{"id":9459,"date":"2018-06-10T01:00:00","date_gmt":"2018-07-27T09:38:48","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e6%af%8f%e6%97%a5%e4%b8%80%e8%8d%afcobicistat-tybost\/"},"modified":"2018-07-27T17:38:50","modified_gmt":"2018-07-27T09:38:50","slug":"%e6%af%8f%e6%97%a5%e4%b8%80%e8%8d%afcobicistat-tybost","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9459\/","title":{"rendered":"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;line-height: 1.75em;\"><img class=\"__bg_gif\"     width=\"auto\" style=\"color: rgb(62, 62, 62);font-size: 16px;line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532684329.gif\" alt=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section class=\"RankEditor\" style=\"margin-top: 20px;white-space: normal;border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"margin-bottom: 0.5em;clear: both;border-width: 0px;border-style: none;border-color: initial;\">\n<section class=\"white\" style=\"border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;background-color: rgb(68, 120, 242);display: inline-block;\">\n<p class=\"brush\" style=\"min-width: 1em;\">\u57fa\u672c\u4fe1\u606f<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">Cobicistat\u7531\u5409\u5229\u5fb7(Gilead)\u7814\u53d1\uff0c\u4e8e2013\u5e749\u670819\u65e5\u83b7\u6b27\u6d32\u836f\u7269\u7ba1\u7406\u5c40(EMA)\u6279\u51c6\u4e0a\u5e02\uff0c\u5546\u54c1\u540d\u4e3aTybost<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;border-width: 1px;border-style: none;border-color: windowtext;padding: 0px;\">\u00ae<\/span><\/sup>\uff1b\u540e\u4e8e2014\u5e749\u670824\u65e5\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(FDA)\u6279\u51c6\u4e0a\u5e02\uff0c\u5546\u54c1\u540d\u4e3aStribild<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;border-width: 1px;border-style: none;border-color: windowtext;padding: 0px;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\uff0c\u7531\u5409\u5229\u5fb7\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u4e0a\u5e02\u9500\u552e\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">Cobicistat\u662f\u7ec6\u80de\u8272\u7d20P4503A\u6291\u5236\u5242\u3002Cobicistat\u4e0e\u5229\u6258\u90a3\u97e6(\u8bfa\u97e6)\u7ed3\u6784\u76f8\u4f3c\uff0c\u80fd\u591f\u6291\u5236\u53c2\u4e0e\u5176\u4ed6\u6297HIV\u836f\u7269\u4ee3\u8c22\u7684\u809d\u836f\u9176\uff0c\u5c24\u5176\u662f\u6291\u5236\u809d\u836f\u9176\u5bf9\u57c3\u66ff\u683c\u97e6(HIV\u6574\u5408\u9176\u6291\u5236\u5242)\u7684\u4ee3\u8c22\u3002\u57c3\u66ff\u683c\u97e6\u5728\u4e0eCobicistat\u8054\u7528\u540e\uff0c\u80fd\u5728\u8f83\u4f4e\u5242\u91cf\u4e0b\u8fbe\u5230\u8f83\u9ad8\u8840\u836f\u6d53\u5ea6\uff0c\u4ece\u800c\u63d0\u9ad8\u4e86\u5bf9\u75c5\u6bd2\u7684\u6291\u5236\u4f5c\u7528\u5e76\u51cf\u5c11\u4e86\u526f\u4f5c\u7528\u3002\u4e0e\u5229\u6258\u90a3\u97e6\u4e0d\u540c\uff0cCobicistat\u4f5c\u4e3a\u552f\u4e00\u83b7\u6279\u7684\u9e21\u5c3e\u9152\u7597\u6cd5(HAART)\u836f\u7269\u589e\u5f3a\u5242\uff0c\u5176\u672c\u8eab\u5e76\u6ca1\u6709\u6297HIV\u75c5\u6bd2\u7684\u6d3b\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">Tybost<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;border-width: 1px;border-style: none;border-color: windowtext;padding: 0px;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u4e3a\u53e3\u670d\u8584\u819c\u8863\u7247\uff0c\u6bcf\u7247\u542b\u6709150 mg Cobicistat\u3002\u63a8\u8350\u8d77\u59cb\u5242\u91cf\u4e3a\uff1a\u4e0e\u6069\u66f2\u4ed6\u6ee8\u6216\u8005\u5730\u745e\u90a3\u97e6\u8054\u7528\uff0c\u6bcf\u6b21150mg\uff0c\u6bcf\u65e51\u6b21\uff0c\u968f\u9910\u670d\u7528\u3002<\/span><\/p>\n<section class=\"RankEditor\" style=\"margin-top: 20px;white-space: normal;border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"margin-bottom: 0.5em;clear: both;border-width: 0px;border-style: none;border-color: initial;\">\n<section class=\"white\" style=\"border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;background-color: rgb(68, 120, 242);display: inline-block;\">\n<p class=\"brush\" style=\"min-width: 1em;\">\u7ed3\u6784\u5f0f<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"width: 273px;height: 132px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532684329.png\" alt=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section class=\"RankEditor\" style=\"margin-top: 20px;white-space: normal;border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"margin-bottom: 0.5em;clear: both;border-width: 0px;border-style: none;border-color: initial;\">\n<section class=\"white\" style=\"border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;background-color: rgb(68, 120, 242);display: inline-block;\">\n<p class=\"brush\" style=\"min-width: 1em;\">\u4f5c\u7528\u673a\u5236<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532684329.png\" alt=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\"  \/><\/p>\n<p><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">Cobicistat(GS-9350)\u662f\u4e00\u79cd\u6709\u6548\u7684CYP3A\u9009\u62e9\u6027\u6291\u5236\u5242\uff0cIC50\u4e3a30 &#8211; 285 nM\u3002Cobicistat(GS-9350)\u662f\u6709\u6548\u7684\u4eba\u7c7b\u7ec6\u80de\u8272\u7d20P450 3A (CYP3A)\u9176\u7684\u9009\u62e9\u6027\u6291\u5236\u5242\u3002<\/span><\/p>\n<section class=\"RankEditor\" style=\"border-width: 0px;border-style: none;border-color: initial;margin-top: 20px;\">\n<section style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-bottom: 0.5em;\">\n<section class=\"white\" style=\"border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;background-color: rgb(68, 120, 242);display: inline-block;\">\n<p class=\"brush\" style=\"min-width:1em;\">\u5408\u6210\u8def\u7ebf<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"width: 0px;height: 0px;clear: both;\"><\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress9-1532684329.jpg\" alt=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section class=\"RankEditor\" style=\"margin-top: 20px;white-space: normal;border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"margin-bottom: 0.5em;clear: both;border-width: 0px;border-style: none;border-color: initial;\">\n<section class=\"white\" style=\"border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;background-color: rgb(68, 120, 242);display: inline-block;\">\n<p class=\"brush\" style=\"min-width: 1em;\">\u7814\u7a76\u5173\u952e\u6570\u636e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532684330.jpg\" alt=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532684330.jpg\" alt=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section class=\"RankEditor\" style=\"margin-top: 20px;white-space: normal;border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"margin-bottom: 0.5em;clear: both;border-width: 0px;border-style: none;border-color: initial;\">\n<section class=\"white\" style=\"border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;background-color: rgb(68, 120, 242);display: inline-block;\">\n<p class=\"brush\" style=\"min-width: 1em;\">\u540c\u9776\u70b9\u5728\u7814\u53ca\u4e0a\u5e02\u836f\u7269<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress7-1532684330.png\" alt=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532684330.jpeg\" alt=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Cobicistat\/Tybost\u00ae\"  \/><\/p>\n<p style=\"text-align: center;\">\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u6e21                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u57fa\u672c\u4fe1\u606f Cobicistat\u7531\u5409\u5229\u5fb7(Gilead)\u7814\u53d1\uff0c\u4e8e2013\u5e749\u670819\u65e5\u83b7\u6b27\u6d32\u836f\u7269\u7ba1\u7406\u5c40(EMA)\u6279 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9460,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9459"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9459"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9459\/revisions"}],"predecessor-version":[{"id":9469,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9459\/revisions\/9469"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9460"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}