{"id":9371,"date":"2018-06-12T01:00:00","date_gmt":"2018-07-27T09:38:14","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/nature%ef%bc%9a%e6%8f%ad%e7%a4%ba%e6%bf%80%e9%85%b6mst1%e5%92%8cmst2%e6%9c%89%e5%8a%a9%e5%90%af%e5%8a%a8%e6%8a%97%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%8f%8d%e5%ba%94\/"},"modified":"2018-07-27T17:38:15","modified_gmt":"2018-07-27T09:38:15","slug":"nature%ef%bc%9a%e6%8f%ad%e7%a4%ba%e6%bf%80%e9%85%b6mst1%e5%92%8cmst2%e6%9c%89%e5%8a%a9%e5%90%af%e5%8a%a8%e6%8a%97%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9371\/","title":{"rendered":"Nature\uff1a\u63ed\u793a\u6fc0\u9176Mst1\u548cMst2\u6709\u52a9\u542f\u52a8\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"__bg_gif\"     style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532684295.gif\" alt=\"Nature\uff1a\u63ed\u793a\u6fc0\u9176Mst1\u548cMst2\u6709\u52a9\u542f\u52a8\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\" title=\"Nature\uff1a\u63ed\u793a\u6fc0\u9176Mst1\u548cMst2\u6709\u52a9\u542f\u52a8\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u5723\u72b9\u8fbe\u513f\u7ae5\u7814\u7a76\u533b\u9662\u7684\u7814\u7a76\u4eba\u5458\u9274\u5b9a\u51fa\u4e24\u79cd\u9690\u85cf\u7684\u9a71\u52a8\u56e0\u5b50\uff0c\u5b83\u4eec\u5f71\u54cd\u62b5\u6297\u764c\u75c7\u548c\u611f\u67d3\u7684T\u7ec6\u80de\u7684\u4ea7\u751f\u3002\u8fd9\u4e24\u79cd\u9690\u85cf\u7684\u9a71\u52a8\u56e0\u5b50\u662f\u6fc0\u9176Mst1\u548cMst2\u3002\u4ed6\u4eec\u8bc1\u5b9eMst1\u548cMst2\u4e00\u8d77\u8c03\u8282\u4e0d\u540c\u7684\u6811\u7a81\u7ec6\u80de\u4e9a\u7fa4\u7684\u529f\u80fd\uff0c\u5176\u4e2d\u6811\u7a81\u7ec6\u80de\u662f\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\uff08\u5305\u62ec\u5bf9\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u81f3\u5173\u91cd\u8981\u7684T\u7ec6\u80de\uff09\u4e2d\u7684\u5173\u952e\u8c03\u8282\u7269\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e745\u670830\u65e5\u5728\u7ebf\u53d1\u8868\u5728Nature\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cHippo\/Mst signalling couples metabolic state and immune function of CD8\u03b1+ dendritic cells\u201d\u3002\u8bba\u6587\u901a\u4fe1\u4f5c\u8005\u4e3a\u5723\u72b9\u8fbe\u513f\u7ae5\u7814\u7a76\u533b\u9662\u7684Hongbo Chi\u535a\u58eb\u548cJiyang Yu\u535a\u58eb\u3002\u8bba\u6587\u7b2c\u4e00\u4f5c\u8005\u4e3aChi\u5b9e\u9a8c\u5ba4\u535a\u58eb\u540e\u7814\u7a76\u5458Xingrong Du\u535a\u58eb\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532684295.jpeg\" alt=\"Nature\uff1a\u63ed\u793a\u6fc0\u9176Mst1\u548cMst2\u6709\u52a9\u542f\u52a8\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\" title=\"Nature\uff1a\u63ed\u793a\u6fc0\u9176Mst1\u548cMst2\u6709\u52a9\u542f\u52a8\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u81eaJiyang Yu \/ St. Jude Children&#8217;s Research Hospital\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">Chi\u8bf4\uff0c\u201c\u6811\u7a81\u7ec6\u80de\u5bf9\u6fc0\u6d3b\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u662f\u81f3\u5173\u91cd\u8981\u7684\uff0c\u5305\u62ec\u542f\u52a8\u62b5\u6297\u80bf\u7624\u7684T\u7ec6\u80de\u3002 \u4f46\u662f\u5bf9\u4e0d\u540c\u6811\u7a81\u7ec6\u80de\u4e9a\u7fa4\u7684\u4e0d\u540c\u529f\u80fd\u7684\u8c03\u63a7\u4ecd\u672a\u5f97\u5230\u5f88\u597d\u7684\u7406\u89e3\u3002\u6211\u4eec\u60f3\u6539\u53d8\u8fd9\u79cd\u60c5\u5f62\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u4e3a\u5f00\u53d1\u901a\u8fc7\u8c03\u8282\u6811\u7a81\u7ec6\u80de\u7684\u6d3b\u6027\u4ece\u800c\u5851\u9020\u8fd9\u79cd\u514d\u75ab\u53cd\u5e94\u6765\u6cbb\u7597\u764c\u75c7\u6216\u514d\u75ab\u75be\u75c5\u7684\u65b0\u7b56\u7565\u63d0\u4f9b\u4e86\u7ebf\u7d22\u3002\u201d&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section class=\"RankEditor\" style=\"margin-top:20px;\">\n<section style=\"display:flex;align-items: center;justify-content: center;\">\n<section style=\"width:19px;height:19px;border-radius:50%;background:#fff;padding:2px;transform:rotate(360deg);-webkit-transform:rotate(360deg);margin-top: -30px;margin-right:-10px;box-sizing: border-box;\">\n<section style=\"width: 15px;height: 15px;border-radius: 100%;background: rgb(68, 120, 242);\"><\/section>\n<\/section>\n<section style=\"padding: 5px 20px;background: rgb(68, 120, 242);\">\n<p class=\"white title\" style=\"font-size:18px;color:rgb(255,255,255);min-width: 1em;\"><strong>\u91c7\u7528\u4f20\u7edf\u65b9\u6cd5<\/strong><\/p>\n<\/section>\n<section style=\"width:26px;height:26px;border-radius:100%;background:#fff;padding:2px;transform:rotate(360deg);-webkit-transform:rotate(360deg);margin-left:-10px;box-sizing: border-box;\">\n<section style=\"width: 22px;height: 22px;border-radius: 100%;background: rgb(68, 120, 242);\"><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4e00\u79cd\u6570\u636e\u9a71\u52a8\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u7b97\u6cd5NetBID\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002Yu\u548c\u4ed6\u7684\u540c\u4e8b\u4eec\u5f00\u53d1\u51faNetBID\uff08\u5168\u79f0\u4e3adata-driven network-based Bayesian inference of drivers\uff09\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">Yu\u548c\u4ed6\u7684\u56e2\u961f\u5c06\u6765\u81eaChi\u5b9e\u9a8c\u5ba4\u548c\u5176\u4ed6\u6765\u6e90\u7684\u57fa\u56e0\u8868\u8fbe\u3001\u5168\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u78f7\u9178\u5316\u86cb\u767d\u8d28\u7ec4\u5b66\u6570\u636e\u6574\u5408\u5728\u4e00\u8d77\uff0c\u4ee5\u4fbf\u53cd\u5411\u8bbe\u8ba1\u5c0f\u9f20\u6811\u7a81\u7ec6\u80de\u4e2d\u7684\u751f\u7269\u7f51\u7edc\u3002\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u5229\u7528NetBID\u5206\u6790\u4e86\u4e0d\u540c\u6811\u7a81\u7ec6\u80de\u4e9a\u7fa4\u7684\u751f\u7269\u7f51\u7edc\u5dee\u5f02\u3002\u4ee4\u4ed6\u4eec\u5403\u60ca\u7684\u662f\uff0cMst1\/2\u548cHippo\u4fe1\u53f7\u901a\u8def\u6210\u4e3a\u6811\u7a81\u7ec6\u80de\u529f\u80fd\u548cT\u7ec6\u80de\u5e94\u7b54\u7684\u5173\u952e\u8c03\u8282\u56e0\u5b50\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">Chi\u8bf4\uff0c\u201c\u5df2\u77e5Hippo\u901a\u8def\u8c03\u8282\u52a8\u7269\u5668\u5b98\u5927\u5c0f\uff0c\u5e76\u4e0d\u8c03\u8282\u662f\u6811\u7a81\u7ec6\u80de\u7684\u514d\u75ab\u529f\u80fd\u3002\u201dYu\u5c06Mst1\/2b\u6bd4\u4f5c\u4e3a\u72af\u7f6a\u9996\u9886\uff0c\u5b83\u7684\u4f5c\u7528\u88ab\u5b83\u7684\u5c0f\u55bd\u5570\u4eec\u6240\u9690\u85cf\u3002Yu\u8bf4\uff0c\u201c\u4e00\u79cd\u6570\u636e\u9a71\u52a8\u7cfb\u7edf\u65b9\u6cd5\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b9\u6cd5\u6765\u5bfb\u627e\u9690\u85cf\u7684\u5bfc\u81f4\u4e0d\u540c\u6811\u7a81\u7ec6\u80de\u4e9a\u7fa4\u4e4b\u95f4\u5dee\u5f02\u529f\u80fd\u7684\u9a71\u52a8\u56e0\u5b50\u3002\u201d<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section class=\"RankEditor\" style=\"margin-top:20px;\">\n<section style=\"display:flex;align-items: center;justify-content: center;\">\n<section style=\"width:19px;height:19px;border-radius:50%;background:#fff;padding:2px;transform:rotate(360deg);-webkit-transform:rotate(360deg);margin-top: -30px;margin-right:-10px;box-sizing: border-box;\">\n<section style=\"width: 15px;height: 15px;border-radius: 100%;background: rgb(68, 120, 242);\"><\/section>\n<\/section>\n<section style=\"padding: 5px 20px;background: rgb(68, 120, 242);\">\n<p class=\"white title\" style=\"font-size:18px;color:rgb(255,255,255);min-width: 1em;\">\u4ee3\u8c22\u548c\u4fe1\u53f7\u8f6c\u5bfc<\/p>\n<\/section>\n<section style=\"width:26px;height:26px;border-radius:100%;background:#fff;padding:2px;transform:rotate(360deg);-webkit-transform:rotate(360deg);margin-left:-10px;box-sizing: border-box;\">\n<section style=\"width: 22px;height: 22px;border-radius: 100%;background: rgb(68, 120, 242);\"><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8fd9\u9879\u7814\u7a76\u7740\u91cd\u5173\u6ce8\u5bf9\u514d\u75ab\u7cfb\u7edf\u4ea7\u751f\u660e\u663e\u5f71\u54cd\u7684\u6811\u7a81\u7ec6\u80de\u4e9a\u7fa4\u3002\u4e00\u79cd\u6811\u7a81\u7ec6\u80de\u4e9a\u7fa4\u662fCD8\u03b1+\u6811\u7a81\u7ec6\u80de\uff0c\u5b83\u4eec\u542f\u52a8\u7528\u4e8e\u62b5\u6297\u80bf\u7624\u548c\u611f\u67d3\u7684CD8 T\u7ec6\u80de\u4ea7\u751f\u3002\u53e6\u4e00\u79cd\u6811\u7a81\u7ec6\u80de\u4e9a\u7fa4\u662fCD8\u03b1-\u6811\u7a81\u7ec6\u80de\uff0c\u5b83\u4eec\u542f\u52a8\u4e0d\u540cT\u7ec6\u80de\u4e9a\u578b\u7684\u4ea7\u751f\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 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15px;\">Yu\u8bf4\uff0c\u201cNetBID\u7b97\u6cd5\u80fd\u591f\u88ab\u7528\u6765\u5206\u6790\u5176\u4ed6\u7684\u6570\u636e\u96c6\u4e2d\u9690\u85cf\u7684\u9a71\u52a8\u56e0\u5b50\u548c\u63a2\u7a76\u751f\u7269\u5b66\u95ee\u9898\u3002\u8fd9\u79cd\u7b97\u6cd5\u5df2\u88ab\u7528\u4e8e\u5206\u6790\u4e0d\u540c\u764c\u75c7\u4e9a\u578b\u4e4b\u95f4\u6216\u8010\u836f\u6027\u4e0e\u654f\u611f\u6027\u764c\u75c7\u60a3\u8005\u4e4b\u95f4\u7684\u751f\u7269\u7f51\u7edc\u5dee\u5f02\uff0c\u4ee5\u4fbf\u9274\u5b9a\u51fa\u6f5c\u5728\u7684\u6cbb\u7597\u9776\u70b9\u548c\u751f\u7269\u6807\u5fd7\u7269\u3002\u5176\u4e2d\u7684\u5173\u952e\u662f\u6570\u636e\u9a71\u52a8\u7684\u548c\u7279\u5b9a\u80cc\u666f\u7684\u7f51\u7edc\u3002\u201d<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">\u539f\u59cb\u51fa\u5904\uff1aXingrong Du, Jing Wen, Yanyan Wang et al.&nbsp;Hippo\/Mst signalling couples metabolic state and immune function of CD8\u03b1+ dendritic cells.&nbsp;Nature, Published online:30 May 2018, doi:10.1038\/s41586-018-0177-0<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 15px;\">\u6765\u6e90\uff1a\u751f\u7269\u8c37<\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532684295.jpeg\" alt=\"Nature\uff1a\u63ed\u793a\u6fc0\u9176Mst1\u548cMst2\u6709\u52a9\u542f\u52a8\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\" title=\"Nature\uff1a\u63ed\u793a\u6fc0\u9176Mst1\u548cMst2\u6709\u52a9\u542f\u52a8\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: center;\">\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u6e21                      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