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\n

\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n


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\u8fd1\u65e5\uff0cSyndax\u548cNektar\u5ba3\u5e03\u4e86\u4e00\u9879\u4e34\u5e8a\u5408\u4f5c\uff0c\u8bc4\u4f30Nektar NKTR-214\u548cSyndax\u7684entinostat\u8054\u5408\u4f7f\u7528\uff0c\u6cbb\u7597\u66fe\u63a5\u53d7\u8fc7\u6297PD-1\uff08\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53-1\uff09\u836f\u7269\u7684\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u3002<\/strong><\/span><\/p>\n

\t<\/span><\/p>\n

\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u7684Syndax\u662f\u4e00\u5bb6\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u5f00\u53d1\u4e86\u4e00\u7cfb\u5217\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u9636\u6bb5\u7684\u521b\u65b0\u6027\u764c\u75c7\u6cbb\u7597\u836f\u7269\u3002\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u65e7\u91d1\u5c71\u7684Nektar Therapeutics\u751f\u7269\u533b\u836f\u516c\u53f8\u5728\u80bf\u7624\u5b66\uff0c\u514d\u75ab\u5b66\u548c\u75bc\u75db\u9886\u57df\u62e5\u6709\u5f3a\u5927\u7684\u836f\u7269\u5f00\u53d1\u7ba1\u9053\uff0c\u4ee5\u53ca\u4e00\u7cfb\u5217\u7ecf\u6279\u51c6\u7684\u5408\u4f5c\u836f\u7269\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

Entinostat\u662fSyndax\u7684\u53e3\u670d\u5c0f\u5206\u5b501\u7c7b\u7279\u5f02\u6027HDAC\u6291\u5236\u5242\u3002\u5728\u4e34\u5e8a\u524d\u8bd5\u9a8c\u4e2d\uff0centinostat\u548cNKTR-214\u7684\u7ec4\u5408\u663e\u8457\u6291\u5236\u4e86\u80be\u548c\u7ed3\u80a0\u764c\u6a21\u578b\u4e2d\u7684\u80bf\u7624\u751f\u957f\u3002<\/strong>\u8be5\u7ec4\u5408\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u968f\u7740\u80bf\u7624\u4e2dCD8 + T\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u7ec6\u80de\u6bd2\u6027\u6d3b\u6027\uff0c\u4ee5\u53ca\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u6291\u5236\u7ec6\u80de\u8c03\u8282\u6025\u5267\u589e\u52a0\u3002\u8fd9\u9879\u6210\u679c\u6700\u8fd1\u53d1\u8868\u5728\u4e862018\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a\uff08American Association of Cancer Research Annual Meeting\uff09\u4e0a\u3002\u6b64\u5916\uff0centinostat\u76ee\u524d\u6b63\u57283\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4e0e\u4f9d\u897f\u7f8e\u5766\uff08exemestane\uff09\u8054\u7528\uff0c\u6cbb\u7597\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff0c\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\u9634\u6027\u7684\u665a\u671f\u4e73\u817a\u764c\uff0c\u5e76\u88abFDA\u6388\u4e88\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\u25b2<\/span><\/strong><\/span><\/strong><\/span><\/strong>Entinostat\u7684\u4f5c\u7528\u673a\u5236\uff08\u56fe\u7247\u6765\u6e90\uff1aSyndax\u5b98\u7f51\uff09<\/span><\/strong><\/p>\n


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NKTR-214\u662f\u4e00\u79cd\u5728\u7814\u7684CD122\u504f\u597d\u6fc0\u52a8\u5242\uff0c\u65e8\u5728\u901a\u8fc7\u9776\u5411CD8+\u6548\u5e94T\u7ec6\u80de\u548c\u81ea\u7136\u6740\u4f24\uff08Natural Killer\uff09\u7ec6\u80de\u7684\u8868\u9762\u4e0a\u7684CD122\u7279\u5f02\u6027\u53d7\u4f53\uff0c\u6765\u523a\u6fc0\u4f53\u5185\u6297\u764c\u7684\u514d\u75ab\u7ec6\u80de\u3002\u5728\u4f53\u5185\u57f9\u517b\u8fd9\u4e9b\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TILs\uff09\u8865\u5145\u514d\u75ab\u7cfb\u7edf\u5bf9\u8bb8\u591a\u60a3\u8005\u81f3\u5173\u91cd\u8981\uff0c\u5c24\u5176\u662f\u5bf9\u90a3\u4e9b\u7f3a\u4e4f\u8db3\u591f\u7684TIL\u800c\u4e0d\u9002\u7528\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7597\u6cd5\u7684\u60a3\u8005\u7fa4\u4f53\u3002\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0cNKTR-214\u5bfc\u81f4\u8fd9\u4e9b\u7ec6\u80de\u8fc5\u901f\u6269\u5f20\uff0c\u5e76\u4e14\u52a8\u5458\u5230\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u3002\u5b83\u5177\u6709\u4e0e\u73b0\u6709\u5df2\u6279\u51c6\u7684\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7c7b\u4f3c\u7684\u7c7b\u6297\u4f53\u7ed9\u836f\u65b9\u6848\u3002<\/span><\/p>\n


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\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0cSyndax\u548cNektar\u5c06\u5408\u4f5c\u8fdb\u884c\u4e00\u9879\u7814\u7a76\u8bc4\u4f30\u8fd9\u4e2a\u7ec4\u5408\u3002<\/span><\/strong>\u8bd5\u9a8c\u76841b\u671f\u90e8\u5206\u65e8\u5728\u786e\u5b9a\u7ec4\u5408\u7ed9\u836f\u65b9\u6848\u7684\u5b89\u5168\u6027\u548c\u63a8\u8350\u5242\u91cf\u30022\u671f\u4e34\u5e8a\u90e8\u5206\u65e8\u5728\u8bc4\u4f30\u7597\u6548\uff0c\u5982\u5ba2\u89c2\u7f13\u89e3\u7387\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff0c\u4ee5\u53ca\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002\u60a3\u8005\u7684\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\u5c06\u7eb3\u5165\u5206\u6790\uff0c\u5305\u62ec\u63a2\u7d22\u6027\u5206\u6790\u7ecf\u5178\u5916\u5468\u8840\u5355\u4e2a\u6838\u7ec6\u80de\u6c34\u5e73\u5347\u9ad8\u7684\u6f5c\u529b\u3002Syndax\u5c06\u8d1f\u8d23\u8fdb\u884c1b \/ 2\u671f\u8bd5\u9a8c\uff0c\u534f\u8bae\u4e2d\u7684\u4e00\u9879\u89c4\u5b9a\u5305\u62ec\u53cc\u65b9\u53ef\u6269\u5927\u5408\u4f5c\u8303\u56f4\uff0c\u57fa\u4e8e\u5171\u540c\u5229\u76ca\u8fdb\u884c\u5173\u952e\u8bd5\u9a8c\u3002<\/span><\/p>\n


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Syndax\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98Briggs W. Morrison\u535a\u58eb\u8bf4\uff1a\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u4e0eNektar\u5408\u4f5c\uff0c\u5efa\u7acb\u4e34\u5e8a\u5408\u4f5c\u6218\u7565\uff0c\u6d4b\u8bd5entinostat\u4e0e\u524d\u6cbf\u514d\u75ab\u7597\u6cd5\u7684\u65b0\u9896\u7ec4\u5408\u3002\u5728\u80be\u7ec6\u80de\u764c\u4e2d\u4f7f\u7528entinostat\u548c\u9ad8\u5242\u91cfIL-2\u6cbb\u7597\u76842\u671f\u4e34\u5e8a\u6570\u636e\u4ee5\u53ca\u6211\u4eec\u4f7f\u7528NKTR-214\u7684\u6709\u524d\u9014\u7684\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u5960\u5b9a\u4e86\u6b64\u6b21\u5408\u4f5c\u7684\u79d1\u5b66\u548c\u4e34\u5e8a\u57fa\u7840\uff0c\u4e0eNektar\u5408\u4f5c\u4f7f\u6211\u4eec\u80fd\u591f\u5bf9\u4e8ePD-1\u96be\u6cbb\u6027\u7684\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u8fdb\u884c\u6709\u6548\u6cbb\u7597\uff0c\u4e5f\u8865\u5145\u4e86\u6211\u4eec\u5728\u7c7b\u4f3c\u4eba\u7fa4\u4e2d\uff0c\u8054\u5408\u4f7f\u7528entinostat\u7684Keytruda\u4ee4\u4eba\u5174\u594b\u7684\u6570\u636e\u3002\u201d<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\u25b2<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong>Jonathan Zalevsky\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1aNektar\uff09<\/span><\/strong><\/p>\n


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Nektar\u9ad8\u7ea7\u526f\u603b\u88c1\u517c\u9996\u5e2d\u79d1\u5b66\u5b98Jonathan Zalevsky\u535a\u58eb\u8bf4\uff1a\u201cNKTR-214\u548centinostat\u7684\u7ec4\u5408\uff0c\u8bc1\u660e\u4e86\u6211\u4eec\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u5177\u6709\u72ec\u7279\u7684\u534f\u540c\u4f5c\u7528\uff0c\u9700\u8981\u5728\u4e34\u5e8a\u4e0a\u8fdb\u4e00\u6b65\u7814\u7a76\u3002\u91cd\u8981\u7684\u662f\uff0c\u6211\u4eec\u89c2\u5bdf\u5230\u7ec4\u5408\u7597\u6cd5\u6cbb\u7597\u540e\uff0c\u7ec6\u80de\u56e0\u5b50\u9633\u6027\u7684\u80bf\u7624\u6d78\u6da6\u6027T\u7ec6\u80de\u7684\u6c34\u5e73\u5347\u9ad8\uff0c\u6211\u4eec\u76f8\u4fe1\u8fd9\u4e00\u91cd\u8981\u7684\u4e34\u5e8a\u524d\u53d1\u73b0\u53ef\u4ee5\u8f6c\u5316\u4e3a\u5bf9\u63a5\u53d7\u68c0\u67e5\u70b9\u6291\u5236\u5242\u540e\uff0c\u96be\u4ee5\u6cbb\u6108\u7684\u60a3\u8005\u7684\u7f13\u89e3\u3002\u6211\u4eec\u671f\u5f85\u4e0eSyndax\u4e00\u8d77\u5408\u4f5c\u5c06\u8fd9\u4e2a\u7ec4\u5408\u63a8\u5411\u4e34\u5e8a\u3002\u201d<\/span><\/p>\n


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\u6211\u4eec\u5e0c\u671b\u8fd9\u9879\u5408\u4f5c\u53ef\u4ee5\u4e3a\u6211\u4eec\u5e26\u6765\u65b0\u578b\u6297\u764c\u7ec4\u5408\u7597\u6cd5\uff0c\u4e3a\u60a3\u6709\u591a\u79cd\u7c7b\u578b\u764c\u75c7\u7684\u60a3\u8005\u5e26\u6765\u7f13\u89e3\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u53c2\u8003\u8d44\u6599:<\/span><\/p>\n

[1] Syndax and Nektar Therapeutics Announce Immuno-Oncology Clinical Trial Collaboration<\/span><\/p>\n

[2] Syndax\u5b98\u7f51<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u660e\u5eb7\u5fb7 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u8fd1\u65e5\uff0cSyndax\u548cNektar\u5ba3\u5e03\u4e86\u4e00\u9879\u4e34\u5e8a\u5408\u4f5c\uff0c\u8bc4\u4f30Nektar NKTR-214\u548cSy […]<\/p>\n","protected":false},"author":1,"featured_media":9098,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9097"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9097"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9097\/revisions"}],"predecessor-version":[{"id":9103,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9097\/revisions\/9103"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9098"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}