{"id":9110,"date":"2018-06-11T01:00:00","date_gmt":"2018-07-27T09:36:32","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e7%9b%98%e7%82%b9-%e7%b3%96%e5%b0%bf%e7%97%85%e7%a0%94%e7%a9%b6%e9%a2%86%e5%9f%9f%e8%bf%91%e6%9c%9f%e8%bf%9b%e5%b1%95%e6%b1%87%e6%80%bb%ef%bc%88%e7%ac%ac57%e6%9c%9f%ef%bc%89\/"},"modified":"2018-07-27T17:36:34","modified_gmt":"2018-07-27T09:36:34","slug":"%e7%9b%98%e7%82%b9-%e7%b3%96%e5%b0%bf%e7%97%85%e7%a0%94%e7%a9%b6%e9%a2%86%e5%9f%9f%e8%bf%91%e6%9c%9f%e8%bf%9b%e5%b1%95%e6%b1%87%e6%80%bb%ef%bc%88%e7%ac%ac57%e6%9c%9f%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9110\/","title":{"rendered":"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"line-height: 1.75em;\"><strong style=\"white-space: normal;font-size: 15px;color: rgb(62, 62, 62);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: 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style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532684193.jpeg\" alt=\"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09\" title=\"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 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style=\"font-size: 15px;\">RK-01\u7684\u72ec\u7279\u914d\u65b9\u5c06\u7f2c\u6c99\u5766\u548c\u585e\u6765\u6614\u5e03\u6dfb\u52a0\u5230\u4e8c\u7532\u53cc\u80cd\u4e2d\uff0c\u53ef\u4ee5\u963b\u65ad\u51e0\u79cd\u4e92\u8865\u7684\u708e\u75c7\u548c\u9ad8\u8840\u7cd6\u673a\u5236\uff0c<\/span><\/strong><span style=\"font-size: 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style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532684193.jpg\" alt=\"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09\" title=\"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">&nbsp;<\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7cd6\u5c3f\u75c5\u662f\u4e00\u79cd\u65e5\u76ca\u4e25\u91cd\u7684\u5168\u7403\u6027\u6d41\u884c\u75c5\u3002<strong>\u622a\u81f32015\u5e74\uff0c\u5168\u7403\u67094\u4ebf\u6210\u5e74\u4eba\u53d7\u5230\u7cd6\u5c3f\u75c5\u7684\u5f71\u54cd\uff0c\u5176\u4e2d\u7ea6\u67091\u4ebf\u5728\u4e2d\u56fd\u3002<\/strong>2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5bf9\u80f0\u5c9b\u7d20\u4ea7\u751f\u62b5\u6297\uff0c\u6216\u4e0d\u80fd\u5206\u6ccc\u51fa\u8db3\u591f\u7684\u80f0\u5c9b\u7d20\u6765\u7ef4\u6301\u6b63\u5e38\u7684\u8840\u7cd6\u6c34\u5e73\u3002\u6301\u7eed\u7684\u9ad8\u7cd6\u6c34\u5e73\u4f1a\u5bfc\u81f4\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\uff0c\u5982\u5fc3\u810f\u75c5\u3001\u4e2d\u98ce\u3001\u80be\u8870\u7aed\u3001\u795e\u7ecf\u75c5\u53d8\u3001\u4e0b\u80a2\u622a\u80a2\u548c\u5931\u660e\u3002\u56e0\u6b64\uff0c\u63a7\u5236\u8840\u7cd6\u662f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u6025\u5207\u9700\u8981\u8fbe\u5230\u7684\u76ee\u6807\u3002<\/span><br  \/><\/p>\n<p><br  \/><\/p>\n<p 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15px;\">\u8be5\u8bd5\u9a8c\u4e2d\u4f7f\u7528\u4e86\u4e24\u79cd\u4e0d\u540c\u7684\u7edf\u8ba1\u65b9\u6cd5\u6765\u8bc4\u4f30\u53e3\u670d\u53f8\u7f8e\u9c81\u80bd\u7684\u6548\u679c\uff1a\u4e3b\u8981\u7edf\u8ba1\u65b9\u6cd5\u7531\u8fd1\u671f\u7684\u76d1\u7ba1\u6307\u5357\u8981\u6c42\uff0c\u4e0d\u7ba1\u662f\u5426\u505c\u6b62\u6cbb\u7597\u548c\u4f7f\u7528\u6025\u6551\u836f\u7269\uff1b\u6b21\u8981\u7edf\u8ba1\u65b9\u6cd5\u63cf\u8ff0\u4e86\u6cbb\u7597\u4e2d\u4e14\u4e0d\u4f7f\u7528\u6025\u6551\u836f\u7269\u7684\u6548\u679c\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4f7f\u7528\u4e3b\u8981\u7edf\u8ba1\u65b9\u6cd5\u7684\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u8bd5\u9a8c\u62b5\u8fbe\u4e86\u5176\u4e3b\u8981\u76ee\u6807\uff0c<strong>\u8bc1\u660e\u53e3\u670d\u53f8\u7f8e\u9c81\u80bd\u572826\u5468\u65f6\u80fd\u66f4\u597d\u5730\u6539\u5584HbA1c\uff0c<\/strong>\u4f46\u5728\u51cf\u91cd\u65b9\u9762\u4e0e\u5bf9\u7167\u7ec4\u6ca1\u6709\u663e\u8457\u5dee\u5f02\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4f7f\u7528\u6b21\u8981\u7edf\u8ba1\u65b9\u6cd5\u7684\u7ed3\u679c\u663e\u793a\uff0c\u53e3\u670d\u53f8\u7f8e\u9c81\u80bd\u7ec4\u7684HbA1c\u6539\u5584\u572826\u5468\u65f6\u4e3a1.4\uff05\uff0c\u572852\u5468\u65f6\u4e3a1.3\uff05\uff0c\u800c\u5bf9\u7167\u7ec4\u7684HbA1c\u6539\u5584\u5206\u522b\u4e3a0.9\uff05\u548c0.8\uff05\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u53e3\u670d\u53f8\u7f8e\u9c81\u80bd\u572826\u5468\u548c52\u5468\u65f6\u663e\u793a\u5e2e\u52a9\u51cf\u91cd4.2kg\u548c4.7kg\uff0c\u800c\u5bf9\u7167\u7ec4\u7684\u8fd9\u4e00\u6570\u636e\u90fd\u4e3a3.8kg\u3002\u53e6\u5916\uff0c\u53e3\u670d\u53f8\u7f8e\u9c81\u80bd\u7ec4\u4e2d\u670972%\u7684\u4eba\u572852\u5468\u65f6\u8fbe\u5230\u7f8e\u56fd\u7cd6\u5c3f\u75c5\u534f\u4f1a\uff08ADA\uff09HbA1c\u6cbb\u7597\u76ee\u6807\uff08\u4f4e\u4e8e7.0\uff05\uff09\uff0c\u800c\u5bf9\u7167\u7ec4\u7684\u8fd9\u4e00\u6bd4\u4f8b\u4e3a47%\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5b89\u5168\u6027\u65b9\u9762\uff0c\u53e3\u670d\u53f8\u7f8e\u9c81\u80bd\u5728\u8bd5\u9a8c\u4e2d\u8868\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5e76\u4e14\u4e0eGLP-1\u7597\u6cd5\u76f8\u4e00\u81f4\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 112, 192);\"><strong><span style=\"font-size: 15px;\">3. \u6cbb\u75971\u578b\u7cd6\u5c3f\u75c5\uff0c\u8d5b\u8bfa\u83f2\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u83b7\u53d7\u7406<\/span><\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8fd1\u65e5\uff0cFDA\u5ba3\u5e03\u5df2\u63a5\u53d7\u8d5b\u8bfa\u83f2\uff08Sanofi\uff09\u5bf9Zynquista\uff08sotagliflozin\uff09\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\u3002\u5982\u679c\u83b7\u6279\uff0c\u53e3\u670dZynquista\u5c06\u7528\u4e8e\u8054\u5408\u80f0\u5c9b\u7d20\u6cbb\u7597\uff0c\u4ee5\u6539\u55841\u578b\u7cd6\u5c3f\u75c5\u6210\u4eba\u60a3\u8005\u7684\u8840\u7cd6\u63a7\u5236\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress9-1532684193.jpeg\" alt=\"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09\" title=\"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">1\u578b\u7cd6\u5c3f\u75c5\u662f\u7cd6\u5c3f\u75c5\u7684\u4e00\u79cd\u7c7b\u578b\uff0c\u8868\u73b0\u4e3a\u60a3\u8005\u7684\u8eab\u4f53\u4e0d\u80fd\u4ea7\u751f\u80f0\u5c9b\u7d20\u4ece\u800c\u5bfc\u81f4\u8840\u7cd6\u6c34\u5e73\u8fc7\u9ad8\u3002\u5176\u81f4\u75c5\u673a\u7406\u662f\u8d1f\u8d23\u4ea7\u751f\u80f0\u5c9b\u7d20\u7684\u80f0\u810f\u03b2\u7ec6\u80de\u906d\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u7834\u574f\uff0c\u539f\u56e0\u53ef\u80fd\u5305\u62ec\u591a\u79cd\u57fa\u56e0\u548c\u73af\u5883\u56e0\u7d20\u3002\u5728\u7f8e\u56fd\u7ea6\u6709125\u4e071\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\uff0c\u5176\u4e2d\u5927\u7ea6\u670919.3\u4e07\u540d\u60a3\u8005\u5c0f\u4e8e20\u5c81\u3002\u5c3d\u7ba1\u63a5\u53d7\u80f0\u5c9b\u7d20\u7c7b\u836f\u7269\u6cbb\u7597\uff0c\u4f46\u4ecd\u7136\u7ea6\u670970%\u76841\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u8fbe\u4e0d\u5230\u9884\u671f\u7684\u5c0f\u4e8e7.0%\u7684\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff08A1C\uff09\u6c34\u5e73\u6307\u6807\uff0c\u56e0\u6b64\u5bf9\u53ef\u4ee5\u548c\u80f0\u5c9b\u7d20\u4e2d\u8054\u5408\u4f7f\u7528\u7684\u65b0\u578b\u53e3\u670d\u836f\u7269\uff0c\u6709\u5927\u91cf\u7684\u672a\u6ee1\u8db3\u9700\u6c42\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">Zynquista\u662f\u8d5b\u8bfa\u83f2\u4e0e\u836f\u660e\u5eb7\u5fb7\u96c6\u56e2\u5408\u4f5c\u4f19\u4f34Lexicon Pharmaceuticals\u5408\u4f5c\u5f00\u53d1\u7684\u4e00\u79cd\u5c0f\u5206\u5b50\u3001\u7814\u7a76\u6027\u53e3\u670dSGLT<\/span><\/strong><span style=\"font-size: 15px;\">\uff08\u94a0\u4f9d\u8d56\u578b\u8461\u8404\u7cd6\u5171\u540c\u8fd0\u8f93\u86cb\u767d\uff0cSodium-glucose transport proteins\uff09<strong>-1\u548cSGLT-2\u53cc\u6291\u5236\u5242\u3002<\/strong>SGLT-1\u548cSGLT-2\u5206\u522b\u5f71\u54cd\u80a0\u9053\u548c\u80be\u810f\u5bf9\u7cd6\uff08\u8461\u8404\u7cd6\uff09\u7684\u5438\u6536\u548c\u6e05\u9664\uff0c\u901a\u8fc7\u63a7\u5236\u8fd9\u4e24\u79cd\u86cb\u767d\u7684\u6d3b\u6027\uff0cZynquista\u6539\u5584\u8840\u7cd6\u63a7\u5236\u5e76\u4ea7\u751f\u989d\u5916\u7684\u4e34\u5e8a\u76ca\u5904\u3002SGLT-2\u6291\u5236\u5242\u5e38\u88ab\u7528\u4e8e2\u578b\u7cd6\u5c3f\u75c5\u7684\u6cbb\u7597\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6b64\u6b21Zynquista\u7684\u65b0\u836f\u7533\u8bf7\u57fa\u4e8einTandem\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\uff0c\u5176\u4e2d\u5305\u62ec\u4e09\u98793\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bc4\u4f30\u4e86Zynquista\u5728\u7ea63,000\u540d\u5355\u72ec\u4f7f\u7528\u80f0\u5c9b\u7d20\u63a7\u5236\u8840\u7cd6\u6548\u679c\u4e0d\u4f73\u7684\u6210\u4eba\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u3002\u5728inTandem1\u4e2d\uff0cZynquista\u8fbe\u5230\u4e86\u4ece\u57fa\u7ebf\u523024\u5468A1C\u6c34\u5e73\u53d8\u5316\u7684\u4e3b\u8981\u7ec8\u70b9\u3002200mg\u5242\u91cf\u7684A1C\u6c34\u5e73\u53d8\u5316\u4e3a0.43%\uff0c400mg\u5242\u91cf\u4e3a0.49%\uff0c\u5b89\u6170\u5242\u4e3a0.08%\u3002inTandem2\u4ea7\u751f\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002\u7b2c\u4e09\u9879inTandem3\u8bd5\u9a8c\u62db\u52df\u4e86\u57fa\u7ebfA1C\u6c34\u5e73\u57287%\u548c11%\u4e4b\u95f4\u76841405\u540d1\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3002\u8fd9\u9879\u968f\u673a\u3001\u53cc\u76f2\u7814\u7a76\u663e\u793a\uff0c\u6cbb\u759724\u5468\u540e\uff0c400mg\u7684Zynquista\u53ef\u4f7f\u57fa\u7ebfA1C\u964d\u4f4e0.79%\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a0.33%\uff08p&lt;0.001\uff09\u3002inTandem3\u8bd5\u9a8c\u8fbe\u5230\u4e86\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u4e3b\u8981\u7ec8\u70b9\uff0c\u5176\u7ed3\u679c\u4e8e\u53bb\u5e749\u6708\u53d1\u8868\u4e8e\u300aNew England Journal of Medicine\u300b\u4e0a\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">4. \u53ef\u7a7f\u6234\u80f0\u5c9b\u7d20\u8f93\u9001\u88c5\u7f6e\u6709\u6548\u964d\u4f4e\u7ed9\u836f\u6210\u672c<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u7684Valeritas Holdings\u516c\u53f8\u8fd1\u65e5\u5ba3\u5e03\u4e86<strong>\u8be5\u516c\u53f8\u7684V-Go\u00ae\u88c5\u7f6e\u4e0e\u6bcf\u65e5\u6ce8\u5c04\u80f0\u5c9b\u7d20\u7ed9\u836f\uff08MDI\uff09\u76f8\u6bd4\u8f83\u7684\u6570\u636e\uff0c\u5305\u62ec\u5728\u8840\u7cd6\u63a7\u5236\u3001\u80f0\u5c9b\u7d20\u5229\u7528\u548c\u4fdd\u5065\u6210\u672c\u65b9\u9762\u7684\u6709\u6548\u6027\u7b49\u7b49\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7cd6\u5c3f\u75c5\u662f\u4e00\u79cd\u6162\u6027\u75be\u75c5\uff0c\u60a3\u8005\u7684\u8eab\u4f53\u65e0\u6cd5\u6b63\u786e\u751f\u4ea7\u6216\u4f7f\u7528\u80f0\u5c9b\u7d20\u3002\u5168\u4e16\u754c\u7ea6\u67094.25\u4ebf\u6210\u5e74\u4eba\u60a3\u6709\u7cd6\u5c3f\u75c5\uff0c\u4ec5\u5728\u7f8e\u56fd\u5c31\u6709\u8fd13000\u4e07\u540d\u60a3\u8005\u30022\u578b\u7cd6\u5c3f\u75c5\u662f\u56fd\u9645\u4e0a\u6700\u5e38\u89c1\u7684\u7cd6\u5c3f\u75c5\u7c7b\u578b\uff0c\u5728\u5168\u7403\u67092\u4ebf\u591a\u540d\u60a3\u8005\uff0c\u5728\u7f8e\u56fd\u5360\u7cd6\u5c3f\u75c5\u75c5\u4f8b\u603b\u6570\u768490\uff05\u81f395\uff05\u3002\u8fd9\u4e9b\u7cd6\u5c3f\u75c5\u60a3\u8005\u9700\u8981\u957f\u671f\u8865\u5145\u80f0\u5c9b\u7d20\uff0c\u63a7\u5236\u8840\u7cd6\u3002<\/span><br  \/><span style=\"font-size: 15px;\"><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">Valeritas\u516c\u53f8\u81f4\u529b\u5f00\u53d1\u80fd\u6539\u5584\u7cd6\u5c3f\u75c5\u60a3\u8005\u751f\u6d3b\u7684\u80f0\u5c9b\u7d20\u8f93\u9001\u88c5\u7f6e\uff0c\u4ed6\u4eec\u7684\u65d7\u8230\u4ea7\u54c1<strong>V-Go\u00ae\u53ef\u7a7f\u6234\u5f0f\u80f0\u5c9b\u7d20\u8f93\u9001\u88c5\u7f6e\u662f\u4e00\u79cd\u7b80\u5355\u4e14\u7ecf\u6d4e\u5b9e\u60e0\u7684basal-bolus\u80f0\u5c9b\u7d20\u8f93\u9001\u65b9\u5f0f\uff0c\u53ef\u4ee5\u50cf\u8d34\u7247\u4e00\u6837\u4f7f\u7528\uff0c\u65e0\u9700\u6bcf\u65e5\u591a\u6b21\u6ce8\u5c04\u836f\u7269\u3002<\/strong>V-Go\u00ae\u80fd\u572824\u5c0f\u65f6\u5185\u8fde\u7eed\u5b9e\u73b0\u9884\u8bbe\u7684\u57fa\u7840\u80f0\u5c9b\u7d20\u7ed9\u836f\u901f\u5ea6\uff0c\u5e76\u4e14\u5728\u8fdb\u9910\u65f6\u6309\u9700\u63d0\u4f9b\u9759\u8109\u6ef4\u6ce8\u7ed9\u836f\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;\"><img class=\"\"       style=\"height: 232px;text-align: center;white-space: normal;width: 529px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532684193.png\" alt=\"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09\" title=\"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09\"  \/><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8fd9\u6b21\u53d1\u5e03\u7ed3\u679c\u7684\u56de\u987e\u6027\u961f\u5217\u7814\u7a76\u5229\u7528\u4e8607\/01\/2011\u81f307\/31\/2017\u8fd9\u6bb5\u65f6\u95f4\u5185HealthCore\u7efc\u5408\u7814\u7a76\u6570\u636e\u5e93\uff08HIRD\uff09\u7684\u6570\u636e\u3002\u5728\u968f\u8bbf\u671f\u95f4\uff0c\u4e24\u7ec42\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\uff08\u5305\u62ec118\u5bf9\u5e73\u8861\u914d\u5bf9\u7ec4\uff0c\u5e73\u5747\u57fa\u7ebf\u7cd6\u5316\u8840\u7ea2\u86cb\u767dHbA1c9.2\uff05\uff09\u76f8\u5bf9\u4e8e\u57fa\u7ebf\u7684\u8840\u7cd6\u63a7\u5236\u6709\u6240\u6539\u5584\uff08\u7528\u836f\u540eHbA1c\u22649\uff05\u7684\u60a3\u8005\uff0c\u524d\/\u540e\uff1aV-Go 49%\/69%\uff0cp&lt;0.001\uff1bMDI 50%\/60%\uff0cp=0.046\uff09\u3002\u5c3d\u7ba1\u4e24\u7ec4\u4eba\u7fa4\u7684\u80f0\u5c9b\u7d20\u836f\u7269\u4f7f\u7528\u548c\u7cd6\u5c3f\u75c5\u76f8\u5173\u836f\u7269\u6210\u672c\u7684\u57fa\u7ebf\u6570\u76ee\u76f8\u4f3c\uff0c\u4f46\u4f7f\u7528V-Go\u00ae\u7684\u60a3\u8005\u7ee7\u7eed\u8d2d\u4e70\u7684\u80f0\u5c9b\u7d20\u836f\u7269\u8f83\u5c11\uff0c\u7cd6\u5c3f\u75c5\u76f8\u5173\u836f\u7269\u6210\u672c\u589e\u52a0\u8f83\u4f4e\uff0c\u4e0eMDI\u7528\u6237\u76f8\u6bd4\uff0cV-Go\u00ae\u4f7f\u7528\u8005\u80f0\u5c9b\u7d20\u603b\u65e5\u5242\u91cf\u4e0b\u964d21\uff05\uff08TDD\uff09\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">5. \u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\u773c\u75c5\u65b0\u7597\u6cd5\u8fbe\u5230\u79ef\u6781\u9876\u7ebf\u7ed3\u679c<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">\u751f\u7269\u533b\u836f\u516c\u53f8Clearside Biomedical\u8fd1\u65e5\u5ba3\u5e03\u51762\u671f\u4e34\u5e8a\u8bd5\u9a8cTYBEE\u83b7\u5f97\u79ef\u6781\u9876\u7ebf\u7ed3\u679c\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u8be5\u8bd5\u9a8c\u8bc4\u4f30\u4e86\u5728\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\uff08DME\uff09\u60a3\u8005\u4e2d\uff0c\u57286\u4e2a\u6708\u7684\u8bc4\u4f30\u671f\u5185\u91c7\u7528\u8109\u7edc\u819c\u4e0a\u76aeCLS- TA\uff08suprachoroidal CLS-TA\uff09\u7597\u6cd5\u8054\u7528\u73bb\u7483\u4f53\u5185\u7ed9\u836f\u7684Eylea\uff08aflibercept\uff09\u7684\u6548\u679c\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress2-1532684193.png\" alt=\"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09\" title=\"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">DME\u662f\u7531\u8840\u7ba1\u6e17\u6f0f\u5f15\u8d77\u7684\u89c6\u7f51\u819c\u80bf\u80c0\uff0c\u5b83\u662f\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e27\u5931\u89c6\u529b\u7684\u6700\u5e38\u89c1\u539f\u56e0\u3002DME\u4f1a\u5f71\u54cd\u9ad8\u8fbe30\uff05\u7684\u7cd6\u5c3f\u75c5\u60a3\u800520\u5e74\u6216\u66f4\u4e45\u3002\u5982\u679c\u672a\u7ecf\u6cbb\u7597\uff0c\u7ea620\uff05-30\uff05\u7684\u60a3\u8005\u4f1a\u51fa\u73b0\u4e2d\u5ea6\u89c6\u529b\u4e27\u5931\uff0c\u4ed6\u4eec\u6025\u9700\u6709\u6548\u7597\u6cd5\u6765\u6539\u5584\u75c5\u60c5\u3002<\/span><br  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8109\u7edc\u819c\u4e0a\u76aeCLS- TA\u662fClearside\u7684\u7b2c\u4e00\u9879\u5728\u7814\u7597\u6cd5\uff0c\u5b83\u662f\u4e00\u79cd\u4e13\u5229\u7684\u76ae\u8d28\u7c7b\u56fa\u9187\u66f2\u5b89\u5948\u5fb7\u60ac\u6d6e\u5242\uff0c\u7528\u4e8e\u901a\u8fc7\u8109\u7edc\u819c\u4e0a\u8154\uff08SCSTM\uff09\u5bf9\u773c\u775b\u540e\u90e8\u7ed9\u836f\u3002CLS-TA\u80fd\u51cf\u5c11\u5bfc\u81f4\u9ec4\u6591\u80bf\u80c0\u7684\u708e\u75c7\u548c\u5176\u4ed6\u5e76\u53d1\u75c7\uff0c\u5b83\u4eec\u662f\u5bfc\u81f4\u89c6\u529b\u635f\u5bb3\u548c\u5931\u660e\u7684\u4e3b\u8981\u539f\u56e0\u3002\u8be5\u7597\u6cd5\u65e8\u5728\u5feb\u901f\u5c06\u5927\u91cf\u836f\u7269\u5206\u6563\u5230\u773c\u775b\u540e\u90e8\uff0c\u5e2e\u52a9\u8db3\u591f\u7684\u836f\u7269\u8fbe\u5230\u5e76\u505c\u7559\u5728\u75be\u75c5\u90e8\u4f4d\uff0c\u5e76\u4e14\u5c3d\u53ef\u80fd\u5ef6\u957f\u4f5c\u7528\u65f6\u95f4\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8fd9\u6b21\u5ba3\u5e03\u7ed3\u679c\u7684TYBEE\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u8bbe\u76f2\u3001\u5bf9\u7167\u7ec4\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7eb3\u5165\u4e8671\u540d\u672a\u7ecf\u6cbb\u7597\u7684DME\u60a3\u8005\u3002\u60a3\u8005\u63091\uff1a1\u968f\u673a\u5206\u7ec4\uff0c\u8054\u5408\u7ec4\u60a3\u8005\u63a5\u53d7\u8109\u7edc\u819c\u4e0a\u76aeCLS-TA\u548c\u73bb\u7483\u4f53\u5185Eylea\uff08\u7b2c0\u548c3\u6708\uff09\uff08\u201c\u8054\u5408\u7ec4\u201d\uff09\uff0c\u5bf9\u7167\u7ec4\u60a3\u8005\u57284\u4e2a\u6708\u5185\u6bcf\u6708\u63a5\u53d7\u4e00\u6b21\u73bb\u7483\u4f53\u5185Eylea\u52a0\u8109\u7edc\u819c\u4e0a\u76ae\u7684\u5047\u624b\u672f\u5bf9\u7167\uff0c\u8fd9\u4e24\u7ec4\u60a3\u8005\u6839\u636e\u9700\u8981\uff0c\u5728\u7b2c4\u548c\u7b2c5\u4e2a\u6708\u63a5\u53d7\u73bb\u7483\u4f53\u5185Eylea\u6cbb\u7597\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7ed3\u679c\u663e\u793a\uff0c<strong>\u4f7f\u7528\u65e9\u671f\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\u6cbb\u7597\u8bd5\u9a8c\uff08ETDRS\uff09\u91cf\u8868\u8bc4\u4f30\u65f6\uff0c\u672c\u8bd5\u9a8c\u57286\u4e2a\u6708\u5185\u8fbe\u5230\u4e86\u6539\u5584\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u7684\u6700\u4f73\u77eb\u6b63\u89c6\u529b\uff08BCVA\uff09\u7684\u4e3b\u8981\u7ec8\u70b9\u3002<\/strong>\u8054\u5408\u7ec4\u60a3\u8005\u5e73\u5747\u83b7\u5f9712.3\u4e2aETDRS\u5b57\u6bcd\uff0c\u800c\u5355\u9760Elyea\u7684\u5bf9\u7167\u7ec4\u60a3\u8005\u5219\u4e3a13.5\u4e2aETDRS\u5b57\u6bcd\uff08p=0.664\uff09\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6b64\u5916\uff0c\u8054\u7528\u8109\u7edc\u819c\u4e0aCLS-TA\u4e0e\u73bb\u7483\u4f53\u5185Eylea\u8fd8\u8fbe\u5230\u4e86\u4e00\u4e2a\u5173\u952e\u7684\u6b21\u8981\u7ec8\u70b9\uff0c\u4e5f\u5373\u60a3\u8005\u57286\u4e2a\u6708\u65f6\u89c6\u7f51\u819c\u4e2d\u592e\u5b50\u533a\u539a\u5ea6\uff08CST\uff09\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u5e73\u5747\u51cf\u5c11\u4e86208\u5fae\u7c73\uff0c\u800c\u5bf9\u7167\u7ec4\u51cf\u5c11\u4e3a177\u5fae\u7c73\uff08p=0.156\uff09\u3002\u6b64\u5916\uff0c\u57286\u4e2a\u6708\u65f6\uff0c\u8054\u5408\u7ec4\u4e2d\u670993\uff05\u7684\u60a3\u8005\u51fa\u73b0CST\u51cf\u5c1150\uff05\u4ee5\u4e0a\uff0c\u800c\u5bf9\u7167\u7ec4\u4e2d\u51fa\u73b0\u51cf\u5c11\u7684\u60a3\u8005\u662f73\uff05\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">CLS-TA\u901a\u5e38\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u6ca1\u6709\u62a5\u9053\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u8054\u5408\u7ec4\u4e2d8.3\uff05\u7684\u60a3\u8005\u51fa\u73b0\u773c\u538b\u4e0d\u826f\u4e8b\u4ef6\uff0c\u9ad8\u4e8e\u5bf9\u7167\u7ec4\u60a3\u8005\u76842.9\uff05\u3002\u8054\u5408\u7ec4\u4e2d\u7ea65.6\uff05\u7684\u60a3\u8005\u4ee5\u53ca\u5bf9\u7167\u7ec4\u4e2d2.9\uff05\u7684\u60a3\u8005\u53d1\u751f\u767d\u5185\u969c\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] The U.S. FDA Approves ARKAY Therapeutics\u2019 IND Application for Evaluating RK-01, a First-in Class \u2018Beta-cell-centric\u2019 Drug Combination Product in Type 2 Diabetes Patients<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2]&nbsp;Racing to grab market share in diabetes, Novo touts its oral semaglutide win over Jardiance in PhIIIa trial<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[3]&nbsp;FDA to review Zynquista\u2122 (sotagliflozin) as potential treatment for type 1 diabetes<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[4]&nbsp;Valeritas\u2019 V-Go\u00ae Wearable Insulin Delivery Device Demonstrates Positive Clinical and Economic Benefits in Patients with Type 2 Diabetes<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[5]&nbsp;Clearside Biomedical Announces Positive Topline Results from Phase 2 Clinical Trial of CLS-TA Used with Eylea in Patients with Diabetic Macular Edema<\/span><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\"><img class=\"\"     style=\"font-size: 10px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532684194.gif\" alt=\"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09\" title=\"\u76d8\u70b9 | \u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u8fd1\u671f\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c57\u671f\uff09\"  \/><\/span><\/p>\n<p style=\"white-space: normal;\">\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u660e\u5eb7\u5fb7                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 1. \u4ee5\u03b2\u7ec6\u80de\u4e3a\u4e2d\u5fc3\uff0c\u7cd6\u5c3f\u75c5\u65b0\u836f\u83b7\u6279\u8fdb\u5165\u4e34\u5e8a \u65e5\u524d\uff0cARKAY Therapeutics\u5ba3\u5e03 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9111,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9110"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9110"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9110\/revisions"}],"predecessor-version":[{"id":9118,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9110\/revisions\/9118"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9111"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9110"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9110"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}