{"id":93625,"date":"2019-04-03T00:00:50","date_gmt":"2019-05-17T07:42:00","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/93625\/"},"modified":"2019-05-17T15:42:02","modified_gmt":"2019-05-17T07:42:02","slug":"9c5462e0c8","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/93625\/","title":{"rendered":"\u60a3\u8005\u9686\u80f8\u540e\u4ea7\u751f\u4e0d\u826f\u53cd\u5e94\uff0c\u8981\u6c42 FDA \u91c7\u53d6\u63aa\u65bd\u964d\u4f4e\u4e73\u623f\u690d\u5165\u7269\u98ce\u9669 | \u4e01\u9999\u65e9\u8bfb"},"content":{"rendered":"
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\"\u60a3\u8005\u9686\u80f8\u540e\u4ea7\u751f\u4e0d\u826f\u53cd\u5e94\uff0c\u8981\u6c42<\/span><\/strong><\/p>\n


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\u7b2c\u4e00\u65f6\u95f4 \u8ffd\u8e2a\u533b\u7597\u70ed\u70b9<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


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42 \u5c81\u7684\u9ad8\u9f84\u4ea7\u5987\u5434\u68a6\u65e9\u524d\u88ab\u786e\u8bca\u4e3a\u300c\u5148\u5929\u6027\u5fc3\u810f\u75c5\u3001\u623f\u95f4\u9694\u7f3a\u635f\u4f34\u80ba\u52a8\u8109\u9ad8\u538b\u300d\uff0c\u4f46\u4e0d\u987e\u533b\u751f\u529d\u963b\u575a\u6301\u751f\u5b50\u30022018 \u5e74 6 \u6708\uff0c\u5434\u68a6\u63a5\u53d7\u4e86\u80ba\u79fb\u690d\u624b\u672f\uff0c\u6210\u4e3a\u4e16\u754c\u9996\u4f8b\u884c\u80ba\u79fb\u690d\u624b\u672f\u7684\u80ba\u52a8\u8109\u9ad8\u538b\u4ea7\u5987\u3002<\/span><\/p>\n


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6 \u6708 16 \u65e5\uff0c\u65e0\u9521\u5e02\u4eba\u6c11\u533b\u9662\u4e3a\u5979\u5256\u8179\u4e00\u5b50\uff0c\u968f\u540e\uff0c\u533b\u9662\u53c8\u4e3a\u5176\u8fdb\u884c\u4e86\u5fc3\u810f\u623f\u95f4\u9694\u7f3a\u635f\u4fee\u8865\u672f+\u80ba\u79fb\u690d\u672f\u30028 \u6708 10 \u65e5\uff0c\u5434\u68a6\u7684\u5b69\u5b50\u5df2\u4ece\u65e9\u4ea7\u7684 2 \u65a4\u591a\u957f\u5230 4 \u65a4\uff0c\u5f53\u5929\u5b89\u6392\u51fa\u9662\u3002<\/span><\/p>\n


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\u60a3\u8005\u9686\u80f8\u540e\u4ea7\u751f\u4e0d\u826f\u53cd\u5e94\uff0c\u8981\u6c42 FDA \u91c7\u53d6\u63aa\u65bd\u964d\u4f4e\u4e73\u623f\u690d\u5165\u7269\u98ce\u9669<\/span><\/strong><\/span><\/p>\n


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\u8fd1\u65e5\uff0c\u6709\u60a3\u8005\u8868\u793a\uff0c\u5728\u63a5\u53d7\u9686\u80f8\u624b\u672f\u540e\uff0c\u4ea7\u751f\u5173\u8282\u808c\u8089\u75bc\u75db\u3001\u8fc7\u654f\u53cd\u5e94\u548c\u75b2\u52b3\u7b49\u75c7\u72b6\uff0c\u53d6\u51fa\u690d\u5165\u7269\u540e\uff0c\u75c7\u72b6\u660e\u663e\u7f13\u89e3\u3002\u751a\u81f3\u6709\u5973\u6027\u60a3\u8005\u63d0\u51fa\uff0c\u5728\u672f\u540e\u591a\u5e74\u60a3\u4e0a\u6dcb\u5df4\u7624\u4e0e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002<\/span><\/p>\n


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\"\u60a3\u8005\u9686\u80f8\u540e\u4ea7\u751f\u4e0d\u826f\u53cd\u5e94\uff0c\u8981\u6c42<\/p>\n

<\/span>\u56fe\u6e90\uff1a\u534e\u76db\u987f\u90ae\u62a5\u622a\u56fe<\/span><\/p>\n


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\u8fd9\u4e9b\u60a3\u8005\u8981\u6c42\uff0cFDA \u5e94\u8be5\u91c7\u53d6\u63aa\u65bd\uff0c\u5bf9\u4e73\u623f\u690d\u5165\u7269\u8fdb\u884c\u76f8\u5173\u7814\u7a76\uff0c\u660e\u786e\u5176\u98ce\u9669\uff0c\u5e76\u53ca\u65f6\u5411\u60a3\u8005\u63d0\u4f9b\u76f8\u5173\u98ce\u9669\u4fe1\u606f\uff0c\u540c\u65f6\u5e94\u52a0\u5f3a\u76d1\u5bdf\uff0c\u7981\u6b62\u4e00\u4e9b\u6709\u5bb3\u690d\u5165\u7269\u7684\u4f7f\u7528\u3002<\/span><\/p>\n


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FDA \u4e8e 2005 \u5e74\u5bf9\u5927\u591a\u6570\u4e73\u623f\u690d\u5165\u7269\u4ea7\u54c1\u89e3\u7981\uff0c\u5e76\u8981\u6c42\u5176\u4e2d\u4e00\u4e9b\u5546\u5bb6\u8fdb\u884c\u76f8\u5173\u7814\u7a76\u3002<\/span><\/p>\n


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\u5728\u4e0a\u8ff0\u60a3\u8005\u63d0\u51fa\u610f\u89c1\u540e\uff0cFDA \u5df2\u7ecf\u52a0\u5f3a\u5ba1\u67e5\u529b\u5ea6\uff0c\u4e8e\u4e0a\u5468\u5411\u4e24\u5bb6\u5927\u578b\u4e73\u623f\u690d\u5165\u7269\u4ea7\u54c1\u5546\u53d1\u51fa\u8b66\u544a\uff0c\u6566\u4fc3\u4ed6\u4eec\u52a0\u5feb\u63d0\u4ea4\u4e73\u623f\u690d\u5165\u7269\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u540c\u65f6\u5efa\u8bae\u4e73\u623f\u690d\u5165\u6750\u6599\u53ef\u52a0\u5165\u5b89\u5168\u7684\u5916\u79d1\u624b\u672f\u6750\u6599\u3002<\/span>\uff08\u6765\u6e90\uff1a\u534e\u76db\u987f\u90ae\u62a5\uff09<\/span><\/p>\n


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Science<\/span><\/strong><\/em> \u8b66\u544a PD-1 \u6297\u4f53\u6cbb\u7597\u52a0\u901f\u80bf\u7624\u751f\u957f\u5f15\u53d1\u8ba8\u8bba<\/span><\/strong><\/p>\n


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PD-1\/PD-L1 \u6297\u4f53\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u662f\u8fd1\u5e74\u6765\u80bf\u7624\u6cbb\u7597\u7684\u7814\u7a76\u70ed\u70b9\u3002\u6b64\u524d\u6709\u7814\u7a76\u8bc1\u660e PD-1 \u6297\u4f53\u5728\u665a\u671f\u764c\u75c7\u60a3\u8005\u6cbb\u7597\u4e2d\u7684\u6548\u679c\u3002<\/span><\/p>\n


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<\/span>\u56fe\u6e90\uff1aScience <\/em>\u7f51\u7ad9\u622a\u56fe<\/span><\/p>\n


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\u8fd1\u65e5\uff0c\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684\u80bf\u7624\u5b66\u5bb6 Razelle Kurzrock \u7ed9\u4e00\u540d 65 \u5c81\u60a3\u7f55\u89c1\u5b50\u5bab\u5185\u819c\u764c<\/span>\uff08\u5df2\u6269\u6563\u5230\u809d\u810f\uff09<\/span>\u7684\u5987\u5973\u8fdb\u884c\u4e86\u6297 PD-1\/PD-L1 \u6cbb\u7597\uff0c\u4f46\u5728\u5f00\u59cb\u7528\u836f 3 \u5468\u540e\uff0c\u60a3\u8005\u809d\u810f\u80bf\u7624\u5f00\u59cb\u53d8\u5927\u3002<\/span><\/p>\n


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\u8fd9\u610f\u5473\u7740\uff0cPD-1 \u6297\u4f53\u6cbb\u7597\u975e\u4f46\u6ca1\u6709\u63a7\u5236\u75c5\u60c5\uff0c\u53ef\u80fd\u8fd8\u52a0\u901f\u4e86\u60a3\u8005\u6b7b\u4ea1\u3002\u7c7b\u4f3c\u7684\u7814\u7a76\u7ed3\u679c\u4e5f\u6709\u62a5\u9053\uff0c\u8868\u660e PD-1 \u6297\u4f53\u6cbb\u7597\u4f1a\u52a0\u901f\u80bf\u7624\u751f\u957f\u3002<\/span><\/p>\n


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\u4f46 PD-1 \u6297\u4f53\u6cbb\u7597\u523a\u6fc0\u80bf\u7624\u751f\u957f\u7684\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\uff0c\u6709\u5b66\u8005\u63a8\u6d4b\u53ef\u80fd\u662f\u5de8\u566c\u7ec6\u80de\u7684\u63a8\u52a8\u4f5c\u7528\u3002\u4e5f\u6709\u4e13\u5bb6\u8ba4\u4e3a\uff0c\u80bf\u7624\u7684\u52a0\u901f\u751f\u957f\u53ef\u80fd\u4e0e PD-1 \u6297\u4f53\u6cbb\u7597\u65e0\u5173\uff0c\u662f\u75be\u75c5\u8fdb\u5c55\u7684\u539f\u56e0\u3002<\/span>\uff08\u6765\u6e90\uff1aScience<\/em>\uff09<\/span><\/p>\n


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4 \u6708 2 \u65e5\uff0c\u56fd\u5bb6\u5e02\u573a\u76d1\u7ba1\u603b\u5c40\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u4e3a\u8fdb\u4e00\u6b65\u52a0\u5f3a\u5bf9\u4fdd\u5065\u98df\u54c1\u4fdd\u5065\u529f\u80fd\u58f0\u79f0\u7684\u7ba1\u7406\uff0c\u73b0\u7ec4\u7ec7\u533b\u5b66\u3001\u836f\u5b66\u3001\u98df\u54c1\u3001\u8425\u517b\u7b49\u9886\u57df\u4e13\u5bb6\u8fdb\u884c\u591a\u6b21\u8bba\u8bc1\uff0c\u7814\u7a76\u63d0\u51fa\u4e86\u8c03\u6574\u4fdd\u5065\u529f\u80fd\u7684\u610f\u89c1\u3002\u5177\u4f53\u5982\u4e0b\uff1a<\/span><\/p>\n


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1. \u5efa\u8bae\u8c03\u6574\u90e8\u5206\u4fdd\u5065\u529f\u80fd\u58f0\u79f0\u8868\u8ff0\u3002\u529f\u80fd\u58f0\u79f0\u8868\u8ff0\u8c03\u6574\u53d1\u5e03\u540e\uff0c\u4fdd\u5065\u98df\u54c1\u4ea7\u54c1\u6ce8\u518c\u8bc1\u4e66\u6301\u6709\u4eba\u6216\u6388\u6743\u751f\u4ea7\u4f01\u4e1a\u53ef\u76f4\u63a5\u8c03\u6574\u5176\u4ea7\u54c1\u7684\u76f8\u5173\u529f\u80fd\u8868\u8ff0\uff0c\u65e0\u9700\u5355\u72ec\u7533\u8bf7\u53d8\u66f4\u6ce8\u518c\uff0c\u5df2\u4e0a\u5e02\u4ea7\u54c1\u53ef\u9500\u552e\u81f3\u4fdd\u8d28\u671f\u7ed3\u675f\u3002<\/span><\/p>\n


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<\/span>\u62df\u8c03\u6574\u529f\u80fd\u58f0\u79f0\u8868\u8ff0\u7684\u4fdd\u5065\u529f\u80fd\uff08\u90e8\u5206\uff09<\/span><\/p>\n

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2. \u5e94\u5f53\u53d6\u6d88\u8fc7\u5f80\u5386\u53f2\u65f6\u671f\u66fe\u6279\u51c6\u8fc7\uff0c\u4f46\u73b0\u5df2\u4e0d\u518d\u53d7\u7406\u5ba1\u8bc4\u5ba1\u6279\u7684\u4fdd\u5065\u529f\u80fd\u3002\u81ea\u53d1\u5e03\u53d6\u6d88\u4e0a\u8ff0\u4fdd\u5065\u529f\u80fd\u4e4b\u65e5\u8d77\uff0c\u76f8\u5173\u4ea7\u54c1\u5e94\u5f53\u7acb\u5373\u505c\u6b62\u751f\u4ea7\uff0c\u5df2\u751f\u4ea7\u7684\u4fdd\u5065\u98df\u54c1\uff0c\u4e0d\u6d89\u53ca\u8d28\u91cf\u5b89\u5168\u7684\uff0c\u53ef\u9500\u552e\u81f3\u4fdd\u8d28\u671f\u7ed3\u675f\u3002<\/span><\/p>\n


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3. \u6709\u90e8\u5206\u4fdd\u5065\u529f\u80fd\u58f0\u79f0\u548c\u8bc4\u4ef7\u65b9\u6cd5\u5bb9\u6613\u4e0e\u836f\u7269\u75be\u75c5\u6cbb\u7597\u6df7\u6dc6\uff0c\u5e94\u5bf9\u73b0\u6709\u90e8\u5206\u529f\u80fd\u58f0\u79f0\u7684\u5b9a\u4f4d\u3001\u8868\u8ff0\u4ee5\u53ca\u76f8\u5173\u529f\u80fd\u8bc4\u4ef7\u65b9\u6cd5\u8fdb\u4e00\u6b65\u7814\u7a76\u8bba\u8bc1\u3001\u5e7f\u6cdb\u5f81\u6c42\u610f\u89c1\u3002<\/span>\uff08\u6765\u6e90\uff1a\u56fd\u5bb6\u5e02\u573a\u76d1\u7ba1\u603b\u5c40\uff09<\/span><\/p>\n


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\u8bfa\u534e\u4ee5 16 \u4ebf\u7f8e\u5143\u6536\u8d2d IFM Tre\uff0c\u63a8\u8fdb\u7814\u53d1\u5148\u5929\u514d\u75ab\u4fe1\u53f7\u53d7\u4f53\u62ee\u6297\u5242<\/strong><\/span><\/p>\n


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4 \u6708 2 \u65e5\uff0c\u8bfa\u534e\u5ba3\u5e03\u5c06\u4ee5 16 \u4ebf\u7f8e\u5143\u7684\u603b\u503c\u6536\u8d2d\u836f\u4f01 IFM Tre\u3002<\/span><\/p>\n


<\/span><\/p>\n

IFM Tre \u516c\u53f8\u4ee5\u5f00\u53d1\u8c03\u8282\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u65b0\u9776\u70b9\u7684\u7597\u6cd5\u4e3a\u4e3b\uff0c\u6838\u5fc3\u4ea7\u54c1\u662f NLRP3 \u62ee\u6297\u5242<\/span>\uff08\u4e00\u79cd\u5148\u5929\u514d\u75ab\u4fe1\u53f7\u53d7\u4f53\u62ee\u6297\u5242\uff09<\/span>\uff0c\u4e3b\u8981\u9002\u5e94\u75c7\u662f NASH\u3001\u75db\u98ce\u3001\u52a8\u8109\u786c\u5316\u3001\u80c3\u80a0\u514d\u75ab\u75be\u75c5\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7b49\u3002\u5176\u4e2d\u4e00\u79cd NLRP3 \u62ee\u6297\u5242\u5df2\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/span><\/p>\n


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\u8bfa\u534e\u751f\u7269\u533b\u5b66\u7814\u7a76\u6240\u4e3b\u5e2d Jay Bradner \u8868\u793a\uff0c\u5c06\u5229\u7528 IFM Tre <\/span>\u5728\u8fd9\u4e00\u9886\u57df\u7684\u4e13\u4e1a\u77e5\u8bc6\u6765\u63a8\u8fdb\u8fd9\u4e9b\u836f\u7269\u7684\u7814\u53d1\u751f\u4ea7\u3002<\/span>\uff08\u6765\u6e90\uff1a\u533b\u836f\u9b54\u65b9\uff09<\/span><\/p>\n


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\u9898\u56fe\u6765\u6e90\uff1a<\/span>\u7ad9\u9177\u6d77\u6d1b<\/span><\/p>\n


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