-01\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff08\u56fe\u7247\u6765\u6e90\uff1a\u827e\u5c14\u5efa\u5b98\u65b9\u7f51\u7ad9\uff09<\/span><\/strong><\/span><\/p>\n


<\/p>\n

CGP-MD-01\u4e34\u5e8a\u8bd5\u9a8c\u662f\u4e00\u98792b\/3\u671f\u5728\u7f8e\u56fd\u8fdb\u884c\u7684\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u5e73\u884c\u7ec4\u7814\u7a76\uff0c\u4e3a\u671f12\u5468\u3002\u8be5\u8bd5\u9a8c\u5305\u62ec\u968f\u673a4\u5468\u7b5b\u67e5\/\u57fa\u7ebf\u671f\uff0c12\u5468\u53cc\u76f2\u6cbb\u7597\u671f\u548c4\u5468\u5b89\u5168\u968f\u8bbf\u671f\u3002834\u540d\u5b9e\u9a8c\u5bf9\u8c61\u5e74\u9f84\u572818\u81f375\u5c81\uff08\u5e73\u574740.1\u5c81\uff09\u4e4b\u95f4\uff0c\u504f\u5934\u75db\u75c5\u53f2\uff08\u6709\u6216\u6ca1\u6709\u5148\u5146\u7684\uff09\u81f3\u5c111\u5e74\uff0c\u5e76\u4e14\u5728\u7b2c1\u6b21\u8bbf\u89c6\u524d\u76843\u4e2a\u6708\u548c28\u5929\u7b5b\u67e5\u57fa\u7ebf\u671f\u95f4\u5e73\u5747\u6bcf\u6708\u67094\u81f314\u6b21\u504f\u5934\u75db\/\u6781\u53ef\u80fd\u504f\u5934\u75db\uff08MPM\uff09\u53d1\u4f5c\u5929\u6570\u3002\u603b\u5171\u670982%\u7684\u60a3\u8005\u5b8c\u6210\u4e86\u7814\u7a76\uff0c\u6240\u6709\u6cbb\u7597\u7ec4\u7684\u505c\u836f\u7387\u76f8\u4f3c\u3002\u5176\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0cAtogepant\u5728\u6240\u6709\u5242\u91cf\u65b9\u6848\u4e2d\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\u3002<\/strong>\u529f\u6548\u5206\u6790\u57fa\u4e8e795\u540d\u6539\u826f\u610f\u5411\u6cbb\u7597\uff08mITT\uff09\u7684\u60a3\u8005\u7fa4\u4f53\uff0c\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u662f\u572812\u5468\u6cbb\u7597\u671f\u5185\u5e73\u5747\u6bcf\u6708MPM\u53d1\u4f5c\u5929\u6570\u4e0e\u57fa\u7ebf\u5bf9\u6bd4\u7684\u53d8\u5316\u3002\u6b64\u5916Atogepant\u8010\u53d7\u6027\u597d\uff0c\u809d\u810f\u5b89\u5168\u6027\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u4f3c\u3002<\/span><\/p>\n


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\u827e\u5c14\u5efa\u6267\u884c\u526f\u603b\u88c1\u517c\u9996\u5e2d\u7814\u53d1\u5b98David Nicholson\u535a\u58eb\u8bf4\u9053\uff1a\u201c\u827e\u5c14\u5efa\u5bf9\u6b64\u6b212b\/3\u671f\u7684\u8bd5\u9a8c\u7ed3\u679c\u611f\u5230\u975e\u5e38\u6ee1\u610f\u3002\u8fd9\u53cd\u6620\u4e86\u827e\u5c14\u5efa\u5bf9\u5f00\u53d1\u504f\u5934\u75db\u9884\u9632\u6027\u7597\u6cd5\u7684\u627f\u8bfa\u3002\u5173\u4e8e\u8bd5\u9a8c\u7ec8\u70b9\u7684\u66f4\u591a\u6570\u636e\u9884\u671f\u5c06\u5728\u672a\u6765\u53ec\u5f00\u7684\u79d1\u5b66\u4f1a\u8bae\u4e0a\u53d1\u5e03\u3002\u8fc7\u53bb\u51e0\u5341\u5e74\u6765\uff0c\u6211\u4eec\u4e00\u76f4\u81f4\u529b\u4e8e\u7814\u7a76\u504f\u5934\u75bc\u7684\u65b0\u7597\u6cd5\u3002\u6211\u4eec\u627f\u8bfa\u5c06\u901a\u8fc7\u521b\u65b0\u578b\u7684\u836f\u7269\u53bb\u89e3\u51b3\u504f\u5934\u75db\u60a3\u8005\u4e00\u76f4\u6ca1\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u8981\uff0c\u4ed6\u4eec\u671f\u5f85\u7740\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u80fd\u7ed9\u4ed6\u4eec\u7684\u65e5\u5e38\u751f\u6d3b\u5e26\u6765\u771f\u6b63\u7ffb\u5929\u5730\u8986\u7684\u53d8\u5316\u3002\u201d<\/span><\/p>\n

 <\/span><\/p>\n

\"\u901f\u9012<\/p>\n

\u25b2\u827e\u5c14\u5efa\u9996\u5e2d\u5546\u52a1\u5b98Bill Meury\u5148\u751f\uff08\u56fe\u7247\u6765\u6e90\uff1a\u827e\u5c14\u5efa\u5b98\u65b9\u7f51\u7ad9\uff09<\/span><\/strong><\/span><\/p>\n


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\u827e\u5c14\u5efa\u9996\u5e2d\u5546\u52a1\u5b98Bill Meury\u5148\u751f\u5728\u4e00\u4efd\u58f0\u660e\u4e2d\u8868\u793a\uff1a\u201c\u8fd9\u9879\u7814\u7a76\u7684\u79ef\u6781\u7ed3\u679c\u8868\u660e\uff0c\u4e0e\u5e02\u573a\u4e0a\u7684\u5176\u4ed6\u7597\u6cd5\u548c\u9884\u9632\u504f\u5934\u75db\u624b\u6bb5\u65b9\u9762\u76f8\u6bd4\uff0c\u53e3\u670d\u7684Atogepant\u7684\u8bd5\u9a8c\u7ed3\u679c\u4ee4\u4eba\u4fe1\u670d\u3002\u6211\u4eec\u5bf9\u8be5\u4ea7\u54c1\u7684\u524d\u666f\u611f\u5230\u632f\u594b\uff0c\u5e76\u5c06\u8fc5\u901f\u8fdb\u5165\u4e0b\u4e00\u4e2a\u5f00\u53d1\u9636\u6bb5\u3002\u827e\u5c14\u5efa\u62e5\u6709\u4e1a\u5185\u6700\u5177\u521b\u65b0\u6027\u548c\u6df1\u5ea6\u7684\u504f\u5934\u75db\u4ea7\u54c1\u7cfb\u5217\u4e4b\u4e00\uff0c\u5176\u4e2dBotox\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u9884\u9632\u6162\u6027\u504f\u5934\u75db\uff0c\u53e3\u670d\u7684Atogepant\u548cUbrogepant\u6b63\u5728\u5f00\u53d1\u9636\u6bb5\uff0c\u7528\u4e8e\u6cbb\u7597\u3001\u9884\u9632\u504f\u5934\u75db\u7684\u6025\u6027\u53d1\u4f5c\u3002\u201d<\/span><\/p>\n


<\/span><\/p>\n

\u6211\u4eec\u671f\u5f85\u8fd9\u6b3e\u504f\u5934\u75db\u65b0\u836f\u53ef\u4ee5\u65e9\u65e5\u7533\u8bf7\u4e0a\u5e02\uff0c\u80fd\u5e2e\u52a9\u5e7f\u5927\u504f\u5934\u75db\u60a3\u8005\u9884\u9632\u504f\u5934\u75db\u7684\u53d1\u751f\uff0c<\/span><\/p>\n


<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] Allergan\u2019s Atogepant Hits the Mark in Phase IIb\/III Episodic Migraine Trial<\/span><\/p>\n

[2] Allergan’s Oral CGRP Receptor Antagonist Atogepant Demonstrates Robust Efficacy and Safety in Episodic Migraine Prevention in a Phase 2b\/3 Clinical Trial<\/span><\/p>\n

[3] \u6cbb\u7597\u504f\u5934\u75db\uff0c\u65b0\u836f\u5173\u952e3\u671f\u4e34\u5e8a\u53d6\u5f97\u6210\u529f<\/span><\/p>\n

[4] \u663e\u8457\u51cf\u5c11\u75c7\u72b6\uff0c\u504f\u5934\u75db\u65b0\u836f3\u671f\u4e34\u5e8a\u7ed3\u679c\u79ef\u6781<\/span><\/p>\n


<\/p>\n

\"\u901f\u9012<\/p>\n<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u660e\u5eb7\u5fb7 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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