{"id":9195,"date":"2018-06-08T01:00:00","date_gmt":"2018-07-27T09:37:12","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e7%9b%98%e7%82%b9-%e8%82%9d%e8%84%8f%e7%96%be%e7%97%85%e9%a2%86%e5%9f%9f%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e6%b1%87%e6%80%bb%ef%bc%88%e7%ac%ac39%e6%9c%9f%ef%bc%89\/"},"modified":"2018-07-27T17:37:13","modified_gmt":"2018-07-27T09:37:13","slug":"%e7%9b%98%e7%82%b9-%e8%82%9d%e8%84%8f%e7%96%be%e7%97%85%e9%a2%86%e5%9f%9f%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e6%b1%87%e6%80%bb%ef%bc%88%e7%ac%ac39%e6%9c%9f%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9195\/","title":{"rendered":"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c39\u671f\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;\"><strong style=\"max-width: 100%;color: rgb(62, 62, 62);line-height: 32px;font-size: 20px;background-color: rgb(255, 255, 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src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532684233.jpeg\" alt=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c39\u671f\uff09\" title=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c39\u671f\uff09\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 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15px;\">MGL-3196\u5c31\u662f\u8fd9\u6837\u4e00\u6b3e\u5145\u6ee1\u6f5c\u529b\u7684\u836f\u7269\u3002\u5b83\u662f\u4e00\u79cdfirst-in-class\u7684\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u3001\u9776\u5411\u809d\u810f\u7684\u7532\u72b6\u817a\u6fc0\u7d20\u53d7\u4f53\uff08THR\uff09\u03b2-\u9009\u62e9\u6027\u6fc0\u52a8\u5242\u3002\u7532\u72b6\u817a\u6fc0\u7d20\u901a\u8fc7\u6fc0\u6d3b\u5176\u03b2\u53d7\u4f53\uff0c\u5728\u63a7\u5236\u8102\u8d28\u4ee3\u8c22\u4e2d\u53d1\u6325\u6838\u5fc3\u4f5c\u7528\uff0c\u5f71\u54cd\u4eba\u4f53\u7684\u591a\u4e2a\u5065\u5eb7\u53c2\u6570\uff0c\u4ece\u80c6\u56fa\u9187\u548c\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u5230\u809d\u810f\u4e2d\u8102\u80aa\u7684\u75c5\u7406\u7d2f\u79ef\u3002\u4f46\u5f88\u591a\u5df2\u6709\u5316\u5408\u7269\u5bf9THR-\u03b2\u7684\u9009\u62e9\u6027\u4e0d\u8db3\uff0c\u52a0\u4e4b\u5316\u5b66\u76f8\u5173\u6bd2\u6027\u548c\u4e0d\u7406\u60f3\u7684\u4f53\u5185\u5206\u5e03\uff0c\u963b\u788d\u4e86\u5b83\u4eec\u5728\u5fc3\u810f\u4ee3\u8c22\u548c\u809d\u810f\u75be\u75c5\u4e2d\u7684\u5e94\u7528\u3002\u800cMGL-3196\u88ab\u8ba4\u4e3a\u53ef\u4ee5\u514b\u670d\u8fd9\u4e9b\u6311\u6218\uff0c\u63d0\u4f9bTHR-\u03b2\u6fc0\u52a8\u5242\u7684\u5168\u90e8\u6cbb\u7597\u6f5c\u529b\u3002<\/span><\/p>\n<p 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style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">2. \u5409\u5229\u5fb7\u91cd\u78c5\u4e19\u809d\u65b0\u836f\u4e2d\u56fd\u83b7\u6279\uff0c\u53ef\u6cbb\u7597\u6240\u6709\u4e19\u809d\u4e9a\u578b<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 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style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><br  \/><\/strong><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><img class=\"\"           style=\"width: 556px;height: 159px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532684233.jpeg\" alt=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c39\u671f\uff09\" title=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c39\u671f\uff09\"  \/><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 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15px;\">\u5728ASTRAL-1\u3001ASTRAL-2\u548cASTRAL-3\u7814\u7a76\u4e2d\uff0c1,035\u540d\u4e0d\u4f34\u809d\u786c\u5316\/\u4f34\u4ee3\u507f\u671f\u809d\u786c\u5316\u7684\u57fa\u56e01-6\u578bHCV\u611f\u67d3\u7684\u521d\u6cbb\u60a3\u8005\u548c\u7ecf\u6cbb\u60a3\u8005\u63a5\u53d7\u4e8612\u5468\u7684\u4e19\u901a\u6c99\u00ae\u6cbb\u7597\u300298%\uff081,015\/1,035\uff09\u7684\u60a3\u8005\u5b9e\u73b0\u4e86SVR12\u3002\u5728ASTRAL-5\u7684\u7814\u7a76\u4e2d\uff0c106\u540d\u4e0d\u4f34\u809d\u786c\u5316\/\u4f34\u4ee3\u507f\u671f\u809d\u786c\u5316\u7684\u57fa\u56e01-6\u578bHCV\u611f\u67d3\u7684\u521d\u6cbb\u60a3\u8005\u548c\u7ecf\u6cbb\u60a3\u8005\u63a5\u53d7\u4e8612\u5468\u7684\u4e19\u901a\u6c99\u00ae\u6cbb\u7597\uff0c\u4ed6\u4eec\u8fd8\u540c\u65f6\u611f\u67d3\u4e86HIV\uff0c\u6b63\u5728\u63a5\u53d7\u5e73\u7a33\u7684\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u6cbb\u7597\u3002\u5176\u4e2d\uff0c95%\uff08101\/106\uff09\u7684\u60a3\u8005\u5b9e\u73b0\u4e86SVR12\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">ASTRAL-4\u7814\u7a76\u8bc4\u4f30\u4e86267\u540d\u5931\u4ee3\u507f\u671f\u809d\u786c\u5316\uff08Child-Pugh B\u7ea7\uff09\u7684\u57fa\u56e01-4\u578b\u548c\u57fa\u56e06\u578bHCV\u611f\u67d3\u60a3\u8005\u63a5\u53d712\u5468\u4e19\u901a\u6c99\u00ae\u8054\u5408\/\u4e0d\u8054\u5408RBV\u6cbb\u7597\u6216\u800524\u5468\u7684\u4e19\u901a\u6c99\u00ae\u6cbb\u7597\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5176\u4e2d\uff0c\u63a5\u53d7\u4e8612\u5468\u7684\u4e19\u901a\u6c99\u00ae\u8054\u5408RBV\u6cbb\u7597\u7684\u5931\u4ee3\u507f\u671f\u809d\u786c\u5316\u7684\u60a3\u8005\uff0c\u5b9e\u73b0\u4e8694%\uff0882\/87\uff09\u7684SVR12\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4e19\u901a\u6c99\u00ae\u6cbb\u7597\u7684\u60a3\u8005\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u226510%\uff09\u5305\u62ec\u5934\u75db\u548c\u75b2\u4e4f\u3002\u5728ASTRAL-4\u4e2d\uff0c\u4f34\u6709\u5931\u4ee3\u507f\u671f\u809d\u786c\u5316\u7684HCV\u611f\u67d3\u60a3\u8005\u63a5\u53d7\u4e19\u901a\u6c99\u00ae\u548cRBV\u6cbb\u7597\u540e\u6700\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\uff08\u226510%\uff09\u5305\u62ec\u75b2\u4e4f\u3001\u8d2b\u8840\u3001\u6076\u5fc3\u3001\u5934\u75db\u3001\u5931\u7720\u548c\u8179\u6cfb\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">3. \u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u79ef\u6781\uff01\u5316\u5408\u7269\u6709\u671b\u6210\u4e3aNAFLD\u548cNASH\u65b0\u836f<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8fd1\u65e5\uff0cNGM Biopharmaceuticals\u5ba3\u5e03\u4e86\u5173\u4e8eNGM282\u5f00\u53d1\u7684\u591a\u4e2a\u79ef\u6781\u7ed3\u679c\u3002NGM282\u662f\u4e00\u79cd\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u7684\u5728\u7814\u65b0\u836f\u3002\u5728NASH\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u63a2\u7d22\u60272\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u63a5\u53d7NGM282\u7684\u60a3\u8005\u7684\u7ec4\u7ec7\u5b66\u6d4b\u91cf\u7ed3\u679c\u5f97\u5230\u6539\u5584\uff0c\u6b64\u5916\uff0cNGM282\u5728\u539f\u53d1\u6027\u786c\u5316\u6027\u80c6\u7ba1\u708e\uff08PSC\uff09\u60a3\u8005\u4e2d\u8fdb\u884c\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u60a3\u8005\u7684\u7ea4\u7ef4\u5316\u548c\u809d\u635f\u4f24\u6807\u5fd7\u7269\u4e5f\u51fa\u73b0\u663e\u8457\u6539\u5584\u3002\u76f8\u5173\u8bba\u6587\u53d1\u8868\u5728\u300a\u67f3\u53f6\u5200\u300b\u4e0a\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532684233.jpeg\" alt=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c39\u671f\uff09\" title=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c39\u671f\uff09\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u75c5\uff08NAFLD\uff09\u6b63\u5728\u8bb8\u591a\u56fd\u5bb6\u6210\u4e3a\u6700\u5e38\u89c1\u7684\u6162\u6027\u809d\u75c5\uff0c<strong>\u5728\u7f8e\u56fd\u5927\u7ea6\u67097500\u4e07\u52301\u4ebf\u7684NAFLD\u60a3\u8005\uff0c\u5728\u4e2d\u56fd\u4ea6\u662f\u6162\u6027\u809d\u75c5\u7684\u4e3b\u8981\u8d1f\u62c5\u4e4b\u4e00\uff0c\u5176\u6cbb\u7597\u65b9\u6cd5\u975e\u5e38\u6709\u9650\u3002<\/strong>NAFLD\u5305\u62ec\u4e00\u7cfb\u5217\u6162\u6027\u809d\u810f\u75be\u75c5\uff0c\u5176\u4e2dNASH\u662f\u6700\u5177\u4fb5\u88ad\u6027\u7684\u7c7b\u578b\u3002NAFLD\u548cNASH\u7684\u75c5\u56e0\u4ecd\u7136\u672a\u5b8c\u5168\u9610\u660e\uff0c\u76ee\u524d\u7684\u6807\u51c6\u62a4\u7406\u662f\u51cf\u80a5\u548c\u5065\u5eb7\u996e\u98df\uff0c\u5c1a\u65e0FDA\u6279\u51c6\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/span><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">NMG282\u662f\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b5019\uff08FGF19\uff09\u7684\u975e\u81f4\u7624\u6027\u53d8\u4f53\uff0c\u662f\u8c03\u8282\u80c6\u6c41\u9178\u5e76\u8d1f\u8d23\u4f53\u5185\u8461\u8404\u7cd6\u548c\u8102\u8d28\u4ee3\u8c22\u7684\u5185\u5206\u6ccc\u80c3\u80a0\u6fc0\u7d20\u3002<strong>\u7814\u7a76\u8005\u8ba4\u4e3aNMG282\u80fd\u591f\u6539\u5584\u809d\u810f\u8102\u80aa\u53d8\u6027\u4ee5\u53ca\u4e0eNAFLD\u548cNASH\u76f8\u5173\u7684\u708e\u75c7\u548c\u7ea4\u7ef4\u5316\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u4e00\u9879\u968f\u673a\uff0c\u53cc\u76f2\uff0c\u5b89\u6170\u5242\u5bf9\u7167\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u6765\u81ea\u4e8e\u7f8e\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u7684166\u4f8b18-75\u5c81\u7684\u60a3\u8005\u53c2\u4e0e\u4e86\u6d4b\u8bd5\u3002\u4ed6\u4eec\u901a\u8fc7\u7ec4\u7ec7\u6d3b\u68c0\u8bc1\u5b9e\u6709NAFLD\u6216NASH\uff0c\u809d\u810f\u8102\u80aa\u542b\u91cf\u81f3\u5c118\uff05\u3002\u53c2\u4e0e\u8005\u63091:1:1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\uff0c\u6bcf\u5929\u63a5\u53d73mg\u62166mg NGM282\uff0c\u6216\u662f\u5b89\u6170\u5242\u6ce8\u5c04\u3002\u572812\u5468\u7684\u6d4b\u8bd5\u671f\u4e2d\uff0c\u6bcf2\u5468\u68c0\u6d4b\u4e00\u6b21\u3002\u4e3a\u4e86\u6d4b\u91cf\u809d\u810f\u8102\u80aa\u51cf\u5c11\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e86\u5177\u6709\u8d28\u5b50\u5bc6\u5ea6\u8102\u80aa\u5206\u6570\u7684\u809d\u810f\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u3002\u4e0e\u5728\u663e\u5fae\u955c\u4e0b\u89c2\u5bdf\u7ec4\u7ec7\u6837\u672c\u7684\u4f20\u7edf\u8bc4\u4f30\u65b9\u6cd5\u76f8\u6bd4\uff0c\u8fd9\u79cd\u6210\u50cf\u624b\u6bb5\u5bf9\u809d\u7ec4\u7ec7\u7684\u53d8\u5316\u6781\u5176\u654f\u611f\u3002\u7ed3\u679c\u663e\u793a\uff0c3mg\u548c6mg\u5242\u91cf\u7684NGM282\u90fd\u80fd\u4f7f\u809d\u8102\u80aa\u542b\u91cf\u8fc5\u901f\u800c\u6301\u7eed\u5730\u8d77\u53d8\u5316\u300219\u4f8b\u63a5\u53d7NGM282\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u67098\u4f8b\u7684\u809d\u7ea4\u7ef4\u5316\u7a0b\u5ea6\u81f3\u5c11\u6539\u5584\u4e86\u4e00\u4e2a\u9636\u6bb5\uff0c\u5176\u4e2d\u67093\u4f8b\u60a3\u8005\u7684\u7ea4\u7ef4\u5316\u6539\u5584\u7a0b\u5ea6\u4e3a\u4e24\u4e2a\u9636\u6bb5\uff08\u7686\u4e3aF3\u5230F1\uff09\u3002<strong>12\u5468\u540e\uff0c84\uff05\u7684\u60a3\u8005\u51fa\u73b0NAS<\/strong><strong>\uff08NAFLD\u6d3b\u6027\u8bc4\u5206\uff09<\/strong><strong>\u6539\u5584\uff0c58\uff05\u7684\u60a3\u8005NAS\u6539\u5584\u7a0b\u5ea6\u8d85\u8fc72\u5206\uff0c<\/strong>\u5305\u62ec\u81f3\u5c111\u5206\u662f\u708e\u75c7\u6216\u809d\u7ec6\u80de\u6c14\u7403\u6837\u53d8\u6539\u5584\u3002NMG282\u8010\u53d7\u826f\u597d\uff0c\u6ca1\u6709\u53d1\u751f\u5371\u53ca\u751f\u547d\u7684\u4e8b\u4ef6\u6216\u60a3\u8005\u6b7b\u4ea1\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">4. FDA\u6279\u51c6\u65b0\u836f\uff0c\u6cbb\u7597\u809d\u75c5\u60a3\u8005\u8840\u5c0f\u677f\u51cf\u5c11<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">Dova Pharmaceuticals\u8fd1\u65e5\u5ba3\u5e03\uff0c<strong>\u7f8e\u56fdFDA\u5df2\u6279\u51c6\u5176\u5b50\u516c\u53f8AkaRx\u7684\u65b0\u836fDoptelet\uff08avatrombopag\uff09\u7247\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u8ba1\u5212\u63a5\u53d7\u533b\u7597\u6216\u7259\u79d1\u624b\u672f\u7684\u6162\u6027\u809d\u75c5\uff08CLD\uff09\u6210\u4eba\u60a3\u8005\u7684\u4f4e\u8840\u5c0f\u677f\u8ba1\u6570<\/strong>\uff08\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff09\u3002\u8fd9\u662f\u76ee\u524d\u83b7\u6279\u7528\u4e8e\u8be5\u7528\u9014\u7684\u9996\u6b3e\u836f\u7269\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress9-1532684233.jpeg\" alt=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c39\u671f\uff09\" title=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c39\u671f\uff09\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8840\u5c0f\u677f\u662f\u9aa8\u9ad3\u4e2d\u4ea7\u751f\u7684\u65e0\u8272\u7ec6\u80de\uff0c\u5e2e\u52a9\u5728\u8840\u7ba1\u4e2d\u5f62\u6210\u8840\u51dd\u5757\uff0c\u9632\u6b62\u51fa\u8840\u3002\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u662f\u8840\u6db2\u4e2d\u7684\u5faa\u73af\u8840\u5c0f\u677f\u6570\u4f4e\u4e8e\u6b63\u5e38\u6570\u91cf\u7684\u4e00\u79cd\u75c5\u75c7\u3002\u5f53\u60a3\u8005\u7684\u8840\u5c0f\u677f\u6570\u6709\u4e2d\u5ea6\u6216\u91cd\u5ea6\u51cf\u5c11\u65f6\uff0c\u53ef\u80fd\u4f1a\u53d1\u751f\u4e25\u91cd\u751a\u81f3\u5371\u53ca\u751f\u547d\u7684\u51fa\u8840\uff0c\u7279\u522b\u662f\u5728\u5b9e\u65bd\u4fb5\u5165\u6027\u624b\u672f\u8fc7\u7a0b\u4e2d\u3002\u4e25\u91cd\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u60a3\u8005\u901a\u5e38\u9700\u8981\u5728\u624b\u672f\u524d\u63a5\u53d7\u8840\u5c0f\u677f\u8f93\u6ce8\uff0c\u4ee5\u589e\u52a0\u8840\u5c0f\u677f\u8ba1\u6570\u3002<\/span><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">Doptelet\uff08avatrombopag\uff09\u662f\u7b2c\u4e8c\u4ee3\u3001\u6bcf\u65e5\u4e00\u6b21\u7684\u53e3\u670d\u9996\u4e2a\u8840\u5c0f\u677f\u751f\u6210\u7d20\uff08TPO\uff09\u53d7\u4f53\u6fc0\u52a8\u5242\u3002<\/span><\/strong><span style=\"font-size: 15px;\">Doptelet\u80fd\u6a21\u62dfTPO\u7684\u4f5c\u7528\uff0c\u5b83\u662f\u6b63\u5e38\u8840\u5c0f\u677f\u751f\u4ea7\u7684\u4e3b\u8981\u8c03\u8282\u8005\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">Doptelet\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5728\u4e24\u9879\u8bd5\u9a8c\uff08ADAPT-1\u548cADAPT-2\uff09\u4e2d\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002\u8fd9\u4e9b\u7814\u7a76\u5171\u5305\u542b435\u540d\u6162\u6027\u809d\u75c5\u548c\u4e25\u91cd\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u60a3\u8005\uff0c\u4ed6\u4eec\u5c06\u63a5\u53d7\u901a\u5e38\u9700\u8981\u8f93\u6ce8\u8840\u5c0f\u677f\u7684\u624b\u672f\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u8bc4\u4f30\u4e86\u4e24\u4e2a\u5242\u91cf\u6c34\u5e73\u7684\u53e3\u670dDoptelet\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u6cbb\u75975\u5929\u7684\u6548\u679c\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c<strong>\u4e24\u79cd\u5242\u91cf\u6c34\u5e73\u7684Doptelet\u7ec4\u6709\u8f83\u9ad8\u6bd4\u4f8b\u7684\u60a3\u8005\u5177\u6709\u589e\u52a0\u7684\u8840\u5c0f\u677f\u8ba1\u6570\uff0c\u5e76\u4e14\u4e0d\u9700\u8981\u5728\u624b\u672f\u5f53\u5929\u548c\u6cbb\u7597\u540e7\u5929\u5185\u63a5\u53d7\u8840\u5c0f\u677f\u8f93\u6ce8\u6216\u4efb\u4f55\u6551\u63f4\u6cbb\u7597\u3002<\/strong>Doptelet\u6700\u5e38\u89c1\u7684\u526f\u4f5c\u7528\u6709\u53d1\u70e7\u3001\u80c3\uff08\u8179\uff09\u75db\u3001\u6076\u5fc3\u3001\u5934\u75db\u3001\u75b2\u52b3\u548c\u624b\u8db3\u80bf\u80c0\uff08\u6c34\u80bf\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599:<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] Madrigal shares soar on promising PhII NASH data, stoking hopes for a new contender<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] China Drug Administration Approves Epclusa\u00ae (Sofosbuvir\/Velpatasvir), Gilead\u2019s Pan-Genotypic Treatment for Chronic Hepatitis C Virus Infection<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[3] NGM Bio Announces Results From Phase 2 Study Of NGM282 In NASH Patients Demonstrating Clinically Significant Improvements In Liver Histology After 12 Weeks<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[4] FDA approves new drug for patients with chronic liver disease who have low blood platelets and are undergoing a medical procedure<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532684233.gif\" alt=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c39\u671f\uff09\" title=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c39\u671f\uff09\"  \/><\/span><\/p>\n<p style=\"white-space: normal;\">\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u660e\u5eb7\u5fb7                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 1. \u663e\u8457\u7f13\u89e3\u75c5\u60c5\uff01NASH\u6f5c\u529b\u65b0\u836f\u516c\u5e0336\u5468\u7ed3\u679c \u65e5\u524d\uff0cMadrigal Pharmace [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9196,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9195"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9195"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9195\/revisions"}],"predecessor-version":[{"id":9202,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9195\/revisions\/9202"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9196"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9195"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9195"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9195"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}