{"id":9513,"date":"2018-06-12T01:00:00","date_gmt":"2018-07-27T09:39:15","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e3%80%90%e4%b8%bd%e7%8f%a0pd-1%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%851%e3%80%91%e5%a4%9a%e4%b8%ad%e5%bf%83%e3%80%81%e5%bc%80%e6%94%be%e3%80%81%e8%af%84%e4%bc%b0lzm009%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e\/"},"modified":"2018-07-27T17:39:16","modified_gmt":"2018-07-27T09:39:16","slug":"%e3%80%90%e4%b8%bd%e7%8f%a0pd-1%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%851%e3%80%91%e5%a4%9a%e4%b8%ad%e5%bf%83%e3%80%81%e5%bc%80%e6%94%be%e3%80%81%e8%af%84%e4%bc%b0lzm009%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9513\/","title":{"rendered":"\u3010\u4e3d\u73e0PD-1\u62db\u52df\u60a3\u80051\u3011\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u3001\u8bc4\u4f30LZM009\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u548c\u521d\u6b65\u7597\u6548\u7684I\u671f\u4e34\u5e8a\u7814\u7a76"},"content":{"rendered":"
\n
    \n
  1. \n

    1.       <\/span><\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

    LZM009<\/span>\u662f\u4e3d\u73e0\u7814\u53d1\u7684\u6297<\/span>PD-1<\/span>\u5355\u514b\u9686\u6297\u4f53\uff0c\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f<\/span>\u665a\u671f\u5b9e\u4f53\u7624\u3002<\/span><\/span><\/span><\/p>\n

     <\/span><\/p>\n

      \n
    1. \n

      2.       <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

      \u8bc4\u4ef7<\/span>LZM009<\/span>\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4e3a<\/span>II<\/span>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8350\u7ed9\u836f\u5242\u91cf<\/span>(RP2D)<\/span>\u7684\u786e\u5b9a\u63d0\u4f9b\u4f9d\u636e\uff1b<\/span><\/span><\/p>\n

      \u8003\u5bdf<\/span>LZM009<\/span>\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u5355\u3001\u591a\u6b21\u9759\u8109\u6ef4\u6ce8\u7ed9\u836f\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81<\/span>(PK<\/span>\u53c2\u6570<\/span>)<\/span>\u3001\u8003\u5bdf<\/span>LZM009<\/span>\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u5355\u3001\u591a\u6b21\u9759\u8109\u6ef4\u6ce8\u7ed9\u836f\u540e\u4ea7\u751f\u6297<\/span>LZM009<\/span>\u6297\u4f53<\/span>(ADA)<\/span>\u7684\u60c5\u51b5\u3002<\/span><\/span><\/p>\n

       <\/span><\/p>\n

        \n
      1. \n

        3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

        \u8bd5\u9a8c\u5206\u7c7b\uff1a<\/span>      <\/span>\u5176\u4ed6<\/span><\/span><\/p>\n

        \u8bd5\u9a8c\u5206\u671f\uff1a<\/span>      I<\/span>\u671f<\/span><\/span><\/p>\n

        \u8bbe\u8ba1\u7c7b\u578b\uff1a<\/span>      <\/span>\u5355\u81c2\u8bd5\u9a8c<\/span><\/span><\/p>\n

        \u968f\u673a\u5316\uff1a<\/span>          <\/span>\u975e\u968f\u673a\u5316<\/span><\/span><\/p>\n

        \u76f2\u6cd5\uff1a<\/span>          <\/span>\u5f00\u653e<\/span><\/span><\/p>\n

        \u8bd5\u9a8c\u8303\u56f4\uff1a<\/span>      <\/span>\u56fd\u5185<\/span><\/span><\/p>\n

            <\/span>\u8bd5\u9a8c\u4eba\u6570\uff1a<\/span>   50-122<\/span><\/span>\u4eba<\/span><\/span><\/p>\n

         <\/span><\/p>\n

          \n
        1. \n

          4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

          1  <\/span>\u5e74\u9f84<\/span>18~70<\/span>\u5c81<\/span>(<\/span>\u5305\u542b\u8fb9\u754c\u503c<\/span>)<\/span>\uff0c\u7537\u5973\u5747\u53ef\uff1b<\/span><\/span><\/p>\n

          2  ECOG <\/span>\u8bc4\u5206\uff1a<\/span>0<\/span>\uff5e<\/span>1<\/span>\u5206\uff1b<\/span><\/span><\/p>\n

          3  <\/span>\u7ecf\u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\u786e\u8bca\u7684\u665a\u671f\u5b9e\u4f53\u7624\uff1b<\/span><\/span><\/p>\n

          4  <\/span>\u6309\u7167<\/span> RECIST 1.1<\/span>\u6807\u51c6\uff0c\u53d7\u8bd5\u8005\u5fc5\u987b\u6709\u81f3\u5c11<\/span>1<\/span>\u4e2a\u53ef\u7ecf<\/span>CT<\/span>\u6216<\/span>MRI<\/span>\u68c0\u67e5\u7684\u53ef\u6d4b\u91cf\u9776\u75c5\u7076\uff1b<\/span><\/span><\/p>\n

          5  <\/span>\u9884\u8ba1\u751f\u5b58\u671f\u2265<\/span>3<\/span>\u4e2a\u6708<\/span><\/span><\/p>\n

          6  <\/span>\u4e3b\u8981\u5668\u5b98\u529f\u80fd\u6b63\u5e38<\/span>(<\/span>\u5728\u5165\u7ec4\u524d<\/span>14<\/span>\u5929<\/span>)<\/span>\uff0c\u5373\u7b26\u5408\u76f8\u5173\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u6807\u51c6\uff1b<\/span><\/span><\/p>\n

          7  <\/span>\u6709\u751f\u6b96\u80fd\u529b\u7684\u7537\u6027\u6216\u6709\u6000\u5b55\u53ef\u80fd\u6027\u7684\u5973\u6027\uff0c\u5fc5\u987b\u5728\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u4f7f\u7528\u9ad8\u5ea6\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\uff0c\u4e14\u5728\u6700\u540e\u4e00\u6b21\u7ed9\u836f\u540e\u7ee7\u7eed\u907f\u5b55<\/span>12<\/span>\u4e2a\u6708\uff1b<\/span><\/span><\/p>\n

          8  <\/span>\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u53d7\u8bd5\u8005\u5fc5\u987b\u5728\u9996\u6b21\u7ed9\u836f\u524d<\/span>72<\/span>\u5c0f\u65f6\u5185\u68c0\u6d4b\u5c3f\u598a\u5a20\u9634\u6027\uff0c\u82e5\u5c3f\u598a\u5a20\u9633\u6027\u6216\u65e0\u6cd5\u786e\u8bc1\u9634\u6027\uff0c\u9700\u8fdb\u884c\u8840\u598a\u5a20\u8fdb\u4e00\u6b65\u68c0\u6d4b\uff1b<\/span><\/span><\/p>\n

          9  <\/span>\u53d7\u8bd5\u8005\u81ea\u613f\u52a0\u5165\u7814\u7a76\uff0c\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff0c\u4f9d\u4ece\u6027\u597d\uff0c\u914d\u5408\u968f\u8bbf\u3002<\/span><\/span><\/p>\n

           <\/span><\/p>\n

            \n
          1. \n

            5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

            1  <\/span>\u65e2\u5f80\u63a5\u53d7\u8fc7\u6297<\/span>PD-1<\/span>\u3001\u6297<\/span>PD-L1<\/span>\u3001\u6297<\/span>PD-L2<\/span>\u6cbb\u7597\uff1b<\/span><\/span><\/p>\n

            2  <\/span>\u5df2\u77e5\u5bf9\u91cd\u7ec4\u4eba\u6e90\u5316\u6297<\/span>PD-1<\/span>\u5355\u514b\u9686\u6297\u4f53\u836f\u7269\u53ca\u5176\u7ec4\u5206\u8fc7\u654f\u8005\uff1b<\/span><\/span><\/p>\n

            3  <\/span>\u598a\u5a20\u6216\u54fa\u4e73\u671f\u5987\u5973\uff1b<\/span><\/span><\/p>\n

            4  HIV<\/span>\u68c0\u6d4b\u7ed3\u679c\u9633\u6027\uff1b<\/span><\/span><\/p>\n

            5  <\/span>\u6d3b\u52a8\u6027\u4e59\u578b\u6216\u4e19\u578b\u809d\u708e\u60a3\u8005\uff1b<\/span><\/span><\/p>\n

            6  <\/span>\u6709\u660e\u786e\u6d3b\u52a8\u6027\u7ed3\u6838\u75c5\u53f2\uff1b<\/span><\/span><\/p>\n

            7  <\/span>\u65e2\u5f80\u4e24\u5e74\u5185\u63a5\u53d7\u7cfb\u7edf\u6cbb\u7597\u7684\u6d3b\u52a8\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5141\u8bb8\u76f8\u5173\u7684\u66ff\u4ee3\u6cbb\u7597\uff1b<\/span><\/span><\/p>\n

            8  <\/span>\u5176\u4ed6\u53ef\u80fd\u5f71\u54cd\u65b9\u6848\u4f9d\u4ece\u6027\u6216\u5e72\u6270\u7ed3\u679c\u89e3\u91ca\u7684\u4e25\u91cd\u7684\u3001\u65e0\u6cd5\u63a7\u5236\u7684\u4f34\u968f\u75be\u75c5\uff0c\u5305\u62ec\u6d3b\u52a8\u6027\u673a\u4f1a\u6027\u611f\u67d3\u6216\u8fdb\u5c55\u671f<\/span>(<\/span>\u4e25\u91cd<\/span>)<\/span>\u611f\u67d3\u3001\u4e0d\u80fd\u63a7\u5236\u7684\u7cd6\u5c3f\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\uff1b<\/span><\/span><\/p>\n

            9  <\/span>\u6cbb\u7597\u5f00\u59cb\u524d<\/span>4<\/span>\u5468\u5185\u63a5\u53d7\u6d3b\u75ab\u82d7\u63a5\u79cd\uff1b<\/span><\/span><\/p>\n

            10  <\/span>\u65e2\u5f80\u63a5\u53d7\u8fc7\u5f02\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6216\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\uff1b<\/span><\/span><\/p>\n

            11  <\/span>\u5177\u6709\u7cbe\u795e\u7c7b\u836f\u7269\u6ee5\u7528\u53f2\u4e14\u65e0\u6cd5\u6212\u9664\u8005\u6216\u6709\u7cbe\u795e\u969c\u788d\u53f2\u8005\uff1b<\/span><\/span><\/p>\n

            12  <\/span>\u65e2\u5f80<\/span>5<\/span>\u5e74\u5185\u6709\u5176\u5b83\u6076\u6027\u80bf\u7624\u75c5\u53f2\uff1b<\/span><\/span><\/p>\n

            13  <\/span>\u6839\u636e\u7814\u7a76\u8005\u7684\u89c2\u70b9\uff0c\u53ef\u80fd\u4f1a\u589e\u52a0\u53c2\u52a0\u7814\u7a76\u76f8\u5173\u7684\u98ce\u9669\u3001\u6216\u8005\u53ef\u80fd\u5e72\u6270\u7814\u7a76\u7ed3\u679c\u7684\u89e3\u91ca\u7684\u5176\u5b83\u91cd\u5ea6\u3001\u6025\u6027\u6216\u6162\u6027\u533b\u5b66\u75be\u75c5\u6216\u7cbe\u795e\u75be\u75c5\u6216\u5b9e\u9a8c\u5ba4\u5f02\u5e38\u3002<\/span><\/span><\/p>\n

             <\/span><\/p>\n

              \n
            1. \n

              6.       <\/span><\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n\n\n\n\n\n
              \n

              \u59d3\u540d <\/span><\/p>\n<\/td>\n

              		\n

              \u6c88\u7433\uff0c\u533b\u5b66\u7855\u58eb <\/span><\/p>\n<\/td>\n

              		\n

              \u804c\u79f0 <\/span><\/p>\n<\/td>\n

              		\n

              \u4e3b\u4efb\u533b\u5e08 <\/span><\/p>\n<\/td>\n<\/tr>\n

              \n

              \u90ae\u653f\u5730\u5740 <\/span><\/p>\n<\/td>\n

              		\n

              \u4e2d\u56fd\u5317\u4eac\u6d77\u6dc0\u533a\u961c\u6210\u8def52\u53f7 <\/span><\/p>\n<\/td>\n

              		\n

              \u90ae\u7f16 <\/span><\/p>\n<\/td>\n

              		\n

              1000022 <\/span><\/p>\n<\/td>\n<\/tr>\n

              \n

              \u5355\u4f4d\u540d\u79f0 <\/span><\/p>\n<\/td>\n

              		\n

              \u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

               <\/span><\/p>\n

              \u672c\u8bd5\u9a8c\u4fe1\u606f\u6765\u81ea<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\u3002<\/span><\/span><\/p>\n

              \u6b22\u8fce\u7533\u529e\u65b9\/CRO\/\u533b\u9662\u63d0\u4f9b\u80bf\u7624\u62db\u52df\u4fe1\u606f\uff0c\u53ef\u4ee5\u53d1\u90ae\u4ef6\u81f3LCSYZMXX@163.com\uff0c\u672c\u516c\u4f17\u53f7\u514d\u8d39\u63a8\u9001\u3002<\/span><\/p>\n

              \n


              <\/p>\n

              \n

              \u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u4fe1\u606f <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

              1.       \u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb LZM009\u662f\u4e3d\u73e0 […]<\/p>\n","protected":false},"author":1,"featured_media":9514,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9513"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=9513"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9513\/revisions"}],"predecessor-version":[{"id":9515,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/9513\/revisions\/9515"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/9514"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=9513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=9513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=9513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}