{"id":9516,"date":"2018-06-11T01:00:00","date_gmt":"2018-07-27T09:39:17","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e9%9a%8f%e6%9c%ba%e5%8f%8c%e7%9b%b2%e5%b9%b3%e8%a1%8c%e5%af%b9%e7%85%a7%e5%9c%a8%e6%97%a2%e5%be%80%e7%bb%8f%e8%bf%87%e6%b2%bb%e7%96%97%e6%99%9a\/"},"modified":"2018-07-27T17:39:18","modified_gmt":"2018-07-27T09:39:18","slug":"%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e9%9a%8f%e6%9c%ba%e5%8f%8c%e7%9b%b2%e5%b9%b3%e8%a1%8c%e5%af%b9%e7%85%a7%e5%9c%a8%e6%97%a2%e5%be%80%e7%bb%8f%e8%bf%87%e6%b2%bb%e7%96%97%e6%99%9a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/9516\/","title":{"rendered":"\u3010\u62db\u52df\u60a3\u8005\u3011\u968f\u673a\u53cc\u76f2\u5e73\u884c\u5bf9\u7167\u5728\u65e2\u5f80\u7ecf\u8fc7\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\u4e2d\u8bc4\u4ef7\u4e19\u6c28\u9178\u5e03\u7acb\u5c3c\u5e03\u6709\u6548\u6027\u5b89\u5168\u6027"},"content":{"rendered":"
\n

1.       <\/span><\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/span><\/p>\n

\u4e19\u6c28\u9178\u5e03\u7acb\u5c3c\u5e03\u662f<\/span>\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53<\/span>VEGFR<\/span>\u548c\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53<\/span>FGFR<\/span>\u7684\u5c0f\u5206\u5b50\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242<\/span>\u3002<\/span><\/p>\n

\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f<\/span>\u65e2\u5f80\u7ecf\u8fc7\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u3002<\/span><\/span><\/span><\/p>\n

 <\/span><\/p>\n

2.       <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u672c\u4e34\u5e8a\u7814\u7a76\u4e3a\u591a\u4e2d\u5fc3\u3001\u968f\u673a\uff08<\/span>2:1<\/span>\uff09\u3001\u5e73\u884c\u5bf9\u7167\u3001\u53cc\u76f2\u3001<\/span>III<\/span>\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u76ee\u7684\u662f\u8bc4\u4ef7\u4e19\u6c28\u9178\u5e03\u7acb\u5c3c\u5e03\u52a0\u6700\u4f73\u652f\u6301\u6cbb\u7597\uff08<\/span>BSC<\/span>\uff09\u5bf9\u6bd4\u5b89\u6170\u5242\u52a0\u6700\u4f73\u652f\u6301\u6cbb\u7597\uff08<\/span>BSC<\/span>\uff09\u6cbb\u7597\u665a\u671f<\/span>HCC<\/span>\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

 \u8bd5\u9a8c\u5206\u7c7b\uff1a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span><\/p>\n

  <\/span>\u8bd5\u9a8c\u5206\u671f\uff1a<\/span> III<\/span>\u671f<\/span><\/span><\/p>\n

  <\/span>\u8bbe\u8ba1\u7c7b\u578b\uff1a\u5e73\u884c\u5206\u7ec4<\/span><\/span><\/p>\n

  <\/span>\u968f\u673a\u5316\uff1a<\/span>   <\/span>\u968f\u673a\u5316<\/span><\/span><\/p>\n

  <\/span>\u76f2\u6cd5\uff1a<\/span>       <\/span>\u53cc\u76f2<\/span><\/span><\/p>\n

  <\/span>\u8bd5\u9a8c\u8303\u56f4\uff1a\u56fd\u5185\u8bd5\u9a8c<\/span> <\/span><\/span><\/p>\n

  <\/span>\u8bd5\u9a8c\u4eba\u6570\uff1a<\/span> 348<\/span><\/span>\u4eba<\/span><\/span><\/p>\n

 <\/span><\/p>\n

4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u81ea\u613f\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff1b<\/span><\/span><\/p>\n

2  18-75<\/span>\u5c81\uff0c\u6027\u522b\u4e0d\u9650<\/span><\/span><\/p>\n

3  <\/span>\u7ecf\u75c5\u7406\u7ec4\u7ec7<\/span>\/<\/span>\u7ec6\u80de\u5b66\u6216\u4e34\u5e8a\u8bca\u65ad\u786e\u8bca\u7684\u665a\u671f<\/span>HCC<\/span>\u60a3\u8005<\/span><\/span><\/p>\n

4  <\/span>\u5df4\u585e\u7f57\u90a3\u809d\u764c\u4e34\u5e8a\u5206\u671f\uff08<\/span>BCLC<\/span>\uff09<\/span>C<\/span>\u671f\u6216<\/span>B<\/span>\u671f\uff0c\u4e0d\u9002\u5408\u63a5\u53d7\u5c40\u90e8\u6cbb\u7597\u6216\u5c40\u90e8\u6cbb\u7597\u5931\u8d25<\/span><\/span><\/p>\n

5  <\/span>\u6839\u636e<\/span>RECIST v1.1<\/span>\u6807\u51c6\u8bc1\u5b9e\u5177\u6709\u81f3\u5c11\u6709\u4e00\u4e2a\u53ef\u6d4b\u91cf\u75c5\u7076\u3002\u4f4d\u4e8e\u65e2\u5f80\u653e\u7597\u7167\u5c04\u91ce\u5185\u6216\u5c40\u90e8\u6cbb\u7597\u533a\u57df\u5185\u7684\u9776\u75c5\u7076\u5982\u679c\u8bc1\u5b9e\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\uff0c\u5219\u8ba4\u4e3a\u5176\u4e3a\u53ef\u6d4b\u91cf\u75c5\u7076<\/span><\/span><\/p>\n

6  <\/span>\u6709\u660e\u786e\u75c5\u5386\u6216\u8bc1\u636e\u8bb0\u5f55\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u79cd\u7cfb\u7edf\u5316\u7597\uff08\u5355\u836f\u6216\u8054\u5408\u7528\u836f\u7684\u5168\u8eab\u5316\u7597\uff09\u548c<\/span>\/<\/span>\u6216\u4e00\u79cd\u5206\u5b50\u9776\u5411\u836f\u7269\u6cbb\u7597\u5931\u8d25\u6216\u4e0d\u8010\u53d7\u7684\u665a\u671f<\/span>HCC<\/span>\u60a3\u8005<\/span><\/span><\/p>\n

7  <\/span>\u524d\u4e00\u6b21\u6297\u80bf\u7624\u6cbb\u7597\u7ed3\u675f\u8ddd\u5f00\u59cb\u672c\u7814\u7a76\u7528\u836f\u2265<\/span>2<\/span>\u5468\uff0c\u4e14\u65e2\u5f80\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u6062\u590d\u81f3<\/span>NCI CTC AE<\/span>\u2264<\/span>1<\/span>\u7ea7<\/span><\/span><\/p>\n

8  <\/span>\u809d\u529f\u80fd\u72b6\u6001<\/span>Child-Pugh A<\/span>\u7ea7\u6216\u8bc4\u5206\u2264<\/span>7<\/span>\u5206\u7684<\/span>B<\/span>\u7ea7<\/span><\/span><\/p>\n

9  ECOG<\/span>\u4f53\u529b\u72b6\u6001\u8bc4\u5206\u4e3a<\/span>0<\/span>\u6216<\/span>1 <\/span><\/span><\/p>\n

10  <\/span>\u9884\u671f\u751f\u5b58\u65f6\u95f4\u2265<\/span>12<\/span>\u5468<\/span><\/span><\/p>\n

11  <\/span>\u5b9e\u9a8c\u5ba4\u68c0\u67e5<\/span> <\/span><\/span><\/p>\n


<\/p>\n

5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u5df2\u77e5\u809d\u7ea4\u7ef4\u677f\u5c42\u764c\u3001\u6df7\u5408\u578b\u809d\u7ec6\u80de\u764c\u3001\u80c6\u7ba1\u7ec6\u80de\u764c\u60a3\u8005<\/span><\/span><\/p>\n

2  <\/span>\u7b5b\u9009\u671f\u5934\u90e8<\/span>MRI<\/span>\u68c0\u67e5\u8bc1\u5b9e\u6709\u8111\u8f6c\u79fb\u7684\u60a3\u8005<\/span><\/span><\/p>\n

3  <\/span>\u5408\u5e76\u95e8\u9759\u8109\u4e3b\u5e72\u764c\u6813\u5835\u585e\u2265<\/span>50%<\/span>\uff0c\u6216\u4e0b\u80a2\u9759\u8109\u764c\u6813<\/span><\/span><\/p>\n

4  <\/span>\u9996\u6b21\u7ed9\u836f\u524d<\/span>5<\/span>\u5e74\u5185\u8bca\u65ad\u4e3a\u5176\u4ed6\u6076\u6027\u80bf\u7624\uff0c\u9664\u5916\u7ecf\u8fc7\u6839\u6cbb\u7684\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\u3001\u76ae\u80a4\u9cde\u72b6\u7ec6\u80de\u764c\u548c<\/span>\/<\/span>\u6216\u7ecf\u8fc7\u6839\u6cbb\u5207\u9664\u7684\u539f\u4f4d\u764c<\/span><\/span><\/p>\n

5  <\/span>\u5728\u672c\u7814\u7a76\u6cbb\u7597\u9996\u6b21\u7ed9\u836f\u524d<\/span>2<\/span>\u5468\u5185\u63a5\u53d7\u8fc7\u53e3\u670d\u6216\u9759\u8109\u7ed9\u4e88\u7684\u6709\u809d\u764c\u9002\u5e94\u75c7\u7684\u4e2d\u836f\u5236\u5242\u6216\u4e2d\u6210\u836f<\/span><\/span><\/p>\n

6  <\/span>\u5728\u9996\u6b21\u7ed9\u836f\u524d<\/span>4<\/span>\u5468\u5185\u63a5\u53d7\u8fc7\u809d\u810f\u6216\u8005\u5176\u5b83\u90e8\u4f4d\u7684\u5c40\u90e8\u6cbb\u7597\uff08\u5305\u62ec\u7ecf\u5bfc\u7ba1\u809d\u52a8\u8109\u5316\u7597\u6813\u585e<\/span>[TACE]<\/span>\u3001\u7ecf\u5bfc\u7ba1\u809d\u52a8\u8109\u6813\u585e<\/span>[TAE]<\/span>\u3001\u809d\u52a8\u8109\u704c\u6ce8<\/span>[HAI]<\/span>\u3001\u5c40\u90e8\u653e\u7597\u3001\u653e\u5c04\u6027\u6813\u585e\u3001\u5c04\u9891\u6d88\u878d\u3001\u51b7\u51bb\u6d88\u878d\u6216\u7ecf\u76ae\u4e59\u9187\u6ce8\u5c04\u7b49\uff09\uff1b\u5728\u9996\u6b21\u7ed9\u836f\u524d<\/span>4<\/span>\u5468\u5185\u8fdb\u884c\u8fc7\u809d\u810f\u6216\u5176\u4ed6\u90e8\u4f4d\u7684\u5927\u624b\u672f\uff1b\u5728\u9996\u6b21\u7ed9\u836f\u524d<\/span>1<\/span>\u5468\u5185\u63a5\u53d7\u5c0f\u624b\u672f\u64cd\u4f5c\uff08\u5982\u5355\u7eaf\u5207\u9664\u672f\u3001\u62d4\u7259\u7b49\uff09<\/span><\/span><\/p>\n

7  <\/span>\u4e2d\u5ea6\u6216\u91cd\u5ea6\u7684\u8179\u6c34\uff08\u9700\u5728\u968f\u673a\u524d<\/span>1<\/span>\u5468\u5185\u7ecf<\/span>B<\/span>\u8d85\u68c0\u67e5\u6216<\/span>CT<\/span>\u626b\u63cf\u786e\u8ba4\uff09\uff0c\u6216\u9700\u8981\u6cbb\u7597\u6027\u7684\u8179\u8154\u7a7f\u523a\u6216\u5f15\u6d41<\/span><\/span><\/p>\n

8  <\/span>\u7b5b\u9009\u671f<\/span>6<\/span>\u4e2a\u6708\u5185\u53d1\u751f\u8fc7\u7ecf\u4e34\u5e8a\u8bca\u65ad\u7684\u809d\u6027\u8111\u75c5\uff0c\u91c7\u7528\u5229\u798f\u6614\u660e\u6216\u4e73\u679c\u7cd6\u63a7\u5236\u7684\u809d\u6027\u8111\u75c5\u60a3\u8005\u4e0d\u5141\u8bb8\u5165\u7ec4<\/span><\/span><\/p>\n

9  <\/span>\u6709\u51fa\u8840\u503e\u5411\u548c\u8840\u6813\u53f2<\/span><\/span><\/p>\n

10  <\/span>\u4e25\u91cd\u5fc3\u8840\u7ba1\u75c5\u53f2<\/span><\/span><\/p>\n

11  <\/span>\u65e0\u6cd5\u63a7\u5236\u7684\u6d3b\u52a8\u6027\u611f\u67d3\uff08<\/span>CTCAE <\/span>\u2265<\/span>2<\/span>\u7ea7\uff09<\/span><\/span><\/p>\n

12  HBV<\/span>\u68c0\u6d4b\u663e\u793a<\/span>HBsAg<\/span>\u9633\u6027\u6216<\/span>HbcAb<\/span>\u9633\u6027\uff0c\u4e14<\/span>HBV-DNA<\/span>\u2265<\/span>104 <\/span>\u62f7\u8d1d\u6570<\/span>\/ml<\/span>\u6216\u2265<\/span>2000 IU\/ml<\/span>\uff08\u7ecf\u6807\u51c6\u6297\u75c5\u6bd2\u6cbb\u7597<\/span>2<\/span>\u5468\u540e<\/span>HBV-DNA<\/span>\u4e0d\u53ef\u6d4b\u7684\u60a3\u8005\u53ef\u4ee5\u5165\u7ec4\uff09<\/span><\/span><\/p>\n

13  <\/span>\u5176\u4ed6\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u5f02\u5e38<\/span><\/span><\/p>\n

14  <\/span>\u598a\u5a20\u6216\u54fa\u4e73\u671f\u5987\u5973\uff1b\u80b2\u9f84\u671f\u5973\u6027\u6216\u7537\u6027\u5728\u7814\u7a76\u671f\u95f4\u65e0\u907f\u5b55\u610f\u613f\u6216\u65e0\u907f\u5b55\u63aa\u65bd<\/span><\/span><\/p>\n

15  <\/span>\u9ad8\u654f\u4f53\u8d28\uff0c\u53ef\u80fd\u5bf9\u8bd5\u9a8c\u836f\u7269\u4e19\u6c28\u9178\u5e03\u7acb\u5c3c\u5e03\u4ea7\u751f\u4e25\u91cd\u8fc7\u654f\u53cd\u5e94\u7684\u60a3\u8005<\/span><\/span><\/p>\n

16  <\/span>\u5728\u9996\u6b21\u670d\u836f\u524d<\/span>4<\/span>\u5468\u5185\u63a5\u53d7\u8fc7\u4efb\u4f55\u5728\u4e2d\u56fd\u672a\u4e0a\u5e02\u7684\u8bd5\u9a8c\u6027\u836f\u7269<\/span><\/span><\/p>\n

17  <\/span>\u7ecf\u7814\u7a76\u8005\u5224\u65ad\u8ba4\u4e3a\u4e0d\u9002\u5408\u53c2\u4e0e\u672c\u8bd5\u9a8c<\/span> <\/span><\/span><\/p>\n

 <\/span><\/p>\n

6.       <\/span><\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n\n\n\n\n\n
\n

\u59d3\u540d <\/span><\/p>\n<\/td>\n

\n

\u79e6\u53d4\u9035 <\/span><\/p>\n<\/td>\n

\n

\u804c\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u4efb\u533b\u5e08 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u90ae\u653f\u5730\u5740 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u6c5f\u82cf\u7701\u5357\u4eac\u5e02\u6768\u516c\u4e9534\u680734\u53f7  <\/span><\/p>\n<\/td>\n

\n

\u90ae\u7f16 <\/span><\/p>\n<\/td>\n

\n

210002 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5355\u4f4d\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u4eba\u6c11\u89e3\u653e\u519b\u7b2c\u516b\u4e00\u533b\u9662 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n

\u672c\u8bd5\u9a8c\u4fe1\u606f\u6765\u81ea<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\u3002<\/span><\/span><\/p>\n

\u6b22\u8fce\u7533\u529e\u65b9\/CRO\/\u533b\u9662\u63d0\u4f9b\u80bf\u7624\u62db\u52df\u4fe1\u606f\uff0c\u53ef\u4ee5\u53d1\u90ae\u4ef6\u81f3LCSYZMXX@163.com\uff0c\u672c\u516c\u4f17\u53f7\u514d\u8d39\u63a8\u9001\u3002<\/span><\/p>\n


<\/p>\n


<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u4fe1\u606f <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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