{"id":9182,"date":"2018-06-08T01:00:00","date_gmt":"2018-07-27T09:37:06","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e9%80%9f%e9%80%92-%e4%bb%a5%ce%b2%e7%bb%86%e8%83%9e%e4%b8%ba%e4%b8%ad%e5%bf%83%ef%bc%8c%e7%b3%96%e5%b0%bf%e7%97%85%e6%96%b0%e8%8d%af%e8%8e%b7%e6%89%b9%e8%bf%9b%e5%85%a5%e4%b8%b4%e5%ba%8a\/"},"modified":"2018-07-27T17:37:07","modified_gmt":"2018-07-27T09:37:07","slug":"%e9%80%9f%e9%80%92-%e4%bb%a5%ce%b2%e7%bb%86%e8%83%9e%e4%b8%ba%e4%b8%ad%e5%bf%83%ef%bc%8c%e7%b3%96%e5%b0%bf%e7%97%85%e6%96%b0%e8%8d%af%e8%8e%b7%e6%89%b9%e8%bf%9b%e5%85%a5%e4%b8%b4%e5%ba%8a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9182\/","title":{"rendered":"\u901f\u9012 | \u4ee5\u03b2\u7ec6\u80de\u4e3a\u4e2d\u5fc3\uff0c\u7cd6\u5c3f\u75c5\u65b0\u836f\u83b7\u6279\u8fdb\u5165\u4e34\u5e8a"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n


<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n

\u65e5\u524d\uff0cARKAY Therapeutics\u5ba3\u5e03\u7f8e\u56fdFDA\u63a5\u53d7\u4e86\u5176\u7cd6\u5c3f\u75c5\u65b0\u836fRK-01\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\u3002RK-01\u662f\u4e00\u6b3e \u201cfirst-in-class\u201d \u7684 \u201c\u4ee5\u03b2\u7ec6\u80de\u4e3a\u4e2d\u5fc3\u201d \u7684\u53e3\u670d\u836f\u7269\u7ec4\u5408\uff0c\u7528\u4e8e2\u578b\u7cd6\u5c3f\u75c5\u7684\u6cbb\u7597<\/strong>\u3002\u5b83\u5305\u542b3\u79cd\u6210\u5206\uff0c\u5206\u522b\u662f\u4e8c\u7532\u53cc\u80cd\uff08metformin\uff09\u3001\u7f2c\u6c99\u5766\uff08valsartan\uff09\u548c\u585e\u6765\u6614\u5e03\uff08celecoxib\uff09\u3002\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u5c06\u5728\u65b0\u8bca\u65ad\u521d\u6cbb\u60a3\u8005\uff0c\u53ca\u80a5\u80d6\u4e14\u5355\u7528\u4e8c\u7532\u53cc\u80cd\u65e0\u6cd5\u6709\u6548\u63a7\u5236\u8840\u7cd6\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\uff0c\u8bc4\u4f30RK-01\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u548c\u4e0e\u4e8c\u7532\u53cc\u80cd\u76f8\u6bd4\u7684\u7597\u6548\u3002
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\"\u901f\u9012<\/span><\/p>\n


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2\u578b\u7cd6\u5c3f\u75c5\u662f\u4e00\u79cd\u5168\u7403\u6027\u6d41\u884c\u75c5\uff0c\u591a\u572835-40\u5c81\u4e4b\u540e\u53d1\u75c5\uff0c\u5360\u7cd6\u5c3f\u75c5\u60a3\u800590%\u4ee5\u4e0a\uff0c\u5f71\u54cd\u5168\u74034\u4ebf\u591a\u4eba\u3002\u7cd6\u5c3f\u75c5\u662f\u5bfc\u81f4\u5931\u660e\u3001\u80be\u8870\u7aed\u3001\u5fc3\u810f\u75c5\u53d1\u4f5c\u3001\u4e2d\u98ce\u548c\u4e0b\u80a2\u622a\u80a2\u7684\u4e3b\u8981\u75c5\u56e0\u30022015\u5e74\uff0c\u7531\u7cd6\u5c3f\u75c5\u76f4\u63a5\u9020\u6210\u7684\u6b7b\u4ea1\u6709160\u4e07\u4f8b\u3002\u76ee\u524d\u7684\u6cbb\u7597\u65b9\u6cd5\u4e3b\u8981\u662f\u63a7\u5236\u75c7\u72b6\uff0c\u4f46\u4e0d\u80fd\u7f13\u89e3\u6f5c\u5728\u7684\u590d\u6742\u75c5\u56e0<\/strong>\u3002\u8fd9\u4e00\u9886\u57df\u8fd8\u5b58\u5728\u5de8\u5927\u7684\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u3002<\/span><\/p>\n

 <\/span><\/p>\n

RK-01\u7684\u72ec\u7279\u914d\u65b9\u5c06\u7f2c\u6c99\u5766\u548c\u585e\u6765\u6614\u5e03\u6dfb\u52a0\u5230\u4e8c\u7532\u53cc\u80cd\u4e2d\uff0c\u53ef\u4ee5\u963b\u65ad\u51e0\u79cd\u4e92\u8865\u7684\u708e\u75c7\u548c\u9ad8\u8840\u7cd6\u673a\u5236<\/span><\/strong>\uff0c\u8fd9\u4e9b\u673a\u5236\u5bfc\u81f4\u4e86\u80f0\u5c9b\u03b2\u7ec6\u80de\u529f\u80fd\u7684\u9010\u6b65\u6076\u5316\uff0c\u800c\u8fd9\u6b63\u662f2\u578b\u7cd6\u5c3f\u75c5\u590d\u6742\u75c5\u7406\u751f\u7406\u5b66\u7684\u6838\u5fc3\u3002\u7f2c\u6c99\u5766\u662f\u4e00\u79cd\u8840\u7ba1\u7d27\u5f20\u7d20II\u53d7\u4f531\u578b\u963b\u65ad\u5242\uff0c\u76ee\u524d\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u9ad8\u8840\u538b\uff1b\u585e\u6765\u6614\u5e03\u662f\u4e00\u79cd\u9009\u62e9\u6027\u73af\u6c27\u5408\u9176-2\uff08Cox-2\uff09\u6291\u5236\u5242\uff0c\u76ee\u524d\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5173\u8282\u708e\u3002\u03b2\u7ec6\u80de\u4e2d\u80be\u7d20-\u8840\u7ba1\u7d27\u5f20\u7d20\u7cfb\u7edf\uff08RAS\uff09\u548cCox-2\u7684\u6fc0\u6d3b\u4e0e2\u578b\u7cd6\u5c3f\u75c5\u7684\u590d\u6742\u75c5\u7406\u751f\u7406\u5b66\u76f8\u5173\u3002Cox-2\u884d\u751f\u7684\u4fc3\u708e\u524d\u5217\u817a\u7d20PGE2\u4f1a\u6291\u5236\u6765\u81ea\u03b2\u7ec6\u80de\u7684GLP-1\u6fc0\u52a8\u5242\u4ecb\u5bfc\u7684\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\u80f0\u5c9b\u7d20\u5206\u6ccc\uff08GDIS\uff09\u3002\u76ee\u524d\u4e00\u4e9b\u5e02\u552e\u836f\u7269\u5747\u4e3aGLP-1\u6fc0\u52a8\u5242\uff0c\u4f46\u73b0\u6709\u7597\u6cd5\u91c7\u7528\u7684\u65b9\u5f0f\u65e0\u6cd5\u963b\u65ad\u708e\u75c7\u5bfc\u81f4\u7684\u03b2\u7ec6\u80de\u529f\u80fd\u53d7\u635f\u3002\u800cRK-01\u53ef\u4ee5\u901a\u8fc7\u7ef4\u6301\u6216\u6062\u590d\u03b2\u7ec6\u80de\uff0c\u63d0\u4f9b\u6301\u4e45\u7684\u8840\u7cd6\u63a7\u5236\uff0c\u751a\u81f3\u5ef6\u8fdf\u548c\u9884\u9632\u4f7f\u7528\u80f0\u5c9b\u7d20<\/strong>\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\"\u901f\u9012<\/p>\n

\u25b2<\/span>RK<\/span><\/strong>-01\u7684\u7814\u53d1\u65f6\u95f4\u7ebf\uff08\u56fe\u7247\u6765\u6e90\uff1aARKAY Therapeutics\u5b98\u65b9\u7f51\u7ad9\uff09<\/span><\/strong><\/p>\n

 <\/span>
<\/p>\n

ARKAY\u7684\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98Ravi Kumar\u535a\u58eb\u8bf4\uff1a \u201c\u6b64\u6b21RK-01\u7684IND\u83b7\u6279\u662fARKAY\u7814\u53d1\u53f2\u4e0a\u7684\u4e00\u4e2a\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u6211\u4eec\u671f\u5f85RK-01\u80fd\u9884\u9632\u4e8c\u7532\u53cc\u80cd\u5931\u6548\uff0c\u7ef4\u6301\u80f0\u5c9b\u7d20\u7684\u5145\u8db3\u72b6\u6001\uff0c\u5e76\u964d\u4f4e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u80f0\u5c9b\u7d20\u4f9d\u8d56\u7684\u98ce\u9669\u3002\u6211\u8c28\u4ee3\u8868\u516c\u53f8\u611f\u8c22\u6211\u4eec\u7684\u79d1\u5b66\u987e\u95ee\uff0c\u4ed6\u4eec\u534f\u52a9ARKAY\u572830\u5929\u5b89\u5168\u671f\u95f4\u5185\uff0c\u63d0\u4f9b\u7ed9FDA\u8981\u6c42\u7684\u66f4\u591a\u4fe1\u606f\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u8fd9\u79cd\u5728\u5408\u5e76\u75c7\u548c\u5171\u5b58\u75be\u75c5\u60c5\u51b5\u4e0b\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u65b0\u7597\u6cd5\uff0c\u6709\u53ef\u80fd\u6210\u4e3a\u9884\u9632\u6216\u5ef6\u7f13\u80f0\u5c9b\u7d20\u6cbb\u7597\u7684\u5f00\u59cb<\/strong>\u3002\u201d<\/span><\/p>\n

 <\/span><\/p>\n

\u6211\u4eec\u671f\u5f85\u8fd9\u4e00\u521b\u65b0\u7597\u6cd5\u80fd\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u9a8c\u8bc1\uff0c\u5c3d\u5feb\u4e3a2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5e26\u6765\u798f\u97f3\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] The U.S. FDA Approves ARKAY Therapeutics\u2019 IND Application for Evaluating RK-01, a First-in Class \u2018Beta-cell-centric\u2019 Drug Combination Product in Type 2 Diabetes Patients <\/span><\/p>\n

[2] ARKAY Therapeutics \u5b98\u7f51<\/span><\/p>\n

[3] \u9996\u6b3e\u4ee5\u80f0\u5c9b\u03b2\u7ec6\u80de\u4e3a\u4e2d\u5fc3\u7684\u7cd6\u5c3f\u75c5\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7<\/span><\/p>\n

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\"\u901f\u9012<\/p>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u660e\u5eb7\u5fb7 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u65e5\u524d\uff0cARKAY Therapeutics\u5ba3\u5e03\u7f8e\u56fdFDA\u63a5\u53d7\u4e86\u5176\u7cd6\u5c3f\u75c5\u65b0\u836fRK-0 […]<\/p>\n","protected":false},"author":1,"featured_media":9183,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9182"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9182"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9182\/revisions"}],"predecessor-version":[{"id":9187,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9182\/revisions\/9187"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9183"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9182"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9182"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}