{"id":9061,"date":"2018-06-12T01:00:00","date_gmt":"2018-07-27T09:36:09","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e9%80%9f%e9%80%92-%e6%b2%bb%e7%96%97nash%e5%8f%8a%e8%82%a0%e8%83%83%e7%97%85%ef%bc%8c%e6%96%b0%e9%94%90c%e8%bd%ae%e8%9e%8d%e8%b5%846500%e4%b8%87%e7%be%8e%e5%85%83\/"},"modified":"2018-07-27T17:36:10","modified_gmt":"2018-07-27T09:36:10","slug":"%e9%80%9f%e9%80%92-%e6%b2%bb%e7%96%97nash%e5%8f%8a%e8%82%a0%e8%83%83%e7%97%85%ef%bc%8c%e6%96%b0%e9%94%90c%e8%bd%ae%e8%9e%8d%e8%b5%846500%e4%b8%87%e7%be%8e%e5%85%83","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9061\/","title":{"rendered":"\u901f\u9012 | \u6cbb\u7597NASH\u53ca\u80a0\u80c3\u75c5\uff0c\u65b0\u9510C\u8f6e\u878d\u8d446500\u4e07\u7f8e\u5143"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n

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\u8fd1\u65e5\uff0c\u5f00\u53d1\u809d\u810f\u3001\u80c3\u80a0\u548c\u4ee3\u8c22\u75be\u75c5\u521b\u65b0\u7597\u6cd5\u7684\u751f\u7269\u533b\u836f\u516c\u53f8Metacrine\u5ba3\u5e03\u5b8c\u62106500\u4e07\u7f8e\u5143\u7684C\u8f6e\u878d\u8d44\uff0c\u7528\u4e8e\u5f00\u53d1\u9886\u5148\u5019\u9009\u836f\u7269MET409\uff0c\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u548c\u5176\u4ed6\u80c3\u80a0\u7c7b\u75be\u75c5\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n


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Metacrine\u6210\u7acb\u4e8e2015\u5e74\uff0c\u76ee\u524d\u5df2\u878d\u8d441.25\u4ebf\u7f8e\u5143\u3002\u81ea\u6210\u7acb\u4ee5\u6765\uff0cMetacrine\u5229\u7528\u5176\u7ecf\u9a8c\u4e30\u5bcc\u7684\u751f\u7269\u3001\u5316\u5b66\u548c\u86cb\u767d\u8d28\u5de5\u7a0b\u56e2\u961f\u53d1\u73b0\u548c\u5f00\u53d1\u65b0\u7597\u6cd5\uff0c\u5efa\u7acb\u4e86\u4ece\u53d1\u73b0\u5230\u5168\u9762\u4e34\u5e8a\u5f00\u53d1\u7684\u57fa\u7840\u8bbe\u65bd\uff0c\u63a8\u52a8\u6f5c\u5728\u7684\u4f18\u79c0\u65b0\u836f\u5f00\u53d1\u3002<\/span><\/p>\n

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Metacrine\u7684\u4e3b\u8981\u7814\u53d1\u9879\u76ee\u4e13\u6ce8\u4e8e\u6cbb\u7597NASH\u7684\u6f5c\u5728\u9776\u70b9\u2014\u2014\u7c7b\u6cd5\u5c3c\u9187X\u53d7\u4f53\uff08FXR\uff09\u3002NASH\u662f\u4e00\u79cd\u8870\u5f31\u6027\u75be\u75c5\uff0c\u6b63\u6210\u4e3a\u809d\u79fb\u690d\u7684\u9996\u8981\u539f\u56e0\uff0c\u76ee\u524d\u5c1a\u65e0\u6279\u51c6\u7684\u7597\u6cd5<\/strong>\u3002\u9664\u6b64\u4e4b\u5916\uff0cMetacrine\u5df2\u7ecf\u786e\u5b9a\u4e86FXR\u5728\u8179\u6cfb\u578b\u80a0\u6613\u6fc0\u7efc\u5408\u5f81\uff08IBS-D\uff09\u548c\u708e\u75c7\u6027\u80a0\u75c5\uff08IBD\uff09\uff0c\u5982\u514b\u7f57\u6069\u75c5\uff08Crohn’s disease\uff09\u548c\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u4e2d\u7684\u6f5c\u5728\u4f5c\u7528\u3002\u901a\u8fc7Metacrine\u5bf9FXR\u6fc0\u52a8\u5242\u7684\u7814\u53d1\u548c\u5e7f\u6cdb\u8868\u5f81\uff0cMET409\u88ab\u9009\u5b9a\u4e3a\u4e34\u5e8a\u5019\u9009\u836f\u7269\u3002MET409\u662f\u4e00\u79cd\u975e\u80c6\u6c41\u9178FXR\u6fc0\u52a8\u5242\uff0c\u5177\u6709\u5f3a\u5927\u7684\u4e34\u5e8a\u524d\u7597\u6548\u548c\u6709\u5229\u7684\u5b89\u5168\u6027<\/strong>\u3002<\/span><\/p>\n


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\u8be5\u8f6e\u6295\u8d44\u7531Venrock Healthcare Partners\u9886\u6295\uff0c\u65b0\u6295\u8d44\u8005\u5305\u62ecFranklin Templeton Investments\u3001Deerfield Management\u3001Arrowmark Partners\u3001Invus\u3001Lilly Asia Ventures\u3001Vivo Capital\u4ee5\u53ca\u5176\u4ed6\u672a\u62ab\u9732\u7684\u6295\u8d44\u8005\u3002\u73b0\u6709\u6295\u8d44\u8005Arch Venture Partners\u3001venBio\u3001Polaris Partners\u3001NEA\u548cAlexandria Venture Investments\u4e5f\u53c2\u4e0e\u4e86\u6b64\u6b21\u878d\u8d44\u3002<\/span><\/p>\n


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Metacrine\u8ba1\u5212\u5229\u7528C\u8f6e\u878d\u8d44\u6765\u63a8\u8fdb\u5305\u62ec\u5176\u9886\u5148\u5019\u9009\u836f\u7269MET409\u5728\u5185\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u7528\u4e8e\u6cbb\u7597NASH\u3001IBS-D\u548cIBD<\/span><\/strong>\u3002\u5e76\u6301\u7eed\u901a\u8fc7\u5185\u90e8\u7814\u53d1\uff0c\u6269\u5927\u4ea7\u54c1\u7ebf\u3002MET409\u76841\u671f\u4e34\u5e8a\u7814\u7a76\u8ba1\u5212\u4e8e\u672c\u6708\u665a\u4e9b\u65f6\u5019\u5f00\u59cb\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\u25b2Metacrine\u8463\u4e8b\u4f1a\u4e3b\u5e2dRich Heyman\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1aSalk Institute\uff09<\/span><\/strong><\/p>\n

  <\/span><\/p>\n

Metacrine\u8463\u4e8b\u4f1a\u4e3b\u5e2dRich Heyman\u535a\u58eb\u8bf4\uff1a\u201cMetacrine\u56e2\u961f\u4e00\u518d\u88ab\u8bc1\u660e\u662f\u79d1\u5b66\u9a71\u52a8\u3001\u9ad8\u6548\u3001\u548c\u6709\u521b\u610f\u7684\u3002\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u80fd\u6709\u4e00\u4e2a\u9886\u5148\u7684\u6295\u8d44\u7fa4\u4f53\u4e0e\u8be5\u516c\u53f8\u5408\u4f5c\uff0c\u5efa\u7acb\u4e00\u4e2a\u6301\u4e45\u7684\u4f01\u4e1a\uff0c\u4e3a\u75c5\u4eba\u5e26\u6765\u6709\u6548\u7684\u836f\u7269\u3002\u201d<\/span><\/p>\n

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 \u201c\u9ad8\u8d28\u91cf\u6295\u8d44\u8005\u7684\u5f3a\u70c8\u5174\u8da3\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86MET409\u6cbb\u7597\u809d\u810f\u548c\u80a0\u80c3\u75be\u75c5\u7684\u6f5c\u529b\uff0c\u201dMetacrine\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Ken Song\u535a\u58eb\u8bf4\uff1a\u201c\u6211\u4eec\u6709\u76ee\u7684\u5730\u8bbe\u8ba1\u4e86\u4e1a\u754c\u9886\u5148\u7684FXR\u6fc0\u52a8\u5242\u4ea7\u54c1\u7ec4\u5408\uff0c\u5177\u6709NASH\u7684\u2018best-in-class\u2019\u7597\u6cd5\u6f5c\u529b\u548cIBS-D\u53caIBD\u7684\u2018first-in-class\u2019\u6f5c\u529b<\/strong>\u3002\u201d<\/span><\/p>\n

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\u6211\u4eec\u671f\u5f85\u6b64\u6b21C\u8f6e\u878d\u8d44\u80fd\u591f\u52a0\u901f\u8fd9\u6b3eMET409\u836f\u7269\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u65e9\u65e5\u4e3aNASH\u548c\u5176\u4ed6\u80c3\u80a0\u75be\u75c5\u60a3\u8005\u5e26\u6765\u6709\u6548\u7597\u6cd5\u3002 <\/span><\/p>\n

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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] Metacrine Completes $65 Million Series C Financing<\/span><\/p>\n

[2] Rich Heyman\u2019s Metacrine tacks on another $65M to tackle a superior NASH drug<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u660e\u5eb7\u5fb7 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053   \u8fd1\u65e5\uff0c\u5f00\u53d1\u809d\u810f\u3001\u80c3\u80a0\u548c\u4ee3\u8c22\u75be\u75c5\u521b\u65b0\u7597\u6cd5\u7684\u751f\u7269\u533b\u836f\u516c\u53f8Metacrine\u5ba3\u5e03\u5b8c\u6210 […]<\/p>\n","protected":false},"author":1,"featured_media":9062,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9061"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9061"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9061\/revisions"}],"predecessor-version":[{"id":9066,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9061\/revisions\/9066"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9062"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}