{"id":9188,"date":"2018-06-08T01:00:00","date_gmt":"2018-07-27T09:37:09","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e5%89%8d%e6%b2%bf-nature%e5%ad%90%e5%88%8a%ef%bc%9a%e5%85%b3%e8%8a%82%e7%82%8e%e8%8d%af%e7%89%a9%e5%b1%85%e7%84%b6%e8%83%bd%e8%ae%a9car-t%e7%96%97%e6%b3%95%e6%9b%b4%e5%ae%89%e5%85%a8\/"},"modified":"2018-07-27T17:37:10","modified_gmt":"2018-07-27T09:37:10","slug":"%e5%89%8d%e6%b2%bf-nature%e5%ad%90%e5%88%8a%ef%bc%9a%e5%85%b3%e8%8a%82%e7%82%8e%e8%8d%af%e7%89%a9%e5%b1%85%e7%84%b6%e8%83%bd%e8%ae%a9car-t%e7%96%97%e6%b3%95%e6%9b%b4%e5%ae%89%e5%85%a8","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9188\/","title":{"rendered":"\u524d\u6cbf | Nature\u5b50\u520a\uff1a\u5173\u8282\u708e\u836f\u7269\u5c45\u7136\u80fd\u8ba9CAR-T\u7597\u6cd5\u66f4\u5b89\u5168"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n


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\u8fd1\u65e5\uff0c\u5728\u300aNature Medicine\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u7684\u4e24\u7bc7\u79d1\u5b66\u8bba\u6587\u4e2d\uff0c\u6765\u81ea\u7ebd\u7ea6\u7eaa\u5ff5\u65af\u9686-\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u548c\u610f\u5927\u5229San Raffaele\u533b\u9662\u79d1\u5b66\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\uff0c\u901a\u8fc7\u5efa\u7acb\u521b\u65b0\u5c0f\u9f20\u6a21\u578b\uff0c\u63ed\u793a\u4e86\u4e0eCAR-T\u7597\u6cd5\u76f8\u5173\u7684\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81(CRS)<\/span>\u548c\u795e\u7ecf\u6bd2\u6027\u4ea7\u751f\u7684\u539f\u56e0\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4ed6\u4eec\u53d1\u73b0\u5728\u4f7f\u7528CAR-T\u7597\u6cd5\u4e4b\u524d\u7ed9\u5c0f\u9f20\u670d\u7528\u67d0\u4e9b\u836f\u7269\uff0c\u53ef\u4ee5\u9632\u6b62CRS\u548c\u795e\u7ecf\u6bd2\u6027\u7684\u4ea7\u751f<\/strong>\uff0c\u800c\u4e14\u8fd9\u4e9b\u836f\u7269\u76ee\u524d\u5df2\u83b7\u6279\u7528\u4e8e\u5176\u5b83\u75be\u75c5\u7684\u6cbb\u7597<\/strong>\u3002<\/span><\/p>\n


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CAR-T\u7597\u6cd5\u5df2\u7ecf\u5728\u6cbb\u7597\u767d\u8840\u75c5\u3001\u6dcb\u5df4\u7624\u7b49\u8840\u764c\u65b9\u9762\u8868\u73b0\u51fa\u663e\u8457\u7684\u7597\u6548\u3002\u5176\u4e2d\u8bfa\u534e(Novartis)\u516c\u53f8\u548cGilead Sciences\u7684\u9776\u5411B\u7ec6\u80de\u6297\u539fCD19\u7684CAR-T\u7597\u6cd5\u5df2\u7ecf\u83b7\u5f97\u4e86FDA\u7684\u6279\u51c6\u3002\u4f46\u662f\uff0c\u8fd9\u4e9bCAR-T\u7597\u6cd5\u901a\u5e38\u4f1a\u5bfc\u81f4\u526f\u4f5c\u7528CRS\u7684\u51fa\u73b0\uff0c\u5728\u6709\u4e9b\u60a3\u8005\u8eab\u4e0a\u751a\u81f3\u51fa\u73b0\u66f4\u4e3a\u4e25\u91cd\u7684\u795e\u7ecf\u6bd2\u6027(neurotoxicity)\u3002\u8fd9\u4e9b\u6bd2\u526f\u4f5c\u7528\u6210\u4e3a\u9650\u5236CAR-T\u7597\u6cd5\u5e7f\u6cdb\u63a8\u5e7f\u7684\u91cd\u8981\u539f\u56e0\u4e4b\u4e00\u3002<\/span><\/p>\n


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\u65e9\u57282009\u5e74\uff0cCAR-T\u7597\u6cd5\u9996\u6b21\u5728\u4eba\u4f53\u4f7f\u7528\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u5c31\u89c2\u5bdf\u5230\u60a3\u8005\u4f53\u5185\u7684\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u4e0a\u5347\uff0c\u4f46\u662f\u7531\u4e8e\u6ca1\u6709\u5408\u9002\u7684\u5c0f\u9f20\u6a21\u578b\uff0c\u79d1\u5b66\u5bb6\u4eec\u5bf9\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u7684\u539f\u56e0\u4e86\u89e3\u751a\u5c11\u3002<\/span><\/p>\n


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\u6765\u81ea\u610f\u5927\u5229\u7684\u7814\u7a76\u4eba\u5458\u5229\u7528\u4eba\u6e90\u5316\u5c0f\u9f20\u767d\u8840\u75c5\u6a21\u578b\uff0c\u53d1\u73b0\u5206\u6ccc\u5bfc\u81f4CRS\u548c\u795e\u7ecf\u6bd2\u6027\u7684IL-1\u548cIL-6\u7ec6\u80de\u56e0\u5b50\u7684\u4e3b\u8981\u7ec6\u80de\u4e0d\u662fCAR-T\u7ec6\u80de\uff0c\u800c\u662f\u5bbf\u4e3b\u7684\u5355\u6838\u7ec6\u80de\u3002\u4f7f\u7528tocilizumab\u963b\u65adIL-6\u53d7\u4f53\u6fc0\u6d3b\uff0c\u6216\u8005\u6e05\u9664\u5bbf\u4e3b\u5355\u6838\u7ec6\u80de\uff0c\u5c31\u80fd\u591f\u9632\u6b62CRS<\/span>\u7684\u4ea7\u751f<\/strong>\uff0c\u4f46\u4e0d\u80fd\u9632\u6b62\u795e\u7ecf\u6bd2\u6027\u7684\u53d1\u751f\u3002Tocilizumab\u662f\u4e00\u6b3e\u5df2\u7ecf\u88abFDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u548cCAR-T\u7597\u6cd5\u4ea7\u751f\u7684CRS\u7684\u836f\u7269\uff0c\u4f46\u5b83\u662f\u4e00\u4e2a\u6bd4\u8f83\u5927\u7684\u86cb\u767d\uff0c\u65e0\u6cd5\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\u3002<\/span><\/p>\n


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\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5bbf\u4e3b\u4e2dIL-1\u7684\u4ea7\u751f\u65e9\u4e8eIL-6\u4ea7\u751f\u597d\u51e0\u4e2a\u5c0f\u65f6\uff0c\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cIL-1\u80fd\u591f\u89e6\u53d1IL-6\u7684\u4ea7\u751f\u3002\u8fd9\u610f\u5473\u7740\uff0cIL-1\u662f\u8c03\u8282IL-6\u548c\u5176\u5b83\u7ec6\u80de\u56e0\u5b50\u7684\u4e3b\u8c03\u63a7\u5b50\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4f7f\u7528\u540d\u4e3aanakinra\u7684IL-1\u53d7\u4f53\u62ee\u6297\u5242\u80fd\u591f\u540c\u65f6\u9632\u6b62CSR\u548c\u795e\u7ecf\u6bd2\u6027\u7684\u4ea7\u751f<\/strong>\u3002Anakinra\u662f\u4e00\u6b3e\u5df2\u7ecf\u83b7\u5f97FDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u836f\u7269\uff0c\u5b83\u662f\u4e00\u4e2a\u5206\u5b50\u91cf\u8f83\u5c0f\u7684\u591a\u80bd\uff0c\u80fd\u591f\u7a7f\u8d8a\u8840\u8111\u5c4f\u969c\u3002<\/span><\/p>\n


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\"\u524d\u6cbf<\/p>\n

<\/span>\u56fe\u7247\u6765\u6e90\uff1a123RF<\/span><\/p>\n


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\u800c\u6765\u81ea\u7ebd\u7ea6\u7684\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u53e6\u4e00\u79cd\u5c0f\u9f20\u6a21\u578b\u8868\u660e\uff0c\u5bbf\u4e3b\u5de8\u566c\u7ec6\u80de\u4ea7\u751f\u7684IL-1\u548cIL-6\u5728\u5bfc\u81f4CRS\u548c\u795e\u7ecf\u6bd2\u6027\u65b9\u9762\u6709\u91cd\u8981\u4f5c\u7528<\/strong>\u3002\u4ed6\u4eec\u7684\u7814\u7a76\u8868\u660e\u5bbf\u4e3b\u5de8\u566c\u7ec6\u80de\u4ea7\u751f\u7684\u4e00\u6c27\u5316\u6c2e(NO)\u5728\u5f15\u53d1CRS\u65b9\u9762\u4e5f\u6709\u91cd\u8981\u4f5c\u7528\u3002\u800c\u4e14\uff0canakinra\u4e0etocilizumab\u76f8\u6bd4\uff0c\u80fd\u591f\u66f4\u6709\u6548\u5730\u9632\u6b62CRS\u7684\u53d1\u751f\uff0c\u540c\u65f6\u4e5f\u4e0d\u4f1a\u5f71\u54cdCAR-T\u7597\u6cd5\u7684\u6297\u764c\u6548\u679c\u3002<\/span><\/p>\n


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\u4e0b\u4e00\u6b65\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u5728\u4eba\u7c7b\u60a3\u8005\u8eab\u4e0a\u68c0\u6d4b\u963b\u65adIL-1\u4fe1\u53f7\u901a\u8def\u5728\u9632\u6cbbCRS\u65b9\u9762\u7684\u7597\u6548\u3002\u6700\u7ec8\uff0c\u4ed6\u4eec\u5e0c\u671b\u5c06IL-1\u53d7\u4f53\u963b\u65ad\u5242\u6574\u5408\u5230CAR-T\u7ec6\u80de\u4e2d\uff0c\u4ece\u800c\u63d0\u9ad8CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u5b89\u5168\u6027\u3002<\/span><\/p>\n


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\u201c\u8fd9\u4e9b\u662f\u975e\u5e38\u91cd\u8981\u7684\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u5b83\u4eec\u8868\u660e\u5728\u4e0d\u5f71\u54cd\u6297\u764c\u6548\u679c\u7684\u540c\u65f6\uff0c\u6709\u65b9\u6cd5\u53ef\u4ee5\u9632\u6cbbCAR-T\u7597\u6cd5\u5bfc\u81f4\u7684\u5305\u62ecCRS\u548c\u795e\u7ecf\u6bd2\u6027\u5728\u5185\u7684\u4e25\u91cd\u6bd2\u526f\u4f5c\u7528\uff0c\u201d\u8f89\u745e(Pfizer)\u516c\u53f8\u514d\u75ab\u80bf\u7624\u7597\u6cd5\u5f00\u53d1\u8d1f\u8d23\u4ebaChris Boshoff\u535a\u58eb\u8868\u793a\u3002<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] Modeling cytokine release syndrome<\/span><\/p>\n

[2] Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due toCAR T cells<\/span><\/p>\n

[3] CAR T cell\u2013induced cytokine release syndrome is mediated bymacrophages and abated by IL-1 blockade<\/span><\/p>\n

[4] New Insights to Improve CART Cells\u2019 Safety<\/span>
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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u660e\u5eb7\u5fb7 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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