{"id":9490,"date":"2018-06-08T01:00:00","date_gmt":"2018-07-27T09:39:03","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e8%a3%b8%e8%b4%a8%e7%b2%92%e8%bd%bd%e4%bd%93%e5%9c%a8%e5%9f%ba%e5%9b%a0%e6%b2%bb%e7%96%97%e8%8d%af%e7%89%a9%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8\/"},"modified":"2018-07-27T17:39:04","modified_gmt":"2018-07-27T09:39:04","slug":"%e8%a3%b8%e8%b4%a8%e7%b2%92%e8%bd%bd%e4%bd%93%e5%9c%a8%e5%9f%ba%e5%9b%a0%e6%b2%bb%e7%96%97%e8%8d%af%e7%89%a9%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9490\/","title":{"rendered":"\u88f8\u8d28\u7c92\u8f7d\u4f53\u5728\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u4e2d\u7684\u5e94\u7528"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><\/span><\/p>\n<section class=\"RankEditor\">\n<section>\n<p><img class=\"__bg_gif\"     style=\"color: rgb(62, 62, 62);font-size: 16px;line-height: 1.75em;white-space: normal;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;background-color: rgb(255, 255, 255);\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532684344.gif\" alt=\"\u88f8\u8d28\u7c92\u8f7d\u4f53\u5728\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u4e2d\u7684\u5e94\u7528\" title=\"\u88f8\u8d28\u7c92\u8f7d\u4f53\u5728\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u4e2d\u7684\u5e94\u7528\"  \/><\/p>\n<section class=\"RankEditor\" style=\"margin-top: 20px;\">\n<section style=\"text-align: center;\">\n<section><span style=\"display: inline-block;width: 30px;height: 2px;background: rgb(68, 120, 242);vertical-align: bottom;\"><\/span><\/section>\n<section style=\"display:inline-block;vertical-align: top;\">\n<section style=\"height: 5px;border-top: 1px solid rgb(68, 120, 242);border-right: 1px solid rgb(68, 120, 242);border-left: 1px solid rgb(68, 120, 242);border-bottom: none;\"><\/section>\n<p class=\"title active\" style=\"padding: 2px 10px;font-size: 18px;color: rgb(68, 120, 242);min-width: 1px;\">\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u7814\u53d1\u6982\u51b5<\/p>\n<section style=\"height: 5px;border-right: 1px solid rgb(68, 120, 242);border-bottom: 1px solid rgb(68, 120, 242);border-left: 1px solid rgb(68, 120, 242);border-top: none;\"><\/section>\n<\/section>\n<section><span style=\"display: inline-block;width: 30px;height: 2px;background: rgb(68, 120, 242);vertical-align: top;\"><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u57fa\u56e0\u6cbb\u7597\u662f\u4e8c\u5341\u4e16\u7eaa\u4e5d\u5341\u5e74\u4ee3\u53d1\u5c55\u8d77\u6765\u7684\u4e00\u79cd\u5168\u65b0\u7684\u75be\u75c5\u6cbb\u7597\u6a21\u5f0f\uff0c\u662f\u901a\u8fc7\u8f7d\u4f53\u5c06\u5916\u6e90\u57fa\u56e0\u5bfc\u5165\u9776\u7ec6\u80de\uff0c\u4ee5\u7ea0\u6b63\u6216\u6539\u5584\u81f4\u75c5\u57fa\u56e0\u6240\u4ea7\u751f\u7684\u7f3a\u9677\uff0c\u8fbe\u5230\u6cbb\u7597\u75be\u75c5\u7684\u76ee\u7684\u3002\u6839\u636e\u201cGene Therapy Clinical Trials Worldwide\u201d\u7684\u7edf\u8ba1\uff0c\u81f32017\u5e7411\u6708\uff0c\u5168\u7403\u8303\u56f4\u5171\u5f00\u5c55\u4e862597\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e3b\u8981\u96c6\u4e2d\u4e8e\u764c\u75c7\u3001\u5355\u57fa\u56e0\u9057\u4f20\u75c5\u4ee5\u53ca\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\u65b9\u9762\u7684\u6cbb\u7597\u30022012\u5e74\uff0c\u6b27\u6d32\u9996\u4e2a\u57fa\u56e0\u6cbb\u7597\u836f\u7269Glybera\u83b7\u5f97\u6279\u51c6\uff0c\u6210\u4e3a\u57fa\u56e0\u6cbb\u7597\u9886\u57df\u7684\u91cc\u7a0b\u7891\uff1b2017\u5e74\uff0cFDA\u6279\u51c63\u6b3e\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u4e0a\u5e02\uff0c\u622a\u6b62\u76ee\u524d\u5168\u7403\u5df2\u6279\u51c68\u4e2a\u57fa\u56e0\u6cbb\u7597\u836f\u7269\uff0c\u5176\u4e2d\u6211\u56fd\u5171\u6279\u51c62\u4e2a\uff1b2018\u5e741\u6708Science\u6742\u5fd7\u53d1\u8868\u9898\u4e3a\u201cGene therapy comes of age\u201d\u7684\u6587\u7ae0\uff0c\u8ba4\u4e3a\u57fa\u56e0\u6cbb\u7597\u8fce\u6765\u4e86\u65b0\u65f6\u4ee3\uff0c\u518d\u6b21\u5f15\u53d1\u533b\u836f\u754c\u5bf9\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u7684\u5e7f\u6cdb\u5173\u6ce8\uff0c\u5927\u578b\u8de8\u56fd\u5236\u836f\u4f01\u4e1a\u4e5f\u5f00\u59cb\u5411\u57fa\u56e0\u6cbb\u7597\u7814\u53d1\u65b9\u9762\u8fdb\u884c\u5b9e\u8d28\u6027\u6295\u8d44\uff0c\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5165\u5feb\u901f\u53d1\u5c55\u9636\u6bb5\u3002<\/span><\/p>\n<section class=\"RankEditor\" style=\"margin-top: 20px;\">\n<section style=\"text-align: center;\">\n<section><span style=\"display: inline-block;width: 30px;height: 2px;background: rgb(68, 120, 242);vertical-align: bottom;\"><\/span><\/section>\n<section style=\"display:inline-block;vertical-align: top;\">\n<section style=\"height: 5px;border-top: 1px solid rgb(68, 120, 242);border-right: 1px solid rgb(68, 120, 242);border-left: 1px solid rgb(68, 120, 242);border-bottom: none;\"><\/section>\n<h1 style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 18px;color: rgb(68, 120, 242);\"><\/span><\/h1>\n<h1 style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 18px;color: rgb(68, 120, 242);\">\u88f8\u8d28\u7c92\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u7684\u7814\u53d1\u73b0\u72b6<\/span><\/h1>\n<section style=\"height: 5px;border-right: 1px solid rgb(68, 120, 242);border-bottom: 1px solid rgb(68, 120, 242);border-left: 1px solid rgb(68, 120, 242);border-top: none;\"><\/section>\n<\/section>\n<section><span style=\"display: inline-block;width: 30px;height: 2px;background: rgb(68, 120, 242);vertical-align: top;\"><\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u88f8\u8d28\u7c92\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u662f\u4ee5\u88f8\u8d28\u7c92\u4f5c\u4e3a\u76ee\u7684\u57fa\u56e0\u8f7d\u4f53\u5f00\u53d1\u7684\u836f\u7269\uff0c\u662f\u8f83\u4e3a\u5e38\u89c1\u7684\u4e00\u79cd\u57fa\u56e0\u6cbb\u7597\u5f62\u5f0f\u3002\u76ee\u524d\u5168\u7403\u8303\u56f4\u5185\u4ee5\u88f8\u8d28\u7c92DNA\u4e3a\u8f7d\u4f53\u7684\u57fa\u56e0\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\u5171\u5f00\u5c55\u4e86442\u4e2a\uff0c\u6392\u540d\u7b2c\u4e09\uff1b\u4e0e\u4ee5\u817a\u75c5\u6bd2\u548c\u9006\u8f6c\u5f55\u75c5\u6bd2\u4e3a\u8f7d\u4f53\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u91cf\u57fa\u672c\u76f8\u5f53\u3002\u540c\u75c5\u6bd2\u8f7d\u4f53\u76f8\u6bd4\uff0c\u88f8\u8d28\u7c92\u8f7d\u4f53\u5177\u6709\u514d\u75ab\u539f\u6027\u548c\u6bd2\u6027\u66f4\u4f4e\u7684\u4f18\u52bf\uff0c\u4e0d\u5b58\u5728\u57fa\u56e0\u6574\u5408\u7684\u98ce\u9669\uff0c\u800c\u4e14\u5728\u751f\u4ea7\u3001\u8fd0\u8f93\u548c\u50a8\u5b58\u8fc7\u7a0b\u4e2d\u66f4\u65b9\u4fbf\uff0c\u66f4\u6709\u5229\u4e8e\u5927\u89c4\u6a21\u751f\u4ea7\u3002\u7ecf\u7edf\u8ba1\uff0c\u4e0a\u8ff0\u4e34\u5e8a\u8bd5\u9a8c\u6709200\u591a\u4e2a(\u5360\u6bd455%)\u5904\u4e8e\u4e34\u5e8a\u2160\u671f\u9636\u6bb5\uff0c\u800c\u8fdb\u5165\u4e34\u5e8a\u2162\u671f\u7684\u53ea\u67099\u4e2a(\u88681)\uff0c\u5176\u4e2d5\u4e2a\u4e34\u5e8a\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u76ee\u7684\u57fa\u56e0\u4e3a\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff0c\u8868\u660e\u88f8\u8d28\u7c92\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u5927\u90e8\u5206\u5904\u4e8e\u4e34\u5e8a\u7814\u7a76\u7684\u65e9\u671f\u9636\u6bb5\uff0c\u4e14\u4ee5\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u7684\u88f8\u8d28\u7c92\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u7814\u7a76\u4f8b\u6570\u6700\u591a\uff0c\u4e34\u5e8a\u8fdb\u5c55\u8f83\u5feb\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"           style=\"width: 558px;height: 738px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress7-1532684344.jpg\" alt=\"\u88f8\u8d28\u7c92\u8f7d\u4f53\u5728\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u4e2d\u7684\u5e94\u7528\" title=\"\u88f8\u8d28\u7c92\u8f7d\u4f53\u5728\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u4e2d\u7684\u5e94\u7528\"  \/><\/p>\n<h1 style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><\/span><\/h1>\n<section class=\"RankEditor\" style=\"margin-top: 20px;\">\n<section style=\"text-align: center;\">\n<section><span style=\"display: inline-block;width: 30px;height: 2px;background: rgb(68, 120, 242);vertical-align: bottom;\"><\/span><\/section>\n<section style=\"display:inline-block;vertical-align: top;\">\n<section style=\"height: 5px;border-top: 1px solid rgb(68, 120, 242);border-right: 1px solid rgb(68, 120, 242);border-left: 1px solid rgb(68, 120, 242);border-bottom: none;\"><\/section>\n<h1 style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 18px;color: rgb(68, 120, 242);\"><\/span><\/h1>\n<h1 style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 18px;color: rgb(68, 120, 242);\">\u91cd\u7ec4\u4eba\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u88f8\u8d28\u7c92\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u7684\u7814\u7a76\u8fdb\u5c55<\/span><\/h1>\n<section style=\"height: 5px;border-right: 1px solid rgb(68, 120, 242);border-bottom: 1px solid rgb(68, 120, 242);border-left: 1px solid rgb(68, 120, 242);border-top: none;\"><\/section>\n<\/section>\n<section><span style=\"display: inline-block;width: 30px;height: 2px;background: rgb(68, 120, 242);vertical-align: top;\"><\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50(HGF)\u5177\u6709\u4fc3\u8840\u7ba1\u751f\u6210\u4f5c\u7528\uff0c\u4e34\u5e8a\u4e0a\u53ef\u7528\u4e8e\u7f3a\u8840\u6027\u75be\u75c5\u7684\u6cbb\u7597\u3002\u76ee\u524d\u5df2\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684HGF\u88f8\u8d28\u7c92\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u67093\u4e2a\uff0c\u5206\u522b\u662f\u65e5\u672cAnGes-MG\u516c\u53f8\u5f00\u53d1\u7684pVAX1-HGF\u3001\u4e2d\u56fd\u4eba\u6c11\u89e3\u653e\u519b\u519b\u4e8b\u533b\u5b66\u79d1\u5b66\u9662\u5f00\u53d1\u7684pUDK-HGF\u3001\u5317\u4eac\u8bfa\u601d\u5170\u5fb7\u751f\u7269\u6280\u672f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u4e0e\u97e9\u56fdViroMed\u516c\u53f8\u5408\u4f5c\u5f00\u53d1\u7684pCK-HGF-X7\u3002\u5176\u4e2d\uff0cpVAX1-HGF\u548cpUDK-HGF\u7684\u76ee\u7684\u57fa\u56e0\u5747\u4e3aHGF\u7684cDNA\u7247\u6bb5\uff0c\u53ea\u8868\u8fbeHGF<\/span><sub><span style=\"font-size:12px;font-family:\u5fae\u8f6f\u96c5\u9ed1,sans-serif;\">728<\/span><\/sub><span style=\"font-size: 15px;\">\u4e00\u79cd\u5f02\u6784\u4f53\uff0c\u800cpCK-HGF-X7\u80fd\u540c\u65f6\u8868\u8fbeHGF<\/span><sub><span style=\"font-size:12px;font-family:\u5fae\u8f6f\u96c5\u9ed1,sans-serif;\">728<\/span><\/sub><span style=\"font-size: 15px;\">\u548cHGF<\/span><sub><span style=\"font-size:12px;font-family:\u5fae\u8f6f\u96c5\u9ed1,sans-serif;\">723<\/span><\/sub><span style=\"font-size: 15px;\">\u4e24\u79cd\u5f02\u6784\u4f53\uff0c\u66f4\u7b26\u5408\u6b63\u5e38\u4eba\u4f53\u4e2dHGF\u7684\u5206\u5e03\u548c\u4f5c\u7528\u673a\u7406\uff0c\u4e34\u5e8a\u524d\u6bd4\u8f83\u7814\u7a76\u7ed3\u679c\u8bc1\u5b9e\u540c\u65f6\u8868\u8fbe2\u79cd\u5f02\u6784\u4f53\u7684HGF\u88f8\u8d28\u7c92\u5177\u6709\u66f4\u5f3a\u7684\u751f\u7269\u5b66\u6d3b\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><\/span><\/p>\n<section class=\"RankEditor\" style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"text-align:center;\">\n<section style=\"display:inline-block;width:60px;\"><img class=\"\"     style=\"width:100%;vertical-align:top;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532684344.gif\" alt=\"\u88f8\u8d28\u7c92\u8f7d\u4f53\u5728\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u4e2d\u7684\u5e94\u7528\" title=\"\u88f8\u8d28\u7c92\u8f7d\u4f53\u5728\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u4e2d\u7684\u5e94\u7528\"  \/><\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5317\u4eac\u8bfa\u601d\u5170\u5fb7\u751f\u7269\u6280\u672f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u5f00\u53d1\u7684\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u2014\u2014pCK-HGF-X7\uff0c\u76ee\u524d\u6b63\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u540c\u65f6\u5f00\u5c55\u2161\/\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5728\u7f8e\u56fd\u5f00\u5c55\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9002\u5e94\u75c7\u4e3a\u5916\u5468\u52a8\u8109\u7f3a\u8840\u6027\u75be\u75c5(Peripheral ArteryDisease\uff0cPAD)\u3001\u7cd6\u5c3f\u75c5\u5468\u56f4\u795e\u7ecf\u75c5\u53d8(Diabetic PeripheralNeuropathy\uff0cDPN)\u548c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7(Amyotrophic LateralSclerosis\uff0cALS)\u3002\u5176\u4e2dpCK-HGF-X7\u6cbb\u7597DPN\u9002\u5e94\u75c7\u4e8e2018\u5e745\u6708\u83b7\u5f97FDA\u518d\u751f\u533b\u5b66\u5148\u8fdb\u7597\u6cd5\u8ba4\u5b9a(Regenerative Medicine Advanced Therapy\uff0cRMAT)\u3002RMAT\u8ba4\u5b9a\u662f2016\u5e7412\u6708\u7f8e\u56fdFDA\u57fa\u4e8e21 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style=\"font-size: 15px;color: rgb(0, 0, 0);\"><\/span><\/p>\n<section class=\"RankEditor\">\n<section style=\"text-align:center;\"><\/section>\n<\/section>\n<section class=\"RankEditor\" style=\"margin-top:20px;\">\n<section style=\"border-color: rgb(68, 120, 242);color: rgb(255, 255, 255);margin-top: 10px;margin-left: 2px;height: 5px;width: 65%;background-color: rgb(68, 120, 242);\"><\/section>\n<section style=\"box-shadow: rgb(68, 120, 242) 0px 0px 4px;margin-right: 3px;margin-left: 3px;padding: 20px;background-color: rgb(254, 254, 254);border-color: rgb(68, 120, 242);\">\n<h1 style=\"white-space: normal;line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(68, 120, 242);font-size: 18px;\"><strong><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1;\">\u8bfa\u601d\u5170\u5fb7\u516c\u53f8<\/span><\/strong><\/span><\/h1>\n<section style=\"border-color: rgb(68, 120, 242);margin-top: 10px;margin-bottom: 10px;\">\n<p style=\"white-space: normal;text-align: 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 \/><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">http:\/\/www.abedia.com\/wiley\/index.html<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/www.clinicaltrials.gov<\/span><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u6e21                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u7814\u53d1\u6982\u51b5 \u57fa\u56e0\u6cbb\u7597\u662f\u4e8c\u5341\u4e16\u7eaa\u4e5d\u5341\u5e74\u4ee3\u53d1\u5c55\u8d77\u6765\u7684\u4e00\u79cd\u5168\u65b0\u7684\u75be\u75c5\u6cbb\u7597\u6a21\u5f0f\uff0c\u662f\u901a\u8fc7\u8f7d\u4f53\u5c06\u5916\u6e90\u57fa\u56e0\u5bfc\u5165\u9776\u7ec6 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