{"id":91645,"date":"2019-04-21T00:00:50","date_gmt":"2019-04-23T04:33:43","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/91645\/"},"modified":"2019-04-23T12:33:44","modified_gmt":"2019-04-23T04:33:44","slug":"3651719a12","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/91645\/","title":{"rendered":"\u6b27\u7f8eBE\u8bd5\u9a8c\u6307\u5bfc\u539f\u5219\u7684\u8981\u70b9\u548c\u542f\u793a"},"content":{"rendered":"
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\"\u6b27\u7f8eBE\u8bd5\u9a8c\u6307\u5bfc\u539f\u5219\u7684\u8981\u70b9\u548c\u542f\u793a\"<\/p>\n

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\u6b27\u7f8e\u56fd\u5bb6\u53e3\u670d\u56fa\u4f53\u5236\u5242\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c<\/strong><\/p>\n

\u6307\u5bfc\u539f\u5219\u7684\u8981\u70b9\u548c\u542f\u793a  <\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u4f5c\u8005<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5f20\u9038\u51e1    \u949f\u5927\u653e<\/p>\n

\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240<\/p>\n

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\u6458\u8981<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5236\u5242\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u662f\u8bc4\u4ef7\u4eff\u5236\u836f\u53e3\u670d\u56fa\u4f53\u5236\u5242\u5185\u5728\u8d28\u91cf\u7684\u5173\u952e\u3002<\/p>\n

\u6b27\u7f8e\u56fd\u5bb6\u836f\u54c1\u7ba1\u7406\u90e8\u95e8\u9881\u5e03\u4e86\u76f8\u5e94\u7684\u6307\u5bfc\u539f\u5219\uff0c\u5e76\u4e14\u5728\u4f7f\u7528\u548c\u5b9e\u9a8c\u7684\u57fa\u7840\u4e0a\u4e0d\u65ad\u4fee\u8ba2\u5b8c\u5584\u3002<\/span><\/p>\n

\u5176\u8981\u70b9\u5305\u62ec\u8bd5\u9a8c\u8bbe\u8ba1\u3001\u53c2\u6bd4\u5236\u5242\u9009\u62e9\u3001<\/span>\u9ad8\u53d8\u5f02\u836f\u7269\u548c\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u7279\u6b8a\u8981\u6c42\u7b49\uff0c\u53cd\u6620\u4e86\u56fd\u9645\u4e0a\u7684\u65b0\u8fdb\u5c55\u3002<\/span><\/p>\n

\u5728\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u5178\u300b\u76f8\u5173\u6307\u5bfc<\/span>\u539f\u5219\u4e2d\uff0c\u5438\u6536\u4e86\u56fd\u9645\u5148\u8fdb\u6807\u51c6\u3002<\/span><\/p>\n

\u6211\u56fd\u6b63\u5728\u5f00\u5c55\u7684\u4eff\u5236\u836f\u8d28\u91cf\u4e00\u81f4\u6027\u8bc4\u4ef7\uff0c\u5bf9\u4fdd\u969c\u53e3\u670d\u56fa\u4f53\u5236\u5242\u751f\u7269\u7b49\u6548\u6709\u91cd<\/span>\u8981\u4f5c\u7528\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b63\u6587<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u5236\u5242\u751f\u7269\u7b49\u6548\u7684\u57fa\u672c\u539f\u5219\u662f20 \u4e16\u7eaa90 \u5e74\u4ee3\u521d\u786e\u5b9a\u7684\uff0c\u5373\u53d7\u8bd5\u5236\u5242\u548c\u53c2\u6bd4\u5236\u5242\u4e3b\u8981\u836f\u52a8\u5b66\u53c2\u6570( AUC \u548cC<\/span>max<\/sub>) \u51e0\u4f55\u5747\u503c\u6bd4\u768490% \u7f6e\u4fe1\u533a\u95f4\u5e94\u843d\u572880% \uff5e125%\u4e4b\u95f4\u3002<\/span><\/p>\n

\u7f8e\u56fd\u3001\u65e5\u672c\u3001\u6b27\u76df\u3001\u52a0\u62ff\u5927\u548c\u5357\u975e\u7b49\u56fd\u76f8\u7ee7\u5236\u5b9a\u4e86\u5404\u81ea\u7684\u6307\u5bfc\u539f\u5219\u3002\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u5178\u300b2000 \u5e74\u7248\u9996\u6b21\u5236\u8ba2\u4e86\u300a\u836f\u7269\u5236\u5242\u4eba\u4f53\u751f\u7269\u5229\u7528\u5ea6\u548c\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6307\u5bfc\u539f\u5219\u300b\uff0c\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u4e5f\u57282005 \u5e743 \u6708\u63a8\u51fa\u4e86\u300a\u5316\u5b66\u5236\u5242\u4eba\u4f53\u751f\u7269\u5229\u7528\u5ea6\u548c\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u3002<\/span><\/p>\n

\u6b27\u76df\u4e8e1992 \u5e746 \u6708\u9881\u5e03\u4e86\u9996\u4e2a\u751f\u7269\u5229\u7528\u5ea6( BA) \u548c\u751f\u7269\u7b49\u6548\u6027( BE) \u7814\u7a76\u6307\u5bfc\u539f\u5219\uff0c2001 \u5e747\u6708\u9881\u5e03\u4e86\u300a\u5bf9\u751f\u7269\u5229\u7528\u5ea6\u548c\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u7684\u8bf4\u660e\u300b\u3002<\/span><\/p>\n

2010 \u5e741 \u6708\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40( EMA) \u9881\u5e03\u4e86\u300a\u751f\u7269\u5229\u7528\u5ea6\u548c\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u6307\u5bfc\u539f\u5219\u300b\uff0c\u5bf9\u65e2\u5f80\u6307\u5bfc\u539f\u5219\u505a\u4e86\u4fee\u8ba2\u3002<\/span><\/p>\n

\u8be5\u6307\u5bfc\u539f\u5219\u4ec5\u9002\u7528\u4e8e\u4eff\u5236\u5316\u5b66\u836f\u54c1\u7684\u666e\u901a\u5236\u5242\uff0c\u4e0d\u5305\u62ec\u8c03\u91ca\u5236\u5242\u3001\u900f\u76ae\u5236\u5242\u3001\u7ecf\u53e3\u5438\u5165\u5236\u5242\u4ee5\u53ca\u65e0\u6cd5\u7528\u836f\u7269\u6d53\u5ea6\u8bc1\u660e\u751f\u7269\u7b49\u6548\u6027\uff0c\u9700\u8981\u836f\u6548\u52a8\u529b\u5b66\u6216\u4e34\u5e8a\u7ec8\u70b9\u8bd5\u9a8c\u8bc1\u660e\u7b49\u6548\u7684\u836f\u7269\u5236\u5242\u3002<\/span><\/p>\n

\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40( FDA) \u4e8e2003 \u5e74\u9881\u5e03\u4e86\u300a\u53e3\u670d\u5236\u5242\u751f\u7269\u5229\u7528\u5ea6\/\u751f\u7269\u7b49\u6548\u6027BA\/BE)\u7814\u7a76\u7684\u603b\u4f53\u8003\u8651\u300b\uff0c\u5e76\u4e14\u9488\u5bf9\u5177\u4f53\u836f\u7269\uff0cFDA \u5747\u7ed9\u51fa\u4e86\u5177\u4f53\u7684\u6307\u5bfc\u610f\u89c1\u3002<\/span><\/p>\n

2007 \u5e74FDA \u53c8\u9881\u5e03\u4e86\u300a\u98df\u7269\u5bf9\u751f\u7269\u5229\u7528\u5ea6\u7684\u5f71\u54cd\u4ee5\u53ca\u9910\u540e\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\uff0c\u4f5c\u4e3a\u5bf9\u4e0a\u4e00\u4e2a\u6307\u5bfc\u539f\u5219\u7684\u8865\u5145\u3002<\/span><\/p>\n

2013 \u5e7412 \u6708FDA \u9881\u5e03\u4e86\u300a\u4ee5\u836f\u52a8\u5b66\u4e3a\u7ec8\u70b9\u8bc4\u4ef7\u6307\u6807\u7684\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u6307\u5bfc\u539f\u5219( \u8349\u6848) \u300b\uff0c\u8be5\u6307\u5bfc\u539f\u5219\u4fee\u8ba2\u5e76\u62df\u66ff\u4ee3\u524d\u4e24\u4e2a\u6307\u5bfc\u539f\u5219\u4e2d\u6709\u5173\u4eff\u5236\u836fBE \u7814\u7a76\u7684\u5185\u5bb9\u3002\u8be5\u6307\u5bfc\u539f\u5219\u4e5f\u9002\u7528\u4e8e\u7f13\u63a7\u91ca\u5236\u5242\u7684BE \u8bd5\u9a8c\u3002<\/span><\/p>\n

\u76f8\u5bf9\u4e8eEMA \u7684\u6307\u5bfc\u539f\u5219\uff0cFDA \u7684\u6307\u5bfc\u539f\u5219\u66f4\u52a0\u7ec6\u81f4\u3001\u5177\u4f53\u548c\u4e25\u683c\u3002<\/span><\/p>\n

\u672c\u6587\u901a\u8fc7\u5bf9EMA \u548cFDA \u6307\u5bfc\u539f\u5219\u7684\u8981\u70b9\u8fdb\u884c\u6bd4\u8f83\uff0c\u4ecb\u7ecd\u56fd\u5916\u5bf9\u53e3\u670d\u5236\u5242\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u7684\u65b0\u89c4\u5b9a\u548c\u89c2\u70b9\uff0c\u4ee5\u53ca\u5bf9\u6211\u56fd\u76f8\u5e94\u9886\u57df\u7684\u542f\u793a\u3002<\/span><\/p>\n

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EMA \u548cFDA \u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c<\/strong><\/p>\n

\u6307\u5bfc\u539f\u5219\u8981\u70b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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1<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u8bbe\u8ba1<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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EMA \u548cFDA \u6307\u5bfc\u539f\u5219\u4e2d\uff0c\u6807\u51c6\u7684\u8bbe\u8ba1\u90fd\u662f2 \u00d72 \u7684\u53cc\u5468\u671f\u4ea4\u53c9\u8bd5\u9a8c\u8bbe\u8ba1\u3002\u5bf9\u4e8e\u957f\u534a\u8870\u671f\u836f\u7269\uff0c\u4e5f\u53ef\u4ee5\u63a5\u53d7\u5e73\u884c\u8bbe\u8ba1\uff0c\u4f46\u4e0d\u540c\u6cbb\u7597\u7ec4\u522b\u7684\u4eba\u53e3\u5b66\u57fa\u7ebf\u503c\u5e94\u8be5\u76f8\u5f53\uff0c\u5982\u5e74\u9f84\u3001\u4f53\u91cd\u3001\u6027\u522b\u3001\u79cd\u65cf\u3001\u5438\u70df\u60c5\u51b5\u548c\u4ee3\u8c22\u80fd\u529b\u7b49\u3002<\/p>\n

\u56e0\u6b64\u5728\u5e73\u884c\u8bd5\u9a8c\u8bbe\u8ba1\u4e2d\uff0c\u6709\u5fc5\u8981\u7b5b\u67e5\u53d7\u8bd5\u8005\u7279\u5b9a\u836f\u7269\u4ee3\u8c22\u9176\u7684\u57fa\u56e0\u578b\u6216\u8868\u578b\uff0c\u5bf9\u53d7\u8bd5\u8005\u5408\u7406\u5206\u7ec4\u3002\u5bf9\u4e8e\u9ad8\u53d8\u5f02\u836f\u7269\uff0c\u63a8\u8350\u4f7f\u7528\u91cd\u590d\u4ea4\u53c9\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u4ee5\u51c6\u786e\u8bc4\u4ef7\u5236\u5242\u7684\u4e2a\u4f53\u5185\u53d8\u5f02\u60c5\u51b5\u3002<\/p>\n

\u4e00\u822c\u8ba4\u4e3a\u5355\u6b21\u7ed9\u836f\u80fd\u66f4\u654f\u611f\u5730\u6bd4\u8f83\u836f\u7269\u91ca\u653e\u8fdb\u5165\u7cfb\u7edf\u5faa\u73af\u7684\u5236\u5242\u95f4\u5dee\u5f02\uff0c\u6240\u4ee5\u6307\u5bfc\u539f\u5219\u5efa\u8bae\u91c7\u7528\u5355\u6b21\u7ed9\u836f\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u5728EMA \u6307\u5bfc\u539f\u5219\u4e2d\uff0c\u67092 \u79cd\u60c5\u51b5\u53ef\u63a5\u53d7\u591a\u6b21\u7ed9\u836f\u7684BE \u8bd5\u9a8c\uff0c<\/span><\/p>\n

\u4e00\u662f\u7531\u4e8e\u5b89\u5168\u6027\/\u8010\u53d7\u6027\u539f\u56e0\uff0c\u53ea\u80fd\u5bf9\u60a3\u8005\u8fdb\u884c\u7814\u7a76\uff0c\u800c\u60a3\u8005\u65e0\u6cd5\u505c\u6b62\u7528\u836f\uff1b<\/span><\/p>\n

\u4e8c\u662f\u7531\u4e8e\u5206\u6790\u65b9\u6cd5\u68c0\u6d4b\u7075\u654f\u5ea6\u4e0d\u591f\uff0c\u9700\u8981\u591a\u6b21\u7ed9\u836f\u8fbe\u5230\u8f83\u9ad8\u7684\u6d53\u5ea6\u3002<\/span><\/p>\n

\u5728\u540e\u4e00\u79cd\u60c5\u51b5\u4e0b\uff0c\u5982\u679c\u6ca1\u6709\u6eb6\u89e3<\/span>\u5ea6\u548c\u5b89\u5168\u6027\u7684\u9650\u5236\uff0c\u4e5f\u53ef\u5355\u6b21\u7ed9\u4e88\u9ad8\u4e8e\u4e34\u5e8a\u7684\u5242\u91cf\u8fdb\u884cBE \u8bd5\u9a8c\u3002<\/span><\/p>\n

\u800cFDA \u6307\u5bfc\u539f\u5219\u89c4\u5b9a\uff0c\u53ea\u6709\u5728\u7b2c1\u79cd\u60c5\u51b5\u65f6\u53ef\u63a5\u53d7\u591a\u6b21\u7ed9\u836f\u7684BE \u8bd5\u9a8c\u3002<\/span><\/p>\n

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2<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9009\u62e9\u53d7\u8bd5\u8005<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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EMA \u548cFDA \u5747\u5efa\u8bae\u4f18\u5148\u9009\u62e9\u5065\u5eb7\u5fd7\u613f\u8005\u4e3a\u53d7\u8bd5\u8005\uff0c\u4f46\u7531\u4e8e\u5b89\u5168\u6027\u539f\u56e0\uff0c\u4e5f\u53ef\u9009\u62e9\u60a3\u8005\u8fdb\u884c\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u3002EMA \u548cFDA \u5747\u8981\u6c42\u6709\u8db3\u591f\u7684\u53d7\u8bd5\u8005\u4f8b\u6570\uff0c\u4ee5\u4fdd\u8bc1\u8bd5\u9a8c\u7684\u628a\u63e1\u5ea6\u3002<\/p>\n

EMA \u5bf9\u53d7\u8bd5\u8005\u4f8b\u6570\u7684\u8981\u6c42\u662f\u4e0d\u5c11\u4e8e12 \u4f8b\uff0c\u5e76\u8ba4\u4e3a\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u5065\u5eb7\u5fd7\u613f\u8005\u4f53\u5185\u6a21\u578b\u8db3\u4ee5\u68c0\u6d4b\u5236\u5242\u7684\u5dee\u522b\uff0c\u5e76\u5141\u8bb8\u5c06\u7ed3\u679c\u5916\u63a8\u5230\u53c2\u6bd4\u836f\u54c1\u88ab\u6279\u51c6\u6cbb\u7597\u7684\u7fa4\u4f53( \u5982\u8001\u5e74\u3001\u513f\u7ae5\u3001\u80be\u6216\u809d\u529f\u80fd\u53d7\u635f\u60a3\u8005\u7b49) \u3002<\/p>\n

FDA \u65b0\u7684\u6307\u5bfc\u539f\u5219\u8981\u6c42\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u7684\u53d7\u8bd5\u4eba\u7fa4\u5177\u6709\u4ee3\u8868\u6027\uff0c\u8981\u8003\u8651\u5e74\u9f84\u3001\u6027\u522b\u548c\u79cd\u65cf\u7b49\u56e0\u7d20\uff0c\u5982\u679c\u8bd5\u9a8c\u836f\u7269\u7684\u9002\u7528\u4eba\u7fa4\u5305\u62ec\u4e0d\u540c\u6027\u522b\uff0c\u5219\u53d7\u8bd5\u4eba\u7fa4\u5e94\u6709\u76f8\u4f3c\u7684\u7537\u5973\u6bd4\u4f8b; \u5982\u679c\u8bd5\u9a8c\u836f\u7269\u4e3b\u8981\u7528\u4e8e\u8001\u5e74\u60a3\u8005\uff0c\u5219\u5efa\u8bae\u5c3d\u53ef\u80fd\u591a\u7684\u5165\u900960 \u5c81\u4ee5\u4e0a\u7684\u8001\u5e74\u5fd7\u613f\u8005\u3002<\/p>\n

\u5bf9\u4e8e\u9ad8\u53d8\u5f02\u836f\u7269\u91c7\u7528\u6bd4\u4f8b\u6807\u5316\u7684\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u65f6\uff0cFDA \u8981\u6c42\u4f8b\u6570\u4e0d\u5c11\u4e8e24 \u4f8b\u3002<\/p>\n

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3<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n
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\u9009\u62e9\u53c2\u6bd4\u836f\u54c1<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6309\u7167EMA \u8981\u6c42\uff0c\u53c2\u6bd4\u5236\u5242\u5e94\u8be5\u662f\u5728\u6b27\u76df\u5df2\u7ecf\u83b7\u5f97\u4e0a\u5e02\u6388\u6743\u7684\u836f\u54c1\uff0c\u5e76\u5177\u6709\u5168\u9762\u7684\u836f\u6548\u548c\u5b89\u5168\u6027\u8d44\u6599\u3002\u56e0\u6b64\u539f\u7814\u4ea7\u54c1\u7684\u6700\u521d\u6279\u51c6\u5242\u578b\u5e94\u8be5\u662f\u9996\u9009\u3002<\/p>\n

FDA \u5bf9\u4e8e\u53c2\u6bd4\u5236\u5242\u7684\u9009\u62e9\u5f88\u660e\u786e\uff0c\u5728\u5904\u65b9\u836f\u53ca\u975e\u5904\u65b9\u836f\u7684\u76ee\u5f55\u4e2d\uff0cFDA \u89c4\u5b9a\u4e86\u53c2\u6bd4\u836f\u54c1\u76ee\u5f55\uff0c\u4ee5\u6b64\u6765\u907f\u514d\u7531\u4e8e\u53c2\u6bd4\u5236\u5242\u4f7f\u7528\u7684\u4e0d\u540c\u800c\u53ef\u80fd\u5bfc\u81f4\u7684\u5404\u4eff\u5236\u54c1\u4e4b\u95f4\u53d1\u751f\u663e\u8457\u7684\u5dee\u5f02\u3002\u6bcf\u4e2a\u54c1\u79cd\u7684\u53c2\u6bd4\u836f\u54c1\u90fd\u975e\u5e38\u660e\u786e\uff0c\u5e76\u7ed9\u51fa\u4e86\u7279\u5b9a\u836f\u5382\u548c\u7279\u5b9a\u89c4\u683c\u3002<\/span><\/p>\n

EMA \u548cFDA \u90fd\u8981\u6c42\u53d7\u8bd5\u5236\u5242\u836f\u7269\u542b\u91cf\u4e0e\u53c2\u6bd4\u5236\u5242\u836f\u7269\u542b\u91cf\u5dee\u503c\u5c0f\u4e8e5%\uff0c\u5bf9\u4e8eBE \u8bd5\u9a8c\u4e2d\u7684\u836f\u54c1\uff0cFDA \u8981\u6c42\u8981\u4fdd\u5b58\u8db3\u91cf\u7684\u7559\u5b58\u6837\u54c1\u3002<\/p>\n

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4<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n
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\u9009\u62e9\u7a7a\u8179\u6216\u9910\u540e\u670d\u836f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

EMA \u8ba4\u4e3a\u7a7a\u8179\u6761\u4ef6\u5728\u8bc4\u4ef7\u5236\u5242\u5dee\u522b\u65f6\u6700\u654f\u611f\uff0c\u4e00\u822c\u53ea\u8981\u6c42\u7a7a\u8179\u7ed9\u836f\u4e0b\u7684\u8bd5\u9a8c\u3002\u4f46\u5982\u679c\u53c2\u6bd4\u5236\u5242\u6ce8\u660e\u9910\u540e\u7ed9\u836f\uff0c\u5219\u4e00\u822c\u5728\u9910\u540e\u6761\u4ef6\u4e0b\u8fdb\u884cBE \u8bd5\u9a8c\u3002<\/span><\/p>\n

\u5982\u679c\u9910\u540e\u7ed9\u836f\u4ec5\u4ec5\u662f\u4e3a\u4e86\u907f\u514d\u60a3\u8005\u957f\u671f\u7528\u836f\u51fa\u73b0\u8010\u53d7\u6027\u95ee\u9898\uff0c\u5219\u4e5f\u53ef\u4ee5\u63a5\u53d7\u7a7a\u8179\u6761\u4ef6\u7684BE \u8bd5\u9a8c; \u5982\u679c\u662f\u57fa\u4e8e\u836f\u52a8\u5b66\u539f\u56e0\u5bfc\u81f4\u836f\u7269\u66b4\u9732\u91cf\u663e\u8457\u4e0d\u540c\u800c\u91c7\u7528\u9910\u540e\u7ed9\u836f\u65b9\u5f0f\u65f6\uff0c\u5219\u53ea\u80fd\u8fdb\u884c\u9910\u540e\u7ed9\u836f\u7684BE \u8bd5\u9a8c\u3002<\/span><\/p>\n

\u5bf9\u4e8e\u7279\u6b8a\u5242\u578b\u7279\u5f81\u7684\u836f\u54c1( \u5982\u5fae\u4e73\u548c\u56fa\u4f53\u5206\u6563\u4f53) \uff0c\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u9700\u8981\u65e2\u5728\u7a7a\u8179\u4e5f\u5728\u9910\u540e\u6761\u4ef6\u8fdb\u884c\uff0c\u9664\u975e\u836f\u54c1\u5fc5\u987b\u4ec5\u5728\u7a7a\u8179\u6216\u4ec5\u5728\u9910\u540e\u670d\u7528\u3002<\/span><\/p>\n

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FDA \u65b0\u7684\u6307\u5bfc\u539f\u5219\u6574\u5408\u4e86\u9910\u540eBE \u7814\u7a76\u7684\u76f8\u5173\u5185\u5bb9\u3002\u8981\u6c42\u9664\u7a7a\u8179\u7ed9\u836f\u5916\uff0c\u8fd8\u8981\u8fdb\u884c\u9910\u540e\u7ed9\u836f\u7684BE\u8bd5\u9a8c\uff0c\u9664\u975e\u53c2\u6bd4\u836f\u54c1\u8bf4\u660e\u4e66\u660e\u786e\u89c4\u5b9a\u7a7a\u8179\u7ed9\u836f\u3002<\/p>\n

\u5bf9\u4e8e\u53ea\u80fd\u9910\u540e\u7ed9\u836f\u7684\u7acb\u5373\u91ca\u653e\u5236\u5242\uff0c\u9664\u9910\u540e\u7ed9\u836f\u5916\uff0c\u53ea\u8981\u6ca1\u6709\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u98ce\u9669\uff0c\u4e5f\u8981\u505a\u7a7a\u8179\u7ed9\u836fBE\u8bd5\u9a8c\u3002<\/p>\n

\u56e0\u6b64\uff0c\u6309\u7167FDA \u7684\u8981\u6c42\uff0c\u5927\u90e8\u5206\u836f\u7269\u5747\u9700\u8981\u8fdb\u884c\u7a7a\u8179\u548c\u9910\u540e2 \u79cd\u6761\u4ef6\u4e0b\u7684BE \u8bd5\u9a8c\u3002\u800c\u5bf9\u4e8e\u7f13\u91ca\u5236\u5242\uff0c\u5747\u8981\u6c42\u5728\u7a7a\u8179\u548c\u9910\u540e2 \u79cd\u6761\u4ef6\u4e0b\u8fdb\u884c\u5355\u6b21\u7ed9\u836f\u7684BE \u8bd5\u9a8c\u3002<\/p>\n

\u5728FDA \u65b0\u7684\u6307\u5bfc\u539f\u5219\u4e2d\uff0c\u5bf9\u4e8e\u98df\u7269\u7ec4\u6210\u4e0eEMA \u8981\u6c42\u76f8\u4f3c\uff0c\u53ea\u89c4\u5b9a\u98df\u7269\u7684\u70ed\u91cf\u548c\u8102\u80aa\u542b\u91cf\uff0c\u4ee5\u53ca\u8bd5\u9a8c\u7528\u9910\u4e2d\uff0c\u86cb\u767d\u3001\u7cd6\u7c7b\u548c\u8102\u80aa\u7684\u70ed\u91cf\u6bd4\u4f8b\u3002<\/p>\n

\u4e0d\u518d\u63a8\u8350\u76f8\u5e94\u7684\u98df\u8c31\uff0c\u56e0\u6b64\u53ef\u4ee5\u6839\u636e\u8bd5\u9a8c\u5730\u70b9\u7684\u996e\u98df\u4e60\u60ef\u9009\u62e9\u98df\u7269\u7ec4\u6210\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n
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\u9009\u62e9\u68c0\u6d4b\u7269\u8d28<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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5.1 \u539f\u5f62\u6216\u4ee3\u8c22\u7269<\/strong>  <\/p>\n

\u539f\u5219\u4e0a\uff0c\u8bc4\u4ef7\u751f\u7269\u7b49\u6548\u6027\u5e94\u8be5\u57fa\u4e8e\u6bcd\u4f53\u5316\u5408\u7269\u7684\u6d4b\u5f97\u6d53\u5ea6\uff0c\u5373\u4fbf\u662f\u975e\u6d3b\u6027\u524d\u836f\uff0c\u8fd9\u5df2\u5f97\u5230\u5171\u8bc6\u3002<\/p>\n

\u6309\u7167EMA \u7684\u8981\u6c42\uff0c\u5982\u679c\u5df2\u7ecf\u6d4b\u4e86\u6bcd\u4f53\u836f\u7269\uff0c\u5219\u4e0d\u9700\u8981\u68c0\u6d4b\u6d3b\u6027\u4ee3\u8c22\u7269\u3002\u4f46FDA \u8981\u6c42\uff0c\u5f53\u4e3b\u8981\u4ee3\u8c22\u7269\u7531\u7cfb\u7edf\u524d\u4ee3\u8c22\u5f62\u6210( \u5982\u9996\u8fc7\u6548\u5e94\u3001\u80a0\u58c1\u6216\u80a0\u8154\u4ee3\u8c22) \u4e14\u5bf9\u836f\u7269\u5b89\u5168\u6027\u6216\u7597\u6548\u6709\u663e\u8457\u5f71\u54cd\u65f6\uff0c\u9700\u8981\u68c0\u6d4b\u8be5\u4ee3\u8c22\u7269\uff0c\u4f46\u4ec5\u5bf9\u539f\u5f62\u836f\u7269\u8fdb\u884c\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\uff0c\u4ee3\u8c22\u7269\u53ea\u4f5c\u4e3a\u652f\u6301\u6570\u636e\u3002<\/p>\n

\u7279\u6b8a\u60c5\u51b5\u4e0b\uff0c\u5982\u975e\u6d3b\u6027\u524d\u836f\u8840\u6d46\u6d53\u5ea6\u5f88\u4f4e\uff0c\u5e76\u4e14\u5feb\u901f\u6e05\u9664\uff0c\u5bfc\u81f4\u96be\u4e8e\u8bc1\u660e\u6bcd\u4f53\u5316\u5408\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u65f6\uff0c\u6216\u8005\u8bd5\u9a8c\u7814\u7a76\u836f\u7269\u6bcd\u4f53\u5316\u5408\u7269\u7684\u5206\u6790\u65b9\u6cd5\u4e0d\u80fd\u6539\u8fdb\u65f6( \u5373\u4f7f\u5728\u9ad8\u5242\u91cf\u4e0b) \uff0c\u53ef\u8003\u8651\u7528\u6d3b\u6027\u4ee3\u8c22\u7269\u6216\u4e3b\u8981\u4ee3\u8c22\u7269\u8fdb\u884cBE \u8bc4\u4ef7\u3002<\/span><\/p>\n

5.2 \u5bf9\u6620\u4f53\u6216\u5916\u6d88\u65cb\u4f53<\/span><\/strong>  <\/span><\/p>\n

\u901a\u5e38\u63a8\u8350\u7528\u975e\u624b\u6027\u7684\u65b9\u6cd5\u8fdb\u884c\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u3002\u6309\u7167FDA \u7684\u8981\u6c42\uff0c\u540c\u65f6\u6ee1\u8db3\u4ee5\u4e0b4 \u79cd\u60c5\u51b5\u65f6\u624d\u9700\u8981\u5bf9\u6620\u4f53\u9009\u62e9\u6027\u5206\u6790\uff1a<\/span><\/p>\n

\u2460 \u4e24\u5bf9\u6620\u5f02\u6784\u4f53\u836f\u6548\u4e0d\u540c\u3002<\/span><\/p>\n

\u2461 \u4e24\u5bf9\u6620\u5f02\u6784\u4f53\u836f\u52a8\u5b66\u4e0d\u540c\u3002<\/span><\/p>\n

\u2462 \u4e24\u5bf9\u6620\u5f02\u6784\u4f53\u4e2d\u5360\u5c11\u6570\u7684\u5f02\u6784\u4f53\u53d1\u6325\u4e3b\u8981\u7597\u6548\u3002<\/span><\/p>\n

\u2463 \u81f3\u5c11\u6709\u4e00\u4e2a\u5bf9\u6620\u5f02\u6784\u4f53\u5438\u6536\u8fc7\u7a0b\u5448\u73b0\u975e\u7ebf\u6027( \u968f\u7740\u836f\u7269\u5438\u6536\u901f\u7387\u7684\u53d8\u5316\uff0c\u4e24\u5bf9\u6620\u5f02\u6784\u4f53\u6d53\u5ea6\u6bd4\u4f8b\u53d1\u751f\u6539\u53d8) \u3002<\/span><\/p>\n

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6<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n
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\u5185\u6e90\u6027\u7269\u8d28\u7684\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u5982\u679c\u8bd5\u9a8c\u836f\u7269\u548c\u5185\u6e90\u6027\u7269\u8d28\u7ed3\u6784\u76f8\u540c\uff0c\u5219\u5e94\u8be5\u7528\u57fa\u7ebf\u6821\u6b63\u6765\u8ba1\u7b97\u836f\u52a8\u5b66\u53c2\u6570\uff0c\u4ee5\u4f7f\u836f\u52a8\u5b66\u53c2\u6570\u8ba1\u7b97\u53cd\u6620\u7ed9\u836f\u540e\u589e\u52a0\u7684\u6d53\u5ea6\u3002<\/p>\n

\u800c\u5bf9\u4e8e\u57fa\u7ebf\u6821\u6b63\u7684\u65b9\u6cd5\uff0c\u7528\u7684\u6700\u591a\u7684\u6821\u6b63\u65b9\u6cd5\u662f\u7ed9\u836f\u540e\u6d4b\u5f97\u6d53\u5ea6\u51cf\u53bb\u57fa\u7ebf\u6d53\u5ea6\uff0c\u800c\u57fa\u7ebf\u6d53\u5ea6\u4e00\u822c\u4e3a\u7ed9\u836f\u524d3 \u4e2a\u4ee5\u4e0a\u6d53\u5ea6\u7684\u5747\u503c\u3002<\/p>\n

EMA \u63a8\u8350\u6807\u51c6\u7f29\u51cf\u57fa\u7ebf\u6821\u6b63\u6cd5\uff0c\u5373\u51cf\u53bb\u4e2a\u4f53\u7684\u5185\u6e90\u6027\u7269\u8d28\u7ed9\u836f\u524d\u6d53\u5ea6\u7684\u5747\u503c\uff0c\u6216\u8005\u51cf\u53bb\u4e2a\u4f53\u7ed9\u836f\u524d\u5185\u6e90\u6027AUC\u3002<\/p>\n

\u4e5f\u6709\u4eba\u7528\u5185\u6e90\u6027\u7269\u8d28\u57fa\u7ebf\u6c34\u5e73\u7684\u5bf9\u6570\u503c\u8fdb\u884c\u6821\u6b63\u3002<\/p>\n

\u6bd4\u8f83\u6210\u719f\u7684\u65b9\u6cd5\u662f\u5728\u7ed9\u836f\u524d\u68c0\u6d4b\u4e0d\u540c\u65f6\u95f4\u70b9\u5185\u6e90\u6027\u7269\u8d28\u6c34\u5e73\uff0c\u4ee5\u83b7\u5f97\u6709\u663c\u591c\u8282\u5f8b\u7684\u57fa\u7ebf\u503c\uff0c\u7ed9\u836f\u540e\u6d53\u5ea6\u7528\u76f8\u5e94\u65f6\u95f4\u70b9\u7684\u6821\u6b63\u503c\u3002
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u4e2a\u65b9\u6cd5\u4e0eFDA \u63a8\u8350\u7684\u65b9\u6cd5\u76f8\u4f3c\uff0c\u5373\u5bf9\u4e8e\u7531\u673a\u4f53\u4ea7\u751f\u7684\u5185\u6e90\u6027\u7269\u8d28\uff0c\u5efa\u8bae\u7ed9\u836f\u524d\u6839\u636e\u836f\u52a8\u5b66\u7279\u5f81\u591a\u70b9\u6d4b\u5b9a\u57fa\u7ebf\u503c\uff0c\u4ece\u7ed9\u836f\u540e\u7684\u8840\u836f\u6d53\u5ea6\u4e2d\u51cf\u53bb\u76f8\u5e94\u7684\u57fa_\u7ebf\u503c\u3002<\/p>\n

\u82e5\u7ecf\u8fc7\u57fa\u7ebf\u6821\u6b63\u540e\u8840\u836f\u6d53\u5ea6\u51fa\u73b0\u8d1f\u503c\uff0c\u5219\u4ee5\u96f6\u8ba1\u3002<\/p>\n

\u6821\u6b63\u524d\u548c\u6821\u6b63\u540e\u7684\u6570\u636e\u5e94\u5206\u522b\u8fdb\u884c\u836f\u52a8\u5b66\u53c2\u6570\u8ba1\u7b97\u548c\u7edf\u8ba1\u5206\u6790\u3002<\/p>\n

\u91c7\u7528\u6821\u6b63\u540e\u7684\u6570\u636e\u8fdb\u884c\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u3002<\/p>\n

FDA \u5f3a\u8c03\u5bf9\u6765\u6e90\u4e8e\u98df\u7269\u7684\u5185\u6e90\u6027\u7269\u8d28\uff0c\u8bd5\u9a8c\u4e2d\u63a7\u5236\u996e\u98df\u7684\u5fc5\u8981\u6027\u3002EMA \u5efa\u8bae\u8003\u8651\u8d85\u6cbb\u7597\u5242\u91cf\u7ed9\u836f\uff0c\u53ea\u8981\u8be5\u5242\u91cf\u80fd\u88ab\u5f88\u597d\u8010\u53d7\uff0c\u4f7f\u7ed9\u836f\u540e\u589e\u52a0\u7684\u8d85\u8fc7\u57fa\u7ebf\u7684\u6d53\u5ea6\u80fd\u88ab\u53ef\u9760\u6d4b\u5b9a\u3002\u4e0d\u7ba1\u4f55\u79cd\u6821\u6b63\u65b9\u6cd5\uff0c\u90fd\u5e94\u8be5\u5728\u8bd5\u9a8c\u524d\u89c4\u5b9a\u3002<\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

7<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n
\n
\n

\u5173\u4e8e\u9ad8\u53d8\u5f02\u836f\u7269<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u9ad8\u53d8\u5f02\u836f\u7269\u548c\u9ad8\u53d8\u5f02\u836f\u7269\u5236\u5242\u5206\u522b\u6307\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u4e2dAUC \u548cCmax\u7684\u4e2a\u4f53\u5185\u53d8\u5f02\u7cfb\u6570\u226530% \u7684\u836f\u7269\u548c\u836f\u7269\u5236\u5242\u3002<\/p>\n

\u4e2a\u4f53\u5185\u53d8\u5f02\u7684\u6765\u6e90\u5305\u62ec\u5f71\u54cd\u751f\u7269\u5229\u7528\u5ea6\u7684\u751f\u7406\u5b66\u56e0\u7d20\u3001\u836f\u7269\u7684\u5185\u5728\u6027\u8d28\u3001\u7269\u7406\u5316\u5b66\u6027\u8d28\u3001\u5236\u5242\u56e0\u7d20\u53ca\u5176\u4ed6\u3002<\/p>\n

\u636e\u7edf\u8ba1\uff0c2003 \uff0d2005 \u5e74\u5728FDA \u505a\u4e0a\u5e02\u8bc4\u4ef7\u7684\u4eff\u5236\u836f\u5236\u5242\u4e2d\uff0c\u6709\u7ea620% \u4e3a\u9ad8\u53d8\u5f02\u836f\u7269\u5236\u5242\u3002\u8fdb\u884c\u9ad8\u53d8\u5f02\u836f\u7269BE \u8bd5\u9a8c\u65f6\uff0c\u9700\u8981\u66f4\u591a\u7684\u53d7\u8bd5\u8005\u624d\u80fd\u8fbe\u5230\u8db3\u591f\u7684\u628a\u63e1\u5ea6\u3002<\/p>\n

\u4f46\u662f\uff0c\u6269\u5927\u53d7\u8bd5\u8005\u4f8b\u6570\u65e2\u4f1a\u5e26\u6765\u4f26\u7406\u5b66\u95ee\u9898\uff0c\u4e5f\u4f1a\u589e\u52a0\u7533\u529e\u8005\u7684\u7ecf\u6d4e\u8d1f\u62c5\u3002<\/p>\n

\u56e0\u6b64\uff0c\u5bf9\u4e8e\u9ad8\u53d8\u5f02\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u95ee\u9898\uff0c\u4e00\u76f4\u4ee5\u6765\u662f\u5404\u56fd\u7814\u7a76\u4eba\u5458\u548c\u836f\u653f\u7ba1\u7406\u90e8\u95e8\u6240\u5173\u5fc3\u7684\u95ee\u9898\u3002<\/p>\n

\u5173\u4e8e\u9ad8\u53d8\u5f02\u836f\u7269\u7684BE \u7814\u7a76\uff0c\u4e00\u4e9b\u4e13\u5bb6\u548c\u673a\u6784\u63d0\u51fa\u7684\u89e3\u51b3\u529e\u6cd5\u6709: <\/span><\/p>\n

\u2460 \u589e\u52a0\u6837\u672c\u91cf\u3002<\/span><\/p>\n

\u2461 \u91cd\u590d\u4ea4\u53c9\u8bbe\u8ba1\u6216\u591a\u5242\u91cf\u8bd5\u9a8c\u8bbe\u8ba1\u3002<\/span><\/p>\n

\u2462 \u653e\u5bbd\u7b49\u6548\u6027\u5224\u65ad\u7684\u9650\u503c\uff0c\u8fd9\u79cd\u65b9\u5f0f\u53c8\u5305\u62ec\u9759\u6001\u653e\u5bbd\u3001\u56fa\u5b9a\u6837\u672c\u91cf\u653e\u5bbd\u548c\u6bd4\u4f8b\u6807\u5316\u7684\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u3002<\/span><\/p>\n

\u6bd4\u4f8b\u6807\u5316\u7684\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u65b9\u6cd5\u662f\u76ee\u524dFDA \u63a8\u8350\u7684\u65b9\u6cd5\uff0c\u5373\u6839\u636e\u53c2\u6bd4\u5236\u5242\u7684\u4e2a\u4f53\u5185\u53d8\u5f02\u7a0b\u5ea6\u653e\u5bbd\u751f\u7269\u7b49\u6548\u6027\u5224\u65ad\u7684\u6807\u51c6\u3002<\/span><\/p>\n

\u4e3a\u4e86\u5224\u65ad\u662f\u5426\u4e3a\u9ad8\u53d8\u5f02\u836f\u7269\uff0c\u9700\u8981\u91c7\u7528\u91cd\u590d\u4ea4\u53c9\u8bd5\u9a8c\u8bbe\u8ba1\u4ee5\u8bc4\u4f30\u836f\u7269\u7684\u4e2a\u4f53\u5185<\/span>\u53d8\u5f02\u7a0b\u5ea6\u3002<\/span><\/p>\n

\u53ef\u91c7\u7528\u90e8\u5206\u91cd\u590d\u7684\u4ea4\u53c9\u8bd5\u9a8c\u8bbe\u8ba1( 3 \u5468\u671f) \u6216\u5b8c\u5168\u91cd\u590d\u7684\u4ea4\u53c9\u8bd5\u9a8c\u8bbe\u8ba1( 4 \u5468\u671f) \uff0c\u5176\u6838\u5fc3\u5747\u5f3a\u8c03\u53c2\u6bd4\u5236\u5242\u8981\u91cd\u590d\u7ed9\u836f1 \u6b21\u3002<\/span><\/p>\n

\u76ee\u524dFDA \u63a8\u8350\u6bd4\u4f8b\u6807\u5316\u7684\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u65b9\u6cd5\uff0c\u5bf9\u4e8e\u9ad8\u53d8\u5f02\u836f\u7269\uff0cAUC \u548c<\/span>C<\/span>max<\/sub>\u7684\u7b49\u6548\u6027\u5224\u65ad\u6807\u51c6\u4e3a: \u4e0a\u9650\/\u4e0b\u9650= exp \uff3b\u00b1 ln( 1.25)\u00b7(<\/span>S<\/span>WR<\/sub>\/S<\/span>WO<\/sub>) \uff3d\u3002<\/span><\/p>\n

S<\/span>WR<\/sub>\u8868\u793a\u53c2\u6bd4\u5236\u5242\u7684\u4e2a\u4f53\u5185\u53d8\u5f02\uff0cS<\/span>WO<\/sub>\u662f\u9884\u5148\u8bbe\u5b9a\u597d\u7684\u5e38\u65700\uff0e 25 ( \u5bf9\u5e94\u7684\u4e2a\u4f53\u5185\u53d8\u5f02\u7cfb\u6570CV =25. 4%) \u3002<\/span><\/p>\n

\u53c2\u6bd4\u5236\u5242\u4e2a\u4f53\u5185\u53d8\u5f02S<\/span>WR<\/sub>\u7684\u754c\u503c\u5b9a\u4e3a0. 294( \u5bf9\u5e94\u7684\u4e2a\u4f53\u5185\u53d8\u5f02\u7cfb\u6570CV = 30%) \uff0c\u5f53S<\/span>WR<\/sub>\u22650. 294 \u65f6\uff0cFDA \u5141\u8bb8\u6839\u636e\u53c2\u6bd4\u5236\u5242\u7684\u4e2a\u4f53\u5185\u53d8\u5f02\u7a0b\u5ea6\u653e\u5bbd\u7b49\u6548\u6027\u5224\u65ad\u63a5\u53d7\u7684\u6807\u51c6\u3002<\/span><\/p>\n

\u4f46\u662f\u8fd9\u79cd\u65b9\u6cd5\u5bf9\u53d7\u8bd5\u5236\u5242\u548c\u53c2\u6bd4\u5236\u5242\u51e0\u4f55\u5747\u503c\u6bd4( GM\uff32) \u7684\u5dee\u522b\u7f3a\u4e4f\u654f\u611f\u6027\uff0c\u6709\u65f6\u4f1a\u51fa\u73b0\u7ed3\u679c\u663e\u793a\u4e24\u4e2a\u5236\u5242\u662f\u7b49\u6548\u7684\uff0c\u4f46\u4e24\u5236\u5242GM\uff32 \u7684\u70b9\u4f30\u8ba1\u503c\u5374\u843d\u572880% \uff5e125% \u4e4b\u5916\u7684\u60c5\u51b5\u3002<\/span><\/p>\n

\u800cBE \u8bd5\u9a8c\u6a21\u62df\u7ed3\u679c\u4e5f\u8868\u660e\uff0c\u5f53\u4e2a\u4f53\u5185\u53d8\u5f02\u8d85\u8fc750% \uff5e 60%\u65f6\uff0c\u5bf9GM\uff32 \u7684\u70b9\u4f30\u8ba1\u503c\u7684\u9650\u5236\u5219\u6210\u4e3a\u4e3b\u5bfc\u6807\u51c6\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0cFDA \u8fd8\u8981\u6c42\u4e24\u5236\u5242GM\uff32\u7684\u70b9\u4f30\u8ba1\u503c\u5e94\u572880% \uff5e125%\u8303\u56f4\u5185\u3002FDA \u63a8\u8350\u7684\u9ad8\u53d8\u5f02\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u5177\u4f53\u7b97\u6cd5\u89c1\u5b55\u916e\u80f6\u56ca\u751f\u7269\u7b49\u6548\u6027\u7684\u6307\u5bfc\u610f\u89c1\u3002<\/span><\/p>\n

2010 \u5e74\u7248EMA \u6307\u5bfc\u539f\u5219\u91c7\u7528\u7684\u65b9\u6cd5\u4e0eFDA \u76f8\u4f3c\uff0c\u4f46\u4e5f\u6709\u4e00\u4e9b\u4e0d\u540c\u3002<\/p>\n

EMA \u53ea\u63a5\u53d7\u5bf9C<\/span>max<\/sub>\u653e\u5bbd\u63a5\u53d7\u6807\u51c6\uff0c\u540c\u65f6\u8bbe\u5b9a\u4e86\u6700\u5927\u7684\u9650\u5ea6\u81f369.84% \uff5e 143\uff0e19%( CV = 50%) \uff0c\u5bf9AUC \u4ecd\u7136\u91c7\u752880% \uff5e125% \u7684\u6807\u51c6\u3002<\/span><\/p>\n

\u5bf9\u4e8e\u9ad8\u53d8\u5f02\u836f\u7269\uff0cEMA \u7684\u63a5\u53d7\u8303\u56f4\u6309\u4e0b\u5f0f\u8ba1\u7b97: \u4e0a\u9650\/\u4e0b\u9650= exp(\u00b1k\u00b7S<\/span>WR<\/sub>) \u3002k \u662f\u4e00\u4e2a\u4e3a0.760 \u7684\u5e38\u6570\uff0c\u4e0e\u6bd4\u4f8b\u6807\u5316\u7684\u8d77\u70b9\u53d8\u5f02\u5ea6( CV = 30%) \u76f8\u5bf9\u5e94\uff0c\u8fd9\u6837\u6bd4\u4f8b\u6807\u5316\u548c\u975e\u6bd4\u4f8b\u6807\u5316\u4e4b\u95f4\u53ef\u5e73\u6ed1\u8fc7\u5ea6\uff0c\u4ee5\u907f\u514d\u5728\u4e2a\u4f53\u53d8\u5f02\u7565\u9ad8\u4e8e30%\u65f6\uff0c\u8fc7\u5ea6\u653e\u5bbd\u6807\u51c6\u3002<\/span><\/p>\n

\u800cFDA \u91c7\u7528\u7684\u6bd4\u4f8b\u6807\u5316\u5e38\u6570\u6709\u66f4\u5927\u7684\u81ea\u7531\u5ea6( \u66f4\u5bbd\u7684\u6807\u51c6) \u3002FDA \u548cEMA \u5bf9\u7f6e\u4fe1\u533a\u95f4\u7684\u653e\u5bbd\u6807\u51c6\u5982\u56fe1 \u6240\u793a\u3002<\/span><\/p>\n

\u56fe1 FDA( a) \u548cEMA( b) \u751f\u7269\u7b49\u6548\u6027\u6807\u51c6\u6bd4\u8f83\u3002<\/span><\/p>\n


<\/p>\n

\"\u6b27\u7f8eBE\u8bd5\u9a8c\u6307\u5bfc\u539f\u5219\u7684\u8981\u70b9\u548c\u542f\u793a\"
<\/p>\n


<\/p>\n

\u65e0\u8bba\u4f55\u79cd\u7b97\u6cd5\uff0c\u91c7\u7528\u6bd4\u4f8b\u6807\u5316\u7684\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u65b9\u6cd5\uff0c\u5747\u53ef\u5927\u5927\u51cf\u5c11\u8bd5\u9a8c\u53d7\u8bd5\u8005\u7684\u4f8b\u6570\uff0c\u5e76\u589e\u52a0\u8bd5\u9a8c\u7684\u628a\u63e1\u5ea6\u3002<\/span>
<\/p>\n

\n
\n
\n
\n

\u4ee5\u963f\u4ed1\u81a6\u9178\u94a0\u4e3a\u4f8b\uff0c\u5b83\u5c5e\u4e8e\u9ad8\u53d8\u5f02\u836f\u7269\uff0cAUC \u548cC<\/span>max<\/sub>\u7684\u4e2a\u4f53\u5185\u53d8\u5f02\u7ea650%\uff0c1 \u987924 \u4f8b\u53d7\u8bd5\u8005\u7684\u53cc\u5468\u671f\u4ea4\u53c9\u8bd5\u9a8c\u628a\u63e1\u5ea6\u53ea\u670950%\uff0c\u5c3d\u7ba1\u53d7\u8bd5\u5236\u5242\u548c\u53c2\u6bd4\u5236\u5242\u53c2\u6570\u7684\u51e0\u4f55\u5747\u503c\u6bd4\u4e3a95%\uff0c\u517690%\u7f6e\u4fe1\u533a\u95f4\u4ecd\u672a\u843d\u572880% \uff5e125% \u4e4b\u95f4\uff0c\u8981\u83b7\u5f9780%\u7684\u628a\u63e1\u5ea6\uff0c\u81f3\u5c11\u9700\u8981106 \u4f8b\u53d7\u8bd5\u8005\u3002<\/span><\/p>\n

\u5982\u679c\u91c7\u75283 \u5468\u671f\u91cd\u590d\u4ea4\u53c9\u8bbe\u8ba1\u3001\u6bd4\u4f8b\u6807\u5316\u7684\u65b9\u6cd5\u8fdb\u884c\u8bc4\u4ef7\uff0c31 \u4f8b\u53d7\u8bd5\u8005\u53ef\u5f97\u523090% \u7684\u628a\u63e1\u5ea6\u3002\u8be5\u65b9\u6cd5\u5df2\u6210\u529f\u7528\u4e8e\u4e00\u9879\u963f\u4ed1\u81a6\u9178\u94a0\u5236\u5242\u7684\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u3002<\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n

8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n
\n
\n

\u5173\u4e8e\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

EMA \u5bf9\u6cbb\u7597\u6307\u6570\u7a84\u7684\u836f\u7269\u6bd4\u8f83\u4e25\u683c\uff0cAUC \u7684\u7b49\u6548\u6027\u6807\u51c6\u7f29\u7a84\u81f390% \uff5e 111\uff0e 11%\uff0c\u5728C<\/span>max<\/sub>\u5bf9\u5b89\u5168\u6027\u3001\u836f\u6548\u6216\u836f\u7269\u6d53\u5ea6\u76d1\u6d4b\u7279\u522b\u91cd\u8981\u7684\u60c5\u51b5\u4e0b\uff0c\u540c\u6837\u9002\u7528\u4e8e\u4e0a\u8ff0\u8303\u56f4\u3002<\/p>\n

FDA \u57282012 \u5e74\u524d\u5bf9\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u63a5\u53d7\u6807\u51c6\u4ecd\u7136\u662f80% \uff5e125%\u3002\u800c\u76ee\u524dFDA \u63a8\u8350\u7684\u662f\u6bd4\u4f8b\u6807\u5316\u7684\u65b9\u6cd5\uff0c\u5728\u7b49\u6548\u6027\u9650\u503c90% \uff5e111%\u57fa\u7840\u4e0a\u6839\u636e\u53c2\u6bd4\u5236\u5242\u7684\u53d8\u5f02\u5ea6\u653e\u5bbd\u6807\u51c6\u3002<\/p>\n

\u5f53\u53c2\u6bd4\u5236\u5242\u7684\u4e2a\u4f53\u5185\u53d8\u5f02CV\u226410% \u65f6\uff0c\u7b49\u6548\u6027\u9650\u503c\u4e3a90% \uff5e111%; CV \u572810% \uff5e 21%\u4e4b\u95f4\u65f6\uff0c\u7b49\u6548\u6027\u9650\u503c\u6bd480% \uff5e 125% \u7a84; CV \uff1e 21% \u65f6\uff0c\u7b49\u6548\u6027\u9650\u503c\u4e3a80% \uff5e125%\u3002<\/p>\n

\u53e6\u5916\u8981\u6c42\u53d7\u8bd5\u5236\u5242\u548c\u53c2\u6bd4\u5236\u5242\u7684\u4e2a\u4f53\u5185\u53d8\u5f02\u6bd4\u503cS<\/span>WT<\/sub> \/S<\/span>WR<\/sub>\u22642\uff0e 5\u3002\u57fa\u4e8e\u8fd9\u4e00\u8981\u6c42\uff0c\u53ea\u80fd\u91c7\u7528\u5b8c\u5168\u91cd\u590d\u7684\u4ea4\u53c9\u8bd5\u9a8c\u8bbe\u8ba1( 4 \u5468\u671f) \u3002<\/p>\n

FDA \u63a8\u8350\u7684\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u5177\u4f53\u7b97\u6cd5\u89c1\u534e\u6cd5\u6797\u7247\u751f\u7269\u7b49\u6548\u6027\u7684\u6307\u5bfc\u610f\u89c1\u3002<\/p>\n

\n
\n
\n
\n
\n
\n
\n

9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n
\n
\n

\u5176\u4ed6<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

EMA \u7684\u6307\u5bfc\u539f\u5219\u53ef\u4ee5\u63a5\u53d72 \u9636\u6bb5\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u4f46\u8981\u6c42\u5fc5\u987b\u5728\u8bd5\u9a8c\u65b9\u6848\u4e2d\u9884\u5148\u89c4\u5b9a\uff0c\u4e3a\u51cf\u5c11I \u7c7b\u9519\u8bef\u7684\u53d1\u751f\uff0c\u8981\u89c4\u5b9a\u8c03\u6574\u540e\u663e\u8457\u6027\u6c34\u5e73\u3002<\/p>\n

\u5728\u5206\u6790\u7b2c1 \u9636\u6bb5\u4ee5\u53ca\u7b2c1 \u548c\u7b2c2 \u9636\u6bb5\u5408\u5e76\u7684\u6570\u636e\u65f6\uff0c\u4f7f\u752894. 12%\u7f6e\u4fe1\u533a\u95f4\u662f\u53ef\u4ee5\u63a5\u53d7\u7684\u3002EMA \u548cFDA \u90fd\u5bf9\u6570\u636e\u7684\u5254\u9664\u505a\u4e86\u8bf4\u660e\uff0c\u5982\u5455\u5410\u548c\u8179\u6cfb\u3001\u975e\u96f6\u57fa\u7ebf\u6d53\u5ea6\u5927\u4e8eC<\/span>max<\/sub><\/span>\u76845% \u4ee5\u53ca<\/span>AUC0 <\/sub><\/span>\uff5e<\/span><\/sub> t <\/span><\/sub>\u8986\u76d6 <\/span>AUC0 <\/sub><\/span>\uff5e<\/span><\/sub> \u221e<\/span><\/sub><\/span>\u5c11\u4e8e80%\u7684\u6570\u636e\u5904\u7406\u3002<\/span><\/p>\n

\u65b0\u7248\u7684FDA \u6307\u5bfc\u539f\u5219\u6307\u51fa: \u5bf9\u4e8e\u534a\u8870\u671f\u8f83\u957f\u7684( 24 h \u4ee5\u4e0a) \u836f\u7269\uff0c\u5982\u679c\u836f\u7269\u5206\u5e03\u548c\u6e05\u9664\u4e2a\u4f53\u5185\u53d8\u5f02\u8f83\u5927\uff0c\u5219\u4e0d\u80fd\u622a\u53d6\u90e8\u5206AUC \u6765\u8bc4\u4ef7\u836f\u7269\u66b4\u9732\u91cf\u3002<\/p>\n

\u56e0\u4e3a\u5728\u7ed9\u836f\u540e\u77ed\u65f6\u95f4\u5185( 5 \uff5e 15 min) \u672a\u91c7\u96c6\u65e9\u671f\u7684\u6837\u672c\uff0c\u5bfc\u81f4\u9996\u4e2a\u6837\u672c\u5373\u4e3aC<\/span>max<\/sub>\uff0c\u5219\u4e00\u822c\u4e0d\u5e94\u5c06\u8be5\u53d7\u8bd5\u8005\u7684\u6570\u636e\u7eb3\u5165\u7edf\u8ba1\u5206\u6790\u3002<\/p>\n

\u53e6\u5916\uff0c\u7279\u6b8a\u95ee\u9898\u70b9\u5219\u8003\u8651\u5230\u4e86\u9152\u7cbe\u5bf9\u975e\u5e38\u91ca\u5236\u5242\u53ef\u80fd\u7684\u5f71\u54cd\u3002<\/p>\n

\n
\n
\n
\n
\n

\u5bf9\u6211\u56fd\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u7684\u542f\u793a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ecf\u8fc7\u8fd120 \u5e74\u7684\u53d1\u5c55\uff0c\u6211\u56fd\u7684\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6c34\u5e73\u6709\u4e86\u8f83\u5927\u7684\u63d0\u9ad8\uff0c\u5e76\u4e14\u65e5\u8d8b\u4e0e\u56fd\u9645\u63a5\u8f68\u3002<\/p>\n

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1<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n
\n
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\u6307\u5bfc\u539f\u5219\u7684\u4fee\u8ba2<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u57282000 \u5e74\u7248\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u5178\u300b\u4e2d\uff0c\u5bf9\u5236\u5242\u751f\u7269\u7b49\u6548\u6027\u7684\u63a5\u53d7\u9650\u5ea6\u89c4\u5b9a\u4e3aAUC \u51e0\u4f55\u5747\u503c\u6bd4\u572880% \uff5e125%\uff0cC<\/span>max<\/sub>\u51e0\u4f55\u5747\u503c\u6bd4\u572870% \uff5e143%\u3002<\/p>\n

\u663e\u7136\uff0c\u6b64\u5904\u660e\u663e\u653e\u5bbd\u4e86<\/span>C<\/span>max<\/sub>\u7684\u63a5\u53d7\u8303\u56f4\u3002<\/span><\/p>\n

\u57282010 \u5e74\u7248\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u5178\u300b\u4e2d\uff0c<\/span>C<\/span>max<\/sub>\u51e0\u4f55\u5747\u503c\u6bd4\u7684\u63a5\u53d7\u8303\u56f4\u7f29\u7a84\u4e3a75% \uff5e135%\u3002\u5728\u5373\u5c06\u53d1\u5e03\u76842015 \u5e74\u7248\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u5178\u300b\u4e2d\uff0c\u8be5\u8303\u56f4\u8fdb\u4e00\u6b65\u7f29\u7a84\u4e3a80% \uff5e125%\u3002<\/span><\/p>\n

\u4e0a\u8ff0\u53d8\u5316\u53cd\u6620\u4e86\u6211\u56fd\u5236\u5242\u5de5\u4e1a\u7684\u6280\u672f\u8fdb\u6b65\uff0c\u4ee5\u53ca\u4e0e\u56fd\u9645\u5148\u8fdb\u6807\u51c6\u9010\u6b65\u63a5\u8f68\u7684\u8fc7\u7a0b\u3002<\/span><\/p>\n

\u5728\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u5178\u300b2015 \u5e74\u7248\u4fee\u8ba2\u7684\u6307\u5bfc\u539f\u5219\u4e2d\uff0c\u8fd8\u660e\u786e\u4e86\u5bf9\u53c2\u6bd4\u836f\u54c1\u3001\u53d7\u8bd5\u836f\u54c1\u4ee5\u53ca\u8bd5\u9a8c\u836f\u54c1\u5305\u88c5\u7684\u89c4\u5b9a; \u5bf9\u53d7\u8bd5\u8005\u548c\u8bd5\u9a8c\u6807\u51c6\u5316\u4e5f\u6709\u65b0\u7684\u89c4\u5b9a; \u5bf9\u4ee3\u8c22\u7269\u3001\u5bf9\u6620\u5f02\u6784\u4f53\u3001\u5185\u6e90\u6027\u7269\u8d28BE\u8bd5\u9a8c\u4e5f\u6709\u5177\u4f53\u89c4\u5b9a\u3002<\/p>\n

\u6b64\u5916\uff0c\u89c4\u5b9a\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6bcf\u5468\u671f\u91c7\u6837\u4e00\u822c\u4e0d\u8d85\u8fc772 h\u3002\u6b64\u6b21\u4fee\u8ba2\u8fd8\u5f15\u5165\u4e86\u5bf9\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u7684\u89c4\u5b9a\u3001\u5bf9\u9ad8\u53d8\u5f02\u836f\u7269\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u7684\u89c4\u5b9a\u3001\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u76f8\u5173\u7684\u4f53\u5916\u6eb6\u51fa\u5ea6\u68c0\u67e5\u4ee5\u53ca\u57fa\u4e8e\u836f\u5242\u5b66\u5206\u7c7b\u7cfb\u7edf\u7684\u751f\u7269\u8c41\u514d\u6982\u5ff5\u3002<\/p>\n

\n
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2<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n
\n

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\u5728\u5236\u5242\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u4e2d\uff0c\u53d1\u73b0\u7684\u95ee\u9898\u6709\uff1a<\/span>
<\/p>\n

\n
\n
\n
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\u2460 \u836f\u7269\u5236\u5242\u4f53\u5916\u4e00\u81f4\u6027\u8bc4\u4ef7\u4e0d\u5145\u5206\uff0c\u5f88\u591a\u836f\u5382\u5728\u5f00\u5c55\u4f53\u5185BE \u8bd5\u9a8c\u524d\u672a\u8fdb\u884c\u7cfb\u7edf\u7684\u6eb6\u51fa\u5ea6\u8bd5\u9a8c\u8003\u5bdf\uff0cBE \u8bd5\u9a8c\u5931\u8d25\u540e\uff0c\u518d\u8fdb\u884c\u4f53\u5916\u6eb6\u51fa\u5ea6\u7684\u6bd4\u8f83\u8bd5\u9a8c\u5bfb\u627e\u539f\u56e0\u3002<\/p>\n

\u2461 \u7531\u4e8e\u53d7\u8bd5\u8005\u4f8b\u6570\u4e0d\u591f\u5bfc\u81f4\u65e0\u6cd5\u5224\u65ad\u5236\u5242\u662f\u5426\u7b49\u6548\uff0c\u6709\u4e9b\u836f\u5382\u65e0\u6cd5\u63a5\u53d7\u7531\u4e8e\u53d7\u8bd5\u8005\u4f8b\u6570\u589e\u52a0\u6240\u5e26\u6765\u7684\u652f\u51fa\u3002<\/p>\n

\u2462 \u53c2\u6bd4\u5236\u5242\u9009\u62e9\u7684\u56f0\u96be\uff0c\u6709\u4e9b\u539f\u7814\u836f\u54c1\u867d\u7136\u83b7\u5f97\u4e86\u8fdb\u53e3\u8bb8\u53ef\uff0c\u4f46\u65e0\u6cd5\u5728\u5e02\u573a\u4e70\u5230\u3002<\/p>\n

\u5bf9\u4e8e\u95ee\u9898\u2460\uff0c\u5efa\u8bae\u91c7\u7528\u591a\u6761\u6eb6\u51fa\u66f2\u7ebf\u8fdb\u884c\u53d7\u8bd5\u5236\u5242\u548c\u53c2\u6bd4\u5236\u5242\u4e00\u81f4\u6027\u8bc4\u4ef7\uff0c\u4f53\u5916\u6eb6\u51fa\u5ea6\u8bd5\u9a8c\u6bd4\u8f83\u5f97\u8d8a\u5145\u5206\uff0c\u5c31\u8d8a\u80fd\u53d1\u73b0\u95ee\u9898\uff0c\u53ca\u65e9\u6539\u8fdb\u3002<\/span><\/p>\n

\u5bf9\u4e8e\u95ee\u9898\u2461\uff0c\u53ef\u4ee5\u53c2\u8003\u672c\u6587\u524d\u9762\u53d9\u8ff0\u7684\u6bd4\u4f8b\u6807\u5316\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u964d\u4f4e\u53d7\u8bd5\u8005\u4f8b\u6570\u3002<\/span><\/p>\n

\u5bf9\u4e8e\u95ee\u9898\u2462\uff0c\u5efa\u8bae\u7814\u53d1\u4eba\u5458\u548c\u7533\u529e\u65b9\u5e94\u53ca\u65f6\u4e86\u89e3\u56fd\u5185\u5916\u7814\u7a76\u52a8\u6001\uff0c\u5c3d\u53ef\u80fd\u591a\u4e0e\u76f8\u5173\u7ba1\u7406\u90e8\u95e8\u548c\u836f\u7269\u5ba1\u8bc4\u90e8\u95e8\u7684\u4e13\u5bb6\u6c9f\u901a\uff0c\u6539\u8fdb\u56fd\u5185\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u7684\u8d28\u91cf\uff0c\u8fdb\u800c\u63d0\u9ad8\u56fd\u5185\u4eff\u5236\u836f\u7684\u7814\u53d1\u6c34\u5e73\u3002<\/span><\/p>\n

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\u5c55\u671b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6211\u4eec\u8981\u7ee7\u7eed\u5173\u6ce8\u56fd\u9645\u4e0a\u5236\u5242\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u548c\u6cd5\u89c4\u7684\u65b0\u8fdb\u5c55\uff0c\u501f\u9274\u53d1\u8fbe\u56fd\u5bb6\u7684\u7ecf\u9a8c\uff0c\u4e3a\u786e\u4fdd\u4eff\u5236\u836f\u54c1\u7684\u5b89\u5168\u3001\u6709\u6548\u548c\u8d28\u91cf\u53ef\u63a7\u800c\u4e0d\u65ad\u52aa\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6765\u6e90<\/strong><\/p>\n

<\/span> <\/section>\n

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<\/p>\n

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\u8bf7\u590d\u5236\u4ee5\u4e0b\u94fe\u63a5\uff0c\u4e0b\u8f7dPDF\u539f\u6587
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https:\/\/pan.baidu.com\/s\/1cxh8qM<\/p>\n<\/section>\n<\/section>\n


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