{"id":9162,"date":"2018-06-08T01:00:00","date_gmt":"2018-07-27T09:36:56","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e9%80%9f%e9%80%92-%e8%be%89%e7%91%9eparp%e6%8a%91%e5%88%b6%e5%89%82%e8%8e%b7%e4%bc%98%e5%85%88%e5%ae%a1%e8%af%84%ef%bc%8c%e6%b2%bb%e7%96%97%e6%99%9a%e6%9c%9f%e4%b9%b3%e8%85%ba%e7%99%8c\/"},"modified":"2018-07-27T17:36:57","modified_gmt":"2018-07-27T09:36:57","slug":"%e9%80%9f%e9%80%92-%e8%be%89%e7%91%9eparp%e6%8a%91%e5%88%b6%e5%89%82%e8%8e%b7%e4%bc%98%e5%85%88%e5%ae%a1%e8%af%84%ef%bc%8c%e6%b2%bb%e7%96%97%e6%99%9a%e6%9c%9f%e4%b9%b3%e8%85%ba%e7%99%8c","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9162\/","title":{"rendered":"\u901f\u9012 | \u8f89\u745ePARP\u6291\u5236\u5242\u83b7\u4f18\u5148\u5ba1\u8bc4\uff0c\u6cbb\u7597\u665a\u671f\u4e73\u817a\u764c"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n


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\u8f89\u745e\u516c\u53f8\uff08Pfizer\uff09\u4eca\u5929\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u63a5\u53d7\u4e86\u5176\u4e3atalazoparib\u9012\u4ea4\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\uff0c\u5e76\u6388\u4e88\u5b83\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c<\/strong>\u3002\u8be5NDA\u7684\u63d0\u4ea4\u662f\u57fa\u4e8e\u4e34\u5e8a\u8bd5\u9a8cEMBRACA\u7684\u7ed3\u679c\u3002\u8be5\u8bd5\u9a8c\u8bc4\u4f30\u4e86talazoparib\u4e0e\u5316\u7597\u76f8\u6bd4\uff0c\u5728\u79cd\u7cfb\uff08\u9057\u4f20\u6027\uff09BRCA<\/em>\u7a81\u53d8\uff08gBRCAm<\/em>\uff09\u7684HER2\u9634\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08MBC\uff09\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u4e5f\u63a5\u53d7\u4e86talazoparib\u7684\u8425\u9500\u6388\u6743\u7533\u8bf7\uff08MAA\uff09\u3002<\/span><\/p>\n


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BRCA1<\/span><\/em>\u548cBRCA2<\/em>\u662f\u4ea7\u751f\u53c2\u4e0eDNA\u4fee\u590d\u7684\u86cb\u767d\u8d28\u7684\u4eba\u7c7b\u57fa\u56e0\u3002\u5f53\u5176\u4e2d\u4efb\u4e00\u57fa\u56e0\u53d1\u751f\u7a81\u53d8\u65f6\uff0cDNA\u4fee\u590d\u5c31\u53ef\u80fd\u65e0\u6cd5\u6b63\u5e38\u8fdb\u884c\uff0c\u4f1a\u5bfc\u81f4\u67d0\u4e9b\u7c7b\u578b\u764c\u75c7\uff08\u5982\u4e73\u817a\u764c\uff09\u7684\u53d1\u751f\u3002BRCA<\/em>\u7a81\u53d8\u53ef\u4ee5\u662f\u9057\u4f20\u6027\uff08\u751f\u6b96\u7ec6\u80de\uff09\u6216\u81ea\u53d1\u6027\uff08\u4f53\u7ec6\u80de\uff09\u3002BRCA1<\/em>\u548cBRCA2<\/em>\u7a81\u53d8\u7ea6\u5360\u9057\u4f20\u6027\u4e73\u817a\u764c\u7ea625\uff05\u81f330\uff05\uff0c\u548c\u6240\u6709\u4e73\u817a\u764c5\uff05\u81f310\uff05\u3002\u636e\u4f30\u8ba1\uff0c\u7ea672\uff05\u7684\u5177\u6709\u9057\u4f20\u6027BRCA1<\/em>\u7a81\u53d8\u7684\u4eba\uff0c\u548c\u7ea669\uff05\u7684\u5177\u6709BRCA2<\/em>\u7a81\u53d8\u7684\u4eba\uff0c\u4f1a\u572880\u5c81\u524d\u60a3\u4e0a\u4e73\u817a\u764c\u3002\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u8868\u660e\uff0cgBRCAm<\/strong><\/em>\u4e73\u817a\u764c\u60a3\u8005\u7684\u5e73\u5747\u5e74\u9f84\u4e3a40-45\u5c81\uff0c\u6bd4\u6574\u4f53\u4e73\u817a\u764c\u4eba\u7fa4\u7684\u60a3\u75c5\u5e74\u9f84\u77ed\u4e8620\u5e74<\/strong>\u3002\u8fd9\u4e9b\u5e74\u8f7b\u7684\u60a3\u8005\u6025\u9700\u6709\u6548\u7597\u6cd5\u6765\u7f13\u89e3\u75be\u75c5\uff0c\u5ef6\u957f\u751f\u547d\u3002<\/span><\/p>\n


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Talazoparib\u662f\u4e00\u6b3e\u5728\u7814\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684PARP\u6291\u5236\u5242\uff0c\u6709\u671b\u4e3a\u8fd9\u7c7b\u4e73\u817a\u764c\u60a3\u8005\u5e26\u6765\u6cbb\u7597\u5e0c\u671b<\/span><\/strong>\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0ctalazoparib\u5177\u6709\u9ad8\u6548\u529b\u4e14\u5177\u6709\u53cc\u91cd\u4f5c\u7528\u673a\u5236\uff0c\u6709\u6f5c\u529b\u901a\u8fc7\u963b\u65adPARP\u9176\u6d3b\u6027\uff0c\u5e76\u5c06PARP\u6355\u83b7\u5728DNA\u635f\u4f24\u90e8\u4f4d\uff0c\u6765\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002Talazoparib\u76ee\u524d\u6b63\u5728\u665a\u671fgBRCAm<\/em>\u4e73\u817a\u764c\u3001\u65e9\u671f\u4e09\u9634\u6027\u4e73\u817a\u764c\u548cDNA\u635f\u4f24\u4fee\u590d\uff08DDR\uff09\u7f3a\u9677\u578b\u524d\u5217\u817a\u764c\uff0c\u4ee5\u53ca\u4e0e\u514d\u75ab\u7597\u6cd5\u7ec4\u5408\u5728\u591a\u79cd\u5b9e\u4f53\u7624\u4e2d\u8bc4\u4f30\u7597\u6548\u3002
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<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong>\u25b2Talazoparib\u7684\u5206\u5b50\u7ed3\u6784\u5f0f\uff08\u56fe\u7247\u6765\u6e90\uff1aBy Ed (Edgar181) [Public domain], from Wikimedia Commons\uff09<\/span><\/strong><\/p>\n


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Talazoparib\u6cbb\u7597\u4e73\u817a\u764c<\/span>\u7684\u7597\u6548\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u4e86\u8bc1\u5b9e\u3002EMBRACA\u8bd5\u9a8c\u5728431\u4f8b\u643a\u5e26\u9057\u4f20\u6027BRCA1\/2<\/em>\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e09\u9634\u6027\uff08TNBC\uff09\u6216\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08ER+\uff09\/HER2-\u60a3\u8005\u4e2d\uff0c\u8bc4\u4f30\u4e86\u6bcf\u65e5\u4e00\u6b21talazoparib\u4e0e\u533b\u751f\u9009\u62e9\u7684\u5316\u7597\uff08\u5361\u57f9\u4ed6\u6ee8[capecitibine]\u3001\u827e\u65e5\u5e03\u6797[eribulin]\u3001\u5409\u897f\u4ed6\u6ee8[gemcitabine]\u6216\u957f\u6625\u745e\u6ee8[vinorelbine]\uff09\u76f8\u6bd4\u7684\u7597\u6548\u3002\u8be5\u7814\u7a76\u62b5\u8fbe\u4e86\u5176\u4e3b\u8981\u7ec8\u70b9\uff0c\u8bc1\u660etalazoparib\u4e0e\u5316\u7597\u76f8\u6bd4\u5177\u6709\u66f4\u4f18\u8d8a\u7684<\/strong><\/span>\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09<\/span><\/strong><\/a>\u3002\u5e76\u4e14PFS\u83b7\u76ca\u5728\u9884\u5148\u8bbe\u5b9a\u7684\u4e9a\u7ec4\u4e2d\u4e00\u81f4\uff0c\u5305\u62ec\u6709\u8111\u8f6c\u79fb\u53f2\u7684\u60a3\u8005\u3001\u66fe\u63a5\u53d7\u8fc7\u5316\u7597\u7684\u60a3\u8005\u3001TNBC\u60a3\u8005\u548cHR+\u60a3\u8005\u3002 <\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\u25b2\u8f89\u745e\u5168\u7403\u4ea7\u54c1\u5f00\u53d1\u90e8\u80bf\u7624\u5b66\u9996\u5e2d\u53d1\u5c55\u5b98Mace Rothenberg\u535a\u58eb<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong>\uff08\u56fe\u7247\u6765\u6e90\uff1a\u8f89\u745e\u5b98\u65b9\u7f51\u7ad9\uff09<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/p>\n


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\u201c\u76f8\u6bd4\u6574\u4f53\u4e73\u817a\u764c\u4eba\u7fa4\uff0c\u60a3\u6709\u9057\u4f20\u6027BRCA<\/em>\u7a81\u53d8\u7684\u5973\u6027\u901a\u5e38\u5728\u66f4\u5e74\u8f7b\u7684\u65f6\u5019\u88ab\u8bca\u65ad\u51fa\u4e73\u817a\u764c\u3002\u5f53\u5979\u4eec\u7684\u75be\u75c5\u53d1\u5c55\u5230\u665a\u671f\uff0c\u6cbb\u7597\u9009\u62e9\u4f1a\u975e\u5e38\u6709\u9650<\/strong>\uff0c\u201d\u8f89\u745e\u5168\u7403\u4ea7\u54c1\u5f00\u53d1\u90e8\u80bf\u7624\u5b66\u9996\u5e2d\u53d1\u5c55\u5b98Mace Rothenberg\u535a\u58eb\u8868\u793a\uff1a\u201c\u4eca\u5929\u7684\u7533\u62a5\u63a5\u53d7\u662f\u8f89\u745e\u836f\u7269\u5f00\u53d1\u7cbe\u51c6\u533b\u5b66\u65b9\u6cd5\u6210\u529f\u7684\u6700\u65b0\u4f8b\u5b50\uff0c\u8fd9\u6b3e\u836f\u7269\u662f\u9488\u5bf9\u4e0eBRCA<\/em>\u7a81\u53d8\u76f8\u5173\u7684\u9519\u8befDNA\u635f\u4f24\u4fee\u590d\u8fc7\u7a0b\u3002 \u6211\u4eec\u73b0\u5728\u79bb\u4e3a\u8fd9\u4e9b\u60a3\u8005\u63d0\u4f9b\u5316\u7597\u7684\u66ff\u4ee3\u9009\u62e9\u66f4\u8fd1\u4e86\u4e00\u6b65\u3002\u201d<\/span><\/p>\n


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\u6211\u4eec\u671f\u5f85\u8fd9\u6b3e\u65b0\u836f\u7684\u5ba1\u6279\u80fd\u591f\u987a\u5229\uff0c\u5c3d\u5feb\u4e3a\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff01<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/h1>\n

[1] U.S. FDA AND EUROPEAN MEDICINES AGENCY ACCEPT REGULATORY SUBMISSIONS FOR REVIEW OF TALAZOPARIB FOR METASTATIC BREAST CANCER PATIENTS WITH AN INHERITED BRCA MUTATION<\/span><\/h1>\n

[2] Mega-blockbuster? Pfizer lines up for a snap review of its PARP drug talazoparib \u2014 and a launch into a crowded market<\/span><\/p>\n


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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u660e\u5eb7\u5fb7 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u8f89\u745e\u516c\u53f8\uff08Pfizer\uff09\u4eca\u5929\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u63a5\u53d7\u4e86\u5176\u4e3atalazoparib\u9012\u4ea4\u7684\u65b0\u836f\u7533\u8bf7\uff08 […]<\/p>\n","protected":false},"author":1,"featured_media":9163,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9162"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9162"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9162\/revisions"}],"predecessor-version":[{"id":9168,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9162\/revisions\/9168"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9163"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9162"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9162"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}