{"id":91667,"date":"2019-05-17T00:00:50","date_gmt":"2019-05-17T06:58:32","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/91667\/"},"modified":"2019-05-17T14:58:35","modified_gmt":"2019-05-17T06:58:35","slug":"364764dd0d","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/91667\/","title":{"rendered":"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><br  \/><\/p>\n<p><img class=\"\"         style=\"text-align: center;width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558076313.png\" alt=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\" title=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\"  \/><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-indent: 28px;text-align: center;line-height: 25.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"text-align: center;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<span style=\"color: rgb(217, 33, 66);\"><strong>\uff08\u4e00\uff09\u5f15&nbsp;&nbsp;\u8a00&nbsp;<\/strong><\/span><strong>&nbsp;&nbsp;<\/strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"text-align: center;\">&nbsp;<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u897f\u683c\u5217\u6c40\u662f\u8fd1\u5e74\u6765\u6700\u6210\u529f\u7684\u5c0f\u5206\u5b50\u836f\u7269\u4e4b\u4e00\uff0c\u6839\u636eIMS\u6570\u636e\uff0c\u897f\u683c\u5217\u6c40\u53ca\u5176\u590d\u65b9\u5236\u5242\u57282017\u5e74\u7684\u9500\u552e\u989d\u8fbe\u523098.75\u4ebf\u7f8e\u5143\uff0c\u5360\u5168\u7403DPP-4\u6291\u5236\u5242\u5e02\u573a\u768461%\u3002\u622a\u6b62\u76ee\u524d\uff0c<\/span><span style=\"font-size: 16px;color: rgb(0, 128, 255);\">Januvia\/Janumet\u7684\u7d2f\u79ef\u9500\u552e\u989d\u5df2\u7ecf\u8fbe\u5230590\u4ebf\u7f8e\u5143<\/span><span style=\"font-size: 16px;\">\uff0c\u4e0d\u4ec5\u5982\u6b64\uff0c\u8be5\u4ea7\u54c1\u7684<\/span><span style=\"font-size: 16px;color: rgb(0, 128, 255);\">\u5316\u5408\u7269\u4e13\u52292022\u5e74\u624d\u5230\u671f\uff08CN1861077\uff09<\/span><span style=\"font-size: 16px;\">\uff0c\u78f7\u9178\u76d0\u6c34\u5408\u7269\u4e13\u5229\u548c\u6676\u578b\u4e13\u5229\u89812024\u5e74\u624d\u5230\u671f\uff0c\u6545Januvia\u7684\u751f\u547d\u5468\u671f\u8fd8\u67094-6\u5e74\uff0cJanumet\u7684\u751f\u547d\u5468\u671f\u8fd8\u67096-8\u5e74\uff0c\u897f\u683c\u5217\u6c40\u6700\u7ec8\u6709\u671b\u4e3a\u9ed8\u6c99\u4e1c\u7f14\u9020\u8fd11000\u4ebf\u7f8e\u5143\u7684\u9500\u552e\u6536\u5165\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u897f\u683c\u5217\u6c40\u4e4b\u6240\u4ee5\u80fd\u591f\u8fd9\u4e48\u6210\u529f\uff0c\u4e00\u65b9\u9762\u662f\u7597\u6548\u548c\u4e0d\u826f\u53cd\u5e94\u65b9\u9762\u7684\u4f18\u52bf\uff0c\u53e6\u4e00\u65b9\u9762\u662f\u9ed8\u6c99\u4e1c\u6210\u529f\u7684\u5f00\u53d1\u7b56\u7565\u3002\u8bfa\u534e\u7684\u7ef4\u683c\u5217\u6c40\u65e9\u57281999\u5e74\u5c31\u7533\u8bf7\u5316\u5408\u7269\u4e13\u5229\u4e86\uff0c\u800c\u9ed8\u6c99\u4e1c2000\u5e74\u624d\u7ec4\u5efa\u4e13\u4e1a\u56e2\u961f\uff0c2002\u5e74\u624d\u7533\u8bf7\u5316\u5408\u7269\u4e13\u5229\u3002\u4f46\u5947\u8ff9\u7684\u662f\uff0cDPP-4\u9776\u70b9\u7684First in class\u4e0d\u662f\u8bfa\u534e\u7684\u7ef4\u683c\u5217\u6c40\uff0c\u800c\u662f\u9ed8\u6c99\u4e1c\u665a\u51fa\u90533\u5e74\u7684\u897f\u683c\u5217\u6c40\u30022006\u5e74\uff0c\u9ed8\u6c99\u4e1c\u7684\u897f\u683c\u5217\u6c40\u83b7\u5f97FDA\u6279\u51c6\uff0c\u4ece\u7533\u8bf7\u5316\u5408\u7269\u4e13\u5229\u5230\u4e0a\u5e02\u4ec5\u4ec5\u7528\u4e864\u5e74\u65f6\u95f4\uff0c\u5176\u7814\u53d1\u6548\u7387\u4e4b\u9ad8\u4e0d\u5f97\u4e0d\u4ee4\u4eba\u6df1\u601d\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u9664\u6b64\u4ee5\u5916\uff0c\u5728\u897f\u683c\u5217\u6c40\u4e0a\u5e02\u4e4b\u540e\uff0c\u9ed8\u6c99\u4e1c\u53c8\u76f8\u7ee7\u63a8\u51fa\u4e86\u897f\u683c\u5217\u6c40\u4e8c\u7532\u53cc\u80cd\u7247Janumet\uff0c\u897f\u683c\u5217\u6c40\u8f9b\u4f10\u4ed6\u6c40\u7247Juvisync\uff0c\u897f\u683c\u5217\u6c40\u4e8c\u7532\u53cc\u80cd\u7f13\u91ca\u7247Janumet XL\uff0c\u897f\u683c\u5217\u6c40\u57c3\u683c\u5217\u51c0\u7247Steglujan\uff0c\u5e76\u901a\u8fc7\u8fd9\u4e00\u7cfb\u5217\u4ea7\u54c1\u6253\u9020\u4e86\u5168\u9762\u7684\u7cd6\u5c3f\u75c5\u4ea7\u54c1\u7ebf\uff0c\u5e76\u5f62\u6210\u4e86\u5b8c\u6574\u7684\u4e13\u5229\u5bb6\u65cf\uff0c\u4e0d\u4f46\u5730\u5ef6\u957f\u897f\u683c\u5217\u6c40\u7684\u751f\u547d\u5468\u671f\uff0c\u5b9e\u73b0\u7ecf\u6d4e\u6548\u76ca\u7684\u6700\u5927\u5316\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u201c\u5916\u884c\u770b\u70ed\u95f9\uff0c\u5185\u884c\u770b\u95e8\u9053\u201d\uff0c\u897f\u683c\u5217\u6c40\u4f5c\u4e3a\u8fd1\u5e74\u6765\u521b\u65b0\u836f\u7684\u6210\u529f\u5178\u8303\uff0c\u63a2\u8ba8\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u8fc7\u7a0b\uff0c\u53ef\u4ee5\u4e3a\u6211\u4eec\u4ee5\u540e\u7684\u5de5\u4f5c\u5e26\u6765\u6216\u591a\u6216\u5c11\u7684\u542f\u793a\u3002\u672c\u6587\u65e8\u5728\u629b\u7816\u5f15\u7389\uff0c\u4e0d\u8db3\u4e4b\u5904\uff0c\u656c\u8bf7\u5e7f\u5927\u8bfb\u8005\u6307\u51fa\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.75em;text-indent: 0em;\"><span style=\"color: rgb(217, 33, 66);font-size: 17px;\"><strong>\uff08\u4e8c\uff09\u80a0\u4fc3\u80f0\u7d20\u53ca\u897f\u683c\u5217\u6c40\u7684\u53d1\u73b0\u57fa\u7840<\/strong><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.75em;text-indent: 0em;\"><span style=\"font-size: 16px;\">&nbsp;&nbsp;&nbsp;&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u65e9\u57281906\u5e74\uff0c\u79d1\u5b66\u5bb6\u4eec\u5c31\u53d1\u73b0\u7cd6\u5c3f\u75c5\u60a3\u8005\u5341\u4e8c\u6307\u80a0\u7c98\u819c\u63d0\u53d6\u7269\u80fd\u591f\u8d77\u5230\u964d\u7cd6\u4f5c\u7528\u3002\u5f53\u65f6\u67093\u540d\u60a3\u8005\u53c2\u4e0e\u6cbb\u7597\uff0c\u5176\u4e2d2\u540d\u8f83\u5e74\u8f7b\uff0c\u4f46\u6700\u7ec8\u964d\u7cd6\u7684\u6548\u679c\u8ba9\u5927\u5bb6\u4e3a\u4e4b\u5174\u594b\uff0c\u53d7\u5230\u5f88\u5927\u7684\u9f13\u821e\u3002\u4f46\u9650\u4e8e\u75c5\u4f8b\uff0c\u53ea\u6709\u8fdb\u4e00\u6b65\u89c2\u5bdf\u624d\u80fd\u5f97\u51fa\u7ed3\u8bba\u3002\u5728\u90a3\u65f6\uff0c<\/span><span style=\"font-size: 16px;color: rgb(0, 128, 255);\">\u9996\u6b21\u63d0\u51fa\u4e86\u80a0\u5185\u56e0\u5b50\u5177\u6709\u6297\u7cd6\u5c3f\u75c5\u80fd\u529b\u7684\u5047\u8bf4<\/span><span style=\"font-size: 16px;\">\uff08\u56fe1\uff09\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 100%;visibility: visible !important;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558076313.jpg\" alt=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\" title=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\">\u56fe1\uff1a\u80a0\u5185\u56e0\u5b50\u5177\u6709\u6297\u7cd6\u5c3f\u75c5\u80fd\u529b\u7684\u5047\u8bf4<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">20\u591a\u5e74\u540e\u76841929\u5e74\uff0cZnnz\u7b49\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0c\u80a0\u7c98\u819c\u91ca\u653e\u7684\u4f53\u6db2\u53ef\u4ee5\u964d\u4f4e\u8840\u6d46\u8461\u8404\u7cd6\u7684\u6d53\u5ea6\u3002\u5e76\u4f7f\u7528\u201cincretin\u201d\uff08\u80a0\u4fc3\u80f0\u7d20\uff09\u6765\u547d\u540d\u8fd9\u7c7b\u5177\u6709\u964d\u7cd6\u4f5c\u7528\u7684\u80a0\u884d\u751f\u56e0\u5b50\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">1932\u5e74\uff0cLa&nbsp;Barre\u7b49\u5728\u7814\u7a76\u4e2d\u53d1\u73b0\uff0c\u5f53\u8fbe\u5230\u76f8\u540c\u8840\u7cd6\u6c34\u5e73\u65f6\uff0c\u53e3\u670d\u8461\u8404\u7cd6\u76f8\u6bd4\u9759\u8109\u6ce8\u5c04\u8461\u8404\u7cd6\u80fd\u523a\u6fc0\u66f4\u591a\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc\u3002\u7531\u6b64\uff0c\u4eba\u4eec\u53d1\u73b0\u4e86\u4eba\u4f53\u81ea\u7136\u5206\u6ccc\u7684\u80a0\u4fc3\u80f0\u7d20\u662f\u6444\u98df\u540e\u7531\u5c0f\u80a0\u5185\u5206\u6ccc\u7ec6\u80de\u53cd\u5e94\u6027\u5206\u6ccc\u7684\u6fc0\u7d20\uff0c\u901a\u8fc7\u523a\u6fc0\u80f0\u5c9b\u03b2\u7ec6\u80de\u5206\u6ccc\u80f0\u5c9b\u7d20\u6765\u964d\u4f4e\u8840\u7cd6\u3002\u6240\u4ee5\uff0c\u6211\u4eec\u53ef\u4ee5\u628a\u80a0\u4fc3\u80f0\u7d20\u770b\u4f5c\u662f\u4e00\u79cd\u6e90\u81ea\u4eba\u4f53\u81ea\u8eab\u7684\u8840\u7cd6\u8c03\u8282\u5668\uff0c\u53ea\u6709\u5728\u8840\u7cd6\u5347\u9ad8\u65f6\uff0c\u5b83\u624d\u4f1a\u523a\u6fc0\u80f0\u5c9b\u7d20\u5206\u6ccc\uff0c\u5c5e\u4e8e\u4e00\u79cd\u81ea\u7136\u7684\u3001\u5185\u6e90\u6027\u7684\u3001\u7b26\u5408\u751f\u7406\u673a\u5236\u7684\u964d\u7cd6\u673a\u5236\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">1964\u5e74\uff0cElrick\u7b49\u4eba\u53d1\u73b0\uff0c\u5728\u76f8\u540c\u8461\u8404\u7cd6\u91cf\u7684\u60c5\u51b5\u4e0b\uff0c\u968f\u7740\u53e3\u670d\u8461\u8404\u7cd6\u7684\u589e\u52a0\uff0c\u8840\u6d46\u80f0\u5c9b\u7d20\u7684\u589e\u52a0\u8d8a\u5927\u3001\u6301\u7eed\u65f6\u95f4\u8d8a\u957f\uff0c\u53e3\u670d\u523a\u6fc0\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc\u660e\u663e\u9ad8\u4e8e\u9759\u8109\u6ce8\u5c04\u6240\u5f15\u8d77\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc\u3002<\/span><span style=\"font-size: 16px;color: rgb(0, 128, 255);\">\u8fd9\u88ab\u89e3\u91ca\u4e3a\u80f0\u5c9b\u7d20\u5206\u6ccc\u53d7\u5230\u989d\u5916\u523a\u6fc0\u7684\u8bc1\u636e\uff0c\u53ef\u80fd\u662f\u7531\u6d88\u5316\u9053\u8461\u8404\u7cd6\u89e6\u53d1\u7684\u80c3\u80a0\u9053\u6216\u809d\u810f\u56e0\u5b50\uff0c\u5e76\u79f0\u6b64\u73b0\u8c61\u4e3a\u201c\u80a0\u4fc3\u80f0\u7d20\u6548\u5e94\u201d<\/span><span style=\"font-size: 16px;\">\uff08\u56fe2\uff09\u3002&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 100%;visibility: visible !important;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558076313.jpg\" alt=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\" title=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\">\u56fe2\uff1a\u201c\u80a0\u4fc3\u80f0\u7d20\u6548\u5e94\u201d\u7684\u7814\u7a76\u6587\u732e<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u5230\u4e86\u4e0a\u4e16\u7eaa80\u5e74\u4ee3\u521d\uff0c\u968f\u7740\u79d1\u6280\u7684\u53d1\u5c55\uff0cPerley\u7b49\u4eba\u8fdb\u4e00\u6b65\u7814\u7a76\u8bc1\u5b9e\uff0c\u5c0f\u80a0\u5185\u5206\u6ccc\u7ec6\u80de\u4ea7\u751f\u7684\u4e00\u79cd\u6fc0\u7d20\u53ef\u8c03\u8282\u80f0\u5c9b\u5bf9\u8fdb\u9910\u7684\u53cd\u5e94\uff0c\u8be5\u6fc0\u7d20\u5728\u9910\u540e\u4f1a\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u7684\u9002\u91cf\u5206\u6ccc\uff0c\u9910\u540e\u80f0\u5c9b\u7d20\u603b\u91cf\u768460%\u662f\u5728\u5176\u4f5c\u7528\u4e0b\u5206\u6ccc\u7684\uff0c\u56e0\u800c\u547d\u540d\u5176\u4e3a\u201c<\/span><span style=\"font-size: 16px;color: rgb(0, 128, 255);\">\u80a0\u4fc3\u80f0\u7d20\uff08Incretin\uff09<\/span><span style=\"font-size: 16px;\">\u201d\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u7d27\u968f\u5176\u540e\u76841986\u5e74\uff0cNauck\u7b49\u4eba\u53d1\u73b0II\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u80a0\u4fc3\u80f0\u7d20\u4f5c\u7528\u51cf\u9000\uff0c\u63d0\u51fa\u4e86<\/span><span style=\"font-size: 16px;color: rgb(0, 128, 255);\">\u80a0\u4fc3\u80f0\u7d20\u7cfb\u7edf\u5f02\u5e38\u53ef\u80fd\u662fII\u578b\u7cd6\u5c3f\u75c5\u7684\u53d1\u75c5\u673a\u5236\u4e4b\u4e00<\/span><span style=\"font-size: 16px;\">\u3002\u80a0\u4fc3\u80f0\u7d20\u662f\u4e00\u7c7b\u80a0\u6e90\u6027\u6fc0\u7d20\uff0c\u5305\u62ec\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\u4fc3\u80f0\u5c9b\u7d20\u591a\u80bd\uff08GIP\uff09\u548c\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1(GLP-1\uff09\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u7ecf\u8fc7\u4e86\u5feb1\u4e2a\u4e16\u7eaa\uff0c\u4e00\u4ee3\u53c8\u4e00\u4ee3\u7684\u79d1\u5b66\u5bb6\u52aa\u529b\u5730\u5bfb\u627e\u90a3\u4e2a\u672a\u77e5\u7684\u53d1\u75c5\u673a\u5236\uff0c\u603b\u7b97\u6709\u4e86\u4e00\u4e9b\u5b9e\u9645\u5e94\u7528\u3002\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u6301\u7eed\u8f93\u6ce8GLP-1\uff0c\u7ed3\u679c\u559c\u4eba\uff0c\u53ef\u663e\u8457\u6539\u5584II\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840\u7cd6\u3002\u4f46\u79d1\u5b66\u7684\u9053\u8def\u603b\u662f\u5145\u6ee1\u7740\u5404\u79cd\u8346\u68d8\uff0c\u4ed6\u4eec\u53d1\u73b0GLP-1\u5728\u4f53\u5185\u7684\u534a\u8870\u671f\u5f88\u77ed\uff0c\u53ea\u6709\u4e0d\u52302\u5206\u949f\uff0c\u6781\u5927\u7684\u9650\u5236\u4e86\u4e34\u5e8a\u7684\u5b9e\u9645\u5e94\u7528\u3002\u540e\u6765\u53d1\u73b0\uff0cGLP-1\u5728\u4f53\u5185\u5931\u6d3b\u7684\u6839\u672c\u662fDPP-4\u7684\u9176\u53ef\u5c06GLP-1\u80bd\u94fe\u65ad\u88c2\u4f7f\u5176\u5931\u6d3b\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 100%;visibility: visible !important;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558076313.jpg\" alt=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\" title=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\">\u56fe3\uff1aDDP\u6291\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u5bf9\u6b64\uff0c\u7814\u7a76\u8005\u4eec\u63d0\u51fa\u4e86\u4e24\u79cd\u7b56\u7565\uff1a<\/span><span style=\"font-size: 16px;color: rgb(0, 128, 255);\">\u5408\u6210\u957f\u6548GLP-1\u7c7b\u4f3c\u7269\u4ee5\u589e\u52a0GLP-1\u6d3b\u6027\uff1b\u6216\u6291\u5236DPP-4\u4f5c\u7528\u4ee5\u963b\u6b62\u5176\u5bf9\u5185\u6e90\u6027GLP-1\u548cGIP\u7684\u706d\u6d3b\u6548\u5e94<\/span><span style=\"font-size: 16px;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(217, 33, 66);font-size: 17px;\"><strong>\uff08\u4e09\uff09\u3001\u897f\u683c\u5217\u6c40\u7684\u836f\u7269\u7279\u6027\u53ca\u836f\u7269\u5316\u5b66\u8fc7\u7a0b&nbsp;&nbsp;<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 16px;color: rgb(255, 76, 0);\">\u56e2\u961f\u6210\u7acb\u4e0e\u7814\u53d1\u7b56\u7565\uff1a<\/span><\/strong><span style=\"font-size: 16px;\">2000\u5e74\u5143\u65e6\u524d\u540e\uff0c\u4e3a\u4e86\u52a0\u5febDPP-4\u6291\u5236\u5242\u5728\u7814\u53d1\uff0c\u9ed8\u6c99\u4e1c\u5728\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u9ed8\u514b\u7814\u7a76\u5b9e\u9a8c\u5ba4\u7ec4\u6210\u4e86\u76f8\u5f53\u89c4\u6a21\u7684\u591a\u5b66\u79d1\u7efc\u5408\u6027\u7814\u53d1\u56e2\u961f\u3002\u8d77\u59cb\uff0c\u5316\u5b66\u5bb6\u4eec\u901a\u8fc7\u4e24\u79cd\u4e0d\u540c\u9014\u5f84\u5bfb\u627e\u76ee\u6807\u5316\u5408\u7269\uff1a\uff081\uff09\u3001\u5bf9\u5df2\u53d1\u8868\u7684DPP-4\u6291\u5236\u5242\u5316\u5b66\u7269\u6587\u732e\u548c\u7ed3\u6784\u8fdb\u884c\u5206\u6790\uff1b\uff082\uff09\u3001\u5bf9\u9ed8\u6c99\u4e1c\u73b0\u6709\u5316\u5408\u7269\u5e93\u8fdb\u884c\u9ad8\u901a\u91cf\u7b5b\u9009\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u5f53\u65f6\uff0c\u5df2\u6709\u6587\u732e\u62a5\u9053\u7684DDP-4\u6291\u5236\u5242\u5316\u5408\u7269\u6709\uff1a\u2460\u3001NVP-728\uff1b\u2461\u3001LAF237\uff1b\u2462\u3001(S)-isoleucine thiazolidide\uff1b\u2463\u3001(S)-cyclohexylglycine pyrrolidide\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 16px;\">&nbsp;&nbsp;&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 100%;visibility: visible !important;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558076313.jpg\" alt=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\" title=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\">&nbsp;\u56fe4\uff1a\u5f00\u53d1\u521d\u671f\u5df2\u62a5\u9053\u7684DDP-4\u6291\u5236\u5242\u76f8\u5173\u5316\u5408\u7269<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 16px;color: rgb(255, 76, 0);\">\u6539\u9020\u521d\u59cb\u7684\u78b0\u58c1\uff1a<\/span><\/strong><span style=\"font-size: 16px;\">NVP-728\u548cLAF237\u5bf9DPP-4\u90fd\u6709\u5f88\u597d\u7684\u6291\u5236\u4f5c\u7528\uff0c\u53ef\u80fd\u662f\u7531\u4e8eDPP-4\u6d3b\u6027\u4f4d\u70b9\u5904\u7684\u4e1d\u6c28\u9178\u6b8b\u57fa\u4e0eNVP-728\u548cLAF237\u4e2d\u6c30\u57fa\u5f62\u6210\u5171\u4ef7\u952e\uff0c\u4f46\u5176\u5bf9DPP-7\u3001DPP-8\u548cDPP-9\u7684\u76f8\u5173\u9176\u7684\u9009\u62e9\u6027\u4e0d\u9ad8\uff0c\u4f1a\u5f15\u53d1\u5927\u9f20\u3001\u72d7\u7684\u813e\u810f\u548c\u80c3\u80a0\u9053\u7b49\u591a\u5668\u5b98\u6bd2\u6027\uff0c\u51cf\u5f31T\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u5f71\u54cd\u673a\u4f53\u514d\u75ab\u529f\u80fd\u3002\u5f53\u5206\u5b50\u7ed3\u6784\u4e2d\u7f3a\u5c11\u6c30\u57fa\uff0c\u5176\u7a33\u5b9a\u6027\u4f1a\u589e\u52a0\uff0c\u800c\u5bf9DPP-4\u7684\u6291\u5236\u4f5c\u7528\u4f1a\u6709\u6240\u964d\u4f4e\u3002\u6700\u540e\uff0c\u7814\u7a76\u4eba\u5458\u51b3\u5b9a\u5bf9(S)-cyclohexylglycine pyrrolidide\u7684\u7ed3\u6784\u8fdb\u884c\u6539\u9020\uff0c\u5728\u73af\u5df1\u70f7\u76844\u4f4d\u5f15\u5165\u6c28\u57fa\u548c\u5c06\u5421\u54af\u73af3\u4f4d\u78b3\u539f\u5b50\u66ff\u6362\u6210\u6742\u539f\u5b50\uff0c\u901a\u8fc7\u6d3b\u6027\u68c0\u6d4b\uff0c\u6700\u7ec8\u7684\u5316\u5408\u7269\u5bf9DPP-4\u6709\u5f88\u597d\u7684\u6291\u5236\u4f5c\u7528\u3002\u4f46\u7814\u7a76\u4eba\u5458\u5e76\u672a\u6b62\u6b65\u4e8e\u6b64\uff0c\u800c\u662f\u9f50\u5934\u5e76\u8fdb\u5f00\u5c55\u9ad8\u901a\u91cf\u7b5b\u9009\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 16px;color: rgb(255, 76, 0);\">\u9ad8\u901a\u91cf\u7b5b\u9009\u9f50\u5934\u5e76\u8fdb\uff1a<\/span><\/strong><span style=\"font-size: 16px;\">\u9664\u4e86\u5bf9\u6587\u732e\u8fdb\u884c\u5206\u6790\u4ee5\u53ca\u7ed3\u6784\u6539\u9020\uff0c\u9ed8\u514b\u56e2\u961f\u52a0\u5feb\u6b65\u4f10\u7b5b\u9009\u4e8680\u4f59\u4e07\u79cd\u5316\u5408\u7269\uff0c\u901a\u8fc7\u5408\u6210\u6539\u901a\u8fc7\u5408\u6210\u6539\u826f2000\u591a\u4e2a\u5316\u5408\u7269\uff0c\u6700\u7ec8\u786e\u5b9a\u4e86\u4e24\u4e2a\u5316\u5408\u7269\uff0c\u5982\u4e0b\u56fe\u6240\u793a\u3002\u5176\u4e2d\u4e00\u4e2a\u662f\u5316\u5408\u7269A\uff08\u03b2-\u6c28\u57fa\u9178\u4e0e\u812f\u6c28\u9178\u7684\u9170\u80fa\u7c7b\u884d\u751f\u7269\uff09\uff0c\u53e6\u4e00\u4e2a\u662f\u5316\u5408\u7269B\uff08\u03b2-\u6c28\u57fa\u54cc\u55ea\u7c7b\u884d\u751f\u7269\uff09\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 617px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558076314.jpg\" alt=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\" title=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\">\u56fe5\uff1a\u03b2-\u6c28\u57fa\u9178\u7c7b\u5316\u5408\u7269\u7684\u521d\u59cb\u9762\u8c8c<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;text-align: center;line-height: 25.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;line-height: 19.5px;font-size: 13px;font-family: \u5b8b\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 16px;color: rgb(255, 76, 0);\">\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u5bf9\u03b2-\u6c28\u57fa\u9178\u7c7b\u5316\u5408\u7269\u7684\u6784\u6548\u5173\u7cfb\u7814\u7a76\u53d1\u73b0\uff1a<\/span><\/strong><span style=\"font-size: 16px;\">\u2460\u3001\u03b2-\u6c28\u57fa\u53ca\u5176\u624b\u6027\u78b3\u539f\u5b50\u7684\u6784\u578b\u5bf9\u6d3b\u6027\u662f\u5fc5\u987b\u7684\uff0cR\u578b\u5316\u5408\u7269\u6d3b\u6027\u4f18\u4e8eS\u578b\uff1b\u2461\u30011\u4f4d\u7fb0\u57fa\u662f\u6d3b\u6027\u5fc5\u9700\u57fa\u56e2\uff1b\u2462\u3001\u82ef\u57fa\u662f\u6d3b\u6027\u5fc5\u9700\u57fa\u56e2\uff0c\u82e5\u7528\u82b3\u6742\u73af\u6216\u73af\u70f7\u57fa\u53d6\u4ee3\uff0c\u6d3b\u6027\u4e0b\u964d\uff0c\u591a\u53d6\u4ee3\u4f18\u4e8e\u5355\u53d6\u4ee3\uff1b\u2463\u3001\u567b\u5511\u70f7\u7c7b\u5316\u5408\u7269\u589e\u52a0\u6216\u51cf\u5c11\u82ef\u57fa\u4e0e\u6c28\u57fa\u4e4b\u95f4\u8fde\u63a5\u94fe\u7684\u78b3\u539f\u5b50\u90fd\u4f1a\u4f7f\u6d3b\u6027\u51cf\u4f4e\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 16px;color: rgb(255, 76, 0);\">\u03b2-\u6c28\u57fa\u9178\u4e0e\u812f\u6c28\u9178\u7684\u9170\u80fa\u7c7b\u884d\u751f\u7269\u7684\u6539\u9020\uff1a<\/span><\/strong><span style=\"font-size: 16px;\">\u79d1\u5b66\u5bb6\u4eec\u7ed3\u5408\u6539\u9020\u540e\u7684(S)-cyclohexylglycine pyrrolidide\u6784\u6548\u5173\u7cfb\uff0c\u5bf9\u5316\u5408\u7269A\u7684\u7ed3\u6784\u8fdb\u884c\u4f18\u5316\uff0c\u66ff\u6362\u56db\u6c22\u5421\u54af\u73af\u4e0a\u7684\u53d6\u4ee3\u57fa\uff0c\u6216\u8005\u5c06\u56db\u6c22\u5421\u54af\u73af\u6362\u6210\u567b\u5511\u70f7\uff0c\u786e\u4fdd\u5176\u5bf9DPP-4\u7684\u6291\u5236\u6d3b\u6027\u53d8\u5316\u4e0d\u5927\u3002\u5728\u7814\u7a76\u4e2d\u53d1\u73b0\uff0c\u82b3\u73af\u4e0a\u6709\u6c1f\u539f\u5b50\u65f6\uff0c\u5bf9\u6d3b\u6027\u6709\u6bd4\u8f83\u5927\u7684\u4fc3\u8fdb\u4f5c\u7528\uff0c\u4f46\u5927\u9f20\u4f53\u5185\u836f\u52a8\u5b66\u8868\u73b0\u4e0d\u4f73\uff0c\u6d88\u9664\u7387\u9ad8\uff0c\u534a\u8870\u671f\u77ed\uff0c\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u4f4e\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 16px;color: rgb(255, 76, 0);\">\u03b2-\u6c28\u57fa\u54cc\u55ea\u7c7b\u884d\u751f\u7269\u7684\u6539\u9020\uff1a<\/span><\/strong><span style=\"font-size: 16px;\">\u7531\u6b64\u540c\u65f6\uff0c\u53e6\u4e00\u56e2\u961f\u5bf9\u5316\u5408\u7269B\u7ed3\u6784\u8fdb\u884c\u6539\u9020\u5e76\u8bbe\u8ba1\u4e86\u4e00\u7cfb\u5217\u5316\u5408\u7269\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u54cc\u55ea\u73af2\u4f4d\u5f15\u5165\u67d0\u4e9b\u53d6\u4ee3\u57fa\u56e2\u6709\u5229\u4e8e\u63d0\u9ad8\u5316\u5408\u7269\u6d3b\u6027\uff0c\u5982\u82c4\u57fa\u53d6\u4ee3\u7531\u4e8eH\u3001Me\u30014-\u6c1f\u82ef\u57fa\u53d6\u4ee3\u7684\u5316\u5408\u7269\u3002\u7531\u4e8e\u54cc\u55ea\u73af\u6613\u6c27\u5316\uff0c\u8fd9\u4e9b\u5316\u5408\u7269\u5728\u52a8\u7269\u4f53\u5185\u7684PK\u6570\u636e\u4e0d\u597d\uff0c\u6e05\u9664\u7387\u9ad8\u3001\u534a\u8870\u671f\u77ed\u3001\u53e3\u670d\u5229\u7528\u5ea6\u4f4e\uff0c\u6210\u836f\u6027\u5dee\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u5bf9\u4e0a\u8ff0\u5316\u5408\u7269\u5728\u809d\u5fae\u7c92\u4f53\u9176\u4e2d\u7684\u4ee3\u8c22\u7269\u7814\u7a76\u53d1\u73b0\uff0c\u4e3b\u8981\u7684\u4ee3\u8c22\u4f4d\u70b9\u53d1\u751f\u5728\u54cc\u55ea\u73af\u4e0a\u3002\u4e8e\u662fKim\u7b49\u5bf9\u54cc\u55ea\u73af\u8fdb\u884c\u7ed3\u6784\u4fee\u9970\uff0c\u4ee5\u4e0d\u6613\u6c27\u5316\u7a20\u5408\u6742\u73af\uff08\u4e09\u5511\u5e76\u54cc\u55ea\uff09\u4ee3\u66ff\u54cc\u55ea\u73af\uff0c\u8fd9\u6837\u4e00\u6765\u4e0d\u4ec5\u53ef\u4ee5\u4fdd\u6301\u8f83\u9ad8\u7684\u6d3b\u6027\uff0c\u540c\u65f6\u8fd8\u80fd\u589e\u5f3a\u5176\u4ee3\u8c22\u7a33\u5b9a\u6027\u3002\u7ed3\u679c\u8868\u660e\uff0c\u4e09\u5511\u5e76\u54cc\u55ea\u76843\u4f4d\u5f15\u5165\u4e09\u6c1f\u7532\u57fa\u6d3b\u6027\u6700\u4f73\uff0c\u4e5f\u5c31\u662f\u672c\u6587\u7684\u4e3b\u89d2\uff1a\u897f\u683c\u5217\u6c40\uff08Sitagliptin\uff09\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 100%;visibility: visible !important;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558076314.png\" alt=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\" title=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\"  \/><span style=\"font-size: 14px;\">&nbsp;\u56fe6\uff1a\u78f7\u9178\u897f\u683c\u5217\u6c40\u5316\u5b66\u7ed3\u6784\u5f0f<\/span><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><strong><span style=\"font-size: 17px;color: rgb(217, 33, 66);\">\uff08\u56db\uff09\u897f\u683c\u5217\u6c40\u7684\u4e34\u5e8a\u7814\u7a76<\/span><\/strong><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u5728\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff0c\u9ed8\u6c99\u4e1c\u7684\u79d1\u5b66\u5bb6\u4eec\u53c8\u5927\u80c6\u91c7\u7528\u4e86I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9f50\u5934\u5e76\u8fdb\uff0c\u548c\u591a\u9879\u6ce8\u518c\u7814\u7a76\u540c\u65f6\u5c55\u5f00\u7b56\u7565\uff0c\u4ec5\u75282\u5e74\u53c81\u4e2a\u5b63\u5ea6\u7684\u65f6\u95f4\u8bc1\u5b9e\u53e3\u670d\u5355\u836f\u6216\u4e0e\u4e8c\u7532\u53cc\u80cd\u53ca\u5176\u4ed6\u964d\u7cd6\u836f\u7269\u8054\u7528\u897f\u683c\u5217\u6c40\u5747\u53ef\u663e\u8457\u6539\u5584\u8840\u7cd6\u63a7\u5236\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u6211\u4eec\u719f\u77e5\uff0c\u6539\u5584\u7cd6\u5c3f\u75c5\u73b0\u72b6\u9700\u89e3\u51b3\u4e09\u5927\u96be\u9898\uff1a<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\uff081\uff09\u63d0\u9ad8HbA1c\u8fbe\u6807\u7387\uff0c\u964d\u4f4e\u4f4e\u8840\u7cd6\u98ce\u9669\uff1b<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\uff082\uff09\u4fdd\u62a4\u80f0\u5c9b\u529f\u80fd\uff0c\u5ef6\u7f13\u7cd6\u5c3f\u75c5\u8fdb\u5c55\uff1b<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\uff083\uff09\u63a7\u5236\u7cd6\u5c3f\u75c5\u4e0e\u5fc3\u8840\u7ba1\u76f8\u5173\u7684\u6f5c\u5728\u98ce\u9669\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 16px;color: rgb(255, 76, 0);\">\u63d0\u9ad8HbA1c\u8fbe\u6807\u7387\uff0c\u964d\u4f4e\u4f4e\u8840\u7cd6\u98ce\u9669\uff1a<\/span><\/strong><span style=\"font-size: 16px;\">\u4e34\u5e8a\u5b9e\u9a8c\u5bf9\u897f\u683c\u5217\u6c40\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u5305\u62ec\u5355\u836f\u6cbb\u7597\u548c\u4e0e\u73b0\u6709\u6297\u7cd6\u5c3f\u75c5\u836f\u7269\u8054\u7528\u6cbb\u7597\u3002\u8fd9\u9879\u4e34\u5e8a\u5b9e\u9a8c\u662f\u56db\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u3001\u5bf9\u7167\u5b9e\u9a8c\uff0c\u6d89\u53ca\u5230\u81f3\u5c112000\u540dII\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3002\u8bc4\u4f30\u4e86\u591a\u9879\u8840\u7cd6\u63a7\u5236\u76f8\u5173\u6307\u6807\uff0c\u5305\u62ec\u7cd6\u5316\u8840\u7ea2\u86cb\u767d(HbAIC)\u6c34\u5e73\u7684\u5e73\u5747\u53d8\u5316\uff0c\u8be5\u6307\u6807\u80fd\u53cd\u5e94\u8fc7\u53bb3-4\u6708\u5e73\u5747\u8840\u7cd6\u6c34\u5e73\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u5728\u7528\u4f5c\u5355\u836f\u7597\u6cd5\u65f6\uff0c\u6bcf\u65e5\u5242\u91cf\u4e3a100\u6216200\u6beb\u514b\u5373\u53ef\u663e\u8457\u51cf\u5c11HbAIC\uff0c\u51e0\u4e4e\u6ca1\u6709\u4e0d\u826f\u53cd\u5e94\uff0c\u4e14\u4f4e\u8840\u7cd6\u4e5f\u6ca1\u6709\u663e\u8457\u589e\u52a0\u3002\u5bf9\u4e8e\u6bcf\u65e5\u670d\u7528\u81f3\u5c111500mg\u4e8c\u7532\u53cc\u80cd\uff0c\u4f46\u4ecd\u7136\u65e0\u6cd5\u5b8c\u5168\u63a7\u5236\u8840\u7cd6\uff08\u5e73\u5747HbAIC\u4e3a8%\uff09\u7684\u60a3\u8005\uff0c\u82e5\u6bcf\u5929\u518d\u6dfb\u52a0\u670d\u7528100mg\u897f\u683c\u5217\u6c40\uff0c\u5373\u53ef\u4f7f47%\u7684\u60a3\u8005\u7684HbAIC\u964d\u81f37%\u4e4b\u4e0b\uff1b\u5b89\u6170\u5242\u6cbb\u7597\u5bf9\u7167\u7ec4\u53ea\u670918.3%\u7684\u60a3\u8005\u7684HbAIC\u964d\u4f4e\u4e860.65%\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u572824\u5468\u7684\u7814\u7a76\u4e2d\uff0c\u897f\u683c\u5217\u6c40\u4f5c\u4e3a\u5421\u683c\u5217\u916e\uff08\u6bcf\u65e530\u621645mg\uff09\u7684\u9644\u52a0\u7597\u6cd5\uff0c\u5e76\u672a\u5b8c\u5168\u63a7\u5236\u8840\u7cd6\uff08\u5e73\u5747HbAIC\u7ea68.1%\uff09\u3002\u4e0e\u5355\u7528\u5421\u683c\u5217\u916e\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u897f\u683c\u5217\u6c40\u4e0e\u4f4e\u8840\u7cd6\u6216\u4f53\u91cd\u589e\u52a0\u7684\u53d1\u751f\u7387\u589e\u52a0\u65e0\u5173\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 16px;color: rgb(255, 76, 0);\">\u4fdd\u62a4\u80f0\u5c9b\u529f\u80fd\uff0c\u5ef6\u7f13\u7cd6\u5c3f\u75c5\u8fdb\u5c55\uff1a<\/span><\/strong><span style=\"font-size: 16px;\">II\u578b\u7cd6\u5c3f\u75c5\u8fdb\u5c55\u7684\u4e00\u4e2a\u91cd\u8981\u539f\u56e0\u662f\u80f0\u5c9b\u529f\u80fd\u7684\u8fdb\u884c\u6027\u8870\u9000\uff0c\u4e3b\u8981\u662f\u6307\u80f0\u5c9b\u03b2\u7ec6\u80de\u80f0\u5c9b\u7d20\u5206\u6ccc\u7f3a\u9677\u548c\u03b1\u7ec6\u80de\u80f0\u9ad8\u8840\u7cd6\u7d20\u5206\u6ccc\u8fc7\u9ad8\u6240\u9020\u6210\u7684\u80f0\u5c9b\u7d20\u4e0e\u80f0\u9ad8\u8840\u7cd6\u7d20\u6bd4\u4f8b\u5931\u8c03\u3002Riche\u7b49\u5728\u7814\u7a76\u897f\u683c\u5217\u6c40\u5ef6\u7f13\u7cd6\u5c3f\u75c5\u8fdb\u7a0b\u673a\u5236\u65f6\u53d1\u73b0\uff0c\u897f\u683c\u5217\u6c40\u901a\u8fc7\u5ef6\u7f13\u80f0\u5c9b\u03b2\u7ec6\u80de\u7684\u51cb\u4ea1\u6765\u4e0a\u8c03\u5176\u5728\u80f0\u5c9b\u4e2d\u7684\u6bd4\u4f8b\uff0c\u540c\u65f6\u6291\u5236\u80f0\u5c9b\u03b1\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u53d1\u6325\u53cc\u91cd\u8c03\u63a7\u4f5c\u7528\uff0c\u4ece\u800c\u6709\u6548\u5ef6\u7f13\u7cd6\u5c3f\u75c5\u8fdb\u5c55\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 16px;color: rgb(255, 76, 0);\">\u63a7\u5236\u7cd6\u5c3f\u75c5\u4e0e\u5fc3\u8840\u7ba1\u76f8\u5173\u7684\u6f5c\u5728\u98ce\u9669\uff1a<\/span><\/strong><span style=\"font-size: 16px;\">\u4e3a\u4e86\u786e\u4fddII\u578b\u7cd6\u5c3f\u75c5\u964d\u7cd6\u836f\u7269\u7684\u5b89\u5168\u6027\uff0c\u7f8e\u56fdFDA\u5efa\u8bae\u964d\u7cd6\u836f\u7269\u5bf9\u5fc3\u8840\u7ba1\u98ce\u9669\u7684\u5f71\u54cd\u9700\u8fdb\u884c\u5168\u9762\u8bc4\u4ef7\uff0c\u4ee5\u53ca\u8bc1\u660e\u65b0\u5f00\u53d1\u7684\u964d\u7cd6\u836f\u7269\u4e0d\u4f1a\u5e26\u6765\u4e0d\u53ef\u63a5\u53d7\u7684\u5fc3\u8840\u7ba1\u98ce\u9669\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">FDA\u4e8e2008\u5e74\u51fa\u53f0\u6cd5\u89c4\uff0c\u8981\u6c42\u65b0\u836f\u7533\u62a5\u9700\u63d0\u4f9b\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7814\u7a76\u6570\u636e\u3002\u897f\u683c\u5217\u6c40\u3001\u6c99\u683c\u5217\u6c40\u3001\u963f\u683c\u5217\u6c40\u3001\u5229\u683c\u5217\u6c40\u7b49DPP-4\u6291\u5236\u5242\u636e\u6b64\u5f00\u5c55\u4e86\u76f8\u5e94\u7684\u5fc3\u8840\u7ba1\u7ec8\u70b9\uff08CVOT\uff09\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">2016\u5e743\u6708\uff0cNEJM\u5728\u7ebf\u53d1\u8868\u7684\u4e00\u9879\u8de8\u56fd\u6027\u7814\u7a76\u53d1\u73b0\uff0c\u80a0\u4fc3\u80f0\u7d20\u7c7b\u964d\u7cd6\u836f\uff08\u5305\u62ecDPP-4\u6291\u5236\u5242\u897f\u683c\u5217\u6c40\u3001\u548c\u5229\u683c\u5217\u6c40\uff0c\u4ee5\u53caGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u827e\u585e\u90a3\u80bd\u548c\u5229\u62c9\u9c81\u80bd\uff09\u5e76\u4e0d\u589e\u52a0\u5fc3\u529b\u8870\u7aed\u4f4f\u9662\u98ce\u9669\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 100%;visibility: visible !important;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558076314.jpg\" alt=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\" title=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\">\u56fe8\uff1a\u5728\u57fa\u7ebf\u65e0\u5fc3\u529b\u8870\u7aed\u75c5\u53f2\u7684\u60a3\u8005\u4e2d\uff0c\u80a0\u4fc3\u80f0\u5c9b\u7d20\u7c7b\u836f\u7269\u6cbb\u7597\u4e0e\u5fc3\u529b\u8870\u7aed\u4f4f\u9662\u7387\u589e\u52a0\u65e0\u5173<\/span><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;text-align: center;line-height: 25.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;line-height: 19.5px;font-size: 13px;font-family: \u5b8b\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 608px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558076314.jpg\" alt=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\" title=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\"  \/><span style=\"font-size: 14px;\">\u56fe9\uff1a\u5728\u57fa\u7ebf\u4f34\u5fc3\u529b\u8870\u7aed\u75c5\u53f2\u7684\u60a3\u8005\u4e2d\uff0c\u80a0\u4fc3\u80f0\u5c9b\u7d20\u7c7b\u836f\u7269\u6cbb\u7597\u4e0d\u589e\u52a0\u5fc3\u529b\u8870\u7aed\u4f4f\u9662\u7387<\/span><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><span style=\"font-size: 16px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><span style=\"color: rgb(217, 33, 66);font-size: 17px;\"><strong>\uff08\u4e94\uff09\u7ed3\u675f\u8bed<\/strong><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><span style=\"color: rgb(217, 33, 66);font-size: 17px;\"><strong>&nbsp;&nbsp;&nbsp;&nbsp;<\/strong><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u6839\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\uff08WHO\uff09\u6570\u636e \uff0c\u57282014\u5e74\u5168\u7403\u67094.22\u4ebf\u7cd6\u5c3f\u75c5\u60a3\u8005\uff0c\u8d85\u8fc780%\u7684\u7cd6\u5c3f\u75c5\u6b7b\u4ea1\u53d1\u751f\u5728\u4f4e\u6536\u5165\u548c\u4e2d\u7b49\u6536\u5165\u56fd\u5bb6\uff1b\u52302030\u5e74\uff0c\u7cd6\u5c3f\u75c5\u5c06\u6210\u4e3a\u5168\u7403\u7b2c\u4e03\u5927\u6b7b\u4ea1\u539f\u56e0\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">Januvia\uff08\u6377\u8bfa\u7ef4\uff09\u4f5c\u4e3a\u5168\u7403\u9996\u4e2a\u4e0a\u5e02\u7684DPP-4\u6291\u5236\u5242\uff0c\u80fd\u591f\u6291\u5236\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1(GLP-1)\u548c\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\u4fc3\u80f0\u5c9b\u7d20\u5206\u6ccc\u591a\u80bd(GIP)\u7684\u706d\u6d3b\uff0c\u63d0\u9ad8\u5185\u6e90\u6027GLP-1\u548cGIP\u7684\u6c34\u5e73\uff0c\u4fc3\u8fdb\u80f0\u5c9b\u03b2\u7ec6\u80de\u91ca\u653e\u80f0\u5c9b\u7d20\uff0c\u540c\u65f6\u6291\u5236\u80f0\u5c9b\u03b1\u7ec6\u80de\u5206\u6ccc\u80f0\u9ad8\u8840\u7cd6\u7d20\uff0c\u4ece\u800c\u63d0\u9ad8\u80f0\u5c9b\u7d20\u6c34\u5e73\uff0c\u964d\u4f4e\u8840\u7cd6\uff0c\u4e14\u4e0d\u6613\u8bf1\u53d1\u4f4e\u8840\u7cd6\u548c\u589e\u52a0\u4f53\u91cd\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u81ea2006\u5e74\u4e0a\u5e02\u81f3\u4eca\uff0c\u4e0d\u4ec5\u4e3aMerck\u516c\u53f8\u521b\u4e0b\u4e86\u9ad8\u989d\u7684\u9500\u552e\u989d\uff0c\u57282017\u5e74\u7684\u5168\u7403\u9500\u552e\u989d\u4e3a59\u4ebf\u7f8e\u5143\uff0c\u8f83\u4e0a\u4e00\u5e74\u5ea6\u4e0b\u964d3.43%\uff0c2018\u5e74\u603b\u4f53\u9500\u552e\u989d\u4e0e2017\u5e74\u6301\u5e73\u3002\u51ed\u501f\u4e0a\u5e02\u5341\u591a\u5e74\u7684\u663e\u8457\u4e34\u5e8a\u7597\u6548\uff0c\u897f\u683c\u5217\u6c40\u7ecf\u53d7\u4f4f\u4e86\u5168\u7403\u5e02\u573a\u7684\u8003\u9a8c\uff0c\u8fd8\u5f15\u9886\u4e86\u5927\u6279DPP-4\u6291\u5236\u5242\u4e0a\u5e02\uff0c\u4e5f\u4e3a\u5176\u4ed6DPP-4\u6291\u5236\u5242\u7684\u5f00\u53d1\u63d0\u4f9b\u4e86\u4e00\u4e9b\u7edd\u4f73\u673a\u4f1a\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u65b0\u836f\u53d1\u73b0\u4e4b\u65c5\u662f\u8270\u8f9b\u7684\uff0c\u9ed8\u6c99\u4e1c\u662f\u5e78\u8fd0\u7684\uff0c\u5f88\u5feb\u5c31\u83b7\u5f97\u4e86\u4ed6\u4eec\u60f3\u8981\u7684\u7ed3\u679c\u3002\u4f46\u5e78\u8fd0\u7684\u80cc\u540e\uff0c\u662f\u4ed6\u4eec\u591a\u5c11\u5e74\u7684\u6c89\u6dc0\u548c\u79ef\u7d2f\uff0c\u5374\u65e0\u6cd5\u8ba1\u7b97\u3002\u7814\u53d1\u4ece\u6765\u6ca1\u6709\u4e00\u77ac\u95f4\u7684\u5e78\u8fd0\uff0c\u6240\u8c13\u7684\u5e78\u8fd0\u90fd\u662f\u5e38\u5e74\u7d2f\u6708\u7684\u4ed8\u51fa\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u53c2\u8003\u6587\u732e<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 15px;\">1.&nbsp;Lyseng-Williamson K A. Sitagliptin[J]. Drugs, 2007, 67(4):587-597.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 15px;\">2.&nbsp;On&nbsp;the treatment of diabetes mellitus by acid extract of duodenal mucous membrane.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 15px;\">3.&nbsp;Contributions a letude des variations physiologiques de la seretion interne du pancreas: relations entre les seretions exteme et intene di pancreas.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 15px;\">4.&nbsp;Plasma insulin response to oral and intravenous glucose administration.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 15px;\">5.&nbsp;Riche DM,East HE,Riche KD. Impact of sitagliptin on markers of beta-cell function: a meta-analysis. Am J Med Sci,2009,337(5) : 321-328.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 15px;\">6.&nbsp;Dicker D. DPP-4 Inhibitors Impact on glycemic control and cardiovascular risk factors. Diabetes care, 2011, 34(Supplement 2): S276-S278.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 15px;\">7.&nbsp;\u80a0\u80f0\u5c9b\u7d20\u57282\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 15px;\">8.&nbsp;DDP-4\u6291\u5236\u5242\u6709\u671b\u89e3\u51b32\u578b\u7cd6\u5c3f\u75c5\u4e09\u5927\u96be\u9898.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 15px;\">9.&nbsp;GLP-1\u7c7b\u4f3c\u7269\u53caDPP-4\u6291\u5236\u5242\u56fd\u5185\u4e0a\u5e02\u60c5\u51b5\u5206\u6790.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 15px;\">10.&nbsp;\u4e8c\u80bd\u57fa\u80bd\u9176-4\u6291\u5236\u5242\u6784\u6548\u5173\u7cfb\u7814\u7a76\u8fdb\u5c55.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 15px;\">11.&nbsp;\u76d8\u70b92018\u5e74\u5168\u7403\u6700\u7545\u9500\u768410\u6b3e\u7cd6\u5c3f\u75c5\u836f\u7269.<\/span><\/p>\n<p><br  \/><\/p>\n<h2 class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;font-size: 22px;max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.4;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 20px;color: rgb(255, 127, 170);\"><strong><span style=\"font-size: 20px;max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI5ODI5NDE2OA==&amp;mid=2247501032&amp;idx=2&amp;sn=0f6700af84ae8f3aa7df6da6811b0519&amp;chksm=ecaa8a1fdbdd03098fcf9b33f0777e10097ad6fad009fb8befe41da103c37668ce6e3dac0560&amp;mpshare=1&amp;scene=21&amp;srcid=&amp;pass_ticket=cLD9hndLTIy79YwTwMvVrUKoaWTLWUT4c9doEKGoSYB9fkrx3nGRx585ELIKAu6L#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5f81\u7a3f\u542f\u4e8b<\/a><\/span><\/strong><\/span><\/h2>\n<section style=\"max-width: 677px;box-sizing: border-box;white-space: normal;background-color: rgb(255, 255, 255);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 3px;margin-left: 3px;padding: 20px;max-width: 677px;box-sizing: border-box;background-color: rgb(254, 254, 254);border-color: rgb(210, 150, 20);box-shadow: rgb(210, 150, 20) 0px 0px 4px;overflow-wrap: break-word !important;\">\n<h2 class=\"\" style=\"margin-bottom: 14px;font-size: 22px;max-width: 100%;line-height: 1.4;font-variant-numeric: normal;letter-spacing: 0.544px;text-align: start;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA5NDk0NTc4MQ==&amp;mid=2650426044&amp;idx=1&amp;sn=c87b281bb6b7baade0105eb459c19ba9&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);font-size: 14px;color: rgb(61, 167, 66);box-sizing: border-box !important;overflow-wrap: break-word !important;\">2019\u836f\u7269\u5206\u79bb\u7eaf\u5316\u548c\u7ed3\u6784\u9274\u5b9a\u53ca\u8d4b\u503c\u6df1\u5ea6\u7814\u8ba8\u4f1a &#8211;CMC\u836f\u7269\u8d28\u91cf\u7cfb\u5217\u7814\u8ba8\u4f1a\u4e4b\u4e09<\/span><\/a><\/h2>\n<p style=\"max-width: 631px;box-sizing: border-box;min-height: 18px;color: rgb(210, 150, 20);font-weight: 700;min-width: 1px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0.54px;color: rgb(51, 51, 51);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(214, 168, 65);overflow-wrap: break-word !important;\">\u540c\u5199\u610f\u8bba\u575b\uff1a<\/span><\/strong><\/p>\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 631px;box-sizing: border-box;border-color: rgb(210, 150, 20);overflow-wrap: break-word !important;\">\n<p style=\"margin-bottom: 5px;max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1.<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650628137&amp;idx=1&amp;sn=31a673ec733f84c6eee6873b1fe626c8&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5199\u610f\u5de8\u732e\uff1a\u6df1\u5ea6\u89e3\u6790\u4e2d\u7f8e\u52a0\u5feb\u836f\u54c1\u7814\u53d1\u7684\u5ba1\u8bc4\u5ba1\u6279\u653f\u7b56\uff0891\u671f\u65e5\u7a0b\u66f4\u65b0\uff09<\/span><\/a><\/p>\n<p style=\"margin-bottom: 5px;max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2.<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650627699&amp;idx=1&amp;sn=cb1df4a9fd9b4bb1582c9f94d3520f73&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b2c93\u671f\u8bba\u575b\u4e282019\u4e2d\u7f8e\u533b\u7597\u6295\u8d44\u8bba\u575b\u548c\u8def\u6f14<\/span><\/a><\/p>\n<p style=\"margin-bottom: 5px;max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">3.<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650628250&amp;idx=2&amp;sn=bbf58c464d6eb350985cf5cf6354af1c&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u540c\u5199\u610f\u534f\u529e\u4e282019\u7ec6\u80de\u6cbb\u7597\u4ea7\u4e1a\u53d1\u5c55\u6e56\u5317\u5cf0\u4f1a\uff08free\uff09<\/span><\/a><\/p>\n<p style=\"margin-bottom: 5px;max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">4.<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650628019&amp;idx=1&amp;sn=5dae65d812e02cc8e74e2a352bbba5d6&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;letter-spacing: 0.54px;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b2c94\u671f\u8bba\u575b\u4e28\u4eff\u5236\u836f\u9009\u9898\u7acb\u9879\u2014\u7b56\u7565\u4e0e\u65b9\u6cd5<\/span><\/a><\/p>\n<p style=\"margin-bottom: 5px;max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">5.<span style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650628093&amp;idx=1&amp;sn=ce26e32435f63b4eb8b913c510cfb31f&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b2c95\u671f\u8bba\u575b\u4e28BD\u4e2d\u7ea7\u73ed\uff1a\u521b\u65b0\u53d1\u9879\u76ee\u7684\u7efc\u5408\u8bc4\u4f30<\/a><\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzU2MDY5MzA0OQ==&amp;mid=2247484428&amp;idx=1&amp;sn=d7540b3b4d54422e4996085f2bbc0079&amp;chksm=fc056e5acb72e74cec1843e4eb3f9cf04dcf6ea93b9d8448da418734b13b6440111ca014de9a&amp;token=1732418045&amp;lang=zh_CN&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"max-width: 100%;line-height: 0;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages __bg_gif\"          style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 556px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558076314.gif\" alt=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\" title=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\"  \/><\/span><\/a><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><img class=\"\"        width=\"676.997px\"  style=\"box-sizing: border-box;font-size: 15px;letter-spacing: 0.54px;text-align: center;overflow-wrap: break-word !important;visibility: visible !important;width: 676.997px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558076315.jpg\" alt=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\" title=\"\u897f\u683c\u5217\u6c40\u7684\u7814\u53d1\u6545\u4e8b\uff1a\u8d77\u6b65\u6bd4\u7ef4\u683c\u5217\u6c40\u665a\uff0c\u5374\u5f2f\u9053\u8d85\u8f66\u6210\u4e3aFirst in class\"  \/><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;background-color: rgb(255, 255, 255);letter-spacing: 0.582857px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u7531\u4ee5\u4e0b\u6210\u5458\u7ec4\u6210\uff1aVoyager88\uff0c\u96f7\u8bfa\u5c9b\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0c\u5360\u5c0f\u5175\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cSophia \uff0c\u5076\u9635\u96e8\uff0c\u96f6\u4e0b274\u2103\uff0cHelen\uff0cZMJ\uff0c\u6da6\u513f\uff0c\u7f8a\u7f8a\u3001<span style=\"max-width: 100%;letter-spacing: 0.582857px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Admiral\u3001<\/span>\u4e8c\u53cb\u6728\u3001\u90ed\u5927\u4fa0\u3001\u8d1d\u58f3\u91cc\u7684\u4e7e\u5764\u548c\u66fe\u6587\u4eae\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1437180999\uff0c\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;background-color: rgb(255, 255, 255);letter-spacing: 0.582857px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;background-color: rgb(255, 255, 255);letter-spacing: 0.582857px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8d23\u4efb\u7f16\u8f91\uff1a\u96f7\u8bfa\u5c9b<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;\uff08\u4e00\uff09\u5f15&nbsp;&#038;nb [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":91668,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/91667"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=91667"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/91667\/revisions"}],"predecessor-version":[{"id":91680,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/91667\/revisions\/91680"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/91668"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=91667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=91667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=91667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}